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La Medicina Del Lavoro Dec 2019.
UNLABELLED
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BACKGROUND:
The Clinica del Lavoro of Milan provided several contributions to industrial hygiene and occupational toxicology during the twentieth century.
OBJECTIVES:
Describe the first years of the laboratory of industrial hygiene of Milan through three figures who played a leading role: Enrico Carlo Vigliani, Nicola Zurlo and Gianmario Cavagna.
METHODS:
Scientific literature of the period 1948-1970 was investigated, also interviewing first-hand witnesses of that period.
RESULTS:
Enrico Vigliani was the first European scholar to understand the importance of a laboratory of industrial hygiene within his institution. Thanks to the support of private (Montecatini) and public (INAIL) institutions he succeeded in creating a laboratory in 1948. Nicola Zurlo, who directed this structure in the first thirty years, conducted innovative studies on chronic mercury intoxication, lead intoxication and silicosis, designing and creating instruments for capturing and analyzing atmospheric dust and protection devices. He conducted analysis of the health effects of organophosphorus insecticides and started to study the air pollution. Zurlo also provided an epistemological and methodological content to the discipline. Gianmario Cavagna, one of the first Italian toxicologists, contributed to the discovery of the origin of fevers caused by the inhalation of metal fumes and to the studies on the pathogenesis of byssinosis, hypothesizing a role of bacterial endotoxins in the genesis of this disease.
CONCLUSIONS:
The contributions provided by these three protagonists to industrial hygiene and occupational toxicology were relevant and made in those years the Clinica del Lavoro of Milan as a landmark, not only in Italy but also abroad.
Topics: History, 20th Century; Humans; Italy; Laboratories; Lead Poisoning; Occupational Health; Occupational Medicine
PubMed: 31846445
DOI: 10.23749/mdl.v110iS1.8875 -
Inquiry : a Journal of Medical Care... 2022Workers in the textile industry risk developing various respiratory and pulmonary diseases due to exposure to cotton dust. The particles from the cotton lint are inhaled...
BACKGROUND
Workers in the textile industry risk developing various respiratory and pulmonary diseases due to exposure to cotton dust. The particles from the cotton lint are inhaled by the workers and results in the breathing problems including asthma, shortness of breath, cough and tightness in the chest. The poor health of labor contributes to the low productivity of the labor and in serious cases loss of jobs leading to the poverty.
OBJECTIVE
To assess the prevalence of respiratory symptoms among the textile workers and associated community. To contrast the health profiles of the textile workers, associated community and the control group to factor out any confounding factors.
METHODS
This study explores the health profiles of the textile workers and associated community and contrast them against the health profile of the control group to factor out any confounding factors. The study is conducted on cotton industry in Kasur, Pakistan. We interviewed 207 workers, 226 people from associated community (living in vicinities of weaving units) and 188 people for control group (from areas far away from weaving units and people are not associated with weaving industry) based on stratified random sampling technique. We employed descriptive methods and logistic regression to explore the association between respiratory diseases and weaving workers.
RESULTS
Overall, prevalence of postnasal drip, byssinosis, asthma, and chronic bronchitis were 47%, 35%, 20%, and 10%, respectively, among the workers. These percentages are significantly higher than the control group. An additional year of work increase the risk of postnasal drip, byssinosis, asthma, and chronic bronchitis by 5-6%. Among workers, 43% and 21% feel difficulty in hearing against noisy background and at low volume, respectively. Due to bad light arrangements at workstations, 21% and 31% workers are suffering from myopia and hyperopia, respectively. Proportions of the workers suffering from continuous headache, skin infection, depression, and low back pain are 28%, 29%, 27%, and 44%, respectively. Chi-square test results confirms that no confounding factor like air pollution is involved in this cause-and-effect study implying the association between the cotton dust and associated diseases is not spurious.
CONCLUSION
Respiratory symptoms were statistically significantly more common in the weaving workers compared to control group. Better environment at workstations, use of protective gears and education are the factors which reduce the risk of associated diseases among workers.
Topics: Asthma; Bronchitis, Chronic; Byssinosis; Cotton Fiber; Dust; Humans; Occupational Exposure; Textiles
PubMed: 35604168
DOI: 10.1177/00469580221088626 -
Annals of Agricultural and... Dec 2020The occupational bioaerosols containing viruses, bacteria, fungi, microbial toxins and plant or animal particles, may evoke infectious, allergic or immunotoxic diseases... (Review)
Review
COVID 19 - Possible interrelations with respiratory comorbidities caused by occupational exposure to various hazardous bioaerosols. Part I. Occurrence, epidemiology and presumed origin of the pandemic.
The occupational bioaerosols containing viruses, bacteria, fungi, microbial toxins and plant or animal particles, may evoke infectious, allergic or immunotoxic diseases which may co-exist as comorbidities with COVID-19 and exacerbate the course of disease. They include hypersensitivity pneumonitis (HP) caused mostly by bacteria, fungi, and particles containing animal proteins, and immunotoxic diseases such as organic dust toxic syndrome (ODTS) and byssinosis, caused mostly by bacterial and fungal toxins. The two most probable scenarios of possible interrelations between these three comorbidities (CM) and COVID-19 are: 1) 'Triggering' - when infection with SARS-CoV-2 triggers severe CM after bioaerosol exposure; 2) 'Reverse triggering' when exposure to bioaerosol exacerbates a symptomless or mild course of COVID-19, and evokes a severe disease. The occupations mostly endangered by COVID-19 as the result of exposure to SARS-CoV-2 bioaerosol, or to other bioaerosols which may exacerbate this disease, include: health care workers, social workers, breeders of fur animals, slaughterhouse workers, workers engaged in the processing and selling of seafood, and probably also agricultural workers, mainly in the developing countries. The authors present a hypothesis for the origin of the present pandemic. It assumes that a mild form of the present SARS-CoV-2 that is supposedly circulating among the Chinese population in the eastern part of the country, mutated under the influence of as yet unknown factor(s) present in the Chinese seafood markets, probably component(s) of bioaerosols, into the virulent and highly contagious form, known as the present SARS-CoV-2, under a scenario similar to that the authors have named 'Reverse triggering'.
Topics: Aerosols; Alveolitis, Extrinsic Allergic; Animals; Byssinosis; COVID-19; Comorbidity; Food-Processing Industry; Hazardous Substances; Health Personnel; Humans; Occupational Exposure; SARS-CoV-2
PubMed: 33356052
DOI: 10.26444/aaem/130871 -
Journal of Ayub Medical College,... 2023Cotton dust is generated during various textile manufacturing processes. Only a few studies from Pakistan assessed cotton dust exposure and explored the relationship of...
BACKGROUND
Cotton dust is generated during various textile manufacturing processes. Only a few studies from Pakistan assessed cotton dust exposure and explored the relationship of duration of work in the textile industry with respiratory health outcomes. We aimed to assess cotton dust exposure and its association with lung function and respiratory symptoms among textile workers in Pakistan.
METHODS
We report findings from the baseline survey of the larger study, MultiTex, among 498 adult male textile workers from six mills conducted between October 2015-March 2016 in Karachi, Pakistan. Data collection included the use of standardized questionnaires; spirometry, and area dust measurements through UCB-PATS. Multivariable logistic and linear regression models were developed to assess the association of risk factors with respiratory symptoms and illnesses.
RESULTS
We found the mean age of workers to be 32.5 (±10) years; around 25% were illiterate. The prevalence of COPD, asthma, and byssinosis was 10%, 17%, and 2%, respectively. The median cotton dust exposure was 0.33 mg/m3 (IQR: 0.12-0.76). Increased duration of work among non-smokers was associated with a decline in lung function, FVC (-245 ml; 95% CI: -385.71, -104.89) and FEV1 (-200 ml; 95% CI: -328.71, -841.1). Workers with certain job titles (machine operators, helpers, and jobbers), those with greater duration of work, and higher dust exposure, were more likely to report respiratory symptoms and illnesses.
CONCLUSIONS
We report a high prevalence of asthma and COPD and a low prevalence of byssinosis. Cotton dust exposure and duration of employment were associated with respiratory health outcomes. Our findings highlight the need for preventive interventions in the textile industry in Pakistan.
Topics: Adult; Male; Humans; Young Adult; Dust; Byssinosis; Textiles; Asthma; Outcome Assessment, Health Care; Pulmonary Disease, Chronic Obstructive
PubMed: 36849387
DOI: 10.55519/JAMC-01-10901 -
Occupational and Environmental Medicine Mar 2023To assess the association of exposure in cotton mills in Karachi with different definitions of byssinosis and lung health.
OBJECTIVES
To assess the association of exposure in cotton mills in Karachi with different definitions of byssinosis and lung health.
METHODS
This cross-sectional survey took place between June 2019 and October 2020 among 2031 workers across 38 spinning and weaving mills in Karachi. Data collection involved questionnaire-based interviews, spirometry and measurements of personal exposure to inhalable dust. Byssinosis was defined using both WHO symptoms-based (work-related chest tightness), and Schilling's criteria (symptoms with decreased forced expiratory volume in 1 s (FEV). Values of FEV/forced vital capacity ratio below the lower limit of normality on postbronchodilator test were considered as 'chronic airflow obstruction' (CAO).
RESULTS
56% of participants had at least one respiratory symptom, while 43% had shortness of breath (grade 1). Prevalence of byssinosis according to WHO criteria was 3%, it was 4% according to Schilling's criteria, and likewise for CAO. We found low inhalable dust exposures (geometric mean: 610 µg/m). Cigarette smoking (≥3.5 pack-years), increasing duration of employment in the textile industry and work in the spinning section were important factors found to be associated with several respiratory outcomes.
CONCLUSION
We found a high prevalence of respiratory symptoms but a low prevalence of byssinosis. Most respiratory outcomes were associated with duration of employment in textile industry. We have discussed the challenges faced in using current, standard guidelines for identifying byssinosis.
Topics: Humans; Byssinosis; Pakistan; Cross-Sectional Studies; Occupational Exposure; Lung; Dust; Textiles; Pulmonary Disease, Chronic Obstructive; Textile Industry
PubMed: 36717255
DOI: 10.1136/oemed-2022-108533 -
Food and Chemical Toxicology : An... May 2023Metal fume fever is a well-known occupational disease that arises from prolonged exposure to subtoxic levels of zinc oxide-containing fumes or dust. This review article... (Review)
Review
Metal fume fever is a well-known occupational disease that arises from prolonged exposure to subtoxic levels of zinc oxide-containing fumes or dust. This review article aims to identify and examine the possible immunotoxicological effects of inhaled zinc oxide nanoparticles. The current most widely accepted pathomechanism for the development of the disease involves the formation of reactive oxygen species following the entry of zinc oxide particles into the alveolus resulting the release of pro-inflammatory cytokines by activation of the Nuclear Factor Kappa B transcriptional signal, thus evoking the symptoms. The role of metallothionein in inducing tolerance is believed to be a key factor in mitigating the development of metal fume fever. The other, poorly proven hypothetical route is that zinc-oxide particles bind to an undefined protein in the body as haptens to form an antigen and act as an allergen. After activation of the immune system, primary antibodies and immune complexes are developed and type 1. hypersensitivity reaction occurs, that can cause asthmatic dyspnoea, urticaria and angioedema. The development of tolerance is explained by the formation of secondary antibodies against primary antibodies. Oxidative stress and immunological processes cannot be completely separated from each other, as they can induce each other.
Topics: Humans; Zinc Oxide; Welding; Lung; Byssinosis; Inhalation Exposure; Air Pollutants, Occupational
PubMed: 36907501
DOI: 10.1016/j.fct.2023.113722 -
Journal of Public Health in Africa Oct 2023Occupational exposure to cotton dust is still an important cause of respiratory problems in textile workers particularly in less developed countries like Egypt. Evaluate...
Occupational exposure to cotton dust is still an important cause of respiratory problems in textile workers particularly in less developed countries like Egypt. Evaluate respiratory symptoms and diseases, and pulmonary function pattern among Egyptian textile workers. Cross sectional comparative study was conducted from December 2019 to September 2020 in a textile factory in Egypt; 364 male workers (184 cotton dust exposed workers, and 180 unexposed workers) were included. Participants were subjected to an interviewing questionnaire, British Medical Research Council questionnaire, anthropometric measurements, pulmonary function tests, and byssinosis grading format. Descriptive and analytic statistics were conducted. Chronic cough, phlegm production, and shortness of breath grade I, II and III were more reported in cotton dust exposed workers than unexposed workers (P#x003C;0.01, P#x003C;0.01, and P=0.02, respectively). Prevalence of chronic bronchitis was significantly higher among cotton dust exposed workers (12%) than unexposed workers (3.9%) (P#x003C;0.01). The mean percent predicted values of lung function indices reflecting large-1irway function (VC, FVC, FEV, FEV%, PEFR, and FEF) were significantly lower in cotton dust exposed workers (P#x003C;0.01). Prevalence of byssinosis was 22.8%. Workers with byssinosis had significantly higher prevalence of respiratory symptoms, chronic bronchitis, cross-shift reduction in PEFR and significant decrease in mean percent predicted values of FVC, FEV, PEFR, FEF, and FEF than workers without byssinosis. This study revealed a substantial association between cotton dust exposure at work and respiratory symptoms and morbidity. Regular measurement of cross shift change in PEFR is recommended among exposed workers for early diagnosis of byssinosis.
PubMed: 38020280
DOI: 10.4081/jphia.2023.2741 -
Eastern Mediterranean Health Journal =... Feb 2022In India, around 20 million workers are engaged in the textile industries. However, the prevalence of byssinosis has been little reported.
BACKGROUND
In India, around 20 million workers are engaged in the textile industries. However, the prevalence of byssinosis has been little reported.
AIMS
To determine the prevalence of byssinosis and other respiratory disorders among workers exposed to cotton dust in textile mills in Delhi, India.
METHODS
Sputum samples were collected from 156 workers employed in 15 cotton textile mills, and expression of epithelial membrane antigen (EMA) and cytokeratin (CK) marker proteins was investigated. Information regarding respiratory symptoms, certain personal characteristics and occupational history was also gathered.
RESULTS
Symptoms were observed in 56.41% of the workers. Expression of EMA and CK was observed in 27.5% and 50% of the workers, respectively. Expression of EMA and CK was significantly associated with smoking and duration of employment.
CONCLUSION
Measures are needed to reduce dust levels in the workplace, and to discourage smoking and alcohol consumption among the textile workers.
Topics: Cotton Fiber; Dust; Humans; Keratins; Mucin-1; Occupational Exposure; Textile Industry
PubMed: 35304912
DOI: 10.26719/emhj.21.058 -
Advances in Respiratory Medicine 2021Cotton dust exposure has been implicated in causing diseases like byssinosis and obstructive airway diseases like COPD and asthma. Long-term exposure to cotton dust...
Cotton dust exposure has been implicated in causing diseases like byssinosis and obstructive airway diseases like COPD and asthma. Long-term exposure to cotton dust causing interstitial lung disease and pulmonary fibrosis has been sparsely reported in the literature. Here, we report a case of an individual with long-term cotton dust exposure who presented with typical symptoms of interstitial lung disease and was managed conservatively.
Topics: Air Pollutants, Occupational; Byssinosis; Dust; Humans; Male; Middle Aged; Occupational Exposure; Pulmonary Fibrosis; Respiratory Function Tests; Risk Factors
PubMed: 34269402
DOI: 10.5603/ARM.a2021.0068