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Anais Brasileiros de Dermatologia 2016Squamous cell carcinoma (SCC) is the second-most common malignant cutaneous cancer, with 60% occurring in the head and neck region. Metastases are uncommon and imply a...
Squamous cell carcinoma (SCC) is the second-most common malignant cutaneous cancer, with 60% occurring in the head and neck region. Metastases are uncommon and imply a more conservative prognosis. This report describes a case of parotid-invasive, facial squamous cell carcinoma, highlighting the importance of its prognostic and therapeutic management. The patient is an 81-year-old female, exhibiting extensive tumoral lesions in the pre-auricular region, affecting the parotid parenchyma and implying the metastatic involvement of the intra-parotid lymph node. Parotid involvement caused by SCC in specificity tumors is discussed herein. Parotid invasion is currently recognized as an isolated variable. It affects survival rates and determines certain changes in case management, such as the broadening of resection areas and adjuvant radiotherapy.
Topics: Aged, 80 and over; Carcinoma, Squamous Cell; Facial Neoplasms; Female; Follow-Up Studies; Humans; Lymph Node Excision; Neck; Parotid Neoplasms; Prognosis
PubMed: 27438204
DOI: 10.1590/abd1806-4841.20163995 -
CMAJ : Canadian Medical Association... Jan 2017
Topics: Facial Neoplasms; Female; Humans; Middle Aged; Nevus; Skin Neoplasms
PubMed: 27920010
DOI: 10.1503/cmaj.160049 -
Trends in Genetics : TIG Jan 2016Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of... (Review)
Review
Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary species studied, the domestic dog (Canis lupus familiaris) and the Tasmanian devil (Sarcophilus harrisii). Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. The dog tumor is not necessarily lethal, while the devil tumor has driven the population to near extinction. Transmissible tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune detection by their hosts, sometimes for long periods of time. In this review, we explore how transmissible tumors in CTVT, DFTD, and as well as the soft-shell clam and Syrian hamster, can advance studies of tumor biology.
Topics: Animals; Biological Evolution; Dog Diseases; Dogs; Facial Neoplasms; Genetic Variation; Marsupialia; Mesocricetus; Mya; Neoplasms; Venereal Tumors, Veterinary
PubMed: 26686413
DOI: 10.1016/j.tig.2015.10.001 -
CMAJ : Canadian Medical Association... Mar 2016
Topics: Adenoma; Facial Neoplasms; Female; Humans; Middle Aged; Muir-Torre Syndrome; Sebaceous Gland Neoplasms
PubMed: 26527831
DOI: 10.1503/cmaj.150171 -
The Oncologist 2011Although cancer can on occasion be caused by infectious agents such as specific bacteria, parasites, and viruses, it is not generally considered a transmissible disease....
Although cancer can on occasion be caused by infectious agents such as specific bacteria, parasites, and viruses, it is not generally considered a transmissible disease. In rare circumstances, however, direct communication from one host to another has been documented. The Tasmanian devil is now threatened with extinction in the wild because of a fatal transmissible cancer, devil facial tumor disease (DFTD). Another example is canine transmissible venereal tumor (CTVT or Sticker's sarcoma) in dogs. There is a vast difference in prognosis between these two conditions. DFTD is often fatal within 6 months, whereas most cases of CTVT are eventually rejected by the host dog, who then is conferred lifelong immunity. In man, only scattered case reports exist about such communicable cancers, most often in the setting of organ or hematopoietic stem cell transplants and cancers arising during pregnancy that are transmitted to the fetus. In about one third of cases, transplant recipients develop cancers from donor organs from individuals who were found to harbor malignancies after the transplantation. The fact that two thirds of the time cancer does not develop, along with the fact that cancer very rarely is transmitted from person to person, supports the notion that natural immunity prevents such cancers from taking hold in man. These observations might hold invaluable clues to the immunobiology and possible immunotherapy of cancer.
Topics: Animal Diseases; Animals; Dogs; Facial Neoplasms; Humans; Marsupialia; Neoplasms; Venereal Tumors, Veterinary
PubMed: 21212437
DOI: 10.1634/theoncologist.2010-0301 -
Dermatology Online Journal Dec 2012A 50-year-old woman presented with a long history of multiple, flesh-colored papules and nodules on her central face, neck, and upper shoulders, as well as pink papules...
A 50-year-old woman presented with a long history of multiple, flesh-colored papules and nodules on her central face, neck, and upper shoulders, as well as pink papules on her scalp. They were neither pruritic nor tender, but the patient desired treatment for cosmesis. Histopathologic examination of a representative facial lesion was consistent with a trichoepithelioma and an upper forehead papule was consistent with cylindroma. She reported a positive family history of similar lesions.
Topics: Facial Neoplasms; Female; Humans; Middle Aged; Neoplastic Syndromes, Hereditary; Skin Neoplasms
PubMed: 23286806
DOI: No ID Found -
Dermatology Online Journal Dec 2005A 35-year-old woman presented with cosmetically disturbing facial plaques, which had been present since birth and were consistent with nevus sebaceus on histopathologic...
A 35-year-old woman presented with cosmetically disturbing facial plaques, which had been present since birth and were consistent with nevus sebaceus on histopathologic examination. Nevus sebaceus is a congenital, hairless plaque, which is found most commonly on the scalp and face and typically becomes thicker and more verrucous in appearance as the patient enters adulthood. There is an association with benign and malignant neoplasms. Typically, these lesions are either removed surgically or the patients are followed clinically. Other therapeutic modalities utilized for cosmesis include carbon dioxide laser and photodynamic therapy.
Topics: Adult; Facial Neoplasms; Female; Head and Neck Neoplasms; Humans; Nevus; Scalp; Skin Neoplasms
PubMed: 16403388
DOI: No ID Found -
Actas Dermo-sifiliograficas 2017
Topics: Adult; Asymptomatic Diseases; Biomarkers, Tumor; Chemotherapy, Adjuvant; Facial Neoplasms; Female; Humans; Interferons; Melanoma; Prognosis; Remission Induction; Skin Neoplasms
PubMed: 27344066
DOI: 10.1016/j.ad.2015.07.024 -
Science (New York, N.Y.) Apr 2023Tasmanian devils have spawned two transmissible cancer lineages, named devil facial tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity...
Tasmanian devils have spawned two transmissible cancer lineages, named devil facial tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and evolution of these clones by analyzing 78 DFT1 and 41 DFT2 genomes relative to a newly assembled, chromosome-level reference. Time-resolved phylogenetic trees reveal that DFT1 first emerged in 1986 (1982 to 1989) and DFT2 in 2011 (2009 to 2012). Subclone analysis documents transmission of heterogeneous cell populations. DFT2 has faster mutation rates than DFT1 across all variant classes, including substitutions, indels, rearrangements, transposable element insertions, and copy number alterations, and we identify a hypermutated DFT1 lineage with defective DNA mismatch repair. Several loci show plausible evidence of positive selection in DFT1 or DFT2, including loss of chromosome Y and inactivation of , but none are common to both cancers. This study reveals the parallel long-term evolution of two transmissible cancers inhabiting a common niche in Tasmanian devils.
Topics: Animals; Facial Neoplasms; Genome; Marsupialia; Phylogeny; Selection, Genetic; Evolution, Molecular
PubMed: 37079675
DOI: 10.1126/science.abq6453 -
Anais Brasileiros de Dermatologia 2017
Topics: Aged; Biopsy; Erythema; Facial Neoplasms; Fatal Outcome; Female; Hemangiosarcoma; Humans; Immunohistochemistry; Skin; Skin Neoplasms
PubMed: 28538905
DOI: 10.1590/abd1806-4841.20175865