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Journal Der Deutschen Dermatologischen... Jun 2014In no other medical field former rare infections of the 1980(th) and 1990(th) occur again as this is seen in the field of venerology which is as well based on the... (Review)
Review
In no other medical field former rare infections of the 1980(th) and 1990(th) occur again as this is seen in the field of venerology which is as well based on the mobility of the population. Increasing rates of infections in Europe, and increasing bacteriological resistances face health professionals with new challenges. The WHO estimates more than 340 million cases of illnesses worldwide every year. Diseases caused by sexually transmitted infections (STI) in a strict sense are syphilis, gonorrhea, lymphogranuloma venereum, granuloma inguinale, and chancroid. In a wider sense, all illnesses are included which can mainly be transmitted through sexual contact. The term "sexual contact" has to be seen widely, from close physical contact to all variants of sexual behavior. This CME article is an overview of the most common occurring sexually transmitted infections in clinical practice. Both, basic knowledge as well as recent developments are discussed below.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Comorbidity; Drug Therapy, Combination; Female; Germany; Humans; Infant, Newborn; Male; Mass Screening; Pregnancy; Sexually Transmitted Diseases
PubMed: 24889293
DOI: 10.1111/ddg.12310 -
Anais Brasileiros de Dermatologia 2020Donovanosis is a chronic, progressive, and indolent bacterial disease that affects the skin and mucous membranes of the genital and perigenital regions, often associated...
Donovanosis is a chronic, progressive, and indolent bacterial disease that affects the skin and mucous membranes of the genital and perigenital regions, often associated with sexual transmission, and with low infectivity. The malignant transformation of donovanosis lesions occurs exceptionally, as is usually seen in long-term ulcerations.
Topics: Granuloma Inguinale; Humans; Skin; Ulcer
PubMed: 33069513
DOI: 10.1016/j.abd.2020.07.002 -
Indian Journal of Sexually Transmitted... 2023Donovanosis is a chronic bacterial infection caused by gram-negative bacterium Klebsiella granulomatosis and is characterized by painless beefy red granulomatous ulcer...
Donovanosis is a chronic bacterial infection caused by gram-negative bacterium Klebsiella granulomatosis and is characterized by painless beefy red granulomatous ulcer which bleeds on touch and is mostly confined to the endemic regions of the world. It is rarest among the sexually transmitted genital ulcer diseases. We hereby report a case of donovanosis in a non-endemic area who initially presented with a solitary genital ulcer. Initial tests did not reveal any aetiology. However after four days of admission, since no aetiology was coming forth, a repeat tissue smear from the lesion revealed Donovan bodies which helped in the bedside diagnosis and management of the case.
PubMed: 37457515
DOI: 10.4103/ijstd.ijstd_68_22 -
Sexually Transmitted Infections Dec 2002Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. The causative organism,... (Review)
Review
Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. The causative organism, Calymmatobacterium granulomatis, has been cultured for the first time in many years and a polymerase chain reaction diagnostic using a colorimetric detection system has been developed. Phylogenetic analysis confirms close similarities with the genus Klebsiella and a proposal made that C granulomatis be reclassified as Klebsiella granulomatis comb nov. Azithromycin has emerged as the drug of choice and should be used if the diagnosis is confirmed or suspected. In donovanosis endemic areas, syndromic management protocols for genital ulceration may need to be adapted locally. A significant donovanosis epidemic was reported in Durban from 1988-97 but the current status of this epidemic is unclear. The donovanosis elimination programme among Aboriginals in Australia appears successful and is a model that could be adopted in other donovanosis endemic areas. Overall, the incidence of donovanosis seems to be decreasing. Increased attention would undoubtedly be paid to donovanosis if policy makers recognised more readily the importance of genital ulcers in fuelling the HIV epidemic.
Topics: Communicable Disease Control; Diagnosis, Differential; Diagnostic Errors; Female; Global Health; Granuloma Inguinale; Humans; Male; Microbiological Techniques; Opportunistic Infections
PubMed: 12473810
DOI: 10.1136/sti.78.6.452 -
The British Journal of Venereal Diseases Mar 1949
Topics: Granuloma; Granuloma Inguinale; Humans
PubMed: 18113380
DOI: 10.1136/sti.25.1.1 -
Scientifica 2015Background. Tuberculosis of the penis (TBP) is rare. Aim. To review the literature. Method. Various internet data bases were searched. Literature Review. TBP could be... (Review)
Review
Background. Tuberculosis of the penis (TBP) is rare. Aim. To review the literature. Method. Various internet data bases were searched. Literature Review. TBP could be primary or secondary, may develop following circumcision performed by a person who had pulmonary Tb, and may be transmitted to the penis from ejaculation, contamination from clothing, or from contact with endometrial secretions, following an earlier pulmonary Tb or Tb elsewhere. TBP presents with a painless/painful small nodule, ulcer, mass on penis which gradually enlarges, and induration/swelling of penis, with or without erectile dysfunction. Inguinal lymph nodes may or may not be palpable. The patient's voiding is normal. There may or may not be history of circumcision, pulmonary Tb, and BCG immunization. TBP mimics penile carcinoma, granulomatous syphilis penile ulcer, genital herpes simplex, granuloma inguinale, and HIV infection. Diagnosis is established by microscopic examination finding of granulomas +/-AFB in penile discharge or biopsy of lesion or culture of Tb organism from discharge or biopsy specimens or positive Elisa serology/PCR for Tb. PTBs respond to first- or 2nd-line anti-Tb 6-month treatment. Close contacts should be screened. Extrapulmonary Tb should be excluded. Conclusions. Clinicians should consider possibility of PTB in cases of penile lesions and erectile failure.
PubMed: 26435877
DOI: 10.1155/2015/601624 -
Folia Medica Cracoviensia 2015We analyzed publications and articles in the PubMed database about the use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology. Literature published in the... (Review)
Review
We analyzed publications and articles in the PubMed database about the use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology. Literature published in the English language, at least in the past two decades, was reviewed. Specific dermatologic indications for TMP-SMX are few but it is often used as the second- or third- line agent. TMP-SMX is used to treat cutaneous nocardiosis and Aeromonas infections. TMP-SMX is a treatment option for cat - scratch disease, granuloma inguinale, melioidosis and Mycobacterium marinum/fortuitum cutaneous infections. TMP-SMX is an alternate choice for treatment of pyodermas and lymphogranuloma venereum. TMP-SMX has been used to treat acne vulgaris in tetracycline and erythromycin - resistant patients. TMP-SMX is still the preferred empiric antibiotic for methicillin - resistant Staphylococcus aureus skin and soft tissue infection in HIV positive population. TMP-SMX is used in dermatology to treat various skin conditions and is one of the most commonly prescribed sulfonamide drugs. TMP-SMX as monotherapy is an effective treatment option in many diseases but due to drug resistance, a combination therapy-usually of two drugs-may be considered.
Topics: Anti-Infective Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Methicillin-Resistant Staphylococcus aureus; Soft Tissue Infections; Staphylococcal Infections; Trimethoprim, Sulfamethoxazole Drug Combination
PubMed: 26774630
DOI: No ID Found -
Canadian Medical Association Journal Apr 1966
Topics: Adult; Granuloma Inguinale; Humans; Male; Tetracycline
PubMed: 4952373
DOI: No ID Found -
Proceedings of the Royal Society of... Jul 1960
Topics: Granuloma Inguinale; Humans; Medical Records
PubMed: 13851907
DOI: No ID Found