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Journal of Speech, Language, and... Sep 2022The aim of this study was to determine whether suprasegmental speech perception contributes unique variance in predictions of reading decoding and comprehension for...
PURPOSE
The aim of this study was to determine whether suprasegmental speech perception contributes unique variance in predictions of reading decoding and comprehension for prelingually deaf children using two devices, at least one of which is a cochlear implant (CI).
METHOD
A total of 104, 5- to 9-year-old CI recipients completed tests of segmental perception (e.g., word recognition in quiet and noise, recognition of vowels and consonants in quiet), suprasegmental perception (e.g., talker and stress discrimination, nonword stress repetition, and emotion identification), and nonverbal intelligence. Two years later, participants completed standardized tests of reading decoding and comprehension. Using regression analyses, the unique contribution of suprasegmental perception to reading skills was determined after controlling for demographic characteristics and segmental perception performance.
RESULTS
Standardized reading scores of the CI recipients increased with nonverbal intelligence for both decoding and comprehension. Female gender was associated with higher comprehension scores. After controlling for gender and nonverbal intelligence, segmental perception accounted for approximately 4% and 2% of the variance in decoding and comprehension, respectively. After controlling for nonverbal intelligence, gender, and segmental perception, suprasegmental perception accounted for an extra 4% and 7% unique variance in reading decoding and reading comprehension, respectively.
CONCLUSIONS
Suprasegmental perception operates independently from segmental perception to facilitate good reading outcomes for these children with CIs. Clinicians and educators should be mindful that early perceptual skills may have long-term benefits for literacy. Research on how to optimize suprasegmental perception, perhaps through hearing-device programming and/or training strategies, is needed.
Topics: Child; Child, Preschool; Cochlear Implantation; Cochlear Implants; Deafness; Female; Hearing; Humans; Reading; Speech Perception
PubMed: 36001864
DOI: 10.1044/2022_JSLHR-22-00035 -
Tidsskrift For Den Norske Laegeforening... Sep 2002
Topics: Child, Preschool; Deafness; Hearing Loss; Hearing Tests; Humans; Infant; Infant, Newborn; Mass Screening
PubMed: 12426889
DOI: No ID Found -
Molecular Therapy : the Journal of the... Sep 2023Hearing loss is a common disorder affecting nearly 20% of the world's population. Recently, studies have shown that inner ear gene therapy can improve auditory function...
Hearing loss is a common disorder affecting nearly 20% of the world's population. Recently, studies have shown that inner ear gene therapy can improve auditory function in several mouse models of hereditary hearing loss. In most of these studies, the underlying mutations affect only a small number of cell types of the inner ear (e.g., sensory hair cells). Here, we applied inner ear gene therapy to the Ildr1 (Ildr1) mouse, a model of human DFNB42, non-syndromic autosomal recessive hereditary hearing loss associated with ILDR1 variants. ILDR1 is an integral protein of the tricellular tight junction complex and is expressed by diverse inner ear cell types in the organ of Corti and the cochlear lateral wall. We simultaneously applied two synthetic adeno-associated viruses (AAVs) with different tropism to deliver Ildr1 cDNA to the Ildr1 mouse inner ear: one targeting the organ of Corti (AAV2.7m8) and the other targeting the cochlear lateral wall (AAV8BP2). We showed that combined AAV2.7m8/AAV8BP2 gene therapy improves cochlear structural integrity and auditory function in Ildr1 mice.
Topics: Humans; Animals; Mice; Receptors, Cell Surface; Deafness; Hearing Loss; Disease Models, Animal; Genetic Therapy
PubMed: 37481704
DOI: 10.1016/j.ymthe.2023.07.014 -
Journal of Traditional Chinese Medicine... Oct 2013Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness. (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.
METHODS
Total 296 patients with non-insulin dependent diabetes mellitus (NIDDM) were randomly divided into two groups. A treatment group of 164 patients (208 ears) was treated with hypoglycemic anti-deafness capsules based on TCM syndrome differentiation. A control group of 132 patients (184 ears) was treated with glibenclamide and conventional drug treatment for deafness. The following were observed: hearing, fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2hPG), 24 h urine glucose (24hUG), improvement of main symptoms, platelet function, and changes in superoxide dismutase (SOD) and lipid peroxide (LPO) levels. In animal studies, Kunming mice, weighing 18-22 g were used. Half of the mice were males and half were females. Wistar rats, weighing 80-120 g were used. Half of the rats were males and half were females. Male Wistar rats, weighing 200-220 g, were also used. Their acute and chronic toxicity was studied.
RESULTS
The hearing improvement was 56.7% in the treatment group and 26.6% in the control group. FPG, 2hPG, and 24hUG were improved significantly (P < 0.05, P < 0.01, P < 0.01, respectively) in the treatment group and 2hPG and 24hUG improved significantly in the control group (P < 0.05, P < 0.05). The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P < 0.01).There was no significant difference in FPG between the two groups (P < 0.05). Main symptoms in the treatment group were significantly more improved than those in the control group (P < 0.05, P < 0.01). In the treatment group, platelet adhesion and aggregation, SOD, and LPO were all significantly improved from before treatment (P < 0.05, P < 0.01). However, in the control group, except LOP (P < 0.05), there were no significant differences from before treatment to after (P < 0.05). In animal studies, no obvious acute or long-term toxicity was observed from capsule administration.
CONCLUSION
Through experiment on animals and clinical trials, we can found that hypoglycemic anti-deafness capsules could decrease blood glucose and serum triglycerides of alloxan-induced diabetic rats. This herbal capsule is effective for safely treating diabetic patients with deafness.
Topics: Adult; Aged; Animals; Blood Glucose; Capsules; Deafness; Diabetes Complications; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Female; Hearing; Humans; Hypoglycemic Agents; Male; Mice; Middle Aged; Rats; Rats, Wistar
PubMed: 24660591
DOI: 10.1016/s0254-6272(14)60037-6 -
Journal of Rehabilitation Research and... 2008The multichannel cochlear implant is the first neural prosthesis to effectively and safely bring electronic technology into a direct physiological relation with the... (Review)
Review
The multichannel cochlear implant is the first neural prosthesis to effectively and safely bring electronic technology into a direct physiological relation with the central nervous system and human consciousness. It is also the first cochlear implant to give speech understanding to tens of thousands of persons with profound deafness and spoken language to children born deaf in more than 80 countries. In so doing, it is the first major advance in research and technology to help deaf children communicate since Sign Language of the Deaf was developed at the Paris deaf school (L'Institut National de Jeunes Sourds de Paris) >200 years ago. Furthermore, biomedical research has been fundamental for ensuring that the multielectrode implant is safe as well as effective. More recent research has also shown that bilateral implants confer the benefits of binaural hearing. Future research using nanotechnology should see high-fidelity sound received, which would help deaf persons communicate in noise and enjoy music. Research should also lead to implants in ears with useful hearing.
Topics: Audiometry; Auditory Threshold; Cochlear Implantation; Cochlear Implants; Cochlear Nerve; Deafness; Electric Stimulation; Electrodes, Implanted; Female; Humans; Male; Prosthesis Design; Risk Assessment; Sensitivity and Specificity; Speech Perception; Treatment Outcome
PubMed: 18816421
DOI: 10.1682/jrrd.2007.05.0064 -
American Journal of Human Genetics Nov 2001As auditory genes and deafness-associated mutations are discovered at a rapid rate, exciting opportunities have arisen to uncover the molecular mechanisms underlying... (Review)
Review
As auditory genes and deafness-associated mutations are discovered at a rapid rate, exciting opportunities have arisen to uncover the molecular mechanisms underlying hearing and hearing impairment. Single genes have been identified to be pathogenic for dominant or recessive forms of nonsyndromic hearing loss, syndromic hearing loss, and, in some cases, even multiple forms of hearing loss. Modifier loci and genes have been found, and investigations into their role in the hearing process will yield valuable insight into the fundamental processes of the auditory system.
Topics: Deafness; Extracellular Matrix; Hearing; Homeostasis; Humans; Ions; Mutation; Phenotype; Transcription Factors
PubMed: 11577373
DOI: 10.1086/324122 -
Deutsches Arzteblatt International Jun 20111-2 out of 1000 newborns have markedly impaired hearing. (Review)
Review
BACKGROUND
1-2 out of 1000 newborns have markedly impaired hearing.
METHODS
Review of the pertinent literature, which was retrieved with a selective search of the following databases: NHS EED (Economic Evaluation Database), HTA (Health Technology Assessment), DARE (Database of Abstracts of Reviews on Effectiveness), Clinical Trials, CDSR (Cochrane Database of Systematic Reviews), and PubMed.
RESULTS
The current scientific evidence favors universal neonatal hearing screening (UNHS) for the early detection of hearing impairment. UNHS is best performed in two stages: first measurement of otoacoustic emissions and then automated assessment of the brainstem auditory evoked response. To be effective, UNHS programs must have a high coverage rate, high sensitivity and specificity, and proper tracking with a low rate of loss to follow-up. Children with positive screening tests for hearing impairment should undergo confirmatory testing as soon as possible and then receive the appropriate treatment. Early intervention is particularly critical for speech acquisition.
CONCLUSION
The early detection and treatment of hearing impairment in newborns and infants has a beneficial effect on language acquisition.
Topics: Cross-Sectional Studies; Deafness; Diagnosis, Computer-Assisted; Evoked Potentials, Auditory, Brain Stem; Humans; Infant; Infant, Newborn; Language Development Disorders; Neonatal Screening; Otoacoustic Emissions, Spontaneous; Predictive Value of Tests; Risk Factors; Speech Perception
PubMed: 21776315
DOI: 10.3238/arztebl.2011.0426 -
Minerva Surgery Apr 2023
Topics: Humans; Aged; Hearing; Deafness; Hearing Tests
PubMed: 34342410
DOI: 10.23736/S2724-5691.21.09044-4 -
Brazilian Journal of Otorhinolaryngology 2005One in every 1,000 newborn suffers from congenital hearing impairment. More than 60% of the congenital cases are caused by genetic factors. In most cases, hearing loss... (Review)
Review
One in every 1,000 newborn suffers from congenital hearing impairment. More than 60% of the congenital cases are caused by genetic factors. In most cases, hearing loss is a multifactorial disorder caused by both genetic and environmental factors. Molecular genetics of deafness has experienced remarkable progress in the last decade. Genes responsible for hereditary hearing impairment are being mapped and cloned progressively. This review focuses on non-syndromic hearing loss, since the gene involved in this type of hearing loss have only recently begun to be identified.
Topics: Deafness; Humans; Molecular Biology; Proteins; Syndrome
PubMed: 16446920
DOI: 10.1016/s1808-8694(15)31313-6 -
JAMA Otolaryngology-- Head & Neck... Jul 2020Multiple studies have evaluated associations between post-cochlear implant (CI) speech recognition outcomes and patient-related factors. Current literature often appears... (Meta-Analysis)
Meta-Analysis
IMPORTANCE
Multiple studies have evaluated associations between post-cochlear implant (CI) speech recognition outcomes and patient-related factors. Current literature often appears equivocal or contradictory, so little is known about the factors that contribute to successful speech recognition outcomes with CIs.
OBJECTIVE
To use a meta-analysis to pool data from the extant literature and provide an objective summary of existing evidence on associations of patient-related factors and CI speech recognition outcomes.
DATA SOURCES
A literature search was performed using PubMed, Scopus, and CINAHL databases in January 2019 using the following search terms: cochlear implant or cochlear implants or cochlear implantation and speech recognition or word recognition or sentence recognition. Studies of postlingually deafened adult CI recipients that reported word or sentence recognition scores were included.
STUDY SELECTION
Inclusion criteria were postlingual adult CI recipients 18 years or older with word or sentence recognition scores at minimum 6-month postimplantation. Studies that included patients undergoing revision or reimplantation surgery were excluded.
DATA EXTRACTION AND SYNTHESIS
Following the Preferred Reporting Items for Systemic Reviews and Meta-analyses (PRISMA) guidelines, 1809 unique articles underwent review by abstract, and 121 articles underwent full-text review, resulting in 13 articles of 1095 patients for a meta-analysis of correlations. Random-effects model was used when the heterogeneity test yielded a low P value (P < .05).
MAIN OUTCOMES AND MEASURES
The planned primary outcome was the pooled correlation values between postimplant speech recognition scores and patient-related factors.
RESULTS
Of the 1095 patients included from the 13 studies, the mean age at implantation ranged from 51.2 to 63.7 years and the mean duration of hearing loss ranged from 9.5 to 31.8 years; for the 825 patients for whom sex was reported, 421 (51.0%) were women. A weak negative correlation was observed between age at implantation and postimplant sentence recognition in quiet (r = -0.31 [95% CI, -0.41 to -0.20]). Other correlations between patient-related factors and postimplant word or sentence recognition were statistically significant, but all correlations were absent to negligible (r = 0.02-0.27).
CONCLUSIONS AND RELEVANCE
Given that most associations were weak, negligible, or absent, patient-related factors often thought to affect CI speech recognition ability offer limited assistance in clinical decision-making in cochlear implantation. Additional research is needed to identify patient-related and other factors that predict CI outcomes, including speech recognition and other important variables related to success with CIs.
Topics: Age Factors; Audiometry, Pure-Tone; Clinical Decision-Making; Cochlear Implants; Deafness; Female; Humans; Male; Middle Aged; Speech Perception; Time-to-Treatment
PubMed: 32407461
DOI: 10.1001/jamaoto.2020.0662