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The Journal of Veterinary Medical... Oct 2023A 31-month-old Holstein dairy cow aborted at 224 days of gestation with ejection of cheese-like lochia. Citrobacter koseri, which commonly exists in the normal flora of...
A 31-month-old Holstein dairy cow aborted at 224 days of gestation with ejection of cheese-like lochia. Citrobacter koseri, which commonly exists in the normal flora of human and animal digestive tracts, was isolated from aborted fetal tissues (liver, spleen, kidney, heart, lung, cerebrum, and skeletal muscle) and fetal membranes. Histopathological examination revealed suppurative fibrinous meningoencephalitis of the cerebrum, cerebellum, and brainstem; suppurative bronchopneumonia; suppurative chorioamnionitis; and fibrous splenic serositis. Numerous gram-negative bacilli were detected in the cytoplasm of macrophages and/or neutrophils in these lesions. Bacteriological investigation and immunohistochemical staining identified the bacilli as C. koseri. This is the first report of cattle abortion caused by C. koseri infection in dairy cattle.
Topics: Female; Animals; Humans; Cattle; Enterobacteriaceae Infections; Citrobacter koseri; Sepsis; Macrophages; Fetus; Cattle Diseases
PubMed: 37661420
DOI: 10.1292/jvms.23-0199 -
SAGE Open Medical Case Reports 2022species are anaerobic gram-negative bacteria that are known to cause infections in immunocompromised hosts, particularly in hospital settings. Their opportunistic...
species are anaerobic gram-negative bacteria that are known to cause infections in immunocompromised hosts, particularly in hospital settings. Their opportunistic nature and tendency to develop antibiotic resistance make species challenging to treat. Renal or perinephric abscess formation as a result of infection is uncommon, having only previously been reported in four cases. We present a case of a 70-year-old man with diabetes and prostate cancer who was diagnosed with an 18 cm perinephric and a 10 cm perihepatic abscess caused by . The patient required drains and re-positioning of the drains multiple times in addition to a prolonged course of antibiotics to achieve complete radiographic resolution. This case highlights the challenges in treating renal and perinephric abscess, as it required drain re-placements two additional times after the initial placement and an additional 4 weeks of antibiotics. Successful treatment for larger abscesses usually requires a two-arm approach, with antibiotics in combination with either percutaneous or surgical abscess drainage.
PubMed: 36337163
DOI: 10.1177/2050313X221135347 -
Archives of Razi Institute Apr 2022The urinary tract infection (UTI) is a prevalent infection that affects people of all ages. Bacterial agents are the most common causes of UTIs. , , , and other , and...
The urinary tract infection (UTI) is a prevalent infection that affects people of all ages. Bacterial agents are the most common causes of UTIs. , , , and other , and () account for a smaller number of infections. These pathogens are transported into the urinary tract from the colonic biotope into dysbacteriosis. Urine samples were randomly collected from 249 outpatients who were suspected of having UTIs. After genital cleaning, 10 mL of urine specimens were collected in a sterilized bowel. Then, the specimens were centrifuged at 2,000 rpm for 5 min and the residue was aerobically incubated with the broth infusion of brain flasks at 37°C for 24 h and then applied with a sterile ring onto blood agar plates and MacConkey agar (OxoidTM). Out of 249 urine samples, the results proved that there were 176 (70.7%) and 51(20.5%) gram-negative and gram-positive bacteria isolates, respectively. However, the results demonstrated that there were 22 (8.8%) urine samples with no growth. In addition, the results showed that eight various antimicrobials are used to treat . In the current study, was treated with eight different antimicrobial agents. The antimicrobial resistance rate for 7 isolates against Cefotaxime, Ceftriaxone, Ciprofloxacin, and Levofloxacin was high for 6 (85.71%) isolates. The results indicated that 6 and 5 isolates had 85.71% and 71.42% antimicrobial resistance against Ceftazidime and Levofloxacin, respectively. Whereas Gentamicin showed a moderate rate of resistance (4 isolates, 57.14%), and Amikacin resistance was found in 5 isolates, accounting for 28.57%. The bacterial isolates had a high susceptibility rate to Imipenem. The gene was found in 6 (85.71%) isolates. However, the recorded data demonstrated that there is no isolate carrying the gene. Among all pathogenic bacteria, was the lowest causative agent of UTI in this study and was highly resistant to most antimicrobials except Imipenem, which was a good antibiotic with 100% sensitivity.
Topics: Agar; Amikacin; Anti-Bacterial Agents; Ceftazidime; Ceftriaxone; Ciprofloxacin; Citrobacter koseri; Gentamicins; Imipenem; Levofloxacin; Microbial Sensitivity Tests; Urinary Tract Infections; Humans
PubMed: 36284941
DOI: 10.22092/ARI.2022.357122.1979 -
Le Infezioni in Medicina Sep 2018Citrobacter koseri is a rare cause of liver abscess with two reported cases in diabetic patients. We report a rare case of C. koseri liver abscess with C. koseri...
Citrobacter koseri is a rare cause of liver abscess with two reported cases in diabetic patients. We report a rare case of C. koseri liver abscess with C. koseri bacteremia in an elderly male with chronic kidney disease. He presented vomiting and weakness without any other signs. He was diagnosed with liver abscess by ultrasound, and blood culture showed C. koseri growth. The patient was treated effectively with a course of antibiotics and drainage. When C. koseri is isolated in patients with comorbidity, such as chronic kidney disease, we should consider the possibility of abscess including liver abscess and utilize a combined treatment of drainage and course of antibiotics for mixed infection.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Breast Neoplasms, Male; Ciprofloxacin; Citrobacter koseri; Combined Modality Therapy; Drainage; Enterobacteriaceae Infections; Humans; Liver Abscess; Male; Pancreatitis; Papilloma, Intraductal; Renal Insufficiency, Chronic
PubMed: 30246771
DOI: No ID Found -
Radiology Case Reports Mar 2021Sometimes the only indicator of a serious infection in a neonate is a fever. has been reported to cause neonatal brain abscesses in the setting of meningitis. Although...
Sometimes the only indicator of a serious infection in a neonate is a fever. has been reported to cause neonatal brain abscesses in the setting of meningitis. Although rare, pneumocephalus, secondary to , carries a very high mortality. A 17-day-old male presented to the emergency department with a fever, decreased oral intake, and lethargy. The patient developed pneumocephalus and cerebral edema and was diagnosed with meningitis, leading to death. This case demonstrates the presentation of meningitis with pneumocephalus and cerebral edema in a neonate presenting with fever.
PubMed: 33384749
DOI: 10.1016/j.radcr.2020.12.039 -
Gut Pathogens Oct 2023Citrobacter koseri (C. koseri) is a Gram-negative, motile, non-spore-forming facultative anaerobic bacillus belonging to the Enterobacteriaceae family. C. koseri...
Citrobacter koseri (C. koseri) is a Gram-negative, motile, non-spore-forming facultative anaerobic bacillus belonging to the Enterobacteriaceae family. C. koseri typically utilizes citrate as the sole carbon source and constitutes part of the normal gastrointestinal flora in humans and animals. As an opportunistic pathogen, C. koseri infections are mainly observed in neonates, elderly individuals, and immunocompromised hosts. C. koseri has been one of the main etiological agents of neonatal meningitis and cerebral abscess. In recent years, an increasing number of cases have been reported in adults with severe infections caused by C. koseri. Here, we report for the first time a clinical case of concurrent C. koseri intra-abdominal infection in a patient with severe asthma and provide a brief review of the relevant literature. With this report, we hope to increase awareness and alertness among clinicians to the possibility of concurrent infection of gut commensal bacteria in asthmatic patients requiring long-term oral corticosteroid administration.
PubMed: 37880761
DOI: 10.1186/s13099-023-00574-9 -
Frontiers in Microbiology 2019species are opportunistic bacterial pathogens that have been implicated in both nosocomial and community-acquired infections. Among the genus , is often isolated from...
species are opportunistic bacterial pathogens that have been implicated in both nosocomial and community-acquired infections. Among the genus , is often isolated from clinical material, and has been known to cause meningitis and brain abscess in neonates and immunocompromised individuals. The virulence determinants of , however, remain largely unknown. Based on traditional methods, the genus has been divided into 11 species, but this has been problematic. Here, we determined an improved, detailed, and more accurate phylogeny of the genus based on whole genome sequence (WGS) data from 129 genomes, 31 of which were sequenced in this study. A maximum likelihood (ML) phylogeny constructed with core genome single-nucleotide polymorphisms (SNPs) classified all isolates into 11 distinct groups, with all strains clustering into a single group. For comprehensive and systematic comparative genomic analyses, we investigated the distribution of virulence factors, resistance genes, and macromolecular secretion systems among the genus. Moreover, combined with group-specific genes analysis, we identified a key gene cluster for iron transport, which is present in the group, but absent in other the groups, suggesting that the high-pathogenicity island (HPI) cluster may be important for the pathogenicity of . Animal experiments showed that loss of the HPI cluster significantly decreased virulence in mice and rat. Further, we provide evidence to explain why is less susceptible than to several antibiotics . Overall, our data reveal novel virulence clusters specific to the predominantly pathogenic strains, which form the basis for elucidating the virulence mechanisms underlying these important pathogens.
PubMed: 31866966
DOI: 10.3389/fmicb.2019.02774 -
The Journal of Clinical and Aesthetic... May 2021
PubMed: 34188743
DOI: No ID Found -
Journal of Nanobiotechnology Feb 2018Use of silver and silver salts is as old as human civilization but the fabrication of silver nanoparticles (Ag NPs) has only recently been recognized. They have been... (Review)
Review
Use of silver and silver salts is as old as human civilization but the fabrication of silver nanoparticles (Ag NPs) has only recently been recognized. They have been specifically used in agriculture and medicine as antibacterial, antifungal and antioxidants. It has been demonstrated that Ag NPs arrest the growth and multiplication of many bacteria such as Bacillus cereus, Staphylococcus aureus, Citrobacter koseri, Salmonella typhii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Vibrio parahaemolyticus and fungus Candida albicans by binding Ag/Ag with the biomolecules present in the microbial cells. It has been suggested that Ag NPs produce reactive oxygen species and free radicals which cause apoptosis leading to cell death preventing their replication. Since Ag NPs are smaller than the microorganisms, they diffuse into cell and rupture the cell wall which has been shown from SEM and TEM images of the suspension containing nanoparticles and pathogens. It has also been shown that smaller nanoparticles are more toxic than the bigger ones. Ag NPs are also used in packaging to prevent damage of food products by pathogens. The toxicity of Ag NPs is dependent on the size, concentration, pH of the medium and exposure time to pathogens.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antioxidants; Bacteria; Bacterial Infections; Fungi; Green Chemistry Technology; Humans; Metal Nanoparticles; Microbial Sensitivity Tests; Mycoses; Nanotechnology; Reactive Oxygen Species; Silver
PubMed: 29452593
DOI: 10.1186/s12951-018-0334-5 -
Annals of the Royal College of Surgeons... Sep 2016Introduction Citrobacter koseri is a well known cause of central nervous system infections in the paediatric setting. Musculoskeletal infections caused by C koseri are... (Review)
Review
Introduction Citrobacter koseri is a well known cause of central nervous system infections in the paediatric setting. Musculoskeletal infections caused by C koseri are rare, with only 14 previously reported cases. We present the first recorded case of C koseri induced septic arthritis of the knee along with a review of the literature. Methods A search of the PubMed, Embase(®) and Google Scholar™ databases was undertaken. Only complete or near complete cases were reviewed. Findings Fourteen musculoskeletal infections were identified. Of these, five were associated with an operative procedure and five involved a septic joint. Surgical treatment was required in the majority of cases and cure was achieved in all cases following prolonged antibiotic use. Conclusions C koseri associated musculoskeletal infections may complicate primary orthopaedic procedures. The organism can present aggressively and can be difficult to identify microbiologically. It is sensitive to newer generation beta-lactams, cephalosporin-based antibiotics and timely surgery.
Topics: Aged; Arthralgia; Arthritis, Infectious; Arthroscopy; Citrobacter koseri; Enterobacteriaceae Infections; Humans; Knee Joint; Male; Musculoskeletal Diseases
PubMed: 27412805
DOI: 10.1308/rcsann.2016.0209