Authors: Zeynep Canan Özdemir, Ersin Töret

Topics: Fibroma; Humans; Infant; Skin Diseases; Skin Neoplasms; Toes

PubMed: 34837378
DOI: No ID Found

Authors: Christoforos Tsikkinis, Sofia Balamoti, Petros Grigoropoulos...

We present our experience on 6 patients (4 females, 2 males) with elastofibroma dorsi. The diagnosis was based on imaging studies along with clinical examination. Surgery was decided due to the symptomatic nature of the tumors along with the consent and willingness of the patients. All patients had an uncomplicated course and long term follow up did not show any disease recurrence.

Topics: Aged; Female; Fibroma; Humans; Male; Middle Aged; Soft Tissue Neoplasms

PubMed: 24965424
DOI: No ID Found

Authors: J S POLSON, C J PATTEE, F M WOOLHOUSE...

Topics: Cortisone; Fibroma; Keloid

PubMed: 14879325
DOI: No ID Found

Review

Authors: Prem Ruben Jayaram, John Walsh, Hamzah Lari...

A nuchal-type fibroma is a rare, benign fibrous tumour that typically occurs in the posterior neck along the midline, but can occur in extra-nuchal locations, most commonly in the back, shoulder and face. We present a biopsy-proven case that arose as a result of heavy gym-related activities. In particular, a heavy barbell was rested on his vertebral prominence at the level of C7/T1 during leg squatting. Repetitive trauma as a cause for extra-nuchal-type fibromas has been sparsely reported, but we suggest that sustained high pressure is an additional required feature. Although this lesion was in the posterior neck, it was contained entirely within the subcutaneous tissues without involvement of the nuchal ligament. Hence, it was considered an extra-nuchal fibroma. A description of key ultrasound and MRI imaging characteristics are provided to assist in making the diagnosis, along with a review of the current literature and a discussion of differential diagnoses.

Topics: Fibroma; Head and Neck Neoplasms; Humans; Neck; Skin Neoplasms; Soft Tissue Neoplasms

PubMed: 34554278
DOI: 10.1007/s00256-021-03912-7

Authors: Prashanth Panta

Topics: Adult; Female; Fibroma; Humans; Mouth Mucosa; Wounds and Injuries

PubMed: 26448815
DOI: 10.11604/pamj.2015.21.220.7498

Review

Authors: Wolfgang Hartmann, Dorothee Harder, Daniel Baumhoer...

The term giant cell-rich tumors of bone refers to a shared morphologic pattern in a group of different osseous lesions, that is, the abundance of osteoclastlike giant cells. Fitting with a broad spectrum of clinical presentations and biological behavior, the recent detection of characteristic molecular alterations in giant cell tumor of bone (H3-3), nonossifying fibroma (KRAS, FGFR1), giant cell granuloma of the jaws (KRAS, FGFR1, TRPV4), and aneurysmal bone cyst (USP6) have contributed significantly to the biological understanding of these morphologically related but clinically distinct lesions and their systematic classification, highlighting differences and pathogenic relationships.

Topics: Bone Cysts, Aneurysmal; Fibroma; Giant Cell Tumors; Giant Cells; Granuloma, Giant Cell; Humans

PubMed: 34742488
DOI: 10.1016/j.path.2021.06.010

Authors: Solange De Noon, Robert Piggott, Jamie Trotman...

The FOS gene family has been implicated in tumourigenesis across several tumour types, particularly mesenchymal tumours. The rare fibrous tumour desmoplastic fibroblastoma is characterised by overexpression of FOSL1. However, previous studies using cytogenetic and molecular techniques did not identify an underlying somatic change involving the FOSL1 gene to explain this finding. Prompted by an unusual index case, we report the discovery of a novel FOSL1 rearrangement in desmoplastic fibroblastoma using whole-genome and targeted RNA sequencing. We investigated 15 desmoplastic fibroblastomas and 15 fibromas of tendon sheath using immunohistochemistry, in situ hybridisation and targeted RNA sequencing. Rearrangements in FOSL1 and FOS were identified in 10/15 and 2/15 desmoplastic fibroblastomas respectively, which mirrors the pattern of FOS rearrangements observed in benign bone and vascular tumours. Fibroma of tendon sheath, which shares histological features with desmoplastic fibroblastoma, harboured USP6 rearrangements in 9/15 cases and did not demonstrate rearrangements in any of the four FOS genes. The overall concordance between FOSL1 immunohistochemistry and RNA sequencing results was 90%. These findings illustrate that FOSL1 and FOS rearrangements are a recurrent event in desmoplastic fibroblastoma, establishing this finding as a useful diagnostic adjunct and expanding the spectrum of tumours driven by FOS gene family alterations. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Topics: Humans; Fibroma, Desmoplastic; Fibroma; Gene Rearrangement; In Situ Hybridization; Soft Tissue Neoplasms; Ubiquitin Thiolesterase

PubMed: 36426824
DOI: 10.1002/path.6038

Authors: Mayara Monique Figueiredo Pinheiro, Antonio Pedro Mendes Schettini, Carlos Alberto Chirano Rodrigues...

Topics: Aged; Fibroma; Humans; Immunohistochemistry; Male; Skin; Skin Neoplasms; Toes

PubMed: 28954126
DOI: 10.1590/abd1806-4841.20176734

Review

Authors: Jude C Nduka, Kimberly Lam, Coonoor R Chandrasekar...

Plantar fibromas are a common diagnosis in orthopaedic foot clinic consultation, diagnosis of plantar fibroma is usually from history and examination, and radiological investigation may be needed to confirm diagnosis. Misdiagnosis, however, of plantar fibroma have been known to happen. The management of five cases of plantar soft tissue swellings were reviewed; the clinical presentation and radiological investigation findings of these cases are discussed with the aim of improving knowledge and awareness.

Topics: Fibroma; Foot Diseases; Humans; Sarcoma; Soft Tissue Neoplasms

PubMed: 33268229
DOI: 10.1016/j.foot.2020.101736

Authors: Aykut Alkan, Fethi Emre Ustabaşıoğlu, Ufuk Usta...

Topics: Humans; Osteoblastoma; Tibia; Fibroma; Diagnosis, Differential

PubMed: 36482109
DOI: 10.4274/balkanmedj.galenos.2022.2022-10-34