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The Pan African Medical Journal 2019Palpebral hidrocystomas are benign tumors also known as cystic apocrine adenoma, cyst of sweat gland, apocrine retention cyst or cyst of Moll. They originate from...
Palpebral hidrocystomas are benign tumors also known as cystic apocrine adenoma, cyst of sweat gland, apocrine retention cyst or cyst of Moll. They originate from eccrine or apocrine sweat glands and often occur on the face and the eyelids. Other atypical locations such as the chest, the shoulders and the foreskin have been reported. Hidrocystoma is a small translucent, shiny cyst. It appears as single or multiple cystic lesion. Their histogenesis is uncertain. Indeed, apocrine hidrocystoma could arise from the residuals of the primitive apocrine glands or of the gland of Moll. The eccrine hidrocystoma could arise from the eccrine glands or the excretory duct of the glands of Moll. Their clinical differentiation is little obvious and diagnosis is based on histological examination. They are characterized by two clinical presentations: isolated hidrocystomas and the associated types. Isolated hidrocystoma is the most common type: hidrocystoma appears as single or multiple cystic lesions and it is not associated with extraocular signs. Apocrine hidrocystomas are solitary in 93% of cases while eccrine hidrocystomas appear most often as multiple lesions. The associated types are more rare and have been only described for the multiple hidrocystomas. If in the majority of cases a treatment based on argon laser is sufficient, more voluminous hidrocystomas require surgical resection. We here report the case of a young patient presenting with translucent nodule in the external canthus of the left eye. Hidrocystoma, molluscum pendulum and syringoma were the suspected diagnoses. Surgical resection was performed as well as histologic examination which confirmed the diagnosis of hidrocystoma.
Topics: Eyelid Neoplasms; Eyelids; Female; Hidrocystoma; Humans; Sweat Gland Neoplasms
PubMed: 31448032
DOI: 10.11604/pamj.2019.33.70.15601 -
Indian Dermatology Online Journal 2018Schopf-Schulz-Passarge syndrome (SSPS) is a rare type of ectodermal dysplasia that has autosomal recessive inheritance. It is characterized by palmoplantar keratoderma,...
Schopf-Schulz-Passarge syndrome (SSPS) is a rare type of ectodermal dysplasia that has autosomal recessive inheritance. It is characterized by palmoplantar keratoderma, hypodontia, hypotrichosis, nail dystrophy, and multiple periocular and eyelid apocrine hidrocystomas. A 36-year-old male presented with multiple eyelid and periocular apocrine hidrocystomas, ichthyosis, palmoplantar keratoderma, hypodontia, nail dystrophy, and thin scalp hair. Skin biopsy from a periocular lesion revealed cyst lined with smooth, thin epithelium, and few areas revealed foci of decapitation secretion consistent with apocrine hidrocystoma. The patient was diagnosed with SSPS.
PubMed: 30505790
DOI: 10.4103/idoj.IDOJ_26_18 -
Acta Dermatovenerologica Alpina,... Jun 2021Eccrine and apocrine hidrocystomas are uncommon, benign, cystic proliferations of the sweat glands usually located on the head and neck area. (Review)
Review
INTRODUCTION
Eccrine and apocrine hidrocystomas are uncommon, benign, cystic proliferations of the sweat glands usually located on the head and neck area.
OBJECTIVES
To describe the key clinical and histopathological characteristics of a large series of hidrocystomas in Greece to improve diagnostic accuracy, and to perform a historical review of the medical term hidrocystoma.
METHODS
A case series of 22 hidrocystomas from 20 consecutive patients treated with surgery at University Hospital of Heraklion in Crete, Greece, from January 1, 1998 to January 1, 2020 was performed along with a comprehensive historical literature review of the term hidrocystoma and its corresponding term hydatis from ancient Greek literature to the present. Data were obtained from medical records. All patients had a histopathologically confirmed diagnosis of hidrocystoma. Formalin-fixed paraffin-embedded (FFPE) sections of 22 tumors of the 20 consecutive patients were retrieved from the pathology laboratory archive and stained for SMA, p63, and GCDFP-15 with immunochemistry and periodic acid-Schiff (PAS) histochemical stain.
RESULTS
Overall, 22 hidrocystomas (11 apocrine and 11 eccrine hidrocystomas) surgically excised from 20 patients were included in this study. Of the 20 patients, 10 (50%) were male and 10 (50%) were female, with a mean age of 56 ± 15 years. Hidrocystomas commonly occurred on the eyelids (73%), inner canthus (9%), eyebrow (4.5%), neck (4.5%), nose (4.5%), and ear (4.5%). All apocrine hidrocystomas stained positive for SMA, GCDFP-15, CAM 5.2, PAS, and PAS-D. No recurrence was observed.
CONCLUSIONS
Here we have presented the clinicopathological characteristics of the largest case series of hidrocystomas in Europe and the Mediterranean region. Only apocrine hidrocystomas stained positive for SMA, GCDFP-15, CAM 5.2, PAS, and PAS-D.
Topics: Adult; Aged; Europe; Eyelids; Female; Hidrocystoma; Humans; Male; Middle Aged; Nose; Sweat Gland Neoplasms
PubMed: 34169699
DOI: No ID Found -
Turkish Journal of Ophthalmology Oct 2016A 29-year-old female patient presented with a painless mass on her upper eyelid medially. She noticed the mass 4 years earlier and it had increased in size over time....
A 29-year-old female patient presented with a painless mass on her upper eyelid medially. She noticed the mass 4 years earlier and it had increased in size over time. She had no diplopia, eyelid swelling, skin lesion overlying the mass, or visual disturbances. On ocular examination, eye movements and funduscopy were normal. The mass was movable and painless with palpation. Magnetic resonance imaging with contrast showed a 12x8x7 mm well-circumscribed cystic lesion with no contrast dye appearance. Surgical removal was performed delicately and no capsular rupture occured. Pathological examination revealed an eccrine hidrocystoma. Our aim is to underline that eccrine hidrocystoma should be included in differential diagnosis of orbital masses.
PubMed: 28058171
DOI: 10.4274/tjo.98853 -
The American Journal of Surgical... Oct 2023Recurrent oncogenic drivers have been identified in a variety of sweat gland tumors. Recently, integration of human papillomavirus type 42 (HPV42) has been reported in...
Recurrent oncogenic drivers have been identified in a variety of sweat gland tumors. Recently, integration of human papillomavirus type 42 (HPV42) has been reported in digital papillary adenocarcinoma (DPA). The main objectives of the present study were (i) to provide an overview of the prevalence of previously identified oncogenic drivers in acral sweat gland tumors and (ii) to genetically characterize tumors in which no recurrent genetic alteration has been identified yet. Cases of acral sweat gland tumors were identified from the database of the French network CARADERM. After histologic review, the presence of previously identified genetic alterations was investigated in the entire cohort (n=79) using a combination of immunohistochemistry and targeted DNA and RNA sequencing. Tumor entities with no recurrent genetic alterations were submitted to whole-transcriptome sequencing. CRTC1::MAML2 fusion was identified in cases of hidradenoma and hidradenocarcinoma (n=9/12 and n=9/12). A p.V600E mutation of BRAF was observed in all cases of tubular adenoma (n=4). YAP1:MAML2 and YAP1::NUTM1 fusions were observed in poroid tumors (n=15/25). ETV6::NTRK3 and TRPS1::PLAG1 fusion transcripts were identified in secretory carcinoma (n=1/1) and cutaneous mixed tumors (n=3/4), respectively. The HPV42 genome was detected in most cases of DPA (n=10/11) and in 1 adnexal adenocarcinoma not otherwise specified. Finally, whole-transcriptome analysis revealed BRD3::NUTM1 or NSD3::NUTM1 fusions in 2 cases of NUT adnexal carcinoma and NCOA4::RET and CCDC6::RET fusion transcripts in 2 cystadenoma/hidrocystoma-like tumors. Our study confirms distinctive cytogenetic abnormalities in a wide number of acral adnexal neoplasms and supports the use of molecular analysis as a valuable aid in the diagnosis of these rare and often difficult to diagnose group of neoplasms.
Topics: Humans; Sweat Gland Neoplasms; Skin Neoplasms; Carcinoma; Acrospiroma; Transcription Factors; Adenocarcinoma, Papillary; Repressor Proteins
PubMed: 37505808
DOI: 10.1097/PAS.0000000000002098 -
American Journal of Ophthalmology Case... Dec 2022To describe a patient with orbital apocrine hidrocystoma presenting with ptosis and subsequent management.
PURPOSE
To describe a patient with orbital apocrine hidrocystoma presenting with ptosis and subsequent management.
OBSERVATIONS
A 43-year-old woman presented to the oculoplastic surgery clinic with a left-sided ptosis and enlarging but painless mass in the sulcus of the left upper eyelid. Magnetic resonance imaging demonstrated a large, circumscribed T2 bright cystic lesion in the extraconal space. Surgical excision and histopathology confirmed a diagnosis of apocrine hidrocystoma.
CONCLUSIONS
Although uncommon, ptosis may be a presenting symptom of an orbital apocrine hidrocystoma, which should be considered in the differential diagnosis for an extraconal cystic lesion. Apocrine hidrocystomas are benign tumors and are cured with surgical excision with rare recurrence.
PubMed: 36393905
DOI: 10.1016/j.ajoc.2022.101747 -
Eplasty 2022What is an apocrine hidrocystoma?How does an apocrine hidrocystoma present?What are the histological features of an apocrinehidrocystoma?What is the treatment and...
What is an apocrine hidrocystoma?How does an apocrine hidrocystoma present?What are the histological features of an apocrinehidrocystoma?What is the treatment and prognosis?
PubMed: 36072057
DOI: No ID Found -
MedGenMed : Medscape General Medicine Sep 2006Hidrocystomas, eccrine and apocrine, are rare cystic lesions that form benign tumors of the sweat glands. In this clinical review, we present a "classic" case of... (Review)
Review
Hidrocystomas, eccrine and apocrine, are rare cystic lesions that form benign tumors of the sweat glands. In this clinical review, we present a "classic" case of hidrocystoma and review the main epidemiologic, histologic, and clinical features. We also review the effectiveness of experimental treatment methods and present information about associated syndromes and differential diagnosis, focusing especially on hidrocystomas' resemblance to basal cell carcinoma.
Topics: Aged; Diagnosis, Differential; Hidrocystoma; Humans; Male; Prevalence; Sweat Gland Neoplasms
PubMed: 17406184
DOI: No ID Found