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British Medical Journal Dec 1961
Topics: Anemia; Anemia, Hypochromic; Anemia, Sideroblastic; Genetic Diseases, X-Linked; Pyridoxine; Vitamin B 6; beta-Thalassemia
PubMed: 13905463
DOI: 10.1136/bmj.2.5269.1756 -
CA: a Cancer Journal For Clinicians 1989
Review
Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Myelophthisic; Chronic Disease; Humans; Hypersplenism; Neoplasms; Red-Cell Aplasia, Pure
PubMed: 2513101
DOI: 10.3322/canjclin.39.5.296 -
California Medicine Dec 1960Idiopathic pulmonary hemosiderosis is a rare condition manifested by recurrent pulmonary hemorrhage of unknown cause, diffuse radiologic abnormalities, cough, hemoptysis...
Idiopathic pulmonary hemosiderosis is a rare condition manifested by recurrent pulmonary hemorrhage of unknown cause, diffuse radiologic abnormalities, cough, hemoptysis and moderate to severe hypochromic anemia. Diagnosis can be confirmed by iron stains of the sputum or lung aspiration or by biopsy. Prolonged spontaneous remission may occur without the use of corticosteroid therapy. Studies here reported indicated that the anemia is hypochromic and microcytic anemia of blood loss and iron deficiency, in spite of the presence of large amounts of iron in the pulmonary tissue. Correction of the anemia by intensive iron therapy and transfusion is considered an important part of therapy.
Topics: Anemia; Anemia, Hypochromic; Anemia, Iron-Deficiency; Anemia, Sideroblastic; Biopsy; Genetic Diseases, X-Linked; Hemoptysis; Hemorrhage; Hemosiderosis; Humans; Lung; Lung Diseases; Rare Diseases; Sputum; Hemosiderosis, Pulmonary
PubMed: 13787318
DOI: No ID Found -
American Family Physician Oct 2000Anemia should not be accepted as an inevitable consequence of aging. A cause is found in approximately 80 percent of elderly patients. The most common causes of anemia... (Review)
Review
Anemia should not be accepted as an inevitable consequence of aging. A cause is found in approximately 80 percent of elderly patients. The most common causes of anemia in the elderly are chronic disease and iron deficiency. Vitamin B12 deficiency, folate deficiency, gastrointestinal bleeding and myelodysplastic syndrome are among other causes of anemia in the elderly. Serum ferritin is the most useful test to differentiate iron deficiency anemia from anemia of chronic disease. Not all cases of vitamin B12 deficiency can be identified by low serum levels. The serum methylmalonic acid level may be useful for diagnosis of vitamin B12 deficiency. Vitamin B12 deficiency is effectively treated with oral vitamin B12 supplementation. Folate deficiency is treated with 1 mg of folic acid daily.
Topics: Aged; Anemia; Anemia, Hypochromic; Diagnosis, Differential; Folic Acid Deficiency; Humans; Myelodysplastic Syndromes; Vitamin B 12 Deficiency
PubMed: 11037074
DOI: No ID Found -
British Medical Journal Nov 1964
Topics: Ancylostomatoidea; Ancylostomiasis; Anemia; Anemia, Hypochromic; Animals; Anthelmintics; Hookworm Infections; Humans; Iron; Tropical Medicine
PubMed: 14204532
DOI: No ID Found -
British Medical Journal Apr 1963
Topics: Anemia; Anemia, Hypochromic; Bone Marrow; Bone Marrow Diseases; Erythroblastosis, Fetal; Hematologic Diseases; Humans; Infant, Newborn
PubMed: 13993610
DOI: 10.1136/bmj.1.5338.1163 -
Experimental Animals Nov 2022Mouse models of red blood cell abnormalities are important for understanding the underlying molecular mechanisms of human erythrocytic diseases. DBA.B6-Mha (Microcytic...
Mouse models of red blood cell abnormalities are important for understanding the underlying molecular mechanisms of human erythrocytic diseases. DBA.B6-Mha (Microcytic hypochromic anemia) congenic mice were generated from the cross between N-ethyl-N-nitrosourea (ENU)-mutagenized male C57BL/6J and female DBA/2J mice as part of the RIKEN large-scale ENU mutagenesis project. The mice were established by backcrossing with DBA/2J mice for more than 20 generations. These mice showed autosomal-dominant microcytic hypochromic anemia with decreased mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) levels and increased red blood cell distribution width (RDW) and plasma ferritin levels. Linkage analysis indicated that the Mha locus was located within an interval of approximately 1.95-Mb between D16Nut1 (58.35 Mb) and D16Mit185 (60.30 Mb) on mouse chromosome 16. Mutation analysis revealed that DBA.B6-Mha mice had a point mutation (c.921-2A>G) at the acceptor site of intron 4 in the coproporphyrinogen oxidase (Cpox) gene, a heme-synthesizing gene. RT-PCR revealed that the Cpox mRNA in DBA.B6-Mha mice caused splicing errors. Our results suggest that microcytic hypochromic anemia in DBA.B6-Mha mice is owing to impaired heme synthesis caused by splice mutations in Cpox. Therefore, the DBA.B6-Mha mice may be used to elucidate the molecular mechanisms underlying microcytic hypochromic anemia caused by mutations in Cpox. Although low MCV levels are known to confer malarial resistance to the host, there were no marked changes in the susceptibility of DBA.B6-Mha mice to rodent malarial (Plasmodium yoelii 17XL) infection.
Topics: Animals; Female; Male; Mice; Anemia, Hypochromic; Coproporphyrinogen Oxidase; Heme; Mice, Inbred C57BL; Mice, Inbred DBA; Mutation
PubMed: 35527013
DOI: 10.1538/expanim.22-0032 -
The Western Journal of Medicine Jun 1981
Topics: Anemia, Hypochromic; Humans; Iron; Iron Deficiencies; Nutritional Physiological Phenomena
PubMed: 7257367
DOI: No ID Found -
Cell Reports Jan 2016The cargo receptor NCOA4 mediates autophagic ferritin degradation. Here we show that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and...
The cargo receptor NCOA4 mediates autophagic ferritin degradation. Here we show that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and spleen, increased levels of transferrin saturation, serum ferritin, and liver hepcidin, and decreased levels of duodenal ferroportin. Despite signs of iron overload, NCOA4-null mice had mild microcytic hypochromic anemia. Under an iron-deprived diet (2-3 mg/kg), mice failed to release iron from ferritin storage and developed severe microcytic hypochromic anemia and ineffective erythropoiesis associated with increased erythropoietin levels. When fed an iron-enriched diet (2 g/kg), mice died prematurely and showed signs of liver damage. Ferritin accumulated in primary embryonic fibroblasts from NCOA4-null mice consequent to impaired autophagic targeting. Adoptive expression of the NCOA4 COOH terminus (aa 239-614) restored this function. In conclusion, NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.
Topics: Anemia, Hypochromic; Animals; Autophagy; Cell Line; Duodenum; Erythrocytes; Erythropoiesis; Female; Ferritins; Hepcidins; Iron; Iron Overload; Iron, Dietary; Liver; Male; Mice; Mice, Knockout; Nuclear Receptor Coactivators; Oxidoreductases; Reactive Oxygen Species; Spleen; Up-Regulation
PubMed: 26776506
DOI: 10.1016/j.celrep.2015.12.065 -
British Medical Journal Jun 1972
Topics: Adult; Amputation, Surgical; Anemia, Hypochromic; Erythrocytes; Female; Hemiplegia; Hemoglobinometry; Hemorrhage; Humans; Iron; Knee Injuries; Male; Self Mutilation
PubMed: 5031714
DOI: 10.1136/bmj.2.5815.691