-
Scientific Reports Dec 2014Topical steroids are used for the treatment of primary atopic dermatitis (AD); however, their associated risk of serious complications is great due to the presence of... (Comparative Study)
Comparative Study Randomized Controlled Trial
Topical steroids are used for the treatment of primary atopic dermatitis (AD); however, their associated risk of serious complications is great due to the presence of vulnerable lesions in young children with AD. Topical calcineurin inhibitors (TCIs) are steroid-free, anti-inflammatory agents used for topical AD therapy. However, their use is prohibited in infants <2 years of age because of their carcinogenic potential. We conducted a randomized, double-blind trial to evaluate the efficacy of TCIs as a secondary AD treatment for children <2 years of age by comparing 1% pimecrolimus cream with 0.05% desonide cream. We performed urinary metabolomics to predict long-term side effects. The 1% pimecrolimus cream displayed similar efficacy and exceptional safety compared with the 0.05% desonide cream. Metabolomics-based long-term toxicity tests effectively predicted long-term side effects using short-term clinical models. This applicable method for the functional interpretation of metabolomics data sets the foundation for future studies involving the prediction of the toxicity and systemic reactions caused by long-term medication administration.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Atopic; Desonide; Double-Blind Method; Female; Humans; Infant; Male; Metabolomics; Predictive Value of Tests; Skin Cream; Tacrolimus; Time Factors
PubMed: 25491116
DOI: 10.1038/srep07408 -
JAMA Dermatology Jul 2020This cohort study uses data from a medical record review of a dermatogynecology practice to describe the association between reduced recurrence of vulvar squamous cell...
This cohort study uses data from a medical record review of a dermatogynecology practice to describe the association between reduced recurrence of vulvar squamous cell carcinoma and use of topical corticosteroids in the treatment of vulvar lichen sclerosus.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Betamethasone; Carcinoma in Situ; Carcinoma, Squamous Cell; Clobetasol; Desonide; Female; Humans; Hydrocortisone; Methylprednisolone; Middle Aged; Neoplasm Recurrence, Local; Vulvar Lichen Sclerosus; Vulvar Neoplasms
PubMed: 32374363
DOI: 10.1001/jamadermatol.2020.1074 -
Acta Medica Indonesiana Oct 2013
Topics: Administration, Oral; Administration, Topical; Adult; Alopecia; Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Desonide; Female; Humans; Lupus Erythematosus, Discoid; Scalp; Treatment Outcome
PubMed: 24448338
DOI: No ID Found -
Dermatology Online Journal Sep 2012Fiddler's neck refers to an irritant contact dermatitis on the submandibular neck of violin and viola players and an allergic contact dermatitis to nickel from the...
Fiddler's neck refers to an irritant contact dermatitis on the submandibular neck of violin and viola players and an allergic contact dermatitis to nickel from the bracket attaching the violin to the chin rest on the violinist's supraclavicular neck. A 26-year-old woman developed submandibular and supraclavicular left neck lesions corresponding to the locations of the chin rest and bracket that was attached to her violin that held it against her neck when she played. Substitution of a composite chin rest, which did not contain nickel, and the short-term application of a low potency topical corticosteroid cream, resulted in complete resolution of the allergic contact dermatitis supraclavicular neck lesion. The irritant contact dermatitis submandibular neck lesion persisted. In conclusion, violin players are predisposed to developing irritant contact dermatitis or allergic contact dermatitis from the chin rest. We respectfully suggest that the submandibular neck lesions from contact with the chin rest be referred to as 'fiddler's neck - type 1,' whereas the supraclavicular neck lesions resulting from contact of the bracket holding the chin rest in place be called 'fiddler's neck - type 2.' A composite chin rest should be considered in patients with a preceding history of allergic contact dermatitis to nickel.
Topics: Adult; Chin; Dermatitis, Allergic Contact; Dermatitis, Irritant; Dermatitis, Occupational; Dermatologic Agents; Desonide; Female; Humans; Music; Neck; Nickel; Skin Cream; Treatment Outcome
PubMed: 23031377
DOI: No ID Found -
Dermatology (Basel, Switzerland) 2010
Topics: Acneiform Eruptions; Aged; Boronic Acids; Bortezomib; Candida albicans; Candidiasis; Desonide; Dexamethasone; Doxycycline; ErbB Receptors; Fluconazole; Folliculitis; Humans; Immunologic Factors; Lenalidomide; Male; Multiple Myeloma; Pyrazines; Thalidomide
PubMed: 19907136
DOI: 10.1159/000258050 -
The Journal of Investigative Dermatology Jun 1978Selected glucocorticoids have been demonstrated to increase the growth rate of human skin fibroblasts in culture, over a physiologically significant concentration range....
Selected glucocorticoids have been demonstrated to increase the growth rate of human skin fibroblasts in culture, over a physiologically significant concentration range. At the same concentrations and identical conditions, the glucocorticoid compounds tested inhibited the growth rate of mouse L-929 cells. We have discussed currently acceptable theories of glucocorticoid mechanism of action that permit this dichotomous effect, the main point being that inhibition can no longer be regarded as the only response of fibroblasts to glucocorticoids. Conclusions drawn from observations of cell cultures affected by addition of glucocorticoids must have considered the source of the cells, as response may vary with source and biologic state of the cells in culture.
Topics: Adult; Animals; Beclomethasone; Cell Line; Cells, Cultured; Desonide; Fibroblasts; Glucocorticoids; Humans; Hydrocortisone; Mice; Mice, Inbred Strains; Skin; Triamcinolone Acetonide
PubMed: 649982
DOI: 10.1111/1523-1747.ep12543546