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British Medical Journal Apr 1947
Topics: Curare
PubMed: 20343511
DOI: 10.1136/bmj.1.4503.578-c -
British Medical Journal Feb 1947
Topics: Curare
PubMed: 20342955
DOI: 10.1136/bmj.1.4492.234-f -
British Journal of Pharmacology Jan 2006Descriptions of the South American arrow poisons known as curares were reported by explorers in the 16th century, and their site of action in producing neuromuscular... (Review)
Review
Descriptions of the South American arrow poisons known as curares were reported by explorers in the 16th century, and their site of action in producing neuromuscular block was determined by Claude Bernard in the mid-19th century. Tubocurarine, the most important curare alkaloid, played a large part in experiments to determine the role of acetylcholine in neuromuscular transmission, but it was not until after 1943 that neuromuscular blocking drugs became established as muscle relaxants for use during surgical anaesthesia. Tubocurarine causes a number of unwanted effects, and there have been many attempts to replace it. The available drugs fall into two main categories: the depolarising blocking drugs and the nondepolarising blocking drugs. The former act by complex mixed actions and are now obsolete with the exception of suxamethonium, the rapid onset and brief duration of action of which remain useful for intubation at the start of surgical anaesthesia. The nondepolarising blocking drugs are reversible acetylcholine receptor antagonists. The main ones are the atracurium group, which possess a built-in self-destruct mechanism that makes them specially useful in kidney or liver failure, and the vecuronium group, which are specially free from unwanted side effects. Of this latter group, the compound rocuronium is of special interest because its rapid onset of action allows it to be used for intubation, and there is promise that its duration of action may be rapidly terminated by a novel antagonist, a particular cyclodextrin, that chelates the drug, thereby removing it from the acetylcholine receptors.
Topics: Animals; Atracurium; History, 16th Century; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Muscle, Skeletal; Nerve Block; Neuromuscular Blocking Agents; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Nicotinic Antagonists; Receptors, Nicotinic; Synaptic Transmission; Tubocurarine; Vecuronium Bromide
PubMed: 16402115
DOI: 10.1038/sj.bjp.0706404 -
The Journal of Physiology Jun 1886
PubMed: 16991433
DOI: 10.1113/jphysiol.1886.sp000221 -
BMC Bioinformatics Mar 2024Even though high-throughput transcriptome sequencing is routinely performed in many laboratories, computational analysis of such data remains a cumbersome process often...
Even though high-throughput transcriptome sequencing is routinely performed in many laboratories, computational analysis of such data remains a cumbersome process often executed manually, hence error-prone and lacking reproducibility. For corresponding data processing, we introduce Curare, an easy-to-use yet versatile workflow builder for analyzing high-throughput RNA-Seq data focusing on differential gene expression experiments. Data analysis with Curare is customizable and subdivided into preprocessing, quality control, mapping, and downstream analysis stages, providing multiple options for each step while ensuring the reproducibility of the workflow. For a fast and straightforward exploration and visualization of differential gene expression results, we provide the gene expression visualizer software GenExVis. GenExVis can create various charts and tables from simple gene expression tables and DESeq2 results without the requirement to upload data or install software packages. In combination, Curare and GenExVis provide a comprehensive software environment that supports the entire data analysis process, from the initial handling of raw RNA-Seq data to the final DGE analyses and result visualizations, thereby significantly easing data processing and subsequent interpretation.
Topics: RNA-Seq; Curare; Reproducibility of Results; Sequence Analysis, RNA; Transcriptome; Software; High-Throughput Nucleotide Sequencing; Gene Expression Profiling
PubMed: 38553675
DOI: 10.1186/s12859-024-05761-2 -
British Journal of Anaesthesia Jan 1948
Topics: Curare
PubMed: 18910373
DOI: 10.1093/bja/21.1.2 -
British Medical Journal Jan 1947
Topics: Curare
PubMed: 20244682
DOI: 10.1136/bmj.1.4489.111-a -
British Medical Journal Apr 1947
Topics: Curare
PubMed: 20248023
DOI: 10.1136/bmj.1.4500.466 -
British Medical Journal Feb 1947
Topics: Curare
PubMed: 20244711
DOI: 10.1136/bmj.1.4493.268-c -
Anaesthesiology Intensive Therapy 2016The aim of the presented review is to highlight the clinical problem of postoperative residual curarization (PORC) following general anaesthesia in the elderly. Possible... (Review)
Review
The aim of the presented review is to highlight the clinical problem of postoperative residual curarization (PORC) following general anaesthesia in the elderly. Possible complications of PORC are described along with age-induced changes in pharmacokinetics of long and intermediate-acting neuromuscular blocking agents. This is intended to facilitate the selection and to promote appropriate intraoperative use of muscle relaxants in patients over the age of 65 years.
Topics: Aged; Aged, 80 and over; Anesthesia Recovery Period; Humans; Neuromuscular Blockade; Neuromuscular Blocking Agents; Neuromuscular Nondepolarizing Agents; Postoperative Complications
PubMed: 27797097
DOI: 10.5603/AIT.2016.0045