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Radiologia 2006
Topics: Back; Dracunculiasis; Humans; Radiography
PubMed: 17058379
DOI: 10.1016/s0033-8338(06)73140-x -
The American Journal of Tropical... Jul 2013This report summarizes the status of the global Dracunculiasis Eradication Program as of the end of 2012. Dracunculiasis (Guinea worm disease) has been eliminated from...
This report summarizes the status of the global Dracunculiasis Eradication Program as of the end of 2012. Dracunculiasis (Guinea worm disease) has been eliminated from 17 of 21 countries where it was endemic in 1986, when an estimated 3.5 million cases occurred worldwide. Only 542 cases were reported from four countries in 2012, and 103 villages still had indigenous transmission. Most remaining cases were reported from the new Republic of South Sudan, whereas Chad, Ethiopia, and Mali each reported 10 cases or less. Political instability and insecurity in Mali may become the main obstacles to interrupting dracunculiasis transmission forever.
Topics: Chad; Disease Eradication; Dracunculiasis; Ethiopia; Global Health; Health Promotion; Humans; Mali; Population Surveillance; Sudan
PubMed: 23843492
DOI: 10.4269/ajtmh.13-0090 -
BMJ (Clinical Research Ed.) Oct 2012To assess the quantity and distribution of evidence from randomised controlled trials for the treatment of the major neglected tropical diseases and to identify gaps in... (Review)
Review
OBJECTIVE
To assess the quantity and distribution of evidence from randomised controlled trials for the treatment of the major neglected tropical diseases and to identify gaps in the evidence with network analysis.
DESIGN
Systematic review and network analysis.
DATA SOURCES
Cochrane Central Register of Controlled Trials and PubMed from inception to 31 August 2011.
STUDY SELECTION
Randomised controlled trials that examined treatment of 16 neglected tropical diseases or complications thereof published in English, French, Spanish, Portuguese, German, or Dutch.
RESULTS
We identified 971 eligible randomised trials. Leishmaniasis (184 trials, 23,039 participants) and geohelminth infections; 160 trials, 46,887 participants) were the most studied, while dracunculiasis (nine trials, 798 participants) and Buruli ulcer (five trials, 337 participants) were least studied. Relative to its global burden of disease, lymphatic filariasis had the fewest trials and participants. Only 11% of trials were industry funded. Either a single trial or trials with fewer than 100 participants comprised the randomised evidence for first or second line treatments for Buruli ulcer, human African trypanosomiasis, American trypanosomiasis, cysticercosis, rabies, echinococcosis, New World cutaneous leishmaniasis, and each of the foodborne trematode infections. Among the 10 disease categories with more than 40 trials, five lacked sufficient head to head comparisons between first or second line treatments.
CONCLUSIONS
There is considerable variation in the amount of evidence from randomised controlled trials for each of the 16 major neglected tropical diseases. Even in diseases with substantial evidence, such as leishmaniasis and geohelminth infections, some recommended treatments have limited supporting data and lack head to head comparisons.
Topics: Anti-Infective Agents; Buruli Ulcer; Dengue; Dracunculiasis; Echinococcosis; Elephantiasis, Filarial; Helminthiasis; Humans; Leishmaniasis, Mucocutaneous; Leprosy; Multicenter Studies as Topic; Neglected Diseases; Rabies; Randomized Controlled Trials as Topic; Research Design; Research Support as Topic; Schistosomiasis; Strongyloidiasis; Trachoma; Trematode Infections; Tropical Medicine; Trypanosomiasis
PubMed: 23089149
DOI: 10.1136/bmj.e6512 -
Le Infezioni in Medicina 2023Dracunculiasis (Guinea Worm Disease) is a chronic disease that is primarily found in the arid and poor areas of our planet where water supply systems consist of open... (Review)
Review
Dracunculiasis (Guinea Worm Disease) is a chronic disease that is primarily found in the arid and poor areas of our planet where water supply systems consist of open wells. This parasitic disease is transmitted to humans not only through the consumption of water contaminated with crustaceans harbouring larvae of , but also through the ingestion of paratenic (frogs) or transport hosts (fish). The natural progression of the disease is caused by adult worms invading connective tissues, leading to blistering and ulceration of the extremities, approximately one year after infection. In 1986, the Guinea Worm Eradication Program (GWEP) was launched and since then, the incidence of the disease has been reduced by over 99%. Indeed, the most recent global report from 2022 shows only 13 cases of human dracunculiasis worldwide, the lowest annual incidence ever reported. The new found knowledge of potential animal reservoirs and the recent discovery of possible edible paratenic hosts could pose challenges to the future eradication of this debilitating disease. Therefore, attempts to eradicate this parasitosis should not be postponed. Intensive research is needed in this neglected area of medicine, now that the goal is within reach.
PubMed: 38075414
DOI: 10.53854/liim-3104-9 -
MMWR. Morbidity and Mortality Weekly... Dec 2017Dracunculiasis (Guinea worm disease) is caused by Dracunculus medinensis, a parasitic worm. Approximately 1 year after a person acquires infection from contaminated...
Dracunculiasis (Guinea worm disease) is caused by Dracunculus medinensis, a parasitic worm. Approximately 1 year after a person acquires infection from contaminated drinking water, the worm emerges through the skin, usually on a lower limb (1). Pain and secondary bacterial infection can cause temporary or permanent disability that disrupts work and schooling. The campaign to eradicate dracunculiasis worldwide began in 1980 at CDC. In 1986, the World Health Assembly called for dracunculiasis elimination,* and the global Guinea Worm Eradication Program, led by the Carter Center and supported by the World Health Organization (WHO), United Nations Children's Fund, CDC, and other partners, began assisting ministries of health in countries with endemic dracunculiasis. In 1986, an estimated 3.5 million cases occurred each year in 20 countries in Africa and Asia (2). Since then, although the goal of eradicating dracunculiasis has not been achieved, considerable progress has been made. Compared with the 1986 estimate, the annual number of reported cases in 2016 has declined by >99%, and cases are confined to three countries with endemic disease. This report updates published (3-4) and unpublished surveillance data reported by ministries of health and describes progress toward dracunculiasis eradication during January 2016-June 2017. In 2016, a total of 25 cases were reported from three countries (Chad [16], South Sudan [six], Ethiopia [three]), compared with 22 cases reported from the same three countries and Mali in 2015 (Table 1). The 14% increase in cases from 2015 to 2016 was offset by the 25% reduction in number of countries with indigenous cases. During the first 6 months of 2017, the overall number of cases declined to eight, all in Chad, from 10 cases in three countries (Chad [four], South Sudan [four] and Ethiopia [two]) during the same period of 2016. Continued active surveillance, aggressive detection, and appropriate management of cases are essential eradication program components; however, epidemiologic challenges, civil unrest, and insecurity pose potential barriers to eradication.
Topics: Disease Eradication; Dracunculiasis; Global Health; Humans
PubMed: 29216028
DOI: 10.15585/mmwr.mm6648a3 -
The New England Journal of Medicine Jan 2013
Topics: Animals; Disease Eradication; Dracunculiasis; Elephantiasis, Filarial; Endemic Diseases; Global Health; Humans; Life Cycle Stages; Malaria; Onchocerciasis; Parasites; Poliomyelitis; Spirurida Infections; Tropical Medicine
PubMed: 23281976
DOI: 10.1056/NEJMra1200391 -
Emerging Infectious Diseases Aug 2020A fragment of a Dracunculus-like worm was extracted from the hind limb of a 2-year-old dog from Toledo, Spain. Cytochrome oxidase I and rRNA sequences confirmed an...
A fragment of a Dracunculus-like worm was extracted from the hind limb of a 2-year-old dog from Toledo, Spain. Cytochrome oxidase I and rRNA sequences confirmed an autochthonous mammalian Dracunculus worm infection in Europe. Sequence analyses suggest close relation to a parasite obtained from a North American opossum.
Topics: Animals; Dogs; Dracunculiasis; Dracunculus Nematode; Europe; Spain
PubMed: 32687046
DOI: 10.3201/eid2608.201661 -
Clinical Medicine (London, England) Mar 2019The term neglected tropical diseases (NTDs) describes a disparate group of diseases which affect populations living in poverty and are important causes of morbidity and...
The term neglected tropical diseases (NTDs) describes a disparate group of diseases which affect populations living in poverty and are important causes of morbidity and mortality worldwide. Global programmes for the control of NTDs benefit large-scale donations made by pharmaceutical companies. A number of NTDs have internationally agreed targets for their control, elimination and eradication. Eradication is defined as the permanent reduction to zero of the worldwide incidence of infection. Elimination is defined as the reduction to zero of the incidence of infection in a specified geographic area. Considerable progress has been made towards elimination and eradication of some NTDs but unexpected new challenges have emerged which threaten the eventual achievement of these goals.
Topics: Animals; Communicable Diseases; Disease Eradication; Dracunculiasis; Global Health; Humans; Neglected Diseases; Tropical Climate; Tropical Medicine; Yaws
PubMed: 30872302
DOI: 10.7861/clinmedicine.19-2-157 -
Journal of the Royal College of... 1999The protracted civil war in the Sudan has had an immense human and economic cost. The consequent collapse of infrastructure in the south of the country has disrupted the... (Review)
Review
The protracted civil war in the Sudan has had an immense human and economic cost. The consequent collapse of infrastructure in the south of the country has disrupted the provision of basic health care, and primary health care schemes to eradicate trypanosomiasis and dracunculiasis have been rendered impossible. Operation Lifeline Sudan, an official United Nations umbrella organisation, has been in a unique position to provide long-term medical, agricultural, livestock, fishery and emergency food aid in both government held and rebel held areas over about the past decade.
Topics: Developing Countries; Female; Humans; Male; Relief Work; Sudan; United Nations; Warfare
PubMed: 10402579
DOI: No ID Found -
International Journal of Infectious... Apr 2021
Topics: Animals; Dracunculiasis; Dracunculus Nematode; Humans; Public Health; Vietnam; Water Supply
PubMed: 33610782
DOI: 10.1016/j.ijid.2021.02.063