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Clinical Case Reports Jul 2021Neural tube defects can be accurately diagnosed prenatally. Every effort must be made to get this and its associations with Craniolacunia right, especially in...
Neural tube defects can be accurately diagnosed prenatally. Every effort must be made to get this and its associations with Craniolacunia right, especially in low-resource settings. This case highlights the importance of three-dimensional CT in diagnosing neonatal skull abnormalities.
PubMed: 34322255
DOI: 10.1002/ccr3.4501 -
Surgical Neurology International 2013Cranioplasty is a surgical intervention aimed at reestablishing the integrity of skull defects, and should be considered the conclusion of a surgical act that began with...
BACKGROUND
Cranioplasty is a surgical intervention aimed at reestablishing the integrity of skull defects, and should be considered the conclusion of a surgical act that began with bone flap removal. Autologous bone is still considered the treatment of choice for cranioplasty. An alternative choice is bioceramic porous hydroxyapatite (HA) as it is one of the materials that meets and comes closest to the biomimetic characteristics of bone.
METHODS
The authors analyzed the clinical charts, compiled by the neurosurgeon, of all patients treated with custom-made porous HA devices (Custom Bone Service Fin-Ceramica, Faenza) from which epidemiological and pathological data as well as material-related complications were extrapolated.
RESULTS
From November 1997 to December 2010, 1549 patients underwent cranioplasty with the implantation of 1608 custom-made porous HA devices. HA was used in 53.8% of patients for decompressive craniectomy after trauma or intracranial hemorrhage, while the remaining cases were for treated for comminuted fracture, cutaneous or osseous resection, cranial malformation, autologous bone reabsorption or infection or rejection of previously implanted material. The incidence of adverse events in patients treated for cranioplasty, as first line treatment was 4.78% (56 events/1171 patients), and 5.02%, (19 events/378 patients) at second line.
CONCLUSION
This study demonstrates that HA is a safe and effective material, is well tolerated in both adult and pediatric patients, and meets the requirements necessary to repair craniolacunia.
PubMed: 23493459
DOI: 10.4103/2152-7806.106290 -
Journal of Applied Biomaterials &... Jul 2015Cranioplasty is a surgical intervention aimed at reestablishing the integrity of skull defects. Autologous bone is still considered the treatment of choice for...
PURPOSE
Cranioplasty is a surgical intervention aimed at reestablishing the integrity of skull defects. Autologous bone is still considered the treatment of choice for cranioplasty. The aims of this study were to characterize and evaluate the efficacy of porous hydroxyapatite (HA) to fill skull defects based on its biomimetic characteristics.
METHODS
The authors analyzed the postmarketing data of all patients treated with custom-made porous HA prostheses (CustomBone Service). Characterization data in terms of physicochemical analysis and mechanical performance of the porous HA prostheses were also reported.
RESULTS
The low incidence of adverse events (5.72%) due to the use of HA porous custom-made prostheses for cranioplasty is related to the biomimetic performance of the prostheses. The composition and morphology of the porosity enable it to be a useful biomimetic prosthesis for the reconstruction of large and complex skull defects, also able to promote osteointegration.
CONCLUSIONS
These collected and analyzed data demonstrate that porous HA is a suitable material to produce custom-made prostheses to repair craniolacunia. It is a biomimetic implant well-tolerated in both adult and pediatric patients and has been shown to be an effective and good alternative for cranial reconstruction.
Topics: Adolescent; Adult; Biocompatible Materials; Biomimetic Materials; Bone Substitutes; Child; Child, Preschool; Durapatite; Female; Humans; Infant; Infant, Newborn; Male; Porosity; Precision Medicine; Product Surveillance, Postmarketing; Prostheses and Implants; Prosthesis Design; Skull; Surveys and Questionnaires; Young Adult
PubMed: 25589160
DOI: 10.5301/jabfm.5000211 -
Neurologia Medico-chirurgica May 1989The authors report a newborn girl with a large meningoencephalocele, 18.5 cm in diameter, at the anterior fontanel. She had several accompanying anomalies, including...
The authors report a newborn girl with a large meningoencephalocele, 18.5 cm in diameter, at the anterior fontanel. She had several accompanying anomalies, including microcephalus, cleft palate, and a uvula bifida. A plain skull x-ray revealed craniolacunia and a computed tomography (CT) scan showed maldevelopment of the cerebrum. The mass was resected, after which the fontanel was noted to bulge. CT demonstrated dilated lateral ventricles. A successful shunting procedure permitted the infant to leave the hospital in good general condition.
Topics: Cleft Palate; Encephalocele; Female; Humans; Infant, Newborn; Meningocele; Microcephaly; Skull; Tomography, X-Ray Computed
PubMed: 2477742
DOI: 10.2176/nmc.29.414 -
Journal of Medical Genetics Jun 1999
Topics: Base Sequence; DNA; DNA Primers; Female; Humans; Infant; Point Mutation; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Skull; Synostosis; Tomography, X-Ray Computed
PubMed: 10874645
DOI: No ID Found