Authors: Walter Belda Junior

Donovanosis is a chronic, progressive, and indolent bacterial disease that affects the skin and mucous membranes of the genital and perigenital regions, often associated with sexual transmission, and with low infectivity. The malignant transformation of donovanosis lesions occurs exceptionally, as is usually seen in long-term ulcerations.

Topics: Granuloma Inguinale; Humans; Skin; Ulcer

PubMed: 33069513
DOI: 10.1016/j.abd.2020.07.002

Authors: V Govindan Nair, N G Pandalai

PubMed: 29009168
DOI: No ID Found

Authors: P J HARE

Topics: Granuloma Inguinale; Humans; Medical Records

PubMed: 13851907
DOI: 10.1177/003591576005300718

Authors: W P Hogarth, R W Hogarth

Topics: Adult; Granuloma Inguinale; Humans; Male; Tetracycline

PubMed: 4952373
DOI: No ID Found

Authors: D Senkadhir Vendhan, Biju Vasudevan, Vinay Gera...

Donovanosis is a chronic bacterial infection caused by gram-negative bacterium Klebsiella granulomatosis and is characterized by painless beefy red granulomatous ulcer which bleeds on touch and is mostly confined to the endemic regions of the world. It is rarest among the sexually transmitted genital ulcer diseases. We hereby report a case of donovanosis in a non-endemic area who initially presented with a solitary genital ulcer. Initial tests did not reveal any aetiology. However after four days of admission, since no aetiology was coming forth, a repeat tissue smear from the lesion revealed Donovan bodies which helped in the bedside diagnosis and management of the case.

PubMed: 37457515
DOI: 10.4103/ijstd.ijstd_68_22

Review

Authors: N O'Farrell

Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. The causative organism, Calymmatobacterium granulomatis, has been cultured for the first time in many years and a polymerase chain reaction diagnostic using a colorimetric detection system has been developed. Phylogenetic analysis confirms close similarities with the genus Klebsiella and a proposal made that C granulomatis be reclassified as Klebsiella granulomatis comb nov. Azithromycin has emerged as the drug of choice and should be used if the diagnosis is confirmed or suspected. In donovanosis endemic areas, syndromic management protocols for genital ulceration may need to be adapted locally. A significant donovanosis epidemic was reported in Durban from 1988-97 but the current status of this epidemic is unclear. The donovanosis elimination programme among Aboriginals in Australia appears successful and is a model that could be adopted in other donovanosis endemic areas. Overall, the incidence of donovanosis seems to be decreasing. Increased attention would undoubtedly be paid to donovanosis if policy makers recognised more readily the importance of genital ulcers in fuelling the HIV epidemic.

Topics: Communicable Disease Control; Diagnosis, Differential; Diagnostic Errors; Female; Global Health; Granuloma Inguinale; Humans; Male; Microbiological Techniques; Opportunistic Infections

PubMed: 12473810
DOI: 10.1136/sti.78.6.452

Authors: H Orr

PubMed: 20319770
DOI: No ID Found

Review

Authors: Wolfgang Fuchs, Norbert H Brockmeyer

In no other medical field former rare infections of the 1980(th) and 1990(th) occur again as this is seen in the field of venerology which is as well based on the mobility of the population. Increasing rates of infections in Europe, and increasing bacteriological resistances face health professionals with new challenges. The WHO estimates more than 340 million cases of illnesses worldwide every year. Diseases caused by sexually transmitted infections (STI) in a strict sense are syphilis, gonorrhea, lymphogranuloma venereum, granuloma inguinale, and chancroid. In a wider sense, all illnesses are included which can mainly be transmitted through sexual contact. The term "sexual contact" has to be seen widely, from close physical contact to all variants of sexual behavior. This CME article is an overview of the most common occurring sexually transmitted infections in clinical practice. Both, basic knowledge as well as recent developments are discussed below.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Comorbidity; Drug Therapy, Combination; Female; Germany; Humans; Infant, Newborn; Male; Mass Screening; Pregnancy; Sexually Transmitted Diseases

PubMed: 24889293
DOI: 10.1111/ddg.12310

Authors: E T Milligan

PubMed: 19987974
DOI: 10.1177/003591573102400451