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BMC Cardiovascular Disorders Apr 2023Cerebrovascular disorders pose a global health concern. Advances in basic and clinical research, including induced pluripotent stem cell models and multi-omic...
Cerebrovascular disorders pose a global health concern. Advances in basic and clinical research, including induced pluripotent stem cell models and multi-omic approaches, have improved our understanding and management of these disorders. However, gaps in our knowledge remain. BMC Cardiovascular Disorders invites authors to submit articles investigating what drives and affects Cerebrovascular disorders to improve patient care.
Topics: Humans; Induced Pluripotent Stem Cells; Cerebrovascular Disorders; Cardiovascular Diseases
PubMed: 37118671
DOI: 10.1186/s12872-023-03225-8 -
Stroke Mar 2020
Topics: Cerebrovascular Disorders; Female; Humans; Incidence; Male; Prevalence; Risk Factors; Stroke
PubMed: 32078448
DOI: 10.1161/STROKEAHA.119.024159 -
Cerebrovascular Diseases (Basel,... 2021
Topics: Cerebrovascular Disorders; Endovascular Procedures; Humans; Immunosuppressive Agents; Mobile Health Units; Neurology; Thrombolytic Therapy
PubMed: 34350880
DOI: 10.1159/000518427 -
Cerebrovascular Diseases (Basel,... 2020
Topics: Biomedical Research; COVID-19; Cerebrovascular Disorders; Coronavirus Infections; Editorial Policies; Humans; Pandemics; Periodicals as Topic; Pneumonia, Viral
PubMed: 32866957
DOI: 10.1159/000510781 -
Stroke and Vascular Neurology Jun 2020Headache is a common accompanying symptom of cerebrovascular diseases. The most common patterns of headache for different cerebrovascular disorders, aetiology and... (Review)
Review
Headache is a common accompanying symptom of cerebrovascular diseases. The most common patterns of headache for different cerebrovascular disorders, aetiology and pathogenesis and diagnostic workup are reviewed with emphasis on distinguishing characteristics. It will be a clinical guide for physicians who treat patients with headache or cerebral vascular disease.
Topics: CADASIL; Cerebrovascular Circulation; Cerebrovascular Disorders; Headache; Hemodynamics; Humans; Intracranial Thrombosis; MELAS Syndrome; Prognosis; Risk Factors; Subarachnoid Hemorrhage; Vasculitis, Central Nervous System; Vasospasm, Intracranial; Vertebral Artery Dissection
PubMed: 32606088
DOI: 10.1136/svn-2020-000333 -
Frontiers in Endocrinology 2022Pituitary adenomas (PAs) have been shown to cause excess cardiovascular disease comorbidity and mortality. Cerebrovascular disease (CeVD) is a small subset of... (Review)
Review
Pituitary adenomas (PAs) have been shown to cause excess cardiovascular disease comorbidity and mortality. Cerebrovascular disease (CeVD) is a small subset of cardiovascular disease with high morbidity, and its risk in patients with pituitary adenomas has been sparingly explored. In this review, we examine what is known about the prevalence of cerebrovascular disease in patients with PAs, from its initial discovery in 1970 to present. An abundance of literature describes increased cerebrovascular mortality in patients with acromegaly, while research on other PA subtypes is less frequent but shows a similarly elevated CeVD mortality relative to healthy populations. We also review how cerebrovascular risk changes after PAs are treated, with PA treatment appearing to prevent further accumulation of cerebrovascular risk without reversing prior elevations. While acromegaly-associated CeVD appears to be caused by elevated growth hormone (GH) levels and Cushing disease's elevated glucocorticoids similarly cause durable alterations in cerebrovascular structure and function, less is known about the mechanisms behind CeVD in other PA subpopulations. Proposed pathophysiologies include growth hormone deficiency inducing vessel wall damage or other hormone deficits causing increased atherosclerotic disease. Early diagnosis and treatment of PAs may be the key to minimizing lifetime CeVD risk elevations. More research is needed to better understand the mechanisms behind the increased CeVD seen in patients with PAs. Physicians caring for PA patients must remain vigilant for signs and symptoms of cerebrovascular disease in this patient population.
Topics: Humans; Pituitary Neoplasms; Acromegaly; Prevalence; Cardiovascular Diseases; Adenoma; Growth Hormone; Cerebrovascular Disorders
PubMed: 36578965
DOI: 10.3389/fendo.2022.1064216 -
Cerebrovascular Diseases (Basel,... 2017
Topics: Biomedical Research; Cerebrovascular Disorders; Editorial Policies; Humans; Peer Review, Research; Periodicals as Topic
PubMed: 28166523
DOI: 10.1159/000456575 -
Monaldi Archives For Chest Disease =... Jun 2020Neurological manifestations in patients with COVID-19 are more frequently being reported. Cerebrovascular events have been reported in around 3% of patients. In this... (Review)
Review
Neurological manifestations in patients with COVID-19 are more frequently being reported. Cerebrovascular events have been reported in around 3% of patients. In this review we summarize the published literature on cerebrovascular events in patients with COVID-19 as available on the PubMed database. So far, 3 studies have reported cerebrovascular events. Cerebrovascular events were identified on screening patients with decreased consciousness or in the presence of focal neurological deficits. These events were common in elderly, critically ill patients and in patients with prior cardio-cerebrovascular comorbidities. The diagnosis of cerebrovascular events was confirmed with computed tomography of the brain in most studies reporting neurological events. Multiple pathological mechanisms have been postulated regarding the process of neurological and vascular injury among which cytokine storm is shown to correlate with mortality. Patients with severe illness are found to have a higher cardio- cerebrovascular comorbidity. With an increasing number of cases and future prospective studies, the exact mechanism by which these cerebrovascular events occur and attribute to the poor outcome will be better understood.
Topics: Betacoronavirus; COVID-19; Cerebrovascular Disorders; Coronavirus Infections; Critical Illness; Global Health; Humans; Incidence; Pandemics; Pneumonia, Viral; SARS-CoV-2
PubMed: 32527073
DOI: 10.4081/monaldi.2020.1341 -
EMBO Reports Nov 2019Neurodegenerative and cerebrovascular diseases cause considerable human suffering, and therapy options for these two disease categories are limited or non-existing. It... (Review)
Review
Neurodegenerative and cerebrovascular diseases cause considerable human suffering, and therapy options for these two disease categories are limited or non-existing. It is an emerging notion that neurodegenerative and cerebrovascular diseases are linked in several ways, and in this review, we discuss the current status regarding vascular dysregulation in neurodegenerative disease, and conversely, how cerebrovascular diseases are associated with central nervous system (CNS) degeneration and dysfunction. The emerging links between neurodegenerative and cerebrovascular diseases are reviewed with a particular focus on pericytes-important cells that ensheath the endothelium in the microvasculature and which are pivotal for blood-brain barrier function and cerebral blood flow. Finally, we address how novel molecular and cellular insights into pericytes and other vascular cell types may open new avenues for diagnosis and therapy development for these important diseases.
Topics: Animals; Blood-Brain Barrier; Brain; Cerebrovascular Disorders; Disease Models, Animal; Humans; Neurodegenerative Diseases; Neurovascular Coupling; Pericytes
PubMed: 31617312
DOI: 10.15252/embr.201948070 -
Osteoarthritis and Cartilage Apr 2018Population-based cohort studies suggest an association between osteoarthritis (OA) and cerebrovascular disease, yet the mechanisms underlying vascular comorbidities in... (Review)
Review
OBJECTIVE
Population-based cohort studies suggest an association between osteoarthritis (OA) and cerebrovascular disease, yet the mechanisms underlying vascular comorbidities in OA remain unclear. The purpose of this narrative review is to discuss the literature examining inflammation in OA with a focus on physiological mechanisms, and whether overlapping mechanisms exist in cerebrovascular dysfunction.
METHOD
A literature search was conducted in PubMed using combinations of search terms: osteoarthritis, cerebrovascular (disease/dysfunction/risk), cardiovascular (disease/dysfunction/risk), aging/ageing, inflammation, inflammatory mediators, cytokine, c-reactive protein, interleukin, advanced glycation end-products, metabolic syndrome, reactive oxidative species, cognitive impairment, (vascular-related) dementia, small cerebral vessel disease, endothelial function, blood-brain barrier, gender/sex, hypertension, peripheral vascular health, and physical activity. Reference lists of identified articles were also researched manually.
RESULTS
Overlapping inflammatory factors that may contribute to onset and progression of both OA and cerebrovascular dysfunction are presented. We describe oxidative mechanisms involving pro-inflammatory cytokines and oxidative species, advanced glycation end-products, sex hormones, microvascular dysfunction and osteoprotegerin, and their specific roles in potentially contributing to OA and cerebrovascular dysfunction.
CONCLUSION
Synthesis of the current literature suggests future investigations may benefit from directly testing cerebrovascular hemodynamics and cognitive function in individuals with or at risk of OA to elucidate common physiological mechanisms.
Topics: Aging; Cerebrovascular Disorders; Disease Progression; Humans; Inflammation; Osteoarthritis
PubMed: 29406252
DOI: 10.1016/j.joca.2018.01.011