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The American Journal of Case Reports Sep 2018BACKGROUND Ocular Kaposi's sarcoma (KS) involving the conjunctiva and ocular adnexa is uncommon and is usually treated with cryotherapy or surgical excision. We report a...
BACKGROUND Ocular Kaposi's sarcoma (KS) involving the conjunctiva and ocular adnexa is uncommon and is usually treated with cryotherapy or surgical excision. We report a case of ocular KS successfully treated with HAART combined with 8 cycles of weekly docetaxel. CASE REPORT Our patient was a 24-year-old, treatment-naïve, HIV-positive (CD4 cell count 198 cells/mm3), homosexual man treated as having atypical hordeolum and subconjunctival hemorrhage, and later confirmed with pathology to have ocular KS with immunohistochemistry study showing KS with positive HHV8, CD34, CD31, and focal positive staining with Factor VIIIRA. HAART therapy was initiated combined with weekly docetaxel. With 2-month treatment of HAART and 8 cycles of weekly docetaxel, the KS of the bulbar conjunctiva and the eyelid partially resolved. CONCLUSIONS HAART combined with weekly docetaxel is an effective and well-tolerated option for ocular KS, which could be considered before cryotherapy or surgical excision.
Topics: Anti-Retroviral Agents; Antineoplastic Agents; Antiretroviral Therapy, Highly Active; Docetaxel; Eye Neoplasms; Gingival Neoplasms; HIV Infections; Humans; Male; Sarcoma, Kaposi; Young Adult
PubMed: 30197412
DOI: 10.12659/AJCR.910374 -
Singapore Medical Journal Mar 2010Necrotising fasciitis is a rare and rapidly spreading soft tissue infection characterised by widespread necrosis of the superficial fascia and usually occurring in the...
Necrotising fasciitis is a rare and rapidly spreading soft tissue infection characterised by widespread necrosis of the superficial fascia and usually occurring in the limbs and the abdominal wall. Periocular necrotising fasciitis is unusual due to the excellent blood supply of the facial region. The usual pathogens are Group A beta-haemolytic Streptococcus and Staphylococcus aureus. We report a case of Pseudomonas necrotising fasciitis of the eyelid with septic shock, initially diagnosed as hordeolum in a young immunocompromised Chinese woman. Early recognition of the condition, followed by timely intervention with surgical debridement and intensive intravenous antibiotic treatment led to a favourable prognosis. It is important for general physicians to recognise the cardinal signs of necrotising fasciitis, as early treatment with timely surgical debridement and supportive medical therapy is the mainstay to successful management.
Topics: Anti-Bacterial Agents; Debridement; Eyelids; Fasciitis, Necrotizing; Female; Humans; Pseudomonas Infections; Pseudomonas aeruginosa; Shock, Septic; Young Adult
PubMed: 20428733
DOI: No ID Found -
Revista Chilena de Infectologia :... Oct 2013Infestation by Demodex spp. in the palpebral edge follicles in humans is common. However, these mites are not routinely diagnosed in patients with or without ocular...
BACKGROUND
Infestation by Demodex spp. in the palpebral edge follicles in humans is common. However, these mites are not routinely diagnosed in patients with or without ocular pathologies in Chile and their relevance is unclear. One of the eye diseases most related to infestation by Demodex spp. is blepharitis, a chronic inflammation of the eyelid margin with intermittent exacerbations, which is very common in ophthalmic practice. Its management is prolonged treatment, which is often ineffective, leading to relapses and frustration of patient and treating physician. Blepharitis can be typed by its etiology into various types, one of them is caused by Demodex folliculorum and another species, D. brevis.
OBJECTIVE
The overall objective was to detect the presence and estimate the rate of infestation of Demodex spp. in healthy subjects and in patients with ocular pathology such as blepharitis, bacterial conjunctivitis, chalazion, and stye.
PATIENTS AND METHODS
Samples of tabs from both lower eyelids of ophthalmologically healthy patients (23) and patients with ocular pathologies (9) were mounted in immersion oil as described in literature, then visualized with a 10x objective and confirmed with 40x objective.
RESULTS
Detection rates of eggs, nymphs or adults of Demodex spp. in patients with and without ophthalmological problems were above and below 0.5 mites per tab, respectively. D.folliculorum was the species most frequently found.
DISCUSSION
The results are consistent with the international literature on both the rate of infestation as the predominant species.
CONCLUSION
This paper is the first study in Chile on this subject and represents a significant contribution to ophthalmic clinical diagnosis and treatment of patients with this disease.
Topics: Adolescent; Adult; Age Factors; Aged; Animals; Blepharitis; Case-Control Studies; Chalazion; Child; Chronic Disease; Conjunctivitis, Bacterial; Cross-Sectional Studies; Female; Hordeolum; Humans; Male; Middle Aged; Mite Infestations; Severity of Illness Index; Young Adult
PubMed: 24248163
DOI: 10.4067/S0716-10182013000500005 -
Clinical & Experimental Optometry Jul 2008Periorbital swelling can be secondary to local infections (for example, hordeolum) or reflective of an adjacent infection (for example, dental disease). Rarely,...
Periorbital swelling can be secondary to local infections (for example, hordeolum) or reflective of an adjacent infection (for example, dental disease). Rarely, periorbital swelling can indicate underlying sinus disease; Pott's puffy tumour is a unique and serious form of this process. This paper presents an unusual way in which a smouldering sinusitis can erode through bone and result in orbital cellulitis or intracranial infection.
Topics: Abscess; Cellulitis; Frontal Bone; Headache; Humans; Male; Middle Aged; Osteomyelitis; Periosteum
PubMed: 18601671
DOI: 10.1111/j.1444-0938.2007.00234.x -
British Medical Journal Dec 1954
Topics: Bacteriology; Carbuncle; Family Practice; General Practice; Hordeolum; Micrococcus; Staphylococcal Infections
PubMed: 13209110
DOI: 10.1136/bmj.2.4900.1322 -
The British Journal of General Practice... Dec 1992
Topics: Anecdotes as Topic; Folklore; Hordeolum
PubMed: 1297380
DOI: No ID Found