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Theranostics 2020Acute kidney injury (AKI) caused by sepsis is a serious disease which mitochondrial oxidative stress and inflammatory play a key role in its pathophysiology. Ceria...
Acute kidney injury (AKI) caused by sepsis is a serious disease which mitochondrial oxidative stress and inflammatory play a key role in its pathophysiology. Ceria nanoparticles hold strong and recyclable reactive oxygen species (ROS)-scavenging activity, have been applied to treat ROS-related diseases. However, ceria nanoparticles can't selectively target mitochondria and the ultra-small ceria nanoparticles are easily agglomerated. To overcome these shortcomings and improve therapeutic efficiency, we designed an ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury. : Ceria nanoparticles were modified with triphenylphosphine (TCeria NPs), followed by coating with ROS-responsive organic polymer (mPEG-TK-PLGA) and loaded atorvastatin (Atv/PTP-TCeria NPs). The physicochemical properties, drug release profiles, mitochondria-targeting ability, antioxidant, anti-apoptotic activity and treatment efficacy of Atv/PTP-TCeria NPs were examined. : Atv/PTP-TCeria NPs could accumulate in kidneys and hold a great ability to ROS-responsively release drug and TCeria NPs could target mitochondria to eliminate excessive ROS. study suggested Atv/PTP-TCeria NPs exhibited superior antioxidant and anti-apoptotic activity. study showed that Atv/PTP-TCeria NPs effectively decreased oxidative stress and inflammatory, could protect the mitochondrial structure, reduced apoptosis of tubular cell and tubular necrosis in the sepsis-induced AKI mice model. This ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin has favorable potentials in the sepsis-induced AKI therapy.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Atorvastatin; Cerium; Drug Delivery Systems; Drug Liberation; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mitochondria; Nanoparticles; Organophosphorus Compounds; Oxidative Stress; Polyesters; Polyethylene Glycols; Polylactic Acid-Polyglycolic Acid Copolymer; Reactive Oxygen Species
PubMed: 32104507
DOI: 10.7150/thno.40395 -
Advanced Materials (Deerfield Beach,... Oct 2019The mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a "blackbox" by nanoresearchers in translating nanomedicines. Often, most of the injected...
The mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a "blackbox" by nanoresearchers in translating nanomedicines. Often, most of the injected nanomaterials are sequestered by the MPS, preventing their delivery to the desired disease areas. Here, this imperfection is exploited by applying nano-antioxidants with preferential liver uptake to directly prevent hepatic ischemia-reperfusion injury (IRI), which is a reactive oxygen species (ROS)-related disease. Ceria nanoparticles (NPs) are selected as a representative nano-antioxidant and the detailed mechanism of preventing IRI is investigated. It is found that ceria NPs effectively alleviate the clinical symptoms of hepatic IRI by scavenging ROS, inhibiting activation of Kupffer cells and monocyte/macrophage cells. The released pro-inflammatory cytokines are then significantly reduced and the recruitment and infiltration of neutrophils are minimized, which suppress subsequent inflammatory reaction involved in the liver. The protective effect of nano-antioxidants against hepatic IRI in living animals and the revealed mechanism herein suggests their future use for the treatment of hepatic IRI in the clinic.
Topics: Animals; Antioxidants; Cerium; Cytokines; Liver; Mice; Nanomedicine; Nanoparticles; Reactive Oxygen Species; Reperfusion Injury; Tissue Distribution
PubMed: 31418951
DOI: 10.1002/adma.201902956 -
ACS Biomaterials Science & Engineering Sep 2021Bioactive glasses (BGs) for biomedical applications are doped with therapeutic inorganic ions (TIIs) in order to improve their performance and reduce the side effects... (Review)
Review
Bioactive glasses (BGs) for biomedical applications are doped with therapeutic inorganic ions (TIIs) in order to improve their performance and reduce the side effects related to the surgical implant. Recent literature in the field shows a rekindled interest toward rare earth elements, in particular cerium, and their catalytic properties. Cerium-doped bioactive glasses (Ce-BGs) differ in compositions, synthetic methods, features, and assessment. This review provides an overview on the recent development of Ce-BGs for biomedical applications and on the evaluation of their bioactivity, cytocompatibility, antibacterial, antioxidant, and osteogenic and angiogenic properties as a function of their composition and physicochemical parameters.
Topics: Anti-Bacterial Agents; Catalysis; Cerium; Glass; Osteogenesis
PubMed: 34468119
DOI: 10.1021/acsbiomaterials.1c00414 -
Nature Communications Mar 2021Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It is correlated with the collateral...
Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It is correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management is a practical strategy that can reduce the risk of chemotherapy-related AKI, but at the cost of chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) that can prevent chemotherapy-induced AKI without interference with chemotherapeutic agents. Specifically, in the renal cortex, CNPs exhibit catalytic activity that decomposes hydrogen peroxide, and subsequently regulate the ROS-involved genes by activating the Nrf2/Keap1 signaling pathway. These restore the redox homeostasis for the protection of kidney tubules. Under an acidic tumor microenvironment, CNPs become inert due to the excessive H that disrupts the re-exposure of active catalytic sites, allowing a buildup of chemotherapy-mediated ROS generation to kill cancer cells. As ROS-modulating agents, CNPs incorporated with context-dependent catalytic activity, hold a great potential for clinical prevention and treatment of AKI in cancer patients.
Topics: A549 Cells; Acute Kidney Injury; Animals; Antineoplastic Agents; Catalytic Domain; Cell Line, Tumor; Cerium; Female; Hep G2 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Kidney Tubules; Mice; Mice, Inbred BALB C; Mice, Nude; NF-E2-Related Factor 2; Nanoparticles; Neoplasms; Oxidation-Reduction; Oxidative Stress; RNA Interference; RNA, Small Interfering; Reactive Oxygen Species; Signal Transduction; Tumor Microenvironment
PubMed: 33664241
DOI: 10.1038/s41467-021-21714-2 -
Applied Microbiology and Biotechnology Jan 2022Cerium has many modern applications such as in renewable energies and the biosynthesis of nanomaterials. In this research, natural struvite was solubilized by...
Cerium has many modern applications such as in renewable energies and the biosynthesis of nanomaterials. In this research, natural struvite was solubilized by Aspergillus niger and the biomass-free struvite leachate was investigated for its ability to recover cerium. It was shown that struvite was completed solubilized following 2 weeks of fungal growth, which released inorganic phosphate (P) from the mineral by the production of oxalic acid. Scanning electron microscopy (SEM) showed that crystals with distinctive morphologies were formed in the natural struvite leachate after mixing with Ce. Energy-dispersive X-ray analysis (EDXA), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) confirmed the formation of cerium phosphate hydrate [Ce(PO)·HO] at lower Ce concentrations and a mixture of phosphate and cerium oxalate decahydrate [Ce(CO)·10HO] at higher Ce concentrations. The formation of these biogenic Ce minerals leads to the removal of > 99% Ce from solution. Thermal decomposition experiments showed that the biogenic Ce phosphates could be transformed into a mixture of CePO and CeO (cerianite) after heat treatment at 1000 °C. These results provide a new perspective of the fungal biotransformation of soluble REE species using struvite leachate, and also indicate the potential of using the recovered REE as biomaterial precursors with possible applications in the biosynthesis of novel nanomaterials, elemental recycling and biorecovery. KEY POINTS: • Cerium was recovered using a struvite leachate produced by A. niger. • Oxalic acid played a major role in struvite solubilization and Ce phosphate biorecovery. • Resulting nanoscale mineral products could serve as a precursor for Ce oxide synthesis.
Topics: Aspergillus niger; Biotransformation; Cerium; Oxalic Acid; Phosphates; Struvite
PubMed: 34981166
DOI: 10.1007/s00253-021-11721-0 -
Wiley Interdisciplinary Reviews.... Jul 2017Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative... (Review)
Review
Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative organs in the body, it is subject to some of the greatest levels of oxidative stress, particularly in neurodegenerative disease. Therefore, cerium oxide nanoparticles are currently being investigated for efficacy in several neurodegenerative disorders and have shown promising levels of neuroprotection. This review discusses the basis for cerium oxide nanoparticle use in neurodegenerative disease and its hypothesized mechanism of action. The review focuses on an up-to-date summary of in vivo work with cerium oxide nanoparticles in animal models of neurodegenerative disease. Additionally, we examine the current state of information regarding biodistribution, toxicity, and safety for cerium oxide nanoparticles at the in vivo level. Finally, we discuss future directions that are necessary if this nanopharmaceutical is to move up from the bench to the bedside. WIREs Nanomed Nanobiotechnol 2017, 9:e1444. doi: 10.1002/wnan.1444 For further resources related to this article, please visit the WIREs website.
Topics: Animals; Antioxidants; Cerium; Humans; Nanoparticles; Neurodegenerative Diseases; Neuroprotection; Oxidative Stress; Tissue Distribution
PubMed: 27860449
DOI: 10.1002/wnan.1444 -
Molecules (Basel, Switzerland) Apr 2022Cerium and its derivatives have been used as remedies for wounds since the early 20th century. Cerium nitrate has attracted most attention in the treatment of deep... (Review)
Review
Cerium and its derivatives have been used as remedies for wounds since the early 20th century. Cerium nitrate has attracted most attention in the treatment of deep burns, followed later by reports of its antimicrobial properties. Its ability to mimic and replace calcium is presumed to be a major mechanism of its beneficial action. However, despite some encouraging results, the overall data are somewhat confusing with seemingly the same compounds yielding opposing results. Despite this, cerium nitrate is currently used in wound treatment in combination with silver sulfadiazine as Flammacérium. Cerium oxide, especially in nanoparticle form (Nanoceria), has lately captured much interest due to its antibacterial properties mediated via oxidative stress, leading to an increase of published reports. The properties of Nanoceria depend on the synthesis method, their shape and size. Recently, the green synthesis route has gained a lot of interest as an alternative environmentally friendly method, resulting in production of effective antimicrobial and antifungal nanoparticles. Unfortunately, as is the case with antibiotics, emerging bacterial resistance against cerium-derived nanoparticles is a growing concern, especially in the case of bacterial biofilm. However, diverse strategies resulting from better understanding of the biology of cerium are promising. The aim of this paper is to present the progress to date in the use of cerium compounds as antimicrobials in clinical applications (in particular wound healing) and to provide an overview of the mechanisms of action of cerium at both the cellular and molecular level.
Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacterial Infections; Burns; Cerium; Humans; Nanoparticles; Wound Healing
PubMed: 35566026
DOI: 10.3390/molecules27092678 -
International Journal of Molecular... Nov 2021The human placenta is a transient organ essential for pregnancy maintenance, fetal development and growth. It has several functions, including that of a selective... (Review)
Review
The human placenta is a transient organ essential for pregnancy maintenance, fetal development and growth. It has several functions, including that of a selective barrier against pathogens and xenobiotics from maternal blood. However, some pollutants can accumulate in the placenta or pass through with possible repercussions on pregnancy outcomes. Cerium dioxide nanoparticles (CeO NPs), also termed nanoceria, are an emerging pollutant whose impact on pregnancy is starting to be defined. CeO NPs are already used in different fields for industrial and commercial applications and have even been proposed for some biomedical applications. Since 2010, nanoceria have been subject to priority monitoring by the Organization for Economic Co-operation and Development in order to assess their toxicity. This review aims to summarize the current methods and models used for toxicology studies on the placental barrier, from the basic ones to the very latest, as well as to overview the most recent knowledge of the impact of CeO NPs on human health, and more specifically during the sensitive window of pregnancy. Further research is needed to highlight the relationship between environmental exposure to CeO and placental dysfunction with its implications for pregnancy outcome.
Topics: Animals; Cerium; Environmental Pollutants; Female; Humans; Metal Nanoparticles; Models, Animal; Placenta; Pregnancy; Trophoblasts
PubMed: 34830142
DOI: 10.3390/ijms222212266 -
ACS Applied Materials & Interfaces Jun 2022A fluorometric glucose biosensor based on fine-tuned chemoenzymatic nanohybrids is herein proposed. The successful integration of an engineered glucose oxidase enzyme...
A fluorometric glucose biosensor based on fine-tuned chemoenzymatic nanohybrids is herein proposed. The successful integration of an engineered glucose oxidase enzyme and an optically responsive polymeric nanogel in a single entity has led to the fabrication of a highly efficient glucose chemobiosensor. The optical responsiveness has been achieved by the loading of preactivated polymeric hydrogel with fluorescent lanthanide, i.e., cerium (III), cations. A comprehensive investigation of the responsiveness of the biomaterial revealed the interplay between the oxidation state of the cerium lanthanide and the fluorescence emission of the polymer. Finally, a full structural, chemical, and biochemical characterization of the reported system supports the chemobiosensors as robust, specific, and sensitive materials that could be utilized to faithfully quantify the amount of glucose in tear fluids.
Topics: Cerium; Glucose; Lanthanoid Series Elements; Nanogels; Polymers
PubMed: 35673709
DOI: 10.1021/acsami.2c04385 -
Fungal Biology 2023Cerium is the most sought-after rare earth element (REE) for application in high-tech electronic devices and versatile nanomaterials. In this research, biomass-free...
Cerium is the most sought-after rare earth element (REE) for application in high-tech electronic devices and versatile nanomaterials. In this research, biomass-free spent culture media of Aspergillus niger and Neurospora crassa containing precipitant ligands (oxalate, carbonate) were investigated for their potential application in biorecovery of Ce from solution. Precipitation occurred after Ce was mixed with biomass-free spent culture media and >99% Ce was recovered from media of both organisms. SEM showed that biogenic crystals with distinctive morphologies were formed in the biomass-free spent medium of A. niger. Irregularly-shaped nanoparticles with varying sizes ranging from 0.5 to 2 μm and amorphous biominerals were formed after mixing the carbonate-laden N. crassa supernatant, resulting from ureolysis of supplied urea, with Ce. Both biominerals contained Ce as the sole metal, and X-ray diffraction (XRD) and thermogravimetric analyses identified the biominerals resulting from the biomass-free A. niger and N. crassa spent media as cerium oxalate decahydrate [Ce(CO)·10HO] and cerium carbonate [Ce(CO)·8HO], respectively. Thermal decomposition experiments showed that the biogenic Ce oxalates and carbonates could be subsequently transformed into ceria (CeO). FTIR confirmed that both amorphous and nanoscale Ce carbonates contained carbonate (CO) groups. FTIR-multivariate analysis could classify the biominerals into three groups according to different Ce concentrations and showed that Ce carbonate biominerals of higher purity were produced when precipitated at higher Ce concentrations. This work provides new understanding of fungal biotransformations of soluble REE species and their biorecovery using biomass-free fungal culture systems and indicates the potential of using recovered REE as precursors for the biosynthesis of novel nanomaterials.
Topics: Cerium; Oxalates; Carbonates; Biotransformation; Culture Media
PubMed: 37495308
DOI: 10.1016/j.funbio.2022.07.006