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British Medical Journal Oct 1955
Topics: Colitis; Colitis, Ulcerative; Cortisone
PubMed: 13260656
DOI: 10.1136/bmj.2.4947.1041 -
British Medical Journal Mar 1952
Topics: Arthritis; Arthritis, Rheumatoid; Cortisone; Hydrocortisone
PubMed: 14904993
DOI: No ID Found -
British Medical Journal Sep 1951
Topics: Cortisone; Heredity; Hypersensitivity; Immune System Diseases
PubMed: 14869638
DOI: No ID Found -
Determination of cortisone and cortisol in human scalp hair using an improved LC-MS/MS-based method.Clinical Chemistry and Laboratory... Jan 2024Human scalp hair is an easily available but complex matrix for determination of cortisone and cortisol, and has been shown to reflect long-term glucocorticoid exposure....
OBJECTIVES
Human scalp hair is an easily available but complex matrix for determination of cortisone and cortisol, and has been shown to reflect long-term glucocorticoid exposure. Hair glucocorticoid analysis has been used to detect hypo- and hypercortisolism. In this study, we describe the development and validation of a LC-MS/MS method for quantification of cortisone and cortisol in human scalp hair, and provide a novel approach for analysis and interpretation of the results.
METHODS
Improved sample preparation using pulverization and solid phase extraction allowed for low sample volumes (10 mg). Baseline chromatographic separation without matrix interference was achieved by reversed phase chromatography and MRM measurement in negative ion mode. Run-to-run time was 8 min. Mixed model analyses were performed to create individual patterns of cortisone and cortisol concentrations.
RESULTS
Matrix matched calibration curves showed excellent linearity up to 100 pg (analyte)/mg (hair) for both cortisone and cortisol (R>0.995). LLOQ was 1.5 and 1.0 pg/mg for cortisone and cortisol, respectively. Matrix effect was negligible for hair color (recoveries 95-105 %). Cortisone and cortisol concentrations decreased from proximal to distal hair segments, following a predictable, but subject-specific pattern, with less individual variation for cortisone than for cortisol.
CONCLUSIONS
This improved LC-MS/MS method is able to accurately quantify cortisone and cortisol in human hair with minimum matrix interference. This new way of data analysis and interpretation including individual patterns of cortisone and cortisol will be of help with detection of pathological concentrations in both the high - and the low ranges of glucocorticoids.
Topics: Humans; Hydrocortisone; Cortisone; Chromatography, Liquid; Glucocorticoids; Scalp; Tandem Mass Spectrometry; Hair
PubMed: 37485925
DOI: 10.1515/cclm-2023-0341 -
History and Philosophy of the Life... Nov 2019Cortisone, initially known as 'compound E' was the medical sensation of the late 1940s and early 1950s. As early as April 1949, only a week after Philip Hench and... (Review)
Review
Cortisone, initially known as 'compound E' was the medical sensation of the late 1940s and early 1950s. As early as April 1949, only a week after Philip Hench and colleagues first described the potential of 'compound E' at a Mayo Clinic seminar, the New York Times reported the drug's promise as a 'modern miracle' in the treatment of rheumatoid arthritis (RA). Given its high profile, it is unsurprising that historians of medicine have been attracted to study the innovation of cortisone. It arrived at the end of a decade of 'therapeutic revolutions', kicked off by penicillin transforming the treatment of bacterial infections and ending with hopes of a revolution in the treatment of non-infectious, chronic inflammatory diseases. Despite these studies of cortisone's introduction, few historians have taken the story forward and considered how cortisone was adopted and adapted into clinical practice. This article tells the longer of how the drug and its derivatives were taken from research laboratories and integrated into clinical practice; what has in recent decades become known as translational medicine (TM). In exploring cortisone's first decade in Britain, we focus specifically on its role in the treatment of RA. Our approach is always to consider cortisone's use in the context of other treatments available to clinicians, and at local and national institutional settings. We do not discuss the many other therapeutic uses of cortisone, which ranged for topical applications for skin diseases to the management of cancers, especially childhood leukaemia, nor do we discuss its close analogue ACTH-AdenoCorticoTropic Hormone. We think there are lessons in our study for TM policies today.
Topics: Arthritis, Rheumatoid; Cortisone; History, 20th Century; Humans; Translational Research, Biomedical; United Kingdom
PubMed: 31701313
DOI: 10.1007/s40656-019-0269-7 -
Arhiv Za Higijenu Rada I Toksikologiju 2022Salivary cortisone strongly correlates with serum cortisol, and since it is less invasive to measure salivary cortisone than serum cortisol and easier than to measure...
Salivary cortisone strongly correlates with serum cortisol, and since it is less invasive to measure salivary cortisone than serum cortisol and easier than to measure cortisol in saliva, as its concentrations are much lower, we wanted to compare salivary cortisone and cortisol levels as markers of noise-induced stress reaction. The study included 104 participants aged 19-30 years, 50 of whom were exposed to occupational noise ≥85 dB(A) and 54 non-exposed, control students. All participants took samples of their saliva with Salivette Cortisol synthetic swabs on three consecutive working days first thing in the morning. Salivary cortisone and cortisol levels were determined with high-performance liquid chromatography. In addition, they completed a 10-item Perceived Stress Scale (PSS-10) questionnaire, and occupationally noise-exposed participants also completed the Health and Safety Executive (HSE) questionnaire on occupational psychosocial risks. The exposed participants had significantly higher cortisone (P<0.001) and cortisol (P<0.001) levels than controls, and the correlation between cortisone and cortisol levels in the exposed participants was strong (ϱ =0.692, P<0.001), which suggests that salivary cortisone can replace cortisol measurements in saliva as a more reliable method than salivary cortisol and less invasive than serum cortisol. However, the level of perceived stress scored on PSS-10 in the exposed participants did not differ significantly from stress reported by controls, but correlated negatively with cortisone levels, which is contrary to our expectations and raises questions as to why.
Topics: Humans; Cortisone; Hydrocortisone; Chromatography, High Pressure Liquid; Occupational Exposure
PubMed: 38146755
DOI: 10.2478/aiht-2023-74-3785 -
British Medical Journal Nov 1955
Topics: Cortisone
PubMed: 13269832
DOI: No ID Found -
British Medical Journal Dec 1953
Topics: Adrenocorticotropic Hormone; Cortisone; Dermatomyositis
PubMed: 13106431
DOI: 10.1136/bmj.2.4850.1357 -
Gut Feb 1997
Topics: Adrenocorticotropic Hormone; Animals; Cortisone; Dogs; History, 20th Century; Stomach Ulcer
PubMed: 9071951
DOI: 10.1136/gut.40.2.289-b -
Canadian Medical Association Journal Nov 1951
Topics: Cortisone; Fibroma; Keloid
PubMed: 14879325
DOI: No ID Found