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Frontiers in Endocrinology 2022There are many organochlorine pollutants in the environment, which can be directly or indirectly exposed to by mothers, and as estrogen endocrine disruptors can cause... (Review)
Review
There are many organochlorine pollutants in the environment, which can be directly or indirectly exposed to by mothers, and as estrogen endocrine disruptors can cause damage to the lactation capacity of the mammary gland. In addition, because breast milk contains a lot of nutrients, it is the most important food source for new-born babies. If mothers are exposed to organochlorine pesticides (OCPs), the lipophilic organochlorine contaminants can accumulate in breast milk fat and be passed to the infant through breast milk. Therefore, it is necessary to investigate organochlorine contaminants in human milk to estimate the health risks of these contaminants to breastfed infants. In addition, toxic substances in the mother can also be passed to the fetus through the placenta, which is also something we need to pay attention to. This article introduces several types of OCPs, such as dichlorodiphenyltrichloroethane (DDT), methoxychlor (MXC), hexachlorocyclohexane (HCH), endosulfan, chlordane, heptachlorand and hexachlorobenzene (HCB), mainly expounds their effects on women's lactation ability and infant health, and provides reference for maternal and infant health. In addition, some measures and methods for the control of organochlorine pollutants are also described here.
Topics: Environmental Pollutants; Female; Humans; Hydrocarbons, Chlorinated; Infant; Milk, Human; Pesticide Residues; Pesticides; Pregnancy
PubMed: 35757428
DOI: 10.3389/fendo.2022.890307 -
Ecotoxicology and Environmental Safety Dec 2021The incidence of metabolic diseases is increasing every year, and several studies have highlighted the activity of persistent organic pollutants (POPs) in causing...
The incidence of metabolic diseases is increasing every year, and several studies have highlighted the activity of persistent organic pollutants (POPs) in causing hyperlipidemia and diabetes, and these compounds are considered to be endocrine disrupting chemicals (EDCs). Chlordane is classified as an endocrine disruptor, but the mechanism of how it functions is still unclear. This study investigates the effects of chlordane exposure on Drosophila larvae. Drosophila was cultured in diet containing 0.01 μM, 0.1 μM, 1 μM, 5 μM, and 10 μM chlordane, and the toxicity of chlordane, the growth and development of Drosophila, the homeostasis of glucose and lipid metabolism and insulin signaling pathway, lipid peroxidation-related indicators and Nrf2 signaling pathway were evaluated. We here found that exposure to high concentrations of chlordane decreased the survival rate of Drosophila and that exposure to low concentrations of chlordane caused disruption of glucose and lipid metabolism, increased insulin secretion and impairment of insulin signaling. Notably, it also led to massive ROS production and lipid peroxidation despite of the activation of Nrf2 signaling pathway, an important pathway for maintaining redox homeostasis. Collectively, chlordane causes lipid peroxidation and disrupts redox homeostasis, which may be a potential mechanism leading to impaired insulin signaling and the metabolism of glucose and lipid, ultimately affects Drosophila development.
Topics: Animals; Chlordan; Drosophila melanogaster; Endocrine Disruptors; Insulin; Metabolic Diseases
PubMed: 34481351
DOI: 10.1016/j.ecoenv.2021.112739 -
IARC Monographs on the Evaluation of... 1991
Review
Topics: Air Pollutants, Occupational; Animals; Carcinogenicity Tests; Case-Control Studies; Chlordan; Cocarcinogenesis; Cohort Studies; Female; Heptachlor; Humans; Liver Neoplasms, Experimental; Neoplasms; Occupational Diseases; Occupational Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors
PubMed: 1842578
DOI: No ID Found -
Environmental Health Perspectives Jan 1999Persistent organic pollutants (POPs) can travel thousands of miles, accumulate in the food chain, and persist in the environment, taking as long as centuries to degrade....
Persistent organic pollutants (POPs) can travel thousands of miles, accumulate in the food chain, and persist in the environment, taking as long as centuries to degrade. POPs are known to play a role in birth defects, cancer, immune system dysfunction, and reproductive problems in wildlife. While the effects of POPs on human health are unclear, many researchers believe that long-term exposure contributes to increasing rates of birth defects, fertility problems, greater susceptibility to disease, diminished intelligence, and certain cancers. Twelve POPs have been identified by the United Nations Environment Programme as requiring urgent regulatory attention. They include the pesticides aldrin, chlordane, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, mirex, and toxaphene. Of the remaining three POPs, polychlorinated biphenyls are industrial products (used in electrical transformers), and dioxins and furans are unintentional by-products of industrial processes.
Topics: Aldrin; Chlordan; DDT; Dieldrin; Dioxins; Endrin; Environmental Exposure; Furans; Heptachlor; Hexachlorobenzene; Humans; Hydrocarbons, Chlorinated; Insecticides; Mirex; Polychlorinated Biphenyls; Toxaphene
PubMed: 9872725
DOI: 10.1289/ehp.99107a18 -
Ecotoxicology and Environmental Safety Jan 2024Chlordane, a previously extensively utilized insecticidal pesticide, has since been prohibited, however, owing to its limited degradability, it continues to persist...
Chlordane, a previously extensively utilized insecticidal pesticide, has since been prohibited, however, owing to its limited degradability, it continues to persist significantly in soil and water reservoirs, subsequently accumulating within plant and animal organisms, representing a substantial threat to human health. Despite extensive research conducted over the past few decades to investigate the toxic effects of chlordane, there remains a notable dearth of studies focusing on its impact on sleep activity. Therefore, in this study, the effects of short-term and long-term exposure to chlordane on the activity and sleep of Drosophila were investigated. When exposed to chlordane at a concentration of 1 μM, Drosophila lost body weight, decreased body size and resulted in lipid metabolism disorders. In addition, chlordane exposure altered the arousal and sleep behaviors of Drosophila. Short-term exposure to chlordane resulted in an increase in night-time sleep duration, while long-term exposure to chlordane resulted in an increase in activity and a decrease in sleep, as evidenced by a decrease in the duration of each sleep session and the appearance of sleep fragmentation. Under conditions of long-term chlordane exposure, reactive oxygen species levels were significantly up-regulated in Drosophila. Our results suggest that long-term chlordane exposure triggers oxidative stress damage in Drosophila, leading to sleep disruption. This study offers novel insights into the harmful impacts of environmental pollutants on human sleep patterns and proposes that mitigating the presence of chlordane in the environment could potentially contribute to the reduction of global sleep disorder prevalence.
Topics: Animals; Humans; Chlordan; Drosophila; Soil Pollutants; Insecticides; Pesticides
PubMed: 38176184
DOI: 10.1016/j.ecoenv.2023.115903 -
International Journal of Andrology Aug 2011Cryptorchidism, hypospadias, subfertility and testicular germ-cell tumour have been suggested to comprise a testicular dysgenesis syndrome (TDS) based on the premise... (Review)
Review
Cryptorchidism, hypospadias, subfertility and testicular germ-cell tumour have been suggested to comprise a testicular dysgenesis syndrome (TDS) based on the premise that each may derive from perturbations of embryonal programming and gonadal development during foetal life. Endocrine-disrupting chemicals have been hypothesized to be associated with these disorders, given the importance of sex steroid hormones in urogenital development and homeostasis. Organochlorines are one such set of compounds which are defined as containing between one and ten covalently bonded chlorine atoms. These compounds are persistent pollutants with long half-lives, accumulate in adipose tissue when ingested, bioaccumulate and biomagnify, and have complex and variable toxicological profiles. Examples of organochlorines include dichloro-diphenyl-trichloroethane and its metabolites, polychlorinated biphenyls, and chlordane. In this comprehensive review of human epidemiologic studies which have tested for associations between organochlorines and facets of TDS, we find evidence for associations between the exposures p,p'-DDE, cis-nonachlor and trans-nonachlor with testicular germ-cell tumour. The sum of the evidence from human epidemiological studies does not indicate any association between specific organochlorines studied and cryptorchidism, hypospadias or fertility. Many other endocrine-disrupting chemicals, including additional organochlorines, have yet to be assessed in relation to disorders associated with TDS, yet study of such chemicals has strong scientific merit given the relevance of such hypotheses to urogenital development.
Topics: Environmental Exposure; Fertility; Gonadal Dysgenesis; Humans; Hydrocarbons, Chlorinated; Male; Testis
PubMed: 21668838
DOI: 10.1111/j.1365-2605.2011.01171.x -
International Journal of Cancer Feb 2016Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life...
Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organochlorine insecticides [p,p'-DDT (dichlorodiphenyltrichloroethane), its primary metabolite, p,p'-DDE, and chlordane] assessed shortly after diagnosis and survival among women with breast cancer. A population-based sample of women diagnosed with a first primary invasive or in situ breast cancer in 1996-1997 and with available organochlorine blood measures (n = 633) were followed for vital status through 2011. After follow-up of 5 and 15 years, we identified 55 and 189 deaths, of which 36 and 74, respectively, were breast cancer-related. Using Cox regression models, we estimated the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for lipid-adjusted organochlorine concentrations with all-cause and breast cancer-specific mortality. At 5 years after diagnosis, the highest tertile of DDT concentration was associated with all-cause (HR = 2.19; 95% CI: 1.02, 4.67) and breast cancer-specific (HR = 2.72; 95% CI: 1.04, 7.13) mortality. At 15 years, middle tertile concentrations of DDT (HR = 1.42; 95% CI 0.99, 2.06) and chlordane (HR = 1.42; 95% CI: 0.94, 2.12) were modestly associated with all-cause and breast cancer-specific mortality. Third tertile DDE concentrations were inversely associated with 15-year all-cause mortality (HR = 0.66; 95% CI: 0.44, 0.99). This is the first population-based study in the United States to show that DDT may adversely impact survival following breast cancer diagnosis. Further studies are warranted given the high breast cancer burden and the ubiquity of these chemicals.
Topics: Body Mass Index; Breast Neoplasms; Chlordan; DDT; Female; Humans; Insecticides; Proportional Hazards Models
PubMed: 26285160
DOI: 10.1002/ijc.29806 -
Chemosphere Jun 2022Persistent organic pollutants (POPs) are of global concern due to their negative effects on humans and the environment, and globally are regulated in the Stockholm...
Persistent organic pollutants (POPs) are of global concern due to their negative effects on humans and the environment, and globally are regulated in the Stockholm Convention on POPs. The present study had Mongolia as a partner in a multinational project funded and coordinated by the United Nations Environment Programme with the aim to monitor POPs in core media, including air (with passive samplers), water, and a pooled human milk sample. Project implementation and all sampling were undertaken by the Institute of Chemistry and Chemical Technology whereas POPs analysis was performed in laboratories abroad. Brominated and chlorinated POPs were analyzed by gas chromatography/mass spectrometry, perfluorinated compounds (PFAS) and isomers of hexabromocyclododecane (HBCD) by liquid chromatography/mass spectrometry. The monitoring results found very low concentrations of PFAS in river water. Toxic equivalents (TEQs) for PCDD/PCDF were low in air and in human samples but had a relatively higher presence of TEQ from dioxin-like PCB than in other countries. With respect to chlorinated POPs, drins, chlordanes, DDTs, heptachlors, and mirex were very low in air and human milk. Elevated levels were found for polychlorinated biphenyls (PCB), hexachlorobenzene (HCB), hexachlorocyclohexanes (HCHs), pentachlorobenzene (PeCBz), and HBCD in air with extreme values for hexachlorobutadiene. The abundance of HCHs and HCB was confirmed in the human milk sample but not for PCB, PeCBz or HBCD. Short-chain chlorinated paraffins (170 ng/g lipid) were the highest among all human milk pools. It is recommended to continue POPs monitoring in the future, especially for those where high concentrations were found.
Topics: Environmental Monitoring; Environmental Pollutants; Fluorocarbons; Hexachlorobenzene; Hexachlorocyclohexane; Humans; Hydrocarbons, Chlorinated; Mongolia; Polychlorinated Biphenyls; Water
PubMed: 35276101
DOI: 10.1016/j.chemosphere.2022.134180 -
Journal of Environmental and Public... 2023The long-term and indiscriminate use of pesticides has resulted in serious health effects. Aside from that, developing countries do not have any monitoring systems in...
The long-term and indiscriminate use of pesticides has resulted in serious health effects. Aside from that, developing countries do not have any monitoring systems in place to prevent the consumption of high levels of pesticides in foods. Therefore, this study aimed to determine pesticide residues and the effect of processing in commonly consumed vegetables in the southwestern part of Ethiopia. In total, 12 samples of 1 kg of each type of vegetable were collected from selected markets. Moreover, as a solution to pesticide residue problems in vegetables, the effect of different processing methods such as washing, peeling, boiling, and their cumulative effect was studied. In the analytical procedure, the modified Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) extraction with florisil as a cleanup sorbent was used and the identification of pesticides was done by using gas chromatography with an electron capture detector (GC-ECD). The parent -DDT was detected at a concentration of 0.015 mg/kg in potato samples from the Serbo market and a concentration of 0.516, 0.232, 0.174, and 1.512 mg/kg in Merkato, Kochi, Serbo, and Shebe onion samples, respectively. P-DDT is detected at a high concentration compared to its metabolites -DDE and -DDD), which is an indication of recent use. DDT and its metabolites, other organochlorines (lindane, -chlordane, dimethachlor, and heptachlor), and pyrethroids (cypermethrin and deltamethrin) exceeded the recommended limits by FAO and WHO in multiple samples of potato, onion, and cabbage. The processing result showed that washing, boiling, and the combination of the two revealed a 100% reduction in -DDT, and -DDT pesticides detected in cabbage. In conclusion, multiple residues were detected in the three vegetables studied, indicating that pesticides were applied intensively. Pesticide levels were reduced by home processing procedures, which is important for consumer safety.
Topics: Pesticide Residues; DDT; Vegetables; Ethiopia; Pesticides; Dichlorodiphenyl Dichloroethylene
PubMed: 36755781
DOI: 10.1155/2023/7503426