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Medicine Dec 2017Fibromyxosarcoma is common in head and neck, vessel, omentum, and reproductive system, with low-grade malignant behavior. However, primary atrial fibromyxosarcoma with...
RATIONALE
Fibromyxosarcoma is common in head and neck, vessel, omentum, and reproductive system, with low-grade malignant behavior. However, primary atrial fibromyxosarcoma with highly malignant behavior is extremely rare.
PATIENT CONCERNS
A 34-year-old female presented with oppression in the chest, short breath, and onset of headache as initial symptoms. The preoperative echocardiogram showed a medium-size echogenic mass close to the posterior leaflet of the mitral valve in the left atrium.
DIAGNOSIS
Primary atrial fibromyxosarcoma with multiple-system metastases.
INTERVENTIONS
The patient underwent surgery, and the tumor was removed completely. The diagnosis of left atrium fibromyxosarcoma was confirmed through postoperative histopathological examination. Positron emission tomography/computed tomography scan was performed, which revealed multiple metastases to left adnexa, bilateral adrenal glands, left iliacus, right lateral ventricle, and skeletal system.
OUTCOMES
The patient died of cerebral hernia caused by hemorrhage from the metastatic brain tumor, 30 days after the surgery, without receiving chemotherapy or radiotherapy.
LESSONS
Cardiac fibromyxosarcoma is a rare primary malignant cardiac neoplasm, probably with systemic metastases. The possibility of malignancy should be considered as differential diagnosis for cardiac mass.
Topics: Adult; Echocardiography; Fatal Outcome; Female; Heart Atria; Heart Neoplasms; Humans; Myxosarcoma; Neoplasm Metastasis; Positron Emission Tomography Computed Tomography
PubMed: 29245258
DOI: 10.1097/MD.0000000000008930 -
BMJ Case Reports Jun 2016A 65-year-old man presented with giant orbital myxofibrosarcoma with no extraorbital extension. Imaging was suggestive of mesenchymal malignancy with significant... (Review)
Review
A 65-year-old man presented with giant orbital myxofibrosarcoma with no extraorbital extension. Imaging was suggestive of mesenchymal malignancy with significant vascularity. Incisional biopsy was suggestive of low-grade fibromyxoid sarcoma. The clinical and imaging features did not support the pathological diagnosis. Histopathology of the exenterated sample revealed features of high-grade myxofibrosarcoma. To the best of our knowledge, this is the largest reported myxofibrosarcoma of the orbit. Adjuvant radiotherapy was advised. Correlating the case history, imaging and histopathology, this case can best be summarised as a natural history of conversion from a low to high-grade myxoid malignancy. We emphasise that the overlapping features of myxoid malignancy (fibromyxosarcoma vs myxofibrosarcoma) and regional variation in tumour morphology in biopsy specimen may mislead the clinician. Therefore, knowledge about the key differentiating features as well as incisional biopsy of each radiologically different area can increase the possibility of correct diagnosis and management of each case.
Topics: Aged; Diagnosis, Differential; Fibrosarcoma; Humans; Male; Neoplasm Grading; Orbital Neoplasms; Radiotherapy, Adjuvant
PubMed: 27298287
DOI: 10.1136/bcr-2015-214107 -
Indian Journal of Otolaryngology and... Jul 2006Spindle cell carcinoma of larynx is rare tumors constituting only 0.6% of laryngeal neoplasm with predominance in elderly males (average 63 yrs). These tumors were...
Spindle cell carcinoma of larynx is rare tumors constituting only 0.6% of laryngeal neoplasm with predominance in elderly males (average 63 yrs). These tumors were described under various names: pseudosarcoma, Carcinosarcoma, fibromyxosarcoma, mixed sarcoma, polypoidal sarcoma. Immunohistochemistry and electron microscopy suggest that spindle cell carcinoma are true neoplasm and spindle cells are part of the neoplasm and not benign reactive fibroblast.
PubMed: 23120325
DOI: 10.1007/BF03050852 -
California Medicine Jan 1962In one hundred consecutive cases in which operations were done on the heart with the surgical field exposed to view and circulation was shunted to extracorporeal...
In one hundred consecutive cases in which operations were done on the heart with the surgical field exposed to view and circulation was shunted to extracorporeal apparatus, there were six deaths. None were attributable to the by-pass procedure. The lesions were of various kinds, congenital and acquired. In one case a fibromyxosarcoma that was obstructing the right ventricular outflow tract and invading the main pulmonary artery was successfully excised.
Topics: Cardiac Surgical Procedures; Death; Extracorporeal Circulation; Heart Defects, Congenital; Heart, Artificial; Thoracic Surgery
PubMed: 13912412
DOI: No ID Found -
BMC Musculoskeletal Disorders Jan 2020Malignant fibrous neoplasms (MFN) of long bones are rare lesions. Moreover, the prognostic determinants of MFN of long bones have not been reported. This study aimed to...
BACKGROUND
Malignant fibrous neoplasms (MFN) of long bones are rare lesions. Moreover, the prognostic determinants of MFN of long bones have not been reported. This study aimed to present epidemiological data and analyse the prognostic factors for survival in patients with MFN.
MATERIALS AND METHODS
The Surveillance, Epidemiology, and End Results (SEER) programme database was used to screen patients with malignant fibrous neoplasms (MFN) of long bones from 1973 to 2015, with attention to fibrosarcoma, fibromyxosarcoma, periosteal fibrosarcoma and malignant fibrous histiocytoma. The prognostic values of overall survival (OS) and cancer-specific survival (CSS) were assessed using the Cox proportional hazards regression model with univariate and multivariate analyses. The Kaplan-Meier method was used to obtain OS and CSS curves.
RESULTS
A total of 237 cases were selected from the SEER database. Malignant fibrous histiocytoma was the most common form of lesion in long bones. Multivariate analysis revealed that independent predictors of OS included age, stage, tumour size and surgery. Age, stage, tumour size and surgery were also independent predictors of CSS. Additionally, the most significant prognostic factor was whether metastasis had occurred at the time of initial diagnosis.
CONCLUSION
Among patients with MFN of long bones, age (> 60 years), tumour size (> 10 cm), distant stage, and non-surgical treatment are factors for poor survival.
Topics: Adolescent; Adult; Bone Neoplasms; Databases, Factual; Female; Fibrosarcoma; Histiocytoma, Benign Fibrous; Humans; Male; Middle Aged; Neoplasm Staging; Population Surveillance; SEER Program; Survival Rate; Young Adult
PubMed: 31969161
DOI: 10.1186/s12891-019-2971-8 -
Canadian Journal of Comparative... Jun 1960
PubMed: 17649231
DOI: No ID Found -
The British Journal of Ophthalmology Jan 1966
Topics: Adult; Humans; Infant; Male; Myxosarcoma; Orbital Neoplasms; Radiation Effects; Radium; Retinoblastoma
PubMed: 5903832
DOI: 10.1136/bjo.50.1.50 -
The British Journal of Ophthalmology Jun 1967
Topics: Eyelids; Female; Humans; Middle Aged; Myxosarcoma
PubMed: 6026598
DOI: 10.1136/bjo.51.6.403 -
The Korean Journal of Gastroenterology... Feb 2010Undifferentiated sarcoma is an uncommon primary malignant tumor of the liver typically occurring in older children. It is also referred to as malignant mesenchymoma,...
Undifferentiated sarcoma is an uncommon primary malignant tumor of the liver typically occurring in older children. It is also referred to as malignant mesenchymoma, fibromyxosarcoma, or mesenchymal sarcoma. We experienced a case of undifferentiated sarcoma in 72-year-old male. Contrast enhanced liver CT scan revealed a 3.4 cm heterogeneously enhancing, ill-defined, and low attenuated mass in the left liver and subtle intrahepatic duct dilatation. And, in tubogram, there were segmental stenosis and occlusion from the hilum to the proximal common bile duct. We did ultrasonography guided liver biopsy. The pathologic finding revealed infiltrative growth of atypical cells with rhabdoid features. Some atypical cells showed clear cytoplasm, but no organoid pattern was identified. The stroma around atypical cells was filled with eosinophilic hyaline material. These tumor cells were positive for vimentin only, and the tumor was consistent with undifferentiated sarcoma of the liver.
Topics: Aged; Bile Ducts, Intrahepatic; Diagnosis, Differential; Dilatation, Pathologic; Humans; Klatskin Tumor; Liver Neoplasms; Male; Positron-Emission Tomography; Sarcoma; Tomography, X-Ray Computed; Tuberculosis; Ultrasonography; Vimentin
PubMed: 20168062
DOI: 10.4166/kjg.2010.55.2.144 -
Canadian Medical Association Journal Nov 1932
PubMed: 20318910
DOI: No ID Found