-
Journal of Postgraduate Medicine 2023Drug-induced hemolytic anemia (DIHA) is a rare complication of drug therapy and usually underdiagnosed. Cefoperazone/sulbactam is a compound prepared from the third...
Drug-induced hemolytic anemia (DIHA) is a rare complication of drug therapy and usually underdiagnosed. Cefoperazone/sulbactam is a compound prepared from the third generation of cephalosporin and β-lactamase inhibitor. There are limited data of DIHA induced from cefoperazone/sulbactam. A 93-year-old female patient, who had an operation on the biliary tract 3 months ago, was admitted to our hospital with an abdominal infection. After cefoperazone/sulbactam was given as anti-infection treatment, the patient developed hemolytic anemia on the third day. Cefoperazone/sulbactam was discontinued and replaced with meropenem. Subsequently the level of red blood cells, hemoglobin, and hematocrit returned to normal. Clinicians should pay attention to monitoring the possible adverse reactions during the use of cefoperazone/sulbactam and should be aware of the occurrence of DIHA, so as to give timely treatment.
Topics: Female; Humans; Aged, 80 and over; Cefoperazone; Sulbactam; Anti-Bacterial Agents; Meropenem; Anemia, Hemolytic; Microbial Sensitivity Tests
PubMed: 34528516
DOI: 10.4103/jpgm.JPGM_1335_20 -
British Medical Journal Jun 1978
Topics: Amidohydrolases; Bacteria; Cefamandole; Cephalosporinase; Cephalosporins; Drug Information Services; Drug Stability
PubMed: 656791
DOI: 10.1136/bmj.1.6126.1548-a -
Antibiotics (Basel, Switzerland) Nov 2022Surgical site infections are among the most prevalent and costly healthcare-associated infections, resulting in poor patient outcomes and even death. Cefazolin is a...
Surgical site infections are among the most prevalent and costly healthcare-associated infections, resulting in poor patient outcomes and even death. Cefazolin is a first-generation cephalosporin antibiotic that is widely used for surgical prophylaxis in a variety of surgical disciplines. Although previous studies showed that cefazolin is effective in preventing surgical site infections, other agents, such as cefuroxime and ceftriaxone, were used excessively for surgical patients. The present analysis included only clinical trials comparing the efficacy of cefazolin to cefuroxime, ceftriaxone, and cefamandole in lowering SSIs using PubMed, Google Scholar, and ClinicalTrials.gov. Review Manager software (RevMan version 5.4) was used to conduct the meta-analyses. A total of 12,446 patients were included in the study. Among these patients, 6327 patients received cefazolin and 6119 patients received cefamandole, cefuroxime, or ceftriaxone. Our analysis showed that cefazolin is as effective as cefuroxime, cefamandole, and ceftriaxone in preventing surgical site infections. Hence, our findings have provided evidence for the use of cefazolin before surgeries because of its efficacy, as previous studies showed that it is inexpensive and safer than other agents.
PubMed: 36358198
DOI: 10.3390/antibiotics11111543 -
Journal of Postgraduate Medicine 2023
Topics: Humans; Cefoperazone; Anti-Bacterial Agents; Anemia, Hemolytic, Autoimmune
PubMed: 36571331
DOI: 10.4103/jpgm.jpgm_248_22 -
Journal of Postgraduate Medicine 2021Glyphosate is the most commonly used broad-spectrum, non-selective herbicide in the world. The toxicity is supposed to be due to uncoupling of oxidative phosphorylation...
Glyphosate is the most commonly used broad-spectrum, non-selective herbicide in the world. The toxicity is supposed to be due to uncoupling of oxidative phosphorylation and the surfactant polyoxyethylene amine (POEA)- mediated cardiotoxicity. Clinical features of this herbicide poisoning are varied, ranging from asymptomatic to even death. There is no antidote and aggressive supportive therapy is the mainstay of treatment for glyphosate poisoning. We present a 69-year-old female patient with suicidal consumption of around 500 ml of Glycel®. Initially, gastric lavage was done and intravenous fluids were given. Within two hours of presentation, the patient developed respiratory distress needing intubation, hypotension needing vasopressor support, and severe lactic acidosis. She also developed acute respiratory distress syndrome, hypokalemia, hypernatremia, and aspiration pneumonia. Our patient was critically ill with multiple poor prognostic factors, but with timely aggressive supportive management, the patient gradually recovered.
Topics: Aged; Cefamandole; Cefoperazone; Clindamycin; Dietary Supplements; Female; Glycine; Herbicides; Humans; Hypernatremia; Hypokalemia; Pneumonia, Aspiration; Potassium; Respiratory Distress Syndrome; Suicide, Attempted; Sulbactam; Treatment Outcome; Glyphosate
PubMed: 33533750
DOI: 10.4103/jpgm.JPGM_766_20 -
Zhejiang Da Xue Xue Bao. Yi Xue Ban =... Dec 2023A 82-year-old man was admitted to hospital with fever, unresponsiveness, elevated hypersensitive C-reactive protein and neutrophile granulocyte. Ceftriaxone was...
A 82-year-old man was admitted to hospital with fever, unresponsiveness, elevated hypersensitive C-reactive protein and neutrophile granulocyte. Ceftriaxone was administrated by intravenous dripping in the emergency room, but the effect was not satisfactory. Following his admission to the ward, cefoperazone sulbactam were given. was identified by blood culture and further confirmed by 16S rRNA sequencing. The lumbar puncture showed that cerebrospinal fluid pressure was 80 mmHO (1 mmHO=0.0098 kPa) and biochemical results were normal. After 11 days of cefoperazone sulbactam treatment, the patient was discharged with negative blood culture. The hypersensitive C-reactive protein and neutrophile granulocyte had also declined. The patient received levofloxacin tablets for anti-infection treatment for 14 d after discharge. No signs of infection were observed in three months' following up.
Topics: Male; Humans; Aged, 80 and over; C-Reactive Protein; Cefoperazone; Flavobacteriaceae Infections; RNA, Ribosomal, 16S; Sulbactam; Sepsis
PubMed: 38105675
DOI: 10.3724/zdxbyxb-2023-0427 -
Antimicrobial Agents and Chemotherapy May 1976The activity of cefamandole was comparable to that of cephalothin, cefazolin, and cephaloridine against Staphylococcus aureus, Streptococcus pyogenes, and Diplococcus...
The activity of cefamandole was comparable to that of cephalothin, cefazolin, and cephaloridine against Staphylococcus aureus, Streptococcus pyogenes, and Diplococcus pneumoniae. In contrast, cefamandole was considerably more active than cephalothin, cefazolin, or cephaloridine against gram-negative facultative bacilli, including Haemophilus influenzae, the most striking disparities being noted with indole-positive Proteus and Enterobacter. Bacteroides fragilis was more susceptible to cefoxitin than to cefamandole or cefazolin (median minimal inhibitory concentration, approximately 8, 32, and 32 mug/ml, respectively); cephalothin exhibited still less activity against this species. The majority of other anaerobes were inhibited by relatively low concentrations of all four cephalosporins. The results indicate a potentially valuable role for cefamandole against facultative gram-negative bacilli, including H. influenzae, but no exceptional activity against anaerobes.
Topics: Aerobiosis; Anaerobiosis; Bacteria; Cephalosporins; Gram-Negative Aerobic Bacteria; Gram-Negative Anaerobic Bacteria; Microbial Sensitivity Tests
PubMed: 949182
DOI: 10.1128/AAC.9.5.852 -
Computational and Mathematical Methods... 2022This study is aimed at obtaining information about the prevalence of nosocomial infections (NIs) and the use of antibiotics in hospitalized patients and providing...
OBJECTIVES
This study is aimed at obtaining information about the prevalence of nosocomial infections (NIs) and the use of antibiotics in hospitalized patients and providing relevant references for further understanding, preventing, and controlling NIs.
METHODS
The medical records of adult patients admitted to a hospital in Shanghai from November to December 2021 were analyzed. The patients were divided into the NI group, community-acquired infection (CAI) group, and uninfected or healed group according to their infection status. The survey results were summarized and analyzed.
RESULTS
A total of 1485 patients were investigated, including 115 patients in the NI group, 172 patients in the CAI group, and 1198 patients in the uninfected or healed group. In the NI group, the main infection site was intra-abdominal tissue (49.6%), followed by lower respiratory tract (unrelated to application of catheters) (13%). There were 73 pathogens detected in the samples submitted from the NI group, mainly including 8 cases (11%) of , 9 cases (12%) of , and 40 cases (55%) of negative microbiological test results. Thirteen of 115 patients with NIs had infections with drug-resistant bacteria, including 9 cases (69.2%) of CRE (), 2 cases (15.38%) of VRE (), 1 case (7.69%) of MRSA (), and 1 case (7.69%) of CRAB (). In terms of medication, single drug use accounted for the majority of the NI group (66.3%) and CAI group (60.6%); both groups had less frequent quadruple drugs. In the uninfected or healed group, single drug occupied 92.0%, and dual drug use accounted for 8.0%. Cefoperazone/sulbactam was the most commonly used antibacterial drug in the NI group (18.0%) and CAI group (17.6%), and piperacillin/tazobactam accounted for 14.0% and 17.6% in the two groups, respectively. In the uninfected or healed group, cefuroxime accounted for 59.8%, followed by cefoperazone/sulbactam (13.3%).
CONCLUSION
This study provides a scientific basis for effective control of NIs. Strict implementation of aseptic techniques, reduction of invasive operations, and rational use of anti-infective drugs can minimize the incidence of nosocomial infection to ultimately achieve effective prevention and control of NIs.
Topics: Adult; Anti-Bacterial Agents; Cefoperazone; China; Community-Acquired Infections; Cross Infection; Drug Resistance, Bacterial; Humans; Inpatients; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Retrospective Studies; Sulbactam; Tertiary Care Centers
PubMed: 35799633
DOI: 10.1155/2022/1157083 -
Clinical Microbiology and Infection :... Jan 2008Sulbactam irreversibly inhibits the hydrolytic activity of beta-lactamases. This compound is commercially available in combination with either ampicillin or... (Review)
Review
Sulbactam irreversibly inhibits the hydrolytic activity of beta-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against beta-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressures for extended-spectrum beta-lactamase-producing Enterobacteriaceae and vancomycin-resistant enterococci. In contrast to clavulanate, sulbactam does not induce class I (Ampc) chromosomal beta-lactamases in Enterobacteriaceae.
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cefoperazone; Drug Combinations; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Microbial Sensitivity Tests; Sulbactam; beta-Lactamase Inhibitors
PubMed: 18154545
DOI: 10.1111/j.1469-0691.2007.01847.x -
Antimicrobial Agents and Chemotherapy Jun 1976Cefoxitin and cefamandole were evaluated in vitro against 263 organisms. Studies were performed in Mueller-Hinton and nutrient broth and agar employing inoculum sizes of...
Cefoxitin and cefamandole were evaluated in vitro against 263 organisms. Studies were performed in Mueller-Hinton and nutrient broth and agar employing inoculum sizes of 10(6) and 10(8) organisms per ml. At obtainable serum levels both antibiotics were bactericidal for nearly all strains of Escherichia coli, Klebsiella, Proteus mirabilis, and Staphylococcus aureus but were inactive against Pseudomonas aeruginosa and enterococcus. In agar, cefamandole appeared to be active against most strains of Enterobacter and indole-positive Proteus, whereas cefoxitin was active against indole-positive Proteus but not Enterobacter. Moreover, in broth medium most strains of Enterobacter were not readily inhibited by either antibiotic and only 40 and 73% of indole-positive Proteus were inhibited by 10 mug of cefamandole per ml in Mueller-Hinton and nutrient broth, respectively. However, in both broth media, 10 mug of cefoxitin per ml continued to be inhibitory and bactericidal for most isolates of indole-positive Proteus. Cefoxitin also was bactericidal against four cephalothin-resistant strains of E. coli. These data suggest that cefoxitin broadens the spectrum of existing cephalosporins by enhancing the activity against indole-positive Proteus species as well as some other Enterobacteriaceae. On the other hand, with the exception of strains of Enterobacter aerogenes, the apparent increased in vitro activity of cefamandole was demonstrated in agar and not in broth.
Topics: Cefoxitin; Cephalosporins; Drug Resistance, Microbial; Enterobacteriaceae; Mandelic Acids; Microbial Sensitivity Tests; Pseudomonas aeruginosa
PubMed: 820241
DOI: 10.1128/AAC.9.6.1019