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Otolaryngologic Clinics of North America Apr 2023Prognosis is defined as the likely outcome or course of a disease and is the result of a complex interplay between patient and tumor factors. Unfortunately, the... (Review)
Review
Prognosis is defined as the likely outcome or course of a disease and is the result of a complex interplay between patient and tumor factors. Unfortunately, the prognosis of patients with laryngeal cancer has not changed significantly over the past several decades. However, as our understanding of these patient and tumor factors becomes more nuanced and the resulting treatment options become more precise, there is the potential to improve the prognosis for these patients.
Topics: Humans; Carcinoma, Squamous Cell; Prognosis; Laryngeal Neoplasms; Neoplasm Staging; Retrospective Studies
PubMed: 37030950
DOI: 10.1016/j.otc.2022.12.005 -
Revue de L'infirmiere 2013Closely linked to heavy smoking, larynx cancer is more common in men but its occurrence is rising in line with the increase in the number of women smokers. France is one...
Closely linked to heavy smoking, larynx cancer is more common in men but its occurrence is rising in line with the increase in the number of women smokers. France is one of the most affected countries in Europe with 3,735 new cases in 2005. In terms of treatment, new endoscopic surgical techniques or radiotherapy are suitable for treating the disease in its early stages. For advanced stages, some patients may benefit from a larynx preserving approach based on chemotherapy and radiotherapy. Otherwise, a total laryngectomy is necessary.
Topics: Cross-Sectional Studies; Early Diagnosis; Female; France; Humans; Laryngeal Neoplasms; Male; Neoplasm Staging; Nursing Diagnosis; Risk Factors; Sex Factors
PubMed: 24245396
DOI: 10.1016/j.revinf.2013.07.017 -
Otolaryngology--head and Neck Surgery :... Jan 2017Objective Laryngeal verrucous carcinoma (LVC) is a rare, locally invasive neoplasm comprising 1% to 3.4% of laryngeal carcinomas. Management strategies are a topic of... (Review)
Review
Objective Laryngeal verrucous carcinoma (LVC) is a rare, locally invasive neoplasm comprising 1% to 3.4% of laryngeal carcinomas. Management strategies are a topic of ongoing conversation, and no definitive treatment protocol based on T stage and presentation exists. This review examines characteristics, treatment modalities, and patient outcomes of LVC. Data Sources PubMed, MEDLINE, EMBASE, and Web of Science. Methods Databases were searched through October 29, 2015, for literature detailing individual patient cases of LVC. Variables analyzed included patient demographics, tumor characteristics, tumor size, treatment, and outcomes. Results Thirty-seven articles with 369 cases were included. LVC was found more commonly in males (13.8:1), at an average age of 58.7 years, and located in the glottis (74.0%). Most patients had local disease at presentation (94.9%). The most common presenting symptom was hoarseness (92.3%). The most common primary treatment was surgery alone (72.3%), with local excision as the most common technique (56.8%). In patients with data available on both surgical modality and T stage, most patients who presented as T1 and were managed surgically underwent local excision (79.2%). Surgical treatment alone led to high rates of disease-free survival at follow-up (86.8%). A large number of patients presenting with T1 disease were disease free at follow-up (88.6%). Overall survival was 80.3%. Conclusion LVC is most often managed surgically. The extent of surgical resection may be guided by T stage, with smaller tumors resected via local excision and larger tumors via partial or total laryngectomy. Regardless of T stage or therapy, LVC has a good posttreatment prognosis.
Topics: Carcinoma, Verrucous; Humans; Laryngeal Neoplasms; Laryngectomy; Neoplasm Staging; Prognosis
PubMed: 27484231
DOI: 10.1177/0194599816662631 -
Postepy Higieny I Medycyny... Dec 2016One of the most common carcinoma occurring in the head and neck is laryngeal cancer. Despite the rapid scientific advances in medicine the prognosis for patients with... (Review)
Review
One of the most common carcinoma occurring in the head and neck is laryngeal cancer. Despite the rapid scientific advances in medicine the prognosis for patients with such type of disease is not satisfying. In the last few years matrix metalloproteinases ‑ MMPs and their tissue inhibitors - TIMPs, mostly MMP‑2 and MMP‑9, arouses a great interest, especially in the process of carcinogenesis. It seems that their impact in the formation and development of laryngeal cancer is significant. MMPs a group of zinc‑ and calcium‑ dependent endopeptidases play crucial role extracellular matrix collagen degradation. That are enzymes, that degrade and the basement membrane by facilitating tumor growth, cell migration and tumor invasion. They are implicated in metastasis and angiogenesis potentiate within the tumor. Clear tendency was observed towards the higher MMPs and TIMPs expression in larynx cancer than in the stroma. Recent studies show correlations between increased MMP‑2 gene expression in the tumor tissue and clinical status, histopathological grading and metastases occurrence. The similar MMP2 over expression dependence were found on tumor recurrence and survival. Many authors pointed out, significant higher MMP‑2 expression as a potential marker of tumor invasiveness and worse prognosis in patients with larynx cancer. However, association of MMP 9 gene expression with laryngeal cancer clinicopathological features and survival of patients are ambiguous. Although, numerous researches show that this relationship does exists. Similar correlations could be found in TIMPs, but further studies are necessary because of small amount of literature.
Topics: Humans; Laryngeal Neoplasms; Matrix Metalloproteinases; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Tissue Inhibitor of Metalloproteinases
PubMed: 28026822
DOI: No ID Found -
Laryngo- Rhino- Otologie Jun 2013Malignant haematological diseases such as the highly malignant diffuse large B-cell lymphoma, the MALT-lymphoma and the extramedullary plasmocytoma are seldom located in... (Review)
Review
Malignant haematological diseases such as the highly malignant diffuse large B-cell lymphoma, the MALT-lymphoma and the extramedullary plasmocytoma are seldom located in the larynx. In this review, clinical symptoms, laryngoscopic findings, further diagnostics as well as therapy concepts are presented. Diagnosis is complicated and delayed due to the absence of classical pathognomic findings. Biopsy of the affected tissue can secure a correct diagnosis and malignant haematological disease can be ruled out.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Biopsy; Diagnosis, Differential; Female; Humans; Laryngeal Neoplasms; Laryngoscopy; Larynx; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasm Staging; Prognosis; Risk Factors
PubMed: 23740416
DOI: 10.1055/s-0033-1341465 -
Otolaryngology--head and Neck Surgery :... Dec 2013To review the pathophysiology of early and late radiation-related tissue changes, methods to differentiate these changes from disease recurrence, and treatment of these... (Review)
Review
OBJECTIVE
To review the pathophysiology of early and late radiation-related tissue changes, methods to differentiate these changes from disease recurrence, and treatment of these changes in the irradiated larynx.
DATA SOURCES
Peer-reviewed publications.
REVIEW METHODS
PubMed database search.
CONCLUSIONS/IMPLICATIONS FOR PRACTICE
Early and late radiation-related changes in the larynx manifest variably between individual patients. Severe radiation-related tissue changes in the larynx and recurrent malignancy share many clinical characteristics, and the presence of malignancy must be considered in these patients. Positron emission tomography may help select patients who need operative biopsy to rule out recurrence. In patients with a cancer-free but dysfunctional larynx, both surgical and nonsurgical treatment options, including hyperbaric oxygen, are available for attempted salvage. Further investigation is needed before hyperbaric oxygen can be considered standard-of-care treatment for these patients.
Topics: Humans; Hyperbaric Oxygenation; Laryngeal Neoplasms; Larynx; Neoplasm Recurrence, Local; Positron-Emission Tomography; Radiation Injuries; Radiotherapy, Adjuvant; Risk Assessment; Salvage Therapy; Time Factors; Treatment Outcome
PubMed: 24013140
DOI: 10.1177/0194599813503802 -
Otolaryngologic Clinics of North America Apr 2023Laryngeal preservation with combined modality therapy involving radiotherapy and chemotherapy is usually the treatment of choice for patients with good performance... (Review)
Review
Laryngeal preservation with combined modality therapy involving radiotherapy and chemotherapy is usually the treatment of choice for patients with good performance status and with locoregionally advanced laryngeal cancer with a functional larynx. Surgical management with total laryngectomy with neck dissection, followed by adjuvant radiation or chemoradiation, is recommended for patients not eligible for laryngeal preservation. This article provides an overview of the current therapeutic approaches used to treat locoregionally advanced laryngeal cancer and outlines other currently investigated therapies.
Topics: Humans; Laryngeal Neoplasms; Treatment Outcome; Combined Modality Therapy; Larynx; Radiotherapy, Adjuvant; Laryngectomy; Neoplasm Staging
PubMed: 37030941
DOI: 10.1016/j.otc.2022.12.004 -
Otolaryngologic Clinics of North America Aug 2008The authors present the value of imaging for preoperative evaluation of structures that are not assessed or incompletely assessed on physical and endoscopic examination.... (Review)
Review
The authors present the value of imaging for preoperative evaluation of structures that are not assessed or incompletely assessed on physical and endoscopic examination. Discussed are CT, MRI, and positron emission tomography-CT and the appropriate selection of each method to provide information, including the presence or absence of extent of disease to the pre-epiglottic and paraglottic spaces and the subglottis, cartilage invasion, extralaryngeal spread of disease, nodal metastasis, and tumor volume.
Topics: Humans; Laryngeal Neoplasms; Laryngectomy; Larynx; Lymph Nodes; Lymphatic Metastasis; Magnetic Resonance Imaging; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Tomography, X-Ray Computed; Vocal Cords
PubMed: 18570954
DOI: 10.1016/j.otc.2008.01.015 -
Journal of Oncology Practice Aug 2016Treatment of larynx cancer has changed dramatically over the past several years. Novel modalities of treatment have been introduced as organ preservation has been... (Review)
Review
Treatment of larynx cancer has changed dramatically over the past several years. Novel modalities of treatment have been introduced as organ preservation has been developed. In addition, new targeted therapies have appeared, and improvements in radiotherapeutic and surgical techniques have been introduced. Thus, a large variety of treatment options is increasing local control rates and overall survival; however, selecting the most appropriate treatment remains a challenging decision. This article focuses on the multidisciplinary care of early-stage and locally advanced larynx cancer and attempts to sum up different approaches. Moreover, it reviews state-of-the-art treatment in larynx preservation, which has been consolidated in recent years.
Topics: Combined Modality Therapy; Humans; Laryngeal Neoplasms; Neoplasm Staging
PubMed: 27511718
DOI: 10.1200/JOP.2016.014225 -
The Laryngoscope May 1967
Topics: Aged; Chondrosarcoma; Humans; Laryngeal Neoplasms; Laryngectomy; Male; Neoplasm Recurrence, Local; Radiography
PubMed: 6026271
DOI: 10.1288/00005537-196705000-00005