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Pharmacology, Biochemistry, and Behavior Aug 1987Four commonly used anorectics which are amphetamine analogues were tested for their action on responsiveness in an acoustic startle test when rats were given daily IP...
Four commonly used anorectics which are amphetamine analogues were tested for their action on responsiveness in an acoustic startle test when rats were given daily IP injections adequate to produce a change in body weight. Drugs were given for 22 days. None of these drugs increased startle responsiveness as does the amphetamine parent compound. Instead, fenfluramine and phenylpropanolamine decreased startle responsiveness and phentermine and diethylpropion produced no change. There was no relationship between drug action and body weight. Partial tolerance was found for the fenfluramine action on startle and complete tolerance was found for its action on body weight gain. The fenfluramine action is compatible with the extensive literature on humans and animals indicating sedative properties.
Topics: Acoustic Stimulation; Animals; Appetite Depressants; Body Weight; Diethylpropion; Drug Tolerance; Fenfluramine; Male; Phentermine; Phenylpropanolamine; Rats; Reflex, Startle
PubMed: 3659098
DOI: 10.1016/0091-3057(87)90203-6 -
British Medical Journal Mar 1968
Clinical Trial
Topics: Adult; Appetite Depressants; Clinical Trials as Topic; Diethylpropion; Electroencephalography; Eye Movements; Fenfluramine; Fluorine; Humans; Phenethylamines; Phenmetrazine; Placebos; Sleep; Substance Withdrawal Syndrome
PubMed: 4868010
DOI: 10.1136/bmj.1.5595.796 -
British Heart Journal Dec 1995Amphetamine-like appetite suppressants, particularly fenfluramines, have been implicated in the aetiology of primary pulmonary hypertension. At one specialist centre in...
OBJECTIVE
Amphetamine-like appetite suppressants, particularly fenfluramines, have been implicated in the aetiology of primary pulmonary hypertension. At one specialist centre in France 20% of patients with primary pulmonary hypertension had been exposed to fenfluramine. The prevalence of primary pulmonary hypertension associated with fenfluramines and other appetite suppressants in the United Kingdom is unknown. This study was performed to measure prior exposure to appetite suppressants in patients with primary pulmonary hypertension.
SETTING
Heart lung transplantation centres in England.
PATIENTS
United Kingdom residents with proven primary pulmonary hypertension referred for consideration of heart lung transplantation.
METHODS
Case surveillance study, obtaining data from the hospital and general practitioner's notes and directly from the patients or their relatives.
RESULTS
55 patients were identified. Drug histories were available from hospital records in all patients, from the general practitioner's notes in 51, and from the patients or relatives in 44. Of these, 3 female patients had been exposed to appetite suppressants (2 fenfluramine, 1 diethylpropion): 2 have since died. In each case exposure was brief and apparently predated the development of symptoms by several years.
CONCLUSIONS
Exposure of patients with severe primary pulmonary hypertension to fenfluramine and other appetite suppressants is uncommon in the United Kingdom unlike in France, where most of the cases associating primary pulmonary hypertension with fenfluramine use have originated. This may reflect more conservative prescribing of these agents in the United Kingdom.
Topics: Adult; Appetite Depressants; Diethylpropion; Female; Fenfluramine; Heart-Lung Transplantation; Humans; Hypertension, Pulmonary; Male; Retrospective Studies; United Kingdom
PubMed: 8541174
DOI: 10.1136/hrt.74.6.660 -
Einstein (Sao Paulo, Brazil) 2013To investigate the prevalence of appetite suppressant use among health sciences students in Southern Brazil.
OBJECTIVE
To investigate the prevalence of appetite suppressant use among health sciences students in Southern Brazil.
METHODS
Undergraduate students (n=300) from seven health science undergraduate courses of the Universidade de Caxias do Sul completed a questionnaire about the use of substances to suppress appetite.
RESULTS
A significant percentage (15%; n=45) of research participants used appetite suppressants at least once in their lives. The most commonly used substances were sympathomimetic stimulant drugs (5%), including amfepramone (3.3%) and fenproporex (1.7%). The lifetime use of appetite suppressants was more prevalent among Nursing (26.7%) and Nutrition (24.4%%) students. There was no reported use of appetite suppressants among medical students. The use of appetite suppressants was significantly more prevalent among women. The majority of those who used these substances did so under medical recommendation. Most of users took appetite suppressants for more than 3 months.
CONCLUSION
Lifetime use of appetite suppressants was substantial, being sympathomimetic stimulant drugs the most commonly used agents. Students enrolled in Nursing and Nutrition courses presented a significantly higher prevalence of lifetime use of appetite suppressants.
Topics: Adolescent; Adult; Amphetamines; Appetite Depressants; Brazil; Diethylpropion; Female; Humans; Male; Obesity; Self Medication; Students, Health Occupations; Surveys and Questionnaires; Sympathomimetics; Time Factors; Young Adult
PubMed: 23579743
DOI: 10.1590/s1679-45082013000100009 -
Value in Health : the Journal of the... Nov 2014
PubMed: 27201685
DOI: 10.1016/j.jval.2014.08.1689 -
Canadian Medical Association Journal Nov 1983
Topics: Diethylpropion; Female; Follow-Up Studies; Humans; Phentermine; Psychoses, Substance-Induced
PubMed: 6627161
DOI: No ID Found -
Canadian Medical Association Journal Jun 1960
Topics: Diethylpropion; Eating; Electrocardiography; Humans; Propiophenones
PubMed: 14422282
DOI: No ID Found -
British Medical Journal Apr 1961
Topics: Appetite; Diethylpropion; Obesity; Propiophenones
PubMed: 13749515
DOI: 10.1136/bmj.1.5231.1009 -
The European Respiratory Journal May 2004
Topics: Appetite Depressants; Diethylpropion; Humans; Hypertension, Pulmonary
PubMed: 15176699
DOI: 10.1183/09031936.04.00119304 -
Journal of the American Chemical Society Oct 2013The direct α-amination of ketones, esters, and aldehydes has been accomplished via copper catalysis. In the presence of catalytic copper(II) bromide, a diverse range of...
The direct α-amination of ketones, esters, and aldehydes has been accomplished via copper catalysis. In the presence of catalytic copper(II) bromide, a diverse range of carbonyl and amine substrates undergo fragment coupling to produce synthetically useful α-amino-substituted motifs. The transformation is proposed to proceed via a catalytically generated α-bromo carbonyl species; nucleophilic displacement of the bromide by the amine then delivers the α-amino carbonyl adduct while the catalyst is reconstituted. The practical value of this transformation is highlighted through one-step syntheses of two high-profile pharmaceutical agents, Plavix and amfepramone.
Topics: Aldehydes; Amines; Bromides; Catalysis; Clopidogrel; Copper; Diethylpropion; Esters; Ticlopidine
PubMed: 24107144
DOI: 10.1021/ja4096472