Review

Authors: Carlos José Soares, André Luis Faria-E-Silva, Monise de Paula Rodrigues...

Polymerization shrinkage stress of resin-based materials have been related to several unwanted clinical consequences, such as enamel crack propagation, cusp deflection, marginal and internal gaps, and decreased bond strength. Despite the absence of strong evidence relating polymerization shrinkage to secondary caries or fracture of posterior teeth, shrinkage stress has been associated with post-operative sensitivity and marginal stain. The latter is often erroneously used as a criterion for replacement of composite restorations. Therefore, an indirect correlation can emerge between shrinkage stress and the longevity of composite restorations or resin-bonded ceramic restorations. The relationship between shrinkage and stress can be best studied in laboratory experiments and a combination of various methodologies. The objective of this review article is to discuss the concept and consequences of polymerization shrinkage and shrinkage stress of composite resins and resin cements. Literature relating to polymerization shrinkage and shrinkage stress generation, research methodologies, and contributing factors are selected and reviewed. Clinical techniques that could reduce shrinkage stress and new developments on low-shrink dental materials are also discussed.

Topics: Composite Resins; Curing Lights, Dental; Dental Stress Analysis; Materials Testing; Polymerization; Resin Cements

PubMed: 28902242
DOI: 10.1590/1807-3107BOR-2017.vol31.0062

Authors: Pascal Magne, Taban Milani

PURPOSE

To assess the mechanical performance and enamel-crack propensity of large MOD composite-resin restorations on maxillary molars with severely undermined cusps.

MATERIALS AND METHODS

Thirty-six extracted maxillary third molars (n = 12) received a standardized slot-type MOD preparation (5-mm depth by 5-mm bucco-palatal width) with severe undercuts, leaving unsupported buccal and lingual enamel cusps. A short-fiber reinforced composite resin base (SFRC, everX Flow, GC) was used for both the experimental direct approach and semi-direct CAD/CAM inlays (Cerasmart 270, GC). In the control group using a direct approach, Gradia Direct (GC) composite resin was used alone without SFRC. Optibond FL (Kerr) adhesive was used in all three groups (also for the immediate dentin sealing of inlays). Artificial masticatory forces were simulated under water using closed-loop servo-hydraulics (MTS Acumen 3). Each specimen was mounted at a 30-degree angle and positioned so that a cylindrical antagonistic cusp (actuator) contacted the internal palatal cusp slope of the restoration. Cyclic loading was applied at a frequency of 5 Hz, starting with a load of 200 N, increasing by 100 N every 2000 cycles. Samples were loaded until fracture and the number of endured cycles and failure modes of each specimen was recorded. Each sample was also evaluated for crack propensity during the experiment and for final failure mode (reparable failures above the CEJ [cementoenamel junction] vs irreparable failures below the CEJ).

RESULTS

Shrinkage-induced cracks (>3 mm) were found in most specimens for both direct groups (66% to 83%) but not with inlays. The survival of inlays with a SFRC base was superior to that of the direct SFRC restorations and Gradia Direct (control) restorations (Kaplan-Meier survival analysis and post-hoc log-rank test p < 0.000). The direct control group without SFRC exhibited not only the poorest survival but also 100% catastrophic failure (vs 42% and 17% for SFRC direct and SFRC inlays, respectively).

CONCLUSION

Large MOD restorations with severely undermined cusps were most favorably restored with an SFRC base and a CAD/CAM inlay, yielding the highest survival rate, more reparable failures and absence of shrinkage-induced cracks. When a low-cost restoration must be chosen, the SFRC base will significantly improve the performance and failure mode of directly layered restorations.

Topics: Composite Resins; Inlays; Dental Enamel; Tooth Cervix; Molar; Dental Stress Analysis; Materials Testing

PubMed: 37097055
DOI: 10.3290/j.jad.b4051477

Review

Authors: Jessica A Kemp, Young Jik Kwon

Modern medicine has been waging a war on cancer for nearly a century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase specificity and decrease systemic toxicities remains. Early diagnosis holds a key to improving prognostic outlook and patient quality of life, and diagnostic tools are on the cusp of a technological revolution. Nanotechnology has steadily expanded into the reaches of cancer chemotherapy, radiotherapy, diagnostics, and imaging, demonstrating the capacity to augment each and advance patient care. Nanomaterials provide an abundance of versatility, functionality, and applications to engineer specifically targeted cancer medicine, accurate early-detection devices, robust imaging modalities, and enhanced radiotherapy adjuvants. This review provides insights into the current clinical and pre-clinical nanotechnological applications for cancer drug therapy, diagnostics, imaging, and radiation therapy.

PubMed: 34727233
DOI: 10.1186/s40580-021-00282-7

Review

Authors: Fiona Robinson, Sonji Wilkes, Nathan Schaefer...

UNLABELLED

Pharmacovigilance, the science and practice of monitoring the effects of medicinals and their safety, is the responsibility of all stakeholders involved in the development, manufacture, regulation, distribution, prescription, and use of drugs and devices. The patient is the stakeholder most impacted by and the greatest source of information on safety issues. It is rare, however, for the patient to take a central role and exert leadership in the design and execution of pharmacovigilance. Patient organizations in the inherited bleeding disorders community are among the most established and empowered, particularly in the rare disorders. In this review, two of the largest bleeding disorders patient organizations, Hemophilia Federation of America (HFA) and National Hemophilia Foundation (NHF), offer insights into the priority actions required of all stakeholders to improve pharmacovigilance. The recent and ongoing increase in incidents raising safety concerns and a therapeutic landscape on the cusp of unprecedented expansion heighten the urgency of a recommitment to the primacy of patient safety and well-being in drug development and distribution.

PLAIN LANGUAGE SUMMARY

Every medical device and therapeutic product has potential benefits and harms. The pharmaceutical and biomedical companies that develop them must demonstrate that they are effective, and the safety risks are limited or manageable, for regulators to approve them for use and sale. After the product has been approved and people are using it in their daily lives, it is important to continue to collect information about any negative side effects or adverse events; this is called pharmacovigilance. Regulators, like the United States (US) Food and Drug Administration, the companies that sell and distribute the products, and healthcare professionals who prescribe them are all required to participate in collecting, reporting, analyzing, and communicating this information. The people with the most firsthand knowledge of the benefits and harms of the drug or device are the patients who use them. They have an important responsibility to learn how to recognize adverse events, how to report them, and to stay informed of any news about the product from the other partners in the pharmacovigilance network. Those partners have a crucial responsibility to provide clear, easy-to-understand information to patients about any new safety concerns that come to light. The community of people with inherited bleeding disorders has recently encountered problems with poor communication of product safety issues, prompting two large US patient organizations, National Hemophilia Foundation and Hemophilia Federation of America, to hold a Safety Summit with all the pharmacovigilance network partners. Together they developed recommendations to improve the collection and communication of information about product safety so that patients can make well-informed, timely decisions about their use of drugs and devices. This article presents these recommendations in the context of how pharmacovigilance is supposed to work and some of the challenges encountered by the community.

PubMed: 36861041
DOI: 10.1177/20420986221146418

Review

Authors: Dimitrios N Nikas, Lampros Lakkas, Katerina K Naka...

Bicuspid aortic valve (BAV) stenosis, a common congenital condition, presents unique challenges for transcatheter aortic valve replacement (TAVI) due to anatomical variations like cusp morphology, coexisting aortopathy and calcification. TAVI offers a viable option for BAV patients with refinements in technique and technology, though ongoing research is essential to optimize patient-specific approaches and long-term results. Key considerations for TAVI in BAV include precise valve sizing, positioning, and the need for rigorous pre-procedural imaging to mitigate risks such as paravalvular leak and stroke. Early results show TAVI's safety and efficacy are comparable to surgery, though BAV patients undergoing TAVI often are exposed to higher rates of post-procedural pacemaker implantation. Emerging data on next-generation self-expandable (SE) and balloon-expandable (BE) valves reveal that while both offer success in this complex anatomical aortic valve variation, gaps remain in the long-term durability and management of BAV-related aortopathy. This review examines the latest advancements in TAVI for BAV, emphasizing how specialized approaches and device selection address BAV's complexities.

PubMed: 39941442
DOI: 10.3390/jcm14030772

Review

Authors: Lola Gutierrez, Mauro Boiago, Chiara De Biase...

Bicuspid aortic valve (BAV) is the most common congenital heart disease, with a prevalence of 1-2% and occurring in >20% of octogenarians referred for aortic valve replacement. However, BAV patients have been systematically excluded from pivotal randomized trials. Since TAVI indications are moving toward low-risk patients, an increase in the number of BAV patients who undergo TAVI is expected. BAV represents a challenge due to its unique morphological features (raphe, extreme asymmetrical valve calcifications, cusp asymmetry and aortopathy) and the lack of consensus about the accurate sizing method. The role of multi-slice computed tomography (MSCT) in the planification of the TAVI procedure is well-established, being useful to define the optimal valve sizing and the implantation strategy. New-generation devices, more experience of the operators and better planification of the procedure have been associated with similar clinical outcomes in bicuspid and tricuspid patients undergoing TAVI.

PubMed: 38002687
DOI: 10.3390/jcm12227074

Review

Authors: Elizabeth A Calle, Katherine L Leiby, MichaSam B Raredon...

PURPOSE OF REVIEW

Whole lung tissue engineering is a relatively new area of investigation. In a short time, however, the field has advanced quickly beyond proof of concept studies in rodents and now stands on the cusp of wide-spread scale up to large animal studies. Therefore, this technology is ever closer to being directly clinically relevant.

RECENT FINDINGS

The main themes in the literature include refinement of the fundamental components of whole lung engineering and increasing effort to direct induced pluripotent stem cells and lung progenitor cells toward use in lung regeneration. There is also increasing need for and emphasis on functional evaluation in the lab and in vivo, and the use of all of these tools to construct and evaluate forthcoming clinically scaled engineered lung.

SUMMARY

Ultimately, the goal of the research described herein is to create a useful clinical product. In the intermediate time, however, the tools described here may be employed to advance our knowledge of lung biology and the organ-specific regenerative capacity of lung stem and progenitor cells.

Topics: Animals; Bioreactors; Humans; Induced Pluripotent Stem Cells; Lung; Lung Diseases; Models, Animal; Regeneration; Stem Cell Transplantation; Tissue Engineering; Tissue Scaffolds

PubMed: 27922848
DOI: 10.1097/ACO.0000000000000425

Review

Authors: Philipp Lauten, Lisa C Costello-Boerrigter, Björn Goebel...

Transcatheter aortic valve implantation (TAVI) is now a commonly used therapy in patients with severe aortic stenosis, even in those patients at low surgical risk. The indications for TAVI have broadened as the therapy has proven to be safe and effective. Most challenges associated with TAVI after its initial introduction have been impressively reduced; however, the possible need for post-TAVI permanent pacemaker implantation (PPI) secondary to conduction disturbances continues to be on the radar. Conduction abnormalities post-TAVI are always of concern given that the aortic valve lies in close proximity to critical components of the cardiac conduction system. This review will present a summary of noteworthy pre-and post-procedural conduction blocks, the best use of telemetry and ambulatory device monitoring to avoid unnecessary PPI or to recognize the need for late PPI due to delayed high-grade conduction blocks, predictors to identify those patients at greatest risk of requiring PPI, important CT measurements and considerations to optimize TAVI planning, and the utility of the MInimizing Depth According to the membranous Septum (MIDAS) technique and the cusp-overlap technique. It is stressed that careful membranous septal (MS) length measurement by MDCT during pre-TAVI planning is necessary to establish the optimal implantation depth before the procedure to reduce the risk of compression of the MS and consequent damage to the cardiac conduction system.

PubMed: 37367395
DOI: 10.3390/jcdd10060230

Review

Authors: Franco Bassetto, Laura Pandis, Federico Facchin...

We are sitting on the cusp of the bioengineered breast era, in which implant-based breast reconstruction is seeing a growing trend and biotechnology research progressively empowers clinical practice. As never before, the choice of biomaterials has acquired great importance for achieving reconstructive outcomes, and the increase in the use of acellular dermal matrices (ADMs) in the field of senology tells us a story of profound upheaval and progress. With the advent of prepectoral breast reconstruction (PPBR), plenty of devices have been proposed to wrap the silicone prosthesis, either completely or partially. However, this has caused a great deal of confusion and dissent with regard to the adoption of feasible reconstructive strategies as well as the original scientific rationale underlying the prepectoral approach. Braxon is the very first device that made prepectoral implant positioning possible, wrapping around the prosthesis and exerting the proven ADM regenerative potential at the implant-tissue interface, taking advantage of the body's physiological healing mechanisms. To date, the Braxon method is among the most studied and practiced worldwide, and more than 50 publications confirm the superior performance of the device in the most varied clinical scenarios. However, a comprehensive record of the working of this pioneering device is still missing. Therefore, our aim with this review is to lay a structured knowledge of surgery with BRAXON and to provide a decision-making tool in the field of PPBR through a complete understanding on the very first device for prepectoral, one decade after its introduction.

PubMed: 36420412
DOI: 10.3389/fsurg.2022.1009356

Authors: Xin Zhou, Xingjing Ren, Dingbang Xiao...

Singularities ubiquitously exist in different fields and play a pivotal role in probing the fundamental laws of physics and developing highly sensitive sensors. Nevertheless, achieving higher-order (≥3) singularities, which exhibit superior performance, typically necessitates meticulous tuning of multiple (≥3) coupled degrees of freedom or additional introduction of nonlinear potential energies. Here we propose theoretically and confirm using mechanics experiments, the existence of an unexplored cusp singularity in the phase-tracked (PhT) steady states of a pair of coherently coupled mechanical modes without the need for multiple (≥3) coupled modes or nonlinear potential energies. By manipulating the PhT singularities in an electrostatically tunable micromechanical system, we demonstrate an enhanced cubic-root response to frequency perturbations. This study introduces a new phase-tracking method for studying interacting systems and sheds new light on building and engineering advanced singular devices with simple and well-controllable elements, with potential applications in precision metrology, portable nonreciprocal devices, and on-chip mechanical computing.

PubMed: 38040766
DOI: 10.1038/s41467-023-43708-y