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Biomolecules Apr 2022The first properties of histamine (HA) that were elucidated were vasodilation and contraction of smooth muscles in the gut after stimulating gastric acid secretion and...
The first properties of histamine (HA) that were elucidated were vasodilation and contraction of smooth muscles in the gut after stimulating gastric acid secretion and constriction of the bronchial area during anaphylaxis [...].
Topics: Anaphylaxis; Bronchi; Histamine; Humans; Muscle, Smooth
PubMed: 35625537
DOI: 10.3390/biom12050609 -
World Journal of Microbiology &... Oct 2022The consumption of foods fraught with histamine can lead to various allergy-like symptoms if the histamine is not sufficiently degraded in the human body. The... (Review)
Review
The consumption of foods fraught with histamine can lead to various allergy-like symptoms if the histamine is not sufficiently degraded in the human body. The degradation occurs primarily in the small intestine, naturally catalyzed by the human diamine oxidase (DAO). An inherent or acquired deficiency in human DAO function causes the accumulation of histamine and subsequent intrusion of histamine into the bloodstream. The histamine exerts its effects acting on different histamine receptors all over the body but also directly in the intestinal lumen. The inability to degrade sufficient amounts of dietary histamine is known as the 'histamine intolerance'. It would be preferable to solve this problem initially by the production of histamine-free or -reduced foods and by the oral supplementation of exogenous DAO supporting the human DAO in the small intestine. For the latter, DAOs from mammalian, herbal and microbial sources may be applicable. Microbial DAOs seem to be the most promising choice due to their possibility of an efficient biotechnological production in suitable microbial hosts. However, their biochemical properties, such as activity and stability under process conditions and substrate selectivity, play important roles for their successful application. This review deals with the advances and challenges of DAOs and other histamine-oxidizing enzymes for their potential application as processing aids for the production of histamine-reduced foods or as orally administered adjuvants to humans who have been eating food fraught with histamine.
Topics: Amine Oxidase (Copper-Containing); Animals; Diamines; Histamine; Humans; Mammals; Oxidation-Reduction; Receptors, Histamine
PubMed: 36208352
DOI: 10.1007/s11274-022-03421-2 -
Nutrients Apr 2024Histamine intolerance is a condition characterized by the accumulation of histamine to a point that exceeds the body's capacity to eliminate it. Researchers have... (Review)
Review
Histamine intolerance is a condition characterized by the accumulation of histamine to a point that exceeds the body's capacity to eliminate it. Researchers have attributed several reasons to this condition, such as genetic factors, alcohol, and dietary deficiencies, among other elements. Symptoms of histamine intolerance have been found to extend beyond the gastrointestinal tract and to the whole body, with these symptoms being sporadic and non-specific. This review will explore various aspects related to histamine intolerance, such as its causes, symptoms, diagnosis, and information related to management.
Topics: Humans; Histamine; Food Intolerance; Food Hypersensitivity
PubMed: 38674909
DOI: 10.3390/nu16081219 -
Nutrients Apr 2021Histamine intolerance is defined as a disequilibrium of accumulated histamine and the capacity for histamine degradation. This clinical term addresses a... (Review)
Review
Histamine intolerance is defined as a disequilibrium of accumulated histamine and the capacity for histamine degradation. This clinical term addresses a non-immunologically mediated pathology when histamine ingested with food is not particularly high, however its degradation is decreased. This paper aims to provide a narrative review on etiopathology, epidemiology, possible diagnostic algorithms and diagnostic challenges of histamine intolerance in children. The clinical picture of histamine intolerance in children is similar to that observed in adults apart from male predominance found in paediatric patients. Both in children and adults, a histamine-reduced diet is typically the treatment of choice. Diamine oxidase supplementation offers another treatment option. There is no symptom or test pathognomonic for histamine intolerance. Nevertheless, manifestations of chronic gastrointestinal symptoms, measurements of diamine oxidase deficits, positive results of histamine provocation tests and improvement in symptoms with histamine-reduced diet considerably increase the probability of histamine intolerance diagnosis. These factors have been included in the proposed diagnostic algorithm for histamine intolerance. In children histamine intolerance most likely co-occurs with allergies and bowel diseases, which creates an additional diagnostic challenge. As the evidence for children is poor further research is needed the determine epidemiology, validate diagnostic algorithms and establish possible treatment options regarding histamine intolerance.
Topics: Child; Food Hypersensitivity; Histamine; Humans
PubMed: 33924863
DOI: 10.3390/nu13051486 -
Journal of Food Protection May 2020In April 2017, an outbreak of histamine fish poisoning causing illness in nine victims associated with consumption of milkfish surimi products (fish ball) occurred in...
ABSTRACT
In April 2017, an outbreak of histamine fish poisoning causing illness in nine victims associated with consumption of milkfish surimi products (fish ball) occurred in Kaohsiung City, southern Taiwan. Of the two suspected frozen milkfish surimi samples, one sample contained 91.06 mg/100 g of histamine, levels that are greater than the potential hazard action level (50 mg/100 g) in most illness cases. Moreover, 28 frozen milkfish surimi samples from retail stores were collected and tested to determine the occurrence of histamine. One (3.6%) of 28 commercial surimi samples had histamine levels greater than the U.S. Food and Drug Administration (FDA) guideline for decomposition of 5 mg/100 g for scombroid fish and/or products. Thirteen histamine-producing bacterial strains isolated from suspected and commercial surimi samples were identified as prolific histamine formers, able to produce 98.4 to 121.8 mg/100 mL of histamine in Trypticase soy broth supplemented with 1.0% l-histidine. In addition, milkfish surimi was inoculated with Raoultella ornithinolytica at 5.0 log CFU/g and stored at 4, 15, 25, and 37°C to investigate bacterial growth and formation of histamine. The histamine contents quickly increased to more than 50 mg/100 g in samples stored at 37 and 25°C within 12 and 24 h, respectively, as well those stored at 15°C within 96 h. To our knowledge, this is the first report in Taiwan to demonstrate that milkfish surimi products could cause histamine intoxication.
Topics: Animals; Enterobacteriaceae; Fish Products; Food Contamination; Foodborne Diseases; Histamine; Taiwan
PubMed: 32330935
DOI: 10.4315/0362-028X.JFP-19-385 -
Clinical Immunology (Orlando, Fla.) Nov 2022Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA by RNA-Seq analysis...
OBJECTIVE
Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA by RNA-Seq analysis and pharmacological blockade of the activity of histamine, a key mast cell mediator, in murine OA.
METHODS
We examined OA synovial tissues and fluids by flow cytometry, immunostaining, single-cell and bulk RNA-Seq, qPCR, and ELISA. Cetirizine, a histamine H1 receptor (HR) antagonist, was used to treat the destabilization of the medial meniscus (DMM) mouse model of OA.
RESULTS
Flow cytometry and immunohistology analysis of OA synovial cells revealed KIT FcεRI and TPSAB1 mast cells. Single-cell RNA-Seq of OA synovial cells identified the expression of prototypical mast cell markers KIT, TPSAB1, CPA3 and HDC, as well as distinctive markers HPGD, CAVIN2, IL1RL1, PRG2, and CKLF, confirmed by bulk RNA-Seq and qPCR. A mast cell prototypical marker expression score classified 40 OA patients into three synovial pathotypes: mast cell-high, -medium, and -low. Additionally, we detected mast cell mediators including histamine, tryptase AB1, CPA3, PRG2, CAVIN2, and CKLF in OA synovial fluids. Elevated HR expression was detected in human OA synovium, and treatment of mice with the H receptor antagonist cetirizine reduced the severity and OA-related mediators in DMM.
CONCLUSION
Based on differential expression of prototypical and distinct mast cell markers, human OA joints can be stratified into mast cell-high, -medium, and -low synovial tissue pathotypes. Pharmacologic blockade of histamine activity holds the potential to improve OA disease outcome.
Topics: Animals; Arthritis, Rheumatoid; Cetirizine; Histamine; Humans; Interleukin-1 Receptor-Like 1 Protein; Mast Cells; Mice; Osteoarthritis; RNA-Seq; Receptors, Histamine H1; Synovial Membrane; Tryptases
PubMed: 36109004
DOI: 10.1016/j.clim.2022.109117 -
California Medicine Oct 1961Some recent discoveries about the formation, storage and catabolism of histamine are reviewed. Histamine is formed by decarboxylation of histidine and stored principally...
Some recent discoveries about the formation, storage and catabolism of histamine are reviewed. Histamine is formed by decarboxylation of histidine and stored principally in the mast cells of connective tissue. Human lung and facial skin are particularly rich in histamine. When histamine is injected intravenously, simulating spontaneous release, it is rapidly metabolized and excreted.
Topics: Histamine; Humans; Lung; Mast Cells; Skin
PubMed: 13866127
DOI: No ID Found -
British Medical Journal Oct 1974
Topics: Animals; Fishes; Food Microbiology; Food-Processing Industry; Foodborne Diseases; Histamine; Humans; Proteus
PubMed: 4472559
DOI: No ID Found -
Current Allergy and Asthma Reports Apr 2011Histamine and the histamine receptors are important regulators of a plethora of biological processes, including immediate hypersensitivity reactions and acid secretion... (Review)
Review
Histamine and the histamine receptors are important regulators of a plethora of biological processes, including immediate hypersensitivity reactions and acid secretion in the stomach. In these roles, antihistamines have found widespread therapeutic applications, while the last receptor to be discovered, the H4 histamine receptor, has become a major target of novel therapeutics. Recent studies involving human genetic variance and the development of mice lacking specific receptors or the ability to generate histamine have shown roles for the histamine pathway that extend well beyond the established roles. These include identification of previously unappreciated mechanisms through which histamine regulates inflammation in allergy, as well as roles in autoimmunity, infection, and pain. As a result, antihistamines may have wider applications in the future than previously predicted.
Topics: Animals; Genetic Variation; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Inflammation; Mice; Receptors, Histamine
PubMed: 21104347
DOI: 10.1007/s11882-010-0163-6 -
Cellular and Molecular Life Sciences :... Aug 2011Wakefulness and consciousness depend on perturbation of the cortical soliloquy. Ascending activation of the cerebral cortex is characteristic for both waking and... (Review)
Review
Wakefulness and consciousness depend on perturbation of the cortical soliloquy. Ascending activation of the cerebral cortex is characteristic for both waking and paradoxical (REM) sleep. These evolutionary conserved activating systems build a network in the brainstem, midbrain, and diencephalon that contains the neurotransmitters and neuromodulators glutamate, histamine, acetylcholine, the catecholamines, serotonin, and some neuropeptides orchestrating the different behavioral states. Inhibition of these waking systems by GABAergic neurons allows sleep. Over the past decades, a prominent role became evident for the histaminergic and the orexinergic neurons as a hypothalamic waking center.
Topics: Animals; Arousal; Biogenic Monoamines; Brain; Histamine; Humans; Hypothalamus, Posterior; Models, Biological; Wakefulness
PubMed: 21318261
DOI: 10.1007/s00018-011-0631-8