Review

Authors:

Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Cyclohexanes; Cyclohexanones; Humans; Risk Factors

PubMed: 2699896
DOI: No ID Found

Review

Authors:

Topics: Animals; Carcinogenicity Tests; Carcinogens; Cyclohexanes; Cyclohexenes; Humans

PubMed: 7869574
DOI: No ID Found

Review

Authors:

Topics: Animals; Carcinogenicity Tests; Carcinogens; Cyclohexanes; Cyclohexenes; Humans; Vinyl Compounds

PubMed: 7869575
DOI: No ID Found

Authors:

Topics: Airway Obstruction; Analgesics; Anesthesia, General; Cyanosis; Cyclohexanes; Female; Humans; Infant; Injections, Intramuscular; Ketamine; Larynx; Pharynx; Salivation; Vomiting

PubMed: 5091899
DOI: No ID Found

Authors: Peihao Chen, Jing Wang, Shuangfeng Zhang...

Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant chemical feedstock furfuryl alcohol. The optically pure cyclohexane skeleton is assembled via a stereoselective Diels-Alder reaction. The dense heteroatom substituents are established sequentially by a series of functional group interconversions on highly oxygenated cyclohexane frameworks, including a chemoselective cyclic anhydride opening, and a decarboxylative hydroxylation. An innovative SmI-mediated concurrent fragmentation, an oxo-bridge ring opening and ester reduction followed by an Upjohn dihydroxylation deliver the highly oxidized skeleton. Ruthenium-catalyzed oxidative alkyne cleavage and formation of the hemiaminal and orthoester under acidic conditions enable the rapid assembly of Tetrodotoxin, anhydro-Tetrodotoxin, 9-epiTetrodotoxin, and 9-epi lactone-Tetrodotoxin.

Topics: Tetrodotoxin; Hydroxylation; Oxidative Stress; Cyclohexanes; Radiopharmaceuticals

PubMed: 38263179
DOI: 10.1038/s41467-024-45037-0

Authors:

Topics: Animals; Body Weight; Cyclohexanes; Cyclohexenes; Dose-Response Relationship, Drug; Female; Liver; Male; Mice; Oocytes; Organ Size; Ovary; Pregnancy; Reproduction; Sperm Count; Spermatids

PubMed: 9114365
DOI: No ID Found

Authors: Tsutomu Takeuchi, Hideto Kameda

Fleishaker and colleagues reported on a double-blind placebo controlled clinical trial of a C-C chemokine-receptor type 5 (CCR5) antagonist, maraviroc, in rheumatoid arthritis (RA) patients with inadequate response to methotrexate, showing that it was ineffective. Two additional CCR5 antagonists, SCH351125 and AZD5672, also failed to demonstrate clinical efficacy. In addition, CCR5-blocking antibodies could not inhibit synovial fluid-induced monocyte chemotaxis. Thus, CCR5 appears not to be a desirable target in RA treatment. Given the multiple functions of CCR5, redundancies in the chemokine system, and patient selection in the trial, we overview the recent understanding for chemokine receptor blockade in the treatment of RA

Topics: Arthritis, Rheumatoid; Cyclohexanes; Female; Humans; Male; Methotrexate; Triazoles

PubMed: 22494450
DOI: 10.1186/ar3775

Authors: J W Dundee

Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Blood Pressure; Cardiac Catheterization; Child; Cyclohexanes; Dreams; Female; Hallucinogens; Humans; Ketamine; Male; Preanesthetic Medication

PubMed: 5131249
DOI: 10.1177/003591577106401120

Authors: N D Abbey, D J Steward

Topics: Adult; Anesthetics; Child; Cyclohexanes; Humans; Ketamine

PubMed: 5016918
DOI: No ID Found

Authors: D L Coppel, J W Dundee

Topics: Anesthetics; Cyclohexanes; Diazepam; Electroconvulsive Therapy; Humans; Ketamine; Preanesthetic Medication

PubMed: 5014262
DOI: 10.1136/bmj.1.5803.805