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International Journal of Molecular... May 2019Jasmonic acid (JA) and its precursors and dervatives, referred as jasmonates (JAs) are important molecules in the regulation of many physiological processes in plant... (Review)
Review
Jasmonic acid (JA) and its precursors and dervatives, referred as jasmonates (JAs) are important molecules in the regulation of many physiological processes in plant growth and development, and especially the mediation of plant responses to biotic and abiotic stresses. JAs biosynthesis, perception, transport, signal transduction and action have been extensively investigated. In this review, we will discuss the initiation of JA signaling with a focus on environmental signal perception and transduction, JA biosynthesis and metabolism, transport of signaling molecules (local transmission, vascular bundle transmission, and airborne transportation), and biological function (JA signal receptors, regulated transcription factors, and biological processes involved).
Topics: Cyclopentanes; Magnoliopsida; Oxylipins; Signal Transduction; Stress, Physiological
PubMed: 31137463
DOI: 10.3390/ijms20102479 -
Plant Communications Sep 2021Biosynthesis/metabolism, perception/signaling, and transport are three essential aspects of the actions of phytohormones. Jasmonates (JAs), including jasmonic acid (JA)... (Review)
Review
Biosynthesis/metabolism, perception/signaling, and transport are three essential aspects of the actions of phytohormones. Jasmonates (JAs), including jasmonic acid (JA) and related oxylipins, are implicated in the regulation of a range of ecological interactions, as well as developmental programs to integrate these interactions. Jasmonoyl-isoleucine (JA-Ile) is the most bioactive JAs, and perception of JA-Ile by its coreceptor, the Skp1-Cullin1-F-box-type (SCF) protein ubiquitin ligase complex SCF-JAZ, in the nucleus derepresses the transcriptional repression of target genes. The biosynthesis and metabolism of JAs occur in the plastid, peroxisome, cytosol, endoplasmic reticulum, and vacuole, whereas sensing of JA-Ile levels occurs in the nucleus. It is increasingly apparent that a number of transporters, particularly members of the jasmonates transporter (JAT) family, located at endomembranes as well as the plasma membrane, constitute a network for modulating and coordinating the metabolic flux and signaling of JAs. In this review, we discuss recent advances in the metabolism, signaling, and especially the transport of JAs, focusing on intracellular compartmentation of these processes. The roles of transporter-mediated cell-cell transport in driving long-distance transport and signaling of JAs are also discussed.
Topics: Biological Transport; Cyclopentanes; Oxylipins; Plant Growth Regulators; Plant Physiological Phenomena; Plants; Signal Transduction
PubMed: 34746762
DOI: 10.1016/j.xplc.2021.100231 -
International Journal of Molecular... Apr 2022Lipid-derived jasmonates (JAs) play a crucial role in a variety of plant development and defense mechanisms. In recent years, significant progress has been made toward... (Review)
Review
Lipid-derived jasmonates (JAs) play a crucial role in a variety of plant development and defense mechanisms. In recent years, significant progress has been made toward understanding the JA signaling pathway. In this review, we discuss JA biosynthesis, as well as its core signaling pathway, termination mechanisms, and the evolutionary origin of JA signaling. JA regulates not only plant regeneration, reproductive growth, and vegetative growth but also the responses of plants to stresses, including pathogen as well as virus infection, herbivore attack, and abiotic stresses. We also focus on the JA signaling pathway, considering its crosstalk with the gibberellin (GA), auxin, and phytochrome signaling pathways for mediation of the trade-offs between growth and defense. In summary, JA signals regulate multiple outputs of plant defense and growth and act to balance growth and defense in order to adapt to complex environments.
Topics: Cyclopentanes; Gene Expression Regulation, Plant; Oxylipins; Plant Growth Regulators; Plants; Signal Transduction
PubMed: 35409303
DOI: 10.3390/ijms23073945 -
International Journal of Molecular... Aug 2021As sessile organisms, plants must tolerate various environmental stresses. Plant hormones play vital roles in plant responses to biotic and abiotic stresses. Among these... (Review)
Review
As sessile organisms, plants must tolerate various environmental stresses. Plant hormones play vital roles in plant responses to biotic and abiotic stresses. Among these hormones, jasmonic acid (JA) and its precursors and derivatives (jasmonates, JAs) play important roles in the mediation of plant responses and defenses to biotic and abiotic stresses and have received extensive research attention. Although some reviews of JAs are available, this review focuses on JAs in the regulation of plant stress responses, as well as JA synthesis, metabolism, and signaling pathways. We summarize recent progress in clarifying the functions and mechanisms of JAs in plant responses to abiotic stresses (drought, cold, salt, heat, and heavy metal toxicity) and biotic stresses (pathogen, insect, and herbivore). Meanwhile, the crosstalk of JA with various other plant hormones regulates the balance between plant growth and defense. Therefore, we review the crosstalk of JAs with other phytohormones, including auxin, gibberellic acid, salicylic acid, brassinosteroid, ethylene, and abscisic acid. Finally, we discuss current issues and future opportunities in research into JAs in plant stress responses.
Topics: Cyclopentanes; Oxylipins; Plant Growth Regulators; Plants; Stress, Physiological
PubMed: 34445272
DOI: 10.3390/ijms22168568 -
Molecular Cancer Apr 2019Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including... (Review)
Review
Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein neddylation is overactivated in multiple human cancers, providing a sound rationale for its targeting as an attractive anticancer therapeutic strategy, as evidence by the development of NEDD8-activating enzyme (NAE) inhibitor MLN4924 (also known as pevonedistat). Neddylation inhibition by MLN4924 exerts significantly anticancer effects mainly by triggering cell apoptosis, senescence and autophagy. Recently, intensive evidences reveal that inhibition of neddylation pathway, in addition to acting on tumor cells, also influences the functions of multiple important components of the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), cancer-associated endothelial cells (CAEs) and some factors, all of which are crucial for tumorigenesis. Here, we briefly summarize the latest progresses in this field to clarify the roles of neddylation in the TME, thus highlighting the overall anticancer efficacy of neddylaton inhibition.
Topics: Cancer-Associated Fibroblasts; Cell Survival; Cellular Senescence; Clinical Trials as Topic; Cyclopentanes; Humans; NEDD8 Protein; Neoplasms; Pyrimidines; Signal Transduction; Tumor Microenvironment
PubMed: 30943988
DOI: 10.1186/s12943-019-0979-1 -
Neuro-oncology Nov 2022
Topics: Humans; Glioblastoma; Cyclopentanes; Pyrimidines; PTEN Phosphohydrolase
PubMed: 35749751
DOI: 10.1093/neuonc/noac159 -
Nature Communications Aug 2023Autophagy, as an intracellular degradation system, plays a critical role in plant immunity. However, the involvement of autophagy in the plant immune system and its...
Autophagy, as an intracellular degradation system, plays a critical role in plant immunity. However, the involvement of autophagy in the plant immune system and its function in plant nematode resistance are largely unknown. Here, we show that root-knot nematode (RKN; Meloidogyne incognita) infection induces autophagy in tomato (Solanum lycopersicum) and different atg mutants exhibit high sensitivity to RKNs. The jasmonate (JA) signaling negative regulators JASMONATE-ASSOCIATED MYC2-LIKE 1 (JAM1), JAM2 and JAM3 interact with ATG8s via an ATG8-interacting motif (AIM), and JAM1 is degraded by autophagy during RKN infection. JAM1 impairs the formation of a transcriptional activation complex between ETHYLENE RESPONSE FACTOR 1 (ERF1) and MEDIATOR 25 (MED25) and interferes with transcriptional regulation of JA-mediated defense-related genes by ERF1. Furthermore, ERF1 acts in a positive feedback loop and regulates autophagy activity by transcriptionally activating ATG expression in response to RKN infection. Therefore, autophagy promotes JA-mediated defense against RKNs via forming a positive feedback circuit in the degradation of JAMs and transcriptional activation by ERF1.
Topics: Animals; Oxylipins; Cyclopentanes; Plant Immunity; Nematoda; Plant Diseases; Plant Roots; Gene Expression Regulation, Plant
PubMed: 37553319
DOI: 10.1038/s41467-023-40472-x -
Chemical Reviews Jun 2021Cyclopentadiene is one of the most reactive dienes in normal electron-demand Diels-Alder reactions. The high reactivities and yields of cyclopentadiene cycloadditions... (Review)
Review
Cyclopentadiene is one of the most reactive dienes in normal electron-demand Diels-Alder reactions. The high reactivities and yields of cyclopentadiene cycloadditions make them ideal as click reactions. In this review, we discuss the history of the cyclopentadiene cycloaddition as well as applications of cyclopentadiene click reactions. Our emphasis is on experimental and theoretical studies on the reactivity and stability of cyclopentadiene and cyclopentadiene derivatives.
Topics: Click Chemistry; Cycloaddition Reaction; Cyclopentanes; Kinetics
PubMed: 33651602
DOI: 10.1021/acs.chemrev.0c01055 -
International Journal of Molecular... Nov 2022For immobile plants, the main means of protection against adverse environmental factors is the biosynthesis of various secondary (specialized) metabolites. The extreme... (Review)
Review
For immobile plants, the main means of protection against adverse environmental factors is the biosynthesis of various secondary (specialized) metabolites. The extreme diversity and high biological activity of these metabolites determine the researchers' interest in plants as a source of therapeutic agents. Oxylipins, oxygenated derivatives of fatty acids, are particularly promising in this regard. Plant oxylipins, which are characterized by a diversity of chemical structures, can exert protective and therapeutic properties in animal cells. While the therapeutic potential of some classes of plant oxylipins, such as jasmonates and acetylenic oxylipins, has been analyzed thoroughly, other oxylipins are barely studied in this regard. Here, we present a comprehensive overview of the therapeutic potential of all major classes of plant oxylipins, including derivatives of acetylenic fatty acids, jasmonates, six- and nine-carbon aldehydes, oxy-, epoxy-, and hydroxy-derivatives of fatty acids, as well as spontaneously formed phytoprostanes and phytofurans. The presented analysis will provide an impetus for further research investigating the beneficial properties of these secondary metabolites and bringing them closer to practical applications.
Topics: Animals; Oxylipins; Cyclopentanes; Plants
PubMed: 36498955
DOI: 10.3390/ijms232314627 -
Journal of Chemical Ecology Jul 2014The plant hormone jasmonate (JA) exerts direct control over the production of chemical defense compounds that confer resistance to a remarkable spectrum of... (Review)
Review
The plant hormone jasmonate (JA) exerts direct control over the production of chemical defense compounds that confer resistance to a remarkable spectrum of plant-associated organisms, ranging from microbial pathogens to vertebrate herbivores. The underlying mechanism of JA-triggered immunity (JATI) can be conceptualized as a multi-stage signal transduction cascade involving: i) pattern recognition receptors (PRRs) that couple the perception of danger signals to rapid synthesis of bioactive JA; ii) an evolutionarily conserved JA signaling module that links fluctuating JA levels to changes in the abundance of transcriptional repressor proteins; and iii) activation (de-repression) of transcription factors that orchestrate the expression of myriad chemical and morphological defense traits. Multiple negative feedback loops act in concert to restrain the duration and amplitude of defense responses, presumably to mitigate potential fitness costs of JATI. The convergence of diverse plant- and non-plant-derived signals on the core JA module indicates that JATI is a general response to perceived danger. However, the modular structure of JATI may accommodate attacker-specific defense responses through evolutionary innovation of PRRs (inputs) and defense traits (outputs). The efficacy of JATI as a defense strategy is highlighted by its capacity to shape natural populations of plant attackers, as well as the propensity of plant-associated organisms to subvert or otherwise manipulate JA signaling. As both a cellular hub for integrating informational cues from the environment and a common target of pathogen effectors, the core JA module provides a focal point for understanding immune system networks and the evolution of chemical diversity in the plant kingdom.
Topics: Animals; Bacteria; Cyclopentanes; Disease Resistance; Fungi; Herbivory; Host-Pathogen Interactions; Oxylipins; Plant Immunity; Plant Proteins; Plants; Repressor Proteins; Signal Transduction
PubMed: 24973116
DOI: 10.1007/s10886-014-0468-3