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Frontiers in Cardiovascular Medicine 2016Hyponatremia is the most common electrolyte abnormality and is often neglected, especially in elderly and seemingly terminal patients. Hyponatremia can be asymptomatic... (Review)
Review
Hyponatremia is the most common electrolyte abnormality and is often neglected, especially in elderly and seemingly terminal patients. Hyponatremia can be asymptomatic or can cause symptoms ranging from nausea and lethargy to convulsions and coma. This condition has become increasingly common over time with a similar time course to the increase in adoption of low salt diets. The popularization of low salt may not be justified in people with normal kidney function in whom the compatible statistically based evidence that salt causes hypertension has been challenged by experimental evidence to the contrary.
PubMed: 27774451
DOI: 10.3389/fcvm.2016.00035 -
Clinical Pediatric Emergency Medicine Dec 2019A 3-year-old boy presented to the emergency department with a chief complaint of "lethargy" and was found to have ptosis with eventual respiratory failure and need for...
A 3-year-old boy presented to the emergency department with a chief complaint of "lethargy" and was found to have ptosis with eventual respiratory failure and need for emergent intubation. There is a broad differential for a patient with respiratory failure, and careful physical examination and history are imperative to reduce morbidity and prevent mortality. After further evaluation and workup, the diagnosis is ultimately revealed.
PubMed: 32288647
DOI: 10.1016/j.cpem.2019.100742 -
JACC. Basic To Translational Science Mar 2023
PubMed: 37034281
DOI: 10.1016/j.jacbts.2022.10.003 -
Medicina (Kaunas, Lithuania) May 2019Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy and is characterized by repetitive profuse vomiting episodes, often in... (Review)
Review
Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy and is characterized by repetitive profuse vomiting episodes, often in association with pallor, lethargy, and diarrhea, presenting within 1-4 h from the ingestion of a triggering food. In 2017, the international consensus guidelines for the diagnosis and management of FPIES were published. They cover all aspects of this syndrome, which in recent decades has attracted the attention of pediatric allergists. In particular, the consensus proposed innovative diagnostic criteria. However, the diagnosis of acute FPIES is still currently discussed because the interest in this disease is relatively recent and, above all, there are no validated panels of diagnostic criteria. We propose some ideas for reflection on the diagnostic and suspicion criteria of acute FPIES with exemplary stories of children certainly or probably suffering from acute FPIES. For example, we believe that new definitions should be produced for mild forms of FPIES, multiple forms, and those with IgE-mediated symptoms. Moreover, we propose two clinical criteria to suspect acute FPIES and to refer the child to the diagnostic oral food challenge.
Topics: Animals; Cattle; Child; Child, Preschool; Dietary Proteins; Enterocolitis; Female; Food Hypersensitivity; Humans; Infant; Lethargy; Male; Milk
PubMed: 31141916
DOI: 10.3390/medicina55060216 -
Journal of the American Veterinary... Dec 2022
Topics: Female; Animals; Lethargy; Anorexia; Chickens; Fever
PubMed: 36563065
DOI: 10.2460/javma.22.10.0475 -
Epigenomics Mar 2018As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant... (Review)
Review
As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant neurodevelopment. We described the characteristics and findings of the 17 studies on epigenetic processes in placental genes and human infant neurobehavior. Studies showed consistent findings in the same cohort of term healthy infants across epigenetic processes (DNA methylation, genome wide, gene and miRNA expression) genomic region (single and multiple genes, imprinted genes and miRNAs) using candidate gene and genome wide approaches and across biobehavioral systems (neurobehavior, cry acoustics and neuroendocrine). Despite limitations, studies support future work on molecular processes in placental genes related to neurodevelopmental trajectories including implications for intervention.
Topics: Arousal; Attention; Brain; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Fetal Development; Fetus; Genome, Human; Humans; Infant; Infant Behavior; Lethargy; MicroRNAs; Motor Activity; Neurogenesis; Neurosecretory Systems; Placenta; Pregnancy
PubMed: 29381081
DOI: 10.2217/epi-2016-0171 -
The Canadian Veterinary Journal = La... Mar 2013A 3.7-kg, 3-year-old intact female domestic shorthaired cat was presented with the chief complaint of anorexia and lethargy of 3 days duration with a noticeable decrease...
A 3.7-kg, 3-year-old intact female domestic shorthaired cat was presented with the chief complaint of anorexia and lethargy of 3 days duration with a noticeable decrease in body condition and a large open wound on her ventral caudal abdomen. A diagnosis of acute mastitis with gland abscessation was made. The patient was successfully treated with oral antibiotics and open wound management using surgical debridement and lavage followed by wound dressings using honey.
Topics: Animals; Anti-Bacterial Agents; Bandages; Cat Diseases; Cats; Female; Gangrene; Honey; Mastitis; Therapeutic Irrigation
PubMed: 23997269
DOI: No ID Found -
BMC Pediatrics Apr 2023There are few reports on the timing of onset and the symptoms of enterovirus A71 (EV-A71) infection, which can easily be misdiagnosed. This study aimed to explore the... (Observational Study)
Observational Study
BACKGROUND
There are few reports on the timing of onset and the symptoms of enterovirus A71 (EV-A71) infection, which can easily be misdiagnosed. This study aimed to explore the clinical characteristics of children with severe EV-A71 infection.
METHODS
This retrospective observational study included children with severe EV-A71 infection admitted to Hebei Children's Hospital between January 2016 and January 2018.
RESULTS
A total of 101 patients were included: 57 males (56.4%) and 44 females (43.6%). They were 1-13 years of age. The symptoms were fever in 94 patients (93.1%), rash in 46 (45.5%), irritability in 70 (69.3%), and lethargy in 56 (55.4%). There were 19 (59.3%) patients with abnormal neurological magnetic resonance imaging [pontine tegmentum (n = 14, 43.8%), medulla oblongata (n = 11, 34.4%), midbrain (n = 9, 28.1%), cerebellum and dentate nucleus (n = 8, 25.0%), basal ganglia (n = 4, 12.5%), cortex (n = 4, 12.5%), spinal cord (n = 3, 9.3%), and meninges (n = 1, 3.1%)]. There was a positive correlation between the ratio of neutrophil count and white blood cell count in cerebrospinal fluid in the first 3 days of the disease (r = 0.415, P < 0.001).
CONCLUSION
The clinical symptoms of EV-A71 infection are fever and/or skin rash, irritability, and lethargy. Some patients have abnormal neurological magnetic resonance imaging. The white blood cell count in the cerebrospinal fluid of children with EV-A71 infection may increase alongside neutrophil counts.
Topics: Male; Female; Humans; Child; Enterovirus; Enterovirus A, Human; Lethargy; Enterovirus Infections; Retrospective Studies; Exanthema; Antigens, Viral; Fever
PubMed: 37055743
DOI: 10.1186/s12887-023-03980-9 -
Paediatrics & Child Health Feb 2019
PubMed: 30792590
DOI: 10.1093/pch/pxy042 -
Equine Veterinary Journal Jul 2013Equine proliferative enteropathy (EPE) is a disease of foals caused by the obligate intracellular organism Lawsonia intracellularis. This emerging disease affects mainly... (Review)
Review
Equine proliferative enteropathy (EPE) is a disease of foals caused by the obligate intracellular organism Lawsonia intracellularis. This emerging disease affects mainly weanling foals and causes fever, lethargy, peripheral oedema, diarrhoea, colic and weight loss. The diagnosis of EPE may be challenging and relies on the presence of hypoproteinaemia, thickening of segments of the small intestinal wall observed upon abdominal ultrasonography, positive serology and molecular detection of L. intracellularis in faeces. Although the clinical entity, diagnostic approach and treatment of EPE are well established and described, the epidemiology for this disease has remained largely unaddressed. This article focuses on new developments in the field of EPE, including epidemiology, pathophysiology, clinical signs, diagnosis, treatment and prevention.
Topics: Animals; Desulfovibrionaceae Infections; Horse Diseases; Horses; Intestinal Diseases; Lawsonia Bacteria
PubMed: 23662705
DOI: 10.1111/evj.12075