-
British Medical Journal May 1973
Topics: Diphenhydramine; Humans; Methaqualone; Sleep Wake Disorders; State Medicine; Substance-Related Disorders; United Kingdom
PubMed: 4712496
DOI: 10.1136/bmj.2.5864.486-b -
British Medical Journal Aug 1970
Topics: Barbiturates; Chloral Hydrate; Diphenhydramine; Glutethimide; Humans; Hypnotics and Sedatives; Methaqualone; Motor Skills; Sleep; Sleep, REM
PubMed: 4318019
DOI: No ID Found -
Internal Medicine (Tokyo, Japan) 2011
Topics: Acute Disease; Aged; Cholinergic Antagonists; Diabetic Neuropathies; Diphenhydramine; Female; Humans; Ultrasonography; Urinary Retention
PubMed: 21963757
DOI: 10.2169/internalmedicine.50.6080 -
Cell Calcium Sep 2020Diphenhydramine (DPH) has been broadly used to treat allergy. When used as a topical medicine, DPH temporarily relieves itching and pain. Although transient receptor...
Diphenhydramine (DPH) has been broadly used to treat allergy. When used as a topical medicine, DPH temporarily relieves itching and pain. Although transient receptor potential type A1 (TRPA1) channel is known to play roles in both acute and chronic itch and pain, whether DPH affects the activities of TRPA1 remains unclear. Using whole-cell patch clamp recordings, we demonstrated that DPH modulates the voltage-dependence of TRPA1. When co-applied with a TRPA1 agonist, DPH significantly enhanced the inward currents while suppressing the outward currents of TRPA1, converting the channel from outwardly rectifying to inwardly rectifying. This effect of DPH occurred no matter TRPA1 was activated by an electrophilic or non-electrophilic agonist and for both mouse and human TRPA1. The modulation of TRPA1 by DPH was maintained in the L906C mutant, which by itself also causes inward rectification of TRPA1, indicating that additional acting sites are present for the modulation of TRPA1 currents by DPH. Our recordings also revealed that DPH partially blocked capsaicin evoked TRPV1 currents. These data suggest that DPH may exert its therapeutic effects on itch and pain, through modulation of TRPA1 in a voltage-dependent fashion.
Topics: Animals; Calcium; Diphenhydramine; Electric Conductivity; Electricity; Extracellular Space; HEK293 Cells; Humans; Ion Channel Gating; Ions; Isothiocyanates; Magnesium; Membrane Potentials; Mice; Mutation; TRPA1 Cation Channel
PubMed: 32634675
DOI: 10.1016/j.ceca.2020.102245 -
Japanese Journal of Pharmacology Dec 1964
Topics: Acetylcholine; Ammonium Compounds; Atropine; Diphenhydramine; Drug Synergism; Epinephrine; Guinea Pigs; Histamine; Ileum; Mice; Muscle Relaxants, Central; Muscle, Smooth; Muscles; Papaverine; Pharmacology; Piperidines; Quaternary Ammonium Compounds; Receptors, Drug; Research; Sensory Receptor Cells
PubMed: 14311834
DOI: 10.1254/jjp.14.458 -
Canadian Medical Association Journal Dec 1963
Topics: Amobarbital; Child; Chloral Hydrate; Diphenhydramine; Humans; Paraldehyde; Phenobarbital; Promethazine; Secobarbital; Sleep Initiation and Maintenance Disorders
PubMed: 14101454
DOI: No ID Found -
Bosnian Journal of Basic Medical... May 2019Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA)B, A, and B-phenethylamine receptors. It is prescribed in former Communist Bloc... (Review)
Review
Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA)B, A, and B-phenethylamine receptors. It is prescribed in former Communist Bloc countries for anxiolysis and related psychiatric disorders. It can be easily obtained in Western countries and is thought to have abuse potential. Abrupt discontinuation has been reported to precipitate an abstinence syndrome. A review of the literature identified 22 reported cases, many of which were notable for severe psychomotor agitation and requirements for aggressive pharmacologic treatment. Neurologic and autonomic signs and symptoms may mimic serotonin or neuroleptic malignant syndrome. Patients were typically younger and had coexisting substance abuse disorders to other drugs. Also presented is a case of a 23-year-old male with an acute phenibut abstinence syndrome. This patient exhibited severe psychomotor agitation requiring physical restraints, dexmedetomidine, lorazepam, haloperidol, diphenhydramine, cyproheptadine, melatonin, olanzapine, and baclofen for symptom control.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; Haloperidol; Humans; Lorazepam; Male; Melatonin; Neuroleptic Malignant Syndrome; Olanzapine; Receptors, GABA; Substance Withdrawal Syndrome; Substance-Related Disorders; Young Adult; gamma-Aminobutyric Acid
PubMed: 30501608
DOI: 10.17305/bjbms.2018.4008 -
Academic Emergency Medicine : Official... Mar 1996
Review
Topics: Anesthesia, Local; Anesthetics, Local; Diphenhydramine; Drug Hypersensitivity; Emergency Medical Services; Humans; Lidocaine; Wounds and Injuries
PubMed: 8673772
DOI: 10.1111/j.1553-2712.1996.tb03419.x -
Scientific Reports Aug 2023Orphenadrine (ORP), dimenhydrinate (DMN), and cinnarizine (CNN) were investigated using green-sensitive spectrofluorometric methods. Method, I used for determination of...
Orphenadrine (ORP), dimenhydrinate (DMN), and cinnarizine (CNN) were investigated using green-sensitive spectrofluorometric methods. Method, I used for determination of DMN in 0.1 M hydrochloric acid (HCl) and 1.0% sodium dodecyl sulphate (SDS) at 286 nm after λ 222 nm, while for determination of ORP in 1.0% w/v SDS involves measuring the fluorescence at 285 nm after λ 220 nm. For DMN and ORP, the detection and quantitation limits were 2.99 and 4.71 and 9.08 and 14.29 ng/mL, respectively. The ranges of DMN and ORP were 0.10-1.0 and 0.04-0.5 µg/mL, respectively, in micellar aqueous solution. Method II, the derivative intensities of DMN and CNN were measured at a fixed of different wavelength between the excitation and the emission wavelengths (Δλ) = 60 nm at 282 and 322 nm, at the zero crossing of each other, respectively. The detection and quantitation limits for DMN and CNN were 1.77 and 0.88 ng/mL and 5.36 and 2.65 ng/mL, correspondingly, through the entire range of 0.1-1.0 µg/mL for DMN and CNN. The linearity was perfectly determined through the higher values of the correlation coefficient ranging from 0.9997 to 0.9999 for both direct and synchronous methods. The precision of the proposed methods was also confirmed via the lower values of the standard deviation which ranged from 0.39 to 1.11. The technique was expanded to analyze this mixture in combined tablets and laboratory-prepared mixtures. The method validation was done depending on the international conference on harmonization (ICH) recommendations. An analysis of the statistical data revealed a high agreement between the proposed data and the comparison methodology. Three different assessment methods demonstrated the greenness of the technique.
Topics: Cinnarizine; Dimenhydrinate; Hydrochloric Acid; Laboratories; Orphenadrine; Spectrometry, Fluorescence
PubMed: 37599333
DOI: 10.1038/s41598-023-40559-x -
Transfusion Medicine Reviews Jan 2007Febrile nonhemolytic and allergic reactions are the most common transfusion reactions, but usually do not cause significant morbidity. In an attempt to prevent these... (Review)
Review
Febrile nonhemolytic and allergic reactions are the most common transfusion reactions, but usually do not cause significant morbidity. In an attempt to prevent these reactions, US physicians prescribe acetaminophen or diphenhydramine premedication before more than 50% of blood component transfusions. Acetaminophen and diphenhydramine are effective therapies for fever and allergy, respectively, so their use in transfusion has some biologic rationale. However, these medications also have potential toxicity, particularly in ill patients, and in the studies performed to date, they have failed to prevent transfusion reactions. Whether the benefits of routine prophylaxis with acetaminophen and diphenhydramine outweigh their risks and cost requires reexamination, particularly in light of the low reaction rates reported at many institutions even when premedication is not prescribed.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Allergic Agents; Blood Component Transfusion; Diphenhydramine; Fever; Humans; Hypersensitivity
PubMed: 17174216
DOI: 10.1016/j.tmrv.2006.09.001