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International Journal of Environmental... Jan 2022The objective was to determine whether trauma in primary dentition causes alterations in the development of permanent dentition. Searches were made in May 2020 using... (Review)
Review
The objective was to determine whether trauma in primary dentition causes alterations in the development of permanent dentition. Searches were made in May 2020 using PubMed, MEDLINE, MEDES, Scopus, Lilacs, and Embase. Papers in English, German, and Spanish, without restrictions in the year of publication, were included. The quality of the studies was analyzed using the NOS Scale. The search retrieved 537 references, and seven studies were included for a qualitative analysis. The results showed that trauma to a deciduous tooth can damage the bud of the permanent tooth. Enamel discoloration and/or hypoplasia were the most common sequelae in the permanent teeth after trauma to the primary predecessor. The type and severity of sequelae in the permanent tooth are associated with the development phase of the bud. Children with trauma of their primary teeth should receive checkups until the eruption of the permanent teeth for the early diagnosis and treatment of possible sequelae. Intrusion of the primary tooth was the trauma that caused the most damage and enamel alterations the most frequent sequelae.
Topics: Child; Humans; Dentition, Permanent; Tooth Avulsion; Tooth Eruption; Tooth, Deciduous; Spain; Tooth Injuries
PubMed: 35055575
DOI: 10.3390/ijerph19020754 -
Australian Dental Journal Jun 2013Developmental enamel defects, presenting as enamel hypoplasia or opacities are caused by damage or disruption to the developing enamel organ as a result of inherited and... (Review)
Review
Developmental enamel defects, presenting as enamel hypoplasia or opacities are caused by damage or disruption to the developing enamel organ as a result of inherited and acquired systemic conditions. The high prevalence of these defects in the primary dentition demonstrates the vulnerability of the teeth to changes in the pre- and postnatal environment. The presence of enamel hypoplasia increases the risk of primary teeth to early childhood caries and tooth wear as the defective enamel is thinner, more plaque retentive and less resistant to dissolution in acid compared to normal enamel. The purpose of this paper was to critically review the aetiology and clinical complications of developmental enamel defects in the primary dentition and propose recommendations for the clinical management of affected teeth.
Topics: Child, Preschool; Dental Caries; Dental Enamel; Dental Enamel Hypoplasia; Female; Humans; Tooth Attrition; Tooth Wear; Tooth, Deciduous
PubMed: 23713631
DOI: 10.1111/adj.12039 -
Stem Cells Translational Medicine Apr 2020Human pulp stem cells (PSCs) include dental pulp stem cells (DPSCs) isolated from dental pulp tissues of human extracted permanent teeth and stem cells from human... (Review)
Review
Human pulp stem cells (PSCs) include dental pulp stem cells (DPSCs) isolated from dental pulp tissues of human extracted permanent teeth and stem cells from human exfoliated deciduous teeth (SHED). Depending on their multipotency and sensitivity to local paracrine activity, DPSCs and SHED exert therapeutic applications at multiple levels beyond the scope of the stomatognathic system. This review is specifically concentrated on PSC-updated biological characteristics and their promising therapeutic applications in (pre)clinical practice. Biologically, distinguished from conventional mesenchymal stem cell markers in vitro, NG2, Gli1, and Celsr1 have been evidenced as PSC markers in vivo. Both perivascular cells and glial cells account for PSC origin. Therapeutically, endodontic regeneration is where PSCs hold the most promises, attributable of PSCs' robust angiogenic, neurogenic, and odontogenic capabilities. More recently, the interplay between cell homing and liberated growth factors from dentin matrix has endowed a novel approach for pulp-dentin complex regeneration. In addition, PSC transplantation for extraoral tissue repair and regeneration has achieved immense progress, following their multipotential differentiation and paracrine mechanism. Accordingly, PSC banking is undergoing extensively with the intent of advancing tissue engineering, disease remodeling, and (pre)clinical treatments.
Topics: Animals; Biological Specimen Banks; Dental Pulp; Humans; Regeneration; Stem Cell Transplantation; Stem Cells; Tooth, Deciduous
PubMed: 31943813
DOI: 10.1002/sctm.19-0398 -
Australian Dental Journal Mar 2016Dental trauma is a significant public health problem because of its frequency, impact on economic productivity and quality of life. It is not a disease and no individual... (Review)
Review
Dental trauma is a significant public health problem because of its frequency, impact on economic productivity and quality of life. It is not a disease and no individual is ever at zero risk of sustaining these potentially life-changing injuries. The aim of this article was to review the literature on the prevalence, incidence, aetiology, prognosis and outcomes of dental trauma. The importance of standardized reporting, oral health policy, adjunctive research methods, prevention and education will also be discussed. A search for relevant articles appearing in databases such as Medline, Cochrane and SSCI formed the basis of this review. Epidemiological studies indicate the annual incidence of dental trauma globally is at about 4.5%. Approximately one-third of children and toddlers (primary teeth) and one-fifth of adolescents and adults (permanent teeth) sustained a traumatic dental injury. The majority involved the maxillary central incisors, mainly from falls in toddlers at home and contact sport in adolescents. Despite these trends, there is considerable variation between studies within and across jurisdictions. There is a need to standardize research with a consistent approach to reporting, classification and methodology. This will improve research and form a greater basis for predicting prognosis. This research basis will assist in consent and clinical management.
Topics: Accidental Falls; Age Factors; Athletic Injuries; Global Health; Humans; Incidence; Prevalence; Prognosis; Quality of Life; Tooth Injuries; Tooth, Deciduous; Treatment Outcome
PubMed: 26923445
DOI: 10.1111/adj.12395 -
Proceedings of the National Academy of... May 2003To isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human...
To isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human deciduous tooth contains multipotent stem cells [stem cells from human exfoliated deciduous teeth (SHED)]. SHED were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. After in vivo transplantation, SHED were found to be able to induce bone formation, generate dentin, and survive in mouse brain along with expression of neural markers. Here we show that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells. SHED are not only derived from a very accessible tissue resource but are also capable of providing enough cells for potential clinical application. Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering.
Topics: Animals; Base Sequence; Cell Separation; DNA Primers; Dentate Gyrus; Hippocampus; Humans; Immunohistochemistry; In Situ Hybridization; Mice; Mice, SCID; Mitochondria; Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Stem Cell Transplantation; Stem Cells; Stromal Cells; Tooth Exfoliation; Tooth, Deciduous; Transcription Factors; Transplantation, Heterologous
PubMed: 12716973
DOI: 10.1073/pnas.0937635100 -
Head & Face Medicine Oct 2017To avoid untoward changes when primary teeth are replaced by permanent teeth, resorption of the material used in primary teeth root canal filling should occur at the... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
To avoid untoward changes when primary teeth are replaced by permanent teeth, resorption of the material used in primary teeth root canal filling should occur at the same rate as root resorption. The Aim of this study was to compare the success rates of a mixed primary root canal filling (MPRCF, ingredients: zinc oxide-eugenol [ZOE], iodoform, calcium hydroxide) to those of ZOE and Vitapex in pulpectomised primary molars.
METHODS
One hundred and sixty primary molars from 155 children (average age 5.88 ± 1.27 years) underwent two-visit pulpectomy using one of the three materials. The clinical and radiographic findings at 6, 12 and 18 months were assessed.
RESULTS
At 6 and 12 months, the MPRCF and ZOE success rates were 100%. The Vitapex group showed clinical success rate and radiographic success rate of 100 and 94.5% at 6 months, and 80.4 and 60.7% at 12 months. The 18-month clinical success rates of the MPRCF, ZOE and Vitapex were 96.2, 92.2 and 71.4% and radiographic success rates were 92.5, 88.2 and 53.6%, respectively. There was a statistically significant difference in the success rates between MPRCF and Vitapex and no significant differences between MPRCF and ZOE. More MPRCF were resorbed at same rate with roots than ZOE and Vitapex. Early resorption of root filling resulted in more failure.
CONCLUSIONS
The mixture of ZOE, iodoform and calcium hydroxide can be considered an effective root canal filling material in pulp involved primary teeth and had no adverse effect on tooth replacement.
TRIAL REGISTRATION
ChiCTR-TRC-14004938 . Registered 13 July 2014.
Topics: Calcium Hydroxide; Child; Child, Preschool; China; Dental Pulp Cavity; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Pulpectomy; Radiography, Dental; Risk Assessment; Root Canal Filling Materials; Silicones; Time Factors; Tooth, Deciduous; Treatment Outcome; Zinc Oxide-Eugenol Cement
PubMed: 29073902
DOI: 10.1186/s13005-017-0145-1 -
Dento Maxillo Facial Radiology Sep 2021This study evaluated the use of a deep-learning approach for automated detection and numbering of deciduous teeth in children as depicted on panoramic radiographs.
OBJECTIVE
This study evaluated the use of a deep-learning approach for automated detection and numbering of deciduous teeth in children as depicted on panoramic radiographs.
METHODS AND MATERIALS
An artificial intelligence (AI) algorithm (CranioCatch, Eskisehir-Turkey) using Faster R-CNN Inception v2 (COCO) models were developed to automatically detect and number deciduous teeth as seen on pediatric panoramic radiographs. The algorithm was trained and tested on a total of 421 panoramic images. System performance was assessed using a confusion matrix.
RESULTS
The AI system was successful in detecting and numbering the deciduous teeth of children as depicted on panoramic radiographs. The sensitivity and precision rates were high. The estimated sensitivity, precision, and F1 score were 0.9804, 0.9571, and 0.9686, respectively.
CONCLUSION
Deep-learning-based AI models are a promising tool for the automated charting of panoramic dental radiographs from children. In addition to serving as a time-saving measure and an aid to clinicians, AI plays a valuable role in forensic identification.
Topics: Algorithms; Artificial Intelligence; Child; Humans; Radiography, Panoramic; Tooth; Tooth, Deciduous; Turkey
PubMed: 33661699
DOI: 10.1259/dmfr.20200172 -
Acta Medica (Hradec Kralove) 2018Nowadays, regenerative and reparative medicine has grown in popularity. Dental stem cells are easily accessible source of adult stem cells. They can be harvested by a... (Review)
Review
Nowadays, regenerative and reparative medicine has grown in popularity. Dental stem cells are easily accessible source of adult stem cells. They can be harvested by a tooth extraction or spontaneous deciduous tooth exfoliation. They have to be isolated, expanded and stored until time they would be needed for individual stem cell therapy. Cryopreservation is both a short-term and long-term storage of tissues or cells at sub-zero temperatures. There are several methods of cryopreservation requiring different technologies. The objective of this review is to compare them and highlight their advantages and disadvantages.
Topics: Adult Stem Cells; Cryopreservation; Dental Pulp; Humans; Regenerative Medicine; Stem Cell Transplantation; Tooth; Tooth Exfoliation; Tooth Extraction; Tooth, Deciduous; Vitrification
PubMed: 30012243
DOI: 10.14712/18059694.2018.16 -
The Chinese Journal of Dental Research 2014Casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) is a bioactive agent with a base of milk products, which has been formulated from two parts: casein... (Review)
Review
Casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) is a bioactive agent with a base of milk products, which has been formulated from two parts: casein phosphopeptides (CPP) and amorphous calcium phosphate (ACP). CPP was produced from milk protein casein and has a remarkable ability to stabilize calcium phosphate in solution and to substantially increase the level of calcium phosphate in dental plaque. CPP-ACP buffers the free calcium and phosphate ion activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel, reducing demineralisation and promoting remineralisation. The free calcium and phosphate ions move out of the CPP, enter the enamel rods and reform onto apatite crystals. Laboratory, animal and human studies have shown that CPP-ACP inhibits cariogenic activity. CPP-ACP is useful in the treatment of white spot lesions, hypomineralised enamel, mild fluorosis, tooth sensitivity and erosion, and prevents plaque accumulation around brackets and other orthodontic appliances. CPP-ACP also facilitates a normal post-eruptive maturation process and is ideal for protecting primary teeth at a time when oral care is difficult. CPP-ACP has commercial potential as an additive to foods, soft drinks and chewing gum, as well as additive to toothpastes and mouthwashes to control dental caries.
Topics: Calcium Phosphates; Cariostatic Agents; Caseins; Dental Enamel; Dental Plaque; Humans; Protective Agents; Tooth Remineralization; Tooth, Deciduous
PubMed: 25028684
DOI: No ID Found -
International Journal of Oral Science Jun 2013Tooth replacement is a common trait to most vertebrates, including mammals. Mammals, however, have lost the capacity for continuous tooth renewal seen in most other... (Review)
Review
Tooth replacement is a common trait to most vertebrates, including mammals. Mammals, however, have lost the capacity for continuous tooth renewal seen in most other vertebrates, and typically have only 1-2 generations of teeth. Here, we review the mechanisms of tooth replacement in reptiles and mammals, and discuss in detail the current and historical theories on control of timing and pattern of tooth replacement and development.
Topics: Animals; Biology; Humans; Mammals; Odontogenesis; Reptiles; Tooth; Tooth Germ; Tooth, Deciduous
PubMed: 23788284
DOI: 10.1038/ijos.2013.36