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Journal of Clinical Immunology Jan 2020
Topics: Humans; Leukocyte Disorders; Neutropenia
PubMed: 31768891
DOI: 10.1007/s10875-019-00718-0 -
Pediatric Annals Jan 2020Leukocytes, or white blood cells, are part of the innate immune system that defends against infectious and foreign agents. In pediatrics, it is important to use... (Review)
Review
Leukocytes, or white blood cells, are part of the innate immune system that defends against infectious and foreign agents. In pediatrics, it is important to use age-specific laboratory values when interpreting results. Infections are the most common cause of leukocytosis or leukopenia in children. Symptoms suggestive of more serious etiologies include persistent fevers, weight loss, bruising, fatigue, and adenopathy. Neutropenia is of special importance in pediatrics due to associations of severe neutropenia with genetic syndromes and overlapping presentations with primary immunodeficiencies. Although the discovery of novel genetic mutations has aided the hematologist/oncologist and the immunologist in managing these conditions, the relationship between clinical phenotype and mutation is still not well known. [Pediatr Ann. 2020;49(1):e17-e26.].
Topics: Child; Humans; Immunologic Deficiency Syndromes; Leukocyte Disorders; Leukocytes; Pediatricians
PubMed: 31930419
DOI: 10.3928/19382359-20191213-01 -
Blood Aug 2018
Topics: Adult; Basophils; Core Binding Factor Alpha 2 Subunit; Humans; Immunophenotyping; Leukocyte Disorders; Male; Neoplasm Proteins; Oncogene Proteins, Fusion; Prognosis
PubMed: 30072416
DOI: 10.1182/blood-2018-05-849901 -
Blood Mar 2024
Topics: Humans; Leukocyte Disorders; Leukocytosis; World Health Organization
PubMed: 38512267
DOI: 10.1182/blood.2023023332 -
Hematology/oncology Clinics of North... Feb 2013
Topics: Humans; Leukocyte Disorders; Neutropenia
PubMed: 23351994
DOI: 10.1016/j.hoc.2012.11.005 -
Blood Oct 2016
Topics: Chemotaxis, Leukocyte; Humans; Leukocyte Disorders; Neutropenia
PubMed: 27789436
DOI: 10.1182/blood-2016-09-737007 -
Methods in Molecular Biology (Clifton,... 2014Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders... (Review)
Review
Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects, and other disorders of chemotaxis, hyperimmunoglobulin E syndrome, Chédiak-Higashi syndrome, neutrophil-specific granule deficiency, chronic granulomatous disease, and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.
Topics: Cell Adhesion; Cell Degranulation; Chemotaxis, Leukocyte; Humans; Leukocyte Disorders; Neutrophils; Oxidation-Reduction; Phagocytosis
PubMed: 24504971
DOI: 10.1007/978-1-62703-845-4_30 -
Hematology/oncology Clinics of North... Feb 2013In vivo animal models have proven very useful to the understanding of basic biologic pathways of the immune system, a prerequisite for the development of innovate... (Review)
Review
In vivo animal models have proven very useful to the understanding of basic biologic pathways of the immune system, a prerequisite for the development of innovate therapies. This article addresses currently available models for defined human monogenetic defects of neutrophil granulocytes, including murine, zebrafish, and larger mammalian species. Strengths and weaknesses of each system are summarized, and clinical investigators may thus be inspired to develop further lines of research to improve diagnosis and therapy by use of the appropriate animal model system.
Topics: Animals; Cattle; Congenital Bone Marrow Failure Syndromes; Disease Models, Animal; Dogs; Granulomatous Disease, Chronic; Humans; Leukocyte Disorders; Leukocyte-Adhesion Deficiency Syndrome; Mice; Neutropenia; Zebrafish
PubMed: 23351993
DOI: 10.1016/j.hoc.2012.10.005 -
Australasian Annals of Medicine May 1955
Topics: Bone Diseases; Child; Eosinophilia; Eosinophilic Granuloma; Humans; Infant; Leukocyte Disorders; Leukocytosis; Liver Diseases
PubMed: 13239521
DOI: 10.1111/imj.1955.4.2.83 -
Blood Aug 2023Neutrophilia and neutropenia commonly lead to inpatient hematology consultation. Quantitative neutrophil abnormalities have a broad differential and include diagnoses...
Neutrophilia and neutropenia commonly lead to inpatient hematology consultation. Quantitative neutrophil abnormalities have a broad differential and include diagnoses that are important to recognize because they may be associated with increased mortality. Neutrophilia can reflect etiologies such as infection, medications, inflammation, splenectomy, and congenital disorders. Neutropenia can arise from infection, medications, autoimmune destruction, sequestration, nutritional deficiency, malignancy, and congenital neutropenia syndromes. In the evaluation of all abnormalities of neutrophil number, the timing of the change, and the patient's historical neutrophil count are crucial.
Topics: Humans; Adult; Neutrophils; Inpatients; Neutropenia; Leukocyte Disorders; Leukocytosis; Referral and Consultation
PubMed: 36279420
DOI: 10.1182/blood.2021014818