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Annals of Clinical Microbiology and... Feb 2022Pyelonephritis is one of the most serious bacterial illnesses during childhood. Gram-negative organisms account for up to 90% of the cases. Gram-positive bacteria are... (Review)
Review
BACKGROUND
Pyelonephritis is one of the most serious bacterial illnesses during childhood. Gram-negative organisms account for up to 90% of the cases. Gram-positive bacteria are uncommon causes of urinary tract infections, and only a few cases caused by Facklamia hominis have been reported in the literature.
CASE PRESENTATION
A five-year-old girl with tracheostomy and gastrostomy and past medical history of congenital lymphangioma presented with a two-week history of with intermittent fever, frequent urination, and vesical tenesmus. Diagnosis of pyelonephritis was made. Urine culture reported colonies with alpha-hemolysis in blood agar at 48-h of incubation and Facklamia hominis was identified by MALDI-TOF. The patient was successfully treated with gentamicin.
CONCLUSIONS
This is the first reported case of pyelonephritis by Facklamia hominis in a child, and the second involving infection in a pediatric patient. Although this pathogen is uncommon, current treatment of F. hominis is a challenge for physicians. This case illustrates the requirement to standardize identification and treatment of care to avoid treatment failure and antimicrobial resistance.
Topics: Aerococcaceae; Anti-Bacterial Agents; Child, Preschool; Female; Fever; Gentamicins; Humans; Pyelonephritis; Treatment Outcome; Urinary Tract Infections
PubMed: 35151319
DOI: 10.1186/s12941-022-00497-4 -
BMC Urology Dec 2020Transurethral resection of the prostate (TUR-P) is one of the most frequent routine procedures in urology. Because of the semisterile environment, postoperative...
BACKGROUND
Transurethral resection of the prostate (TUR-P) is one of the most frequent routine procedures in urology. Because of the semisterile environment, postoperative infections, including sepsis, are a common complication, with Escherichia coli, Klebsiella spp., Proteus mirabilis or Enterococcus faecalis as frequently isolated pathogens. Facklamia hominis is a gram-positive, facultatively anaerobic, alpha-hemolytic, catalase-negative coccus that was first described in 1997. To date, only a few cases of infectious complications have been described. We report the first case of postoperative bacteremia due to Facklamia hominis after TUR-P.
CASE PRESENTATION
An 82-year-old man developed fever only a few hours after elective TUR-P because of benign prostate syndrome. After cultivation of blood cultures, antibiotic therapy with ceftriaxone was intravenously administered and changed to oral cotrimoxazole before discharge of the afebrile patient. One anaerobic blood culture revealed Facklamia hominis. Under antibiotic therapy, the patient remained afebrile and showed no signs of infections during follow-up.
CONCLUSIONS
Fever and bacteremia are frequent complications after TUR-P. This study is the first report of Facklamia hominis in a postoperative blood culture after TUR-P. To date, there are only a few reports of patients with infectious complications and isolation of Facklamia hominis in various patient samples. Because Facklamia hominis resembles viridans streptococci on blood agar analysis, this pathogen may often be misidentified. In this case identification of Facklamia hominis was possible with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. It has been postulated that Facklamia hominis might be a facultative pathogen and that its incidence will increase in the future.
Topics: Aerococcaceae; Aged, 80 and over; Bacteremia; Gram-Positive Bacterial Infections; Humans; Male; Postoperative Complications; Transurethral Resection of Prostate
PubMed: 33287796
DOI: 10.1186/s12894-020-00762-8 -
JAAD Case Reports May 2021
PubMed: 33898677
DOI: 10.1016/j.jdcr.2021.03.017 -
Journal of Clinical Microbiology Apr 1999Three strains of a gram-positive catalase-negative, facultatively anaerobic coccus-shaped organism originating from human clinical samples were characterized by...
Three strains of a gram-positive catalase-negative, facultatively anaerobic coccus-shaped organism originating from human clinical samples were characterized by phenotypic and molecular taxonomic methods. Sequencing of genes encoding 16S rRNA showed that the strains are phylogenetically closely related (99.9 to 100% sequence similarity) and represent a new subline within the genus Facklamia. The unknown bacterium was readily distinguished from all currently described species of the genus Facklamia (viz., Facklamia hominis, Facklamia ignava, and Facklamia sourekii) by biochemical tests and electrophoretic analysis of whole-cell proteins. Based on phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium be classified as Facklamia languida sp. nov. The type strain of F. languida is CCUG 37842.
Topics: Bacillaceae; Bacillaceae Infections; Genes, Bacterial; Humans; Molecular Sequence Data; Phenotype; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Species Specificity
PubMed: 10074542
DOI: 10.1128/JCM.37.4.1161-1164.1999 -
Microbiology Resource Announcements Apr 2019The genome sequence of a strain isolated from the urine of a patient with acute cystitis and sepsis is reported. The genome contains and (M) genes, consistent with the...
The genome sequence of a strain isolated from the urine of a patient with acute cystitis and sepsis is reported. The genome contains and (M) genes, consistent with the isolate's phenotypic resistance to macrolides and tetracycline.
PubMed: 31023809
DOI: 10.1128/MRA.00100-19 -
New Microbes and New Infections Jan 2016Facklamia hominis is a Gram-positive bacterium that was first isolated from various human samples, excluding abscesses of the scapula. We here report the first scapular...
Facklamia hominis is a Gram-positive bacterium that was first isolated from various human samples, excluding abscesses of the scapula. We here report the first scapular abscess infection due to F. hominis, found in Marseille, France. We also reviewed all cases published in the literature.
PubMed: 26862429
DOI: 10.1016/j.nmni.2015.11.003 -
Journal of Clinical Microbiology Jul 1998Two strains of a hitherto-undescribed gram-positive, catalase-negative coccus isolated from human sources were characterized by phenotypic and molecular taxonomic...
Two strains of a hitherto-undescribed gram-positive, catalase-negative coccus isolated from human sources were characterized by phenotypic and molecular taxonomic methods. Comparative 16S rRNA gene sequencing studies demonstrated that the unknown strains are genealogically identical and constitute a new line close to, but distinct from, Facklamia hominis. The unknown bacterium was readily distinguished from F. hominis by biochemical tests and electrophoretic analysis of whole-cell proteins. On the basis of phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium be classified as Facklamia ignava sp. nov. The type strain of Facklamia ignava is CCUG 37419.
Topics: Aged; Aged, 80 and over; Bacillaceae; Bacillaceae Infections; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Female; Humans; Molecular Sequence Data; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Sequence Analysis, DNA; rRNA Operon
PubMed: 9650988
DOI: 10.1128/JCM.36.7.2146-2148.1998 -
Revista Espanola de Quimioterapia :... Jun 2019
Topics: Aerococcaceae; Child; Gram-Positive Bacterial Infections; Humans; Male; Penile Diseases; Polymerase Chain Reaction; RNA, Ribosomal, 16S
PubMed: 31037933
DOI: No ID Found -
Annals of the Rheumatic Diseases Dec 2020To determine if plasma microbial small RNAs (sRNAs) are altered in patients with rheumatoid arthritis (RA) compared with control subjects, associated with RA...
OBJECTIVES
To determine if plasma microbial small RNAs (sRNAs) are altered in patients with rheumatoid arthritis (RA) compared with control subjects, associated with RA disease-related features, and altered by disease-modifying antirheumatic drugs (DMARDs).
METHODS
sRNA sequencing was performed on plasma from 165 patients with RA and 90 matched controls and a separate cohort of 70 patients with RA before and after starting a DMARD. Genome alignments for RA-associated bacteria, representative bacterial and fungal human microbiome genomes and environmental bacteria were performed. Microbial genome counts and individual sRNAs were compared across groups and correlated with disease features. False discovery rate was set at 0.05.
RESULTS
Genome counts of , , , spp, , spp, and were significantly decreased in the plasma of RA compared with control subjects. Three microbial transfer RNA-derived sRNAs were increased in RA versus controls and inversely associated with disease activity. Higher total microbial sRNA reads were associated with lower disease activity in RA. Baseline total microbial sRNAs were threefold higher among patients who improved with DMARD versus those who did not but did not change significantly after 6 months of treatment.
CONCLUSION
Plasma microbial sRNA composition is altered in RA versus control subjects and associated with some measures of RA disease activity. DMARD treatment does not alter microbial sRNA abundance or composition, but increased abundance of microbial sRNAs at baseline was associated with disease activity improvement at 6 months.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; RNA, Bacterial; RNA, Fungal; RNA, Small Untranslated
PubMed: 32958509
DOI: 10.1136/annrheumdis-2020-217589 -
Case Reports in Infectious Diseases 2012Facklamia hominis is a rare causative organism of infective endocarditis (IE). Only few cases of infection due to F. hominis have been reported in the literature. We...
Facklamia hominis is a rare causative organism of infective endocarditis (IE). Only few cases of infection due to F. hominis have been reported in the literature. We describe a case of IE due to Gram-positive, alpha-haemolytic, catalase-negative coccus F. hominis in an adult patient with rheumatic mitral stenosis. Isolated mitral stenosis is an uncommon valve lesion predisposing to IE. The following paper is being presented to emphasize the possibility of IE due to F. hominis, and laboratories need to be alert of the potential significance in appropriate clinical setting.
PubMed: 23320210
DOI: 10.1155/2012/307852