-
Emergency (Tehran, Iran) 2017Clinical research usually involves patients with a certain disease or a condition. The generalizability of clinical research findings is based on multiple factors...
Clinical research usually involves patients with a certain disease or a condition. The generalizability of clinical research findings is based on multiple factors related to the internal and external validity of the research methods. The main methodological issue that influences the generalizability of clinical research findings is the sampling method. In this educational article, we are explaining the different sampling methods in clinical research.
PubMed: 28286859
DOI: No ID Found -
Nature Communications Dec 2021Since its inception 10 years ago Nature Communications has strived to publish papers of high quality and relevance to communities of researchers across the whole of the...
Since its inception 10 years ago Nature Communications has strived to publish papers of high quality and relevance to communities of researchers across the whole of the natural sciences. In more recent years, we have happily seen an increase in the submission and publication of clinical research studies. To serve the clinical community to the best of our ability we have clarified our on what we expect to see on submission of clinical research papers and we are launching a Clinical Collection that presents under one umbrella a selection of the interesting papers we have published in this area
Topics: Biomedical Research; Clinical Trials as Topic; Editorial Policies; Humans; Periodicals as Topic
PubMed: 34916501
DOI: 10.1038/s41467-021-27389-z -
Current Dermatology Reports 2021The immense growth of social media has afforded new opportunities in dermatology clinical research. This review serves to outline how social media has impacted clinical... (Review)
Review
PURPOSE OF REVIEW
The immense growth of social media has afforded new opportunities in dermatology clinical research. This review serves to outline how social media has impacted clinical research and to explore future avenues for which social media can make a significant impact in dermatology clinical research.
RECENT FINDINGS
Recent clinical trials augmented by social media have demonstrated increased participant enrollment, shortened recruitment timelines, and decreased recruitment cost. The incorporation of social media into clinical research has also afforded greater access to teledermatology and the initiation of virtual clinical trials.
SUMMARY
Clinical research serves as a primary source of evidence for refining healthcare practices by expanding the understanding of patient demographics, methods for improving patient care, and new therapeutic discoveries. Since its initiation, social media has played an integral and ever-expanding role in clinical research.
PubMed: 34840860
DOI: 10.1007/s13671-021-00350-5 -
Cureus Feb 2023Clinical research is an alternative terminology used to describe medical research. Clinical research involves people, and it is generally carried out to evaluate the... (Review)
Review
Clinical research is an alternative terminology used to describe medical research. Clinical research involves people, and it is generally carried out to evaluate the efficacy of a therapeutic drug, a medical/surgical procedure, or a device as a part of treatment and patient management. Moreover, any research that evaluates the aspects of a disease like the symptoms, risk factors, and pathophysiology, among others may be termed clinical research. However, clinical trials are those studies that assess the potential of a therapeutic drug/device in the management, control, and prevention of disease. In view of the increasing incidences of both communicable and non-communicable diseases, and especially after the effects that Coronavirus Disease-19 (COVID-19) had on public health worldwide, the emphasis on clinical research assumes extremely essential. The knowledge of clinical research will facilitate the discovery of drugs, devices, and vaccines, thereby improving preparedness during public health emergencies. Therefore, in this review, we comprehensively describe the critical elements of clinical research that include clinical trial phases, types, and designs of clinical trials, operations of trial, audit, and management, and ethical concerns.
PubMed: 36938261
DOI: 10.7759/cureus.35077 -
Acta Dermato-venereologica Jan 2020Chronic pruritus is a frequent global condition. The pathophysiology, underlying aetiology, clinical manifestation, associated burden and response to therapy of chronic... (Review)
Review
Chronic pruritus is a frequent global condition. The pathophysiology, underlying aetiology, clinical manifestation, associated burden and response to therapy of chronic pruritus varies from patient to patient, making clinical research and management of this condition challenging. There are still several unmet needs, such as the need to standardize translational research protocols, diagnostic and therapeutic procedures and to enhance the knowledge of the humanistic and economic burden associated with chronic pruritus. Basic and clinical research is of the utmost importance to target these matters. Clinical research has the potential to identify new relevant mechanisms in affected patients, which may lead to identification of novel therapy targets. This article discusses in depth current shortcomings in the daily care of patients with chronic pruritus and the challenges clinical researchers and physicians treating chronic pruritus face in addressing these matters.
Topics: Animals; Antipruritics; Biomedical Research; Chronic Disease; Humans; Pruritus; Research Design; Risk Factors; Treatment Outcome
PubMed: 31940048
DOI: 10.2340/00015555-3348 -
Clinics and Practice Oct 2023Prehospital care plays a critical role in improving patient outcomes, particularly in cases of time-sensitive emergencies such as trauma, cardiac failure, stroke,... (Review)
Review
Prehospital care plays a critical role in improving patient outcomes, particularly in cases of time-sensitive emergencies such as trauma, cardiac failure, stroke, bleeding, breathing difficulties, systemic infections, etc. In recent years, there has been a growing interest in clinical research in prehospital care, and several challenges and opportunities have emerged. There is an urgent need to adapt clinical research methodology to a context of prehospital care. At the same time, there are many barriers in prehospital research due to the complex context, posing unique challenges for research, development, and evaluation. Among these, this review allows the highlighting of limited resources and infrastructure, ethical and regulatory considerations, time constraints, privacy, safety concerns, data collection and analysis, selection of a homogeneous study group, etc. The analysis of the literature also highlights solutions such as strong collaboration between emergency medical services (EMS) and hospital care, use of (mobile) health technologies and artificial intelligence, use of standardized protocols and guidelines, etc. Overall, the purpose of this narrative review is to examine the current state of clinical research in prehospital care and identify gaps in knowledge, including the challenges and opportunities for future research.
PubMed: 37887090
DOI: 10.3390/clinpract13050114 -
Asia-Pacific Journal of Oncology Nursing 2020Clinical research nursing is a specialty practice that has evolved over the past century. Clinical research nurses (CRNs) work directly (e.g., direct care provider and... (Review)
Review
Clinical research nursing is a specialty practice that has evolved over the past century. Clinical research nurses (CRNs) work directly (e.g., direct care provider and advance clinician) or indirectly (e.g., manager, educator, and study co-ordinator) to support clinic research. For more than 50 years, oncology nurses have contributed to the body of evidence describing and validating the responsibilities and importance of the nurse in clinical research, especially the study co-ordinator role. This article will focus on the CRN study co-ordinator role in oncology clinical trials highlighting the historical evolution of the role, the contributions of dedicated members of the Oncology Nursing Society, and the future landscape of clinical research nursing through the International Association of CRNs.
PubMed: 32642493
DOI: 10.4103/apjon.apjon_10_20 -
Journal of Research in Nursing : JRN Mar 2022As nurses, we identify our profession as a caring one, but how does this identity translate from a conceptual definition, to real-world practice for the Clinical...
BACKGROUND
As nurses, we identify our profession as a caring one, but how does this identity translate from a conceptual definition, to real-world practice for the Clinical Research Nurse?
AIM
To offer a novel, four-point conceptual model that encapsulates the Clinical Research Nurse's intrinsic value, active leadership, and direct contribution to high quality, person-centered, safe care, addressing current misperceptions of research nursing.
METHODS
This paper describes the provision of 'care', safely delivered by the Clinical Research Nurse through a four-point conceptual model and case-driven example.
DISCUSSION
Clinical research nursing is conceptualized within the domains of Care and Trust, Role, Impact, and Integration. The case example demonstrates real-world application of these domains and the expertise required to balance the complexities of clinical needs and research demands in a healthcare environment.
CONCLUSIONS
This paper offers a mechanism for understanding the importance of the Clinical Research Nurse and their role in maintaining safety and a high-level view of the care arena. These reflections are considered with an international application for the role.
PubMed: 35392206
DOI: 10.1177/17449871211073760 -
Frontiers in Pharmacology 2018Clinical research workforce development efforts have focused on both increasing the size of the workforce of investigators and professionals working in the clinical... (Review)
Review
Clinical research workforce development efforts have focused on both increasing the size of the workforce of investigators and professionals working in the clinical research enterprise, but also the education and training of those individuals to ensure the quality of study performance to improve the public's health. A major contribution to these efforts has been the establishment of core competencies for clinical research professionals by the Joint Task Force for Clinical Trial Competency. This article reviews the development of the clinical research core competencies, their wide adoption and influence on job descriptions, education, training, and academic accreditation.
PubMed: 30386238
DOI: 10.3389/fphar.2018.01148