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Dysphagia Feb 2023Swallowing disorders are common in neurological diseases, with dysphagia representing one of the most prevalent complications that may cause poor quality of life, reduce... (Review)
Review
Swallowing disorders are common in neurological diseases, with dysphagia representing one of the most prevalent complications that may cause poor quality of life, reduce independence, and increase mortality. Rapid identification of dysphagia is necessary to reduce the risk of penetration and aspiration, and to early start rehabilitation protocols. Among the methods that can be used to evaluate dysphagia and its components, ultrasound imaging has been suggested to support the evaluation of dysphagia by providing measures of both static and dynamic anatomical components. The aim of this systematic review is to evaluate the usefulness of ultrasonography in neurogenic dysphagia according to current literature. From 2000 to 2020, 633 studies with the appropriate search terms for ultrasound and dysphagia were identified. After screening them, 10 studies were included in the qualitative analysis. Patients with the following neurologic conditions were studied with ultrasonography for dysphagia: Parkinson's disease, muscle dystrophy, amyotrophic lateral sclerosis, and stroke. The main outcomes of ultrasonography were swallowing muscles thickness (e.g., tongue), and dynamic measures such as hyoid displacement. The different protocols used in the studies, as well as their outcomes, did not allow to provide standard procedures and normative or cut-off values in the presented diseases. Because there are a variety of tools, methods, and techniques that have been used in the studies that were reviewed, it is difficult to evaluate them using established standards. However, ultrasonography correlates well with clinical evaluation of dysphagia and therefore has prognostic and rehabilitation potential. Future studies should aim to develop and utilize a common interdisciplinary protocol that includes standard procedures and outcomes to define normative values applicable in the different conditions.
Topics: Humans; Deglutition Disorders; Quality of Life; Deglutition; Nervous System Diseases; Ultrasonography
PubMed: 35556172
DOI: 10.1007/s00455-022-10459-9 -
Stroke Mar 2012Swallowing screens after acute stroke identify those patients who do not need a formal swallowing evaluation and who can safely take food and medications by mouth. We... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND AND PURPOSE
Swallowing screens after acute stroke identify those patients who do not need a formal swallowing evaluation and who can safely take food and medications by mouth. We conducted a systematic review to identify swallowing screening protocols that met basic requirements for reliability, validity, and feasibility.
METHODS
We searched MEDLINE and supplemented results with references identified through other databases, journal tables of contents, and bibliographies. All relevant references were reviewed and evaluated with specific criteria.
RESULTS
Of 35 protocols identified, 4 met basic quality criteria. These 4 had high sensitivities of ≥87% and high negative predictive values of ≥91% when a formal swallowing evaluation was used as the gold standard. Two protocols had greater sample sizes and more extensive reliability testing than the others.
CONCLUSIONS
We identified only 4 swallowing screening protocols for patients with acute stroke that met basic criteria. Cost-effectiveness of screening, including costs associated with false-positive results and impact of screening on morbidity, mortality, and length of hospital stay, requires elucidation.
Topics: Clinical Competence; Clinical Protocols; Deglutition; Eating; Feasibility Studies; Humans; Predictive Value of Tests; Reproducibility of Results; Stroke
PubMed: 22156697
DOI: 10.1161/STROKEAHA.111.638254 -
The Journal of Pharmacy and Pharmacology Apr 2017The aim of this review was to map the currently available evidence on acceptability of oral paediatric medicines to aid in the selection of suitable platform... (Review)
Review
OBJECTIVES
The aim of this review was to map the currently available evidence on acceptability of oral paediatric medicines to aid in the selection of suitable platform formulations for the development of new acceptable paediatric products.
METHODS
This process used a defined search strategy of indexed publications and included methods to assess the quality of the evidence retrieved.
KEY FINDINGS
Taste/palatability was the most extensively studied area of paediatric medicine acceptability yet standard methods or criteria that define what is classed as acceptable to children is still to be defined. There have been many reports on the acceptability of medicines to paediatric populations yet major gaps in the acceptability knowledge base exist including the shape and dimensions of tablets, minitablets and capsules swallowed whole in infants and children; size and overall volume of multiparticulates; volume of liquids completely swallowed in infants and children; duration of retention within the oral cavity, size and taste of orodispersible tablets, lozenges and chewable tablets and the number of solid units dosed at each time point.
CONCLUSIONS
The review highlights where further information is required to support knowledge around acceptability of age-appropriate medicines. An algorithm to aid in selection of a formulation that is likely to be acceptable based on the age range to be treated by the medicine is presented as a result of this review.
Topics: Administration, Oral; Child; Child, Preschool; Deglutition; Dosage Forms; Drug Compounding; Humans; Infant; Pharmaceutical Preparations; Tablets; Taste
PubMed: 27524471
DOI: 10.1111/jphp.12610 -
Current Opinion in Otolaryngology &... Jun 2008Swallowing disorders impact the health and quality of millions of lives of patients across the age spectrum. The broad scope of the problem is in contrast to the volume... (Review)
Review
PURPOSE OF REVIEW
Swallowing disorders impact the health and quality of millions of lives of patients across the age spectrum. The broad scope of the problem is in contrast to the volume of methods that we have to treat the problem. Investigators are testing interventions that go beyond the swallowing system and are targeting those that cross or overlap with swallowing function. This review will highlight the potential clinical implications of respiratory-swallowing cross-system interaction in health and disease.
RECENT FINDINGS
A collection of current studies demonstrates a tight neural coupling between the central control of respiration and swallowing. Results from recent studies suggest that this neural coupling may be altered under certain conditions of development, age, disease, and eating/swallowing tasks.
SUMMARY
The functional significance of cross-system neural control on respiratory-swallowing coordination is far from understood. Preliminary data, however, show destabilization of respiratory-swallowing patterns in various neurological diseases and in head and neck cancer. These findings suggest the need to develop a line of research that tests the effects of therapeutic strategies that transcend swallowing and include cross-system interactions such as respiratory-swallow phase patterning.
Topics: Aging; Deglutition; Deglutition Disorders; Humans; Quality of Life; Respiration Disorders; Respiratory Physiological Phenomena
PubMed: 18475070
DOI: 10.1097/MOO.0b013e3282febd4b -
Journal of Applied Physiology... Feb 2014The upper airway is a complex muscular tube that is used by the respiratory and digestive systems. The upper airway is invested with several small and anatomically... (Review)
Review
The upper airway is a complex muscular tube that is used by the respiratory and digestive systems. The upper airway is invested with several small and anatomically peculiar muscles. The muscle fiber orientations and their nervous innervation are both extremely complex, and how the activity of the muscles is initiated and adjusted during complex behaviors is poorly understood. The bulk of the evidence suggests that the entire assembly of tongue and laryngeal muscles operate together but differently during breathing and swallowing, like a ballet rather than a solo performance. Here we review the functional anatomy of the tongue and laryngeal muscles, and their neural innervation. We also consider how muscular activity is altered as respiratory drive changes, and briefly address upper airway muscle control during swallowing.
Topics: Animals; Deglutition; Humans; Laryngeal Muscles; Pharyngeal Muscles; Respiration; Respiratory Mechanics; Tongue
PubMed: 24092695
DOI: 10.1152/japplphysiol.00670.2013 -
Journal of the Formosan Medical... Oct 2022The anterior-superior movement of the hyoid bone plays a significant role in securing the airway and smooth passage of food through the cricopharyngeal muscle. The hyoid... (Review)
Review
The anterior-superior movement of the hyoid bone plays a significant role in securing the airway and smooth passage of food through the cricopharyngeal muscle. The hyoid bone can be detected easily with instruments such as the videofluoroscopic swallow study (VFSS) and ultrasonography (US), which have made quantitative kinematic analysis possible. Dysphagia is a critical issue in different diseases, including stroke, Parkinson's disease (PD), head and neck cancer, and amyotrophic lateral sclerosis (ALS), and the data obtained on these diseases from swallowing kinematic analysis has been accumulating. In this review article, we aimed to present the distinct features of kinematic analysis of hyoid movement in stroke, PD, head and neck cancer, and ALS. We also present the possible relationship between altered hyoid kinematics and dysphagia.
Topics: Amyotrophic Lateral Sclerosis; Biomechanical Phenomena; Deglutition; Deglutition Disorders; Head and Neck Neoplasms; Humans; Hyoid Bone; Parkinson Disease; Stroke
PubMed: 35469721
DOI: 10.1016/j.jfma.2022.04.007 -
Journal of Medicine and Life Dec 2023
Topics: Humans; Deglutition Disorders; Deglutition
PubMed: 38585519
DOI: 10.25122/jml-2023-1032 -
Dysphagia Aug 2023Muscle fatigue is the diminution of force required for a particular action over time. Fatigue may be particularly pronounced in aging muscles, including those used for... (Review)
Review
Muscle fatigue is the diminution of force required for a particular action over time. Fatigue may be particularly pronounced in aging muscles, including those used for swallowing actions. Because risk for swallowing impairment (dysphagia) increases with aging, the contribution of muscle fatigue to age-related dysphagia is an emerging area of interest. The use of animal models, such as mice and rats (murine models) allows experimental paradigms for studying the relationship between muscle fatigue and swallowing function with a high degree of biological precision that is not possible in human studies. The goal of this article is to review basic experimental approaches to the study of murine tongue muscle fatigue related to dysphagia. Traditionally, murine muscle fatigue has been studied in limb muscles through direct muscle stimulation and behavioral exercise paradigms. As such, physiological and bioenergetic markers of muscle fatigue that have been validated in limb muscles may be applicable in studies of cranial muscle fatigue with appropriate modifications to account for differences in muscle architecture, innervation ratio, and skeletal support. Murine exercise paradigms may be used to elicit acute fatigue in tongue muscles, thereby enabling study of putative muscular adaptations. Using these approaches, hypotheses can be developed and tested in mice and rats to allow for future focused studies in human subjects geared toward developing and optimizing treatments for age-related dysphagia.
Topics: Humans; Rats; Mice; Animals; Muscle Fatigue; Deglutition Disorders; Muscle, Skeletal; Tongue; Deglutition
PubMed: 36401630
DOI: 10.1007/s00455-022-10537-y -
Einstein (Sao Paulo, Brazil) Dec 2013This study aimed to investigate international scientific papers published on the subject of cervical auscultation and its use in speech therapy. The study involved a... (Review)
Review
This study aimed to investigate international scientific papers published on the subject of cervical auscultation and its use in speech therapy. The study involved a qualitative review of the literature spanning the last 10 years. Articles were selected from the PubMed database using the following keywords: cervical auscultation, swallowing and swallowing disorders. Research was included that was conducted on adult humans (over 18 years of age) and was written in English. Each citation retrieved from the database was analyzed independently by each of the study researchers to ascertain its relevance for inclusion in the study. The methodology involved formulating the research question, locating and selecting studies and critically evaluating the articles according to the precepts of the Cochrane Handbook. As a result, 35 studies were identified; 13 articles were analyzed because they allowed access to the full text and were related directly to the subject. We found that the studies were performed with groups of healthy subjects and subjects with different types of base pathology. Some studies compared the patterns found in the different groups. Some of the research sought to study the pattern of swallowing sounds with different factors - evaluator experience, the specificity and sensitivity of the method and how to improve the technique of cervical auscultation through the use of instruments other than the stethoscope. The conclusion of this critical analysis is that cervical auscultation is an important tool to be used in conjunction with other assessment methods in the routine clinical evaluation of swallowing.
Topics: Auscultation; Deglutition; Deglutition Disorders; Humans; Pharynx; Speech Therapy
PubMed: 24488399
DOI: 10.1590/s1679-45082013000400024 -
Scientific Reports May 2023Swallowing function is associated with systemic factors. Whether trunk or appendicular skeletal muscle mass is a better indicator of swallowing-related muscle... (Observational Study)
Observational Study
Swallowing function is associated with systemic factors. Whether trunk or appendicular skeletal muscle mass is a better indicator of swallowing-related muscle characteristics in community-dwelling older adults is not clear. Hence, we investigated the association between the characteristics of swallowing-related muscles (e.g., mass and quality) and trunk muscle mass. Community-dwelling older adults aged ≥ 65 years (n = 141; men: n = 45, women: n = 96) were recruited for this cross-sectional observational study via a health survey conducted in 2018. Trunk muscle mass index (TMI) and appendicular skeletal muscle mass index (SMI) were measured using bioelectrical impedance analysis. Cross-sectional areas (CSAs) and echo intensity (EI) of the geniohyoid muscle (GHM) and tongue were evaluated using an ultrasonic diagnostic apparatus. Multiple regression analysis was used to examine the relationship of the characteristics of swallowing-related muscle with TMI and SMI. Multiple regression analysis showed that CSA of the GHM was positively associated with both TMI (B = 24.9, p < 0.001) and SMI (B = 13.7, p = 0.002). EIs of swallowing-related muscles were not associated with TMI and SMI. Trunk muscle mass was associated with swallowing-related muscle mass and not muscle quality. The results of this study shed light on the elucidation of association of dysphagia with TMI and SMI.
Topics: Male; Humans; Female; Aged; Deglutition; Muscle, Skeletal; Deglutition Disorders; Independent Living; Neck Muscles; Sarcopenia
PubMed: 37188715
DOI: 10.1038/s41598-023-34905-2