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International Ophthalmology Clinics 2019
Review
Topics: Cornea; Corneal Neovascularization; Fluorescein Angiography; Fundus Oculi; Humans; Limbus Corneae; Reproducibility of Results
PubMed: 31569131
DOI: 10.1097/IIO.0000000000000283 -
Medicine Jan 2021To introduce a limbus-centered continuous circular capsulorhexis (CCC) marking technique.Compared with traditional capsulotomy diameter mark technique, a self-designed... (Observational Study)
Observational Study
To introduce a limbus-centered continuous circular capsulorhexis (CCC) marking technique.Compared with traditional capsulotomy diameter mark technique, a self-designed limbus-centered capsulotomy mark (LCM) was used to perform the routine cataract surgery in this observational study. Ten eyes were included in each group. The area outer/inner 5.5-mm CCC ring, the furthest/nearest distance from the capsule margin to the intraocular lens (IOL) margin, the CCC total coverage IOL area were measured and compared between this 2 groups.No significant differences were found for all the comparison parameters between the 2 groups (all P > .05). However, the capsule total coverage area, area inner 5.5-mm ring was lower in the LCM group, which demonstrated advantage of LCM.The limbus-centered capsulotomy diameter mark, as an inexpensive and convenient method, helps to perform limbus-centered capsulorhexis with not only a 360° overlapping capsular edge but also well-centered IOL optics.
Topics: Capsulorhexis; China; Humans; Limbus Corneae; Phacoemulsification; Writing
PubMed: 33466181
DOI: 10.1097/MD.0000000000024109 -
Clinical & Experimental Ophthalmology Jul 2015
Topics: Amnion; Epithelium, Corneal; Humans; Limbus Corneae; Religion and Medicine; Wound Healing
PubMed: 26177780
DOI: 10.1111/ceo.12550 -
Journal Francais D'ophtalmologie Feb 2019
Topics: Child; Dermoid Cyst; Eye Neoplasms; Female; Humans; Limbus Corneae
PubMed: 30679127
DOI: 10.1016/j.jfo.2018.04.025 -
Journal Francais D'ophtalmologie Mar 2019The corneal limbus is a privileged region on the border between two quite different microenvironments, where corneal epithelial stem cells, numerous melanocytes, and... (Review)
Review
The corneal limbus is a privileged region on the border between two quite different microenvironments, where corneal epithelial stem cells, numerous melanocytes, and antigen-presenting cells are all concentrated within a richly vascularized and innervated stroma. This situation within the ocular surface confers on it the key functions of barrier, epithelial renewal and defense of the cornea. As an immunological crossroads and since the corneoscleral limbus is directly exposed to external insults such as caustic agents, ultraviolet radiation, microbial agents, and allergens, it is the potential site of many tumoral, degenerative or inflammatory pathologies and may progress under certain conditions to limbal stem cell deficiency.
Topics: Carcinogenesis; Conjunctiva; Cornea; Corneal Diseases; Epithelium, Corneal; Eye Neoplasms; Humans; Limbus Corneae; Stem Cells
PubMed: 30833005
DOI: 10.1016/j.jfo.2019.02.001 -
Clinical & Experimental Ophthalmology Aug 2004Pseudogerontoxon is a lesion that resembles a small segment of arcus senilis or gerontoxon and is seen in many individuals with limbal vernal or atopic...
Pseudogerontoxon is a lesion that resembles a small segment of arcus senilis or gerontoxon and is seen in many individuals with limbal vernal or atopic keratoconjunctivitis. It is an important clinical finding because pseudogerontoxon is often times the only clinical evidence of previous allergic eye disease. To the authors' knowledge, pseudogerontoxon has only rarely been mentioned, and has never been pictured, in the peer-reviewed literature. Three examples are presented of this important clinical entity.
Topics: Adult; Arcus Senilis; Conjunctivitis, Allergic; Female; Humans; Limbus Corneae; Male
PubMed: 15281982
DOI: 10.1111/j.1442-9071.2004.00849.x -
Klinische Monatsblatter Fur... Dec 2012
Topics: Corneal Diseases; Humans; Limbus Corneae; Microscopy, Confocal; Ophthalmoscopy; Tomography, Optical Coherence
PubMed: 23258668
DOI: 10.1055/s-0032-1328040 -
IEEE Transactions on Bio-medical... Aug 2017The aim of this study was to develop computational methods for estimating limbus position based on the measurements of three-dimensional (3-D) corneoscleral topography... (Comparative Study)
Comparative Study
OBJECTIVE
The aim of this study was to develop computational methods for estimating limbus position based on the measurements of three-dimensional (3-D) corneoscleral topography and ascertain whether corneoscleral limbus routinely estimated from the frontal image corresponds to that derived from topographical information.
METHODS
Two new computational methods for estimating the limbus position are proposed: One based on approximating the raw anterior eye height data by series of Zernike polynomials and one that combines the 3-D corneoscleral topography with the frontal grayscale image acquired with the digital camera in-built in the profilometer. The proposed methods are contrasted against a previously described image-only-based procedure and to a technique of manual image annotation.
RESULTS
The estimates of corneoscleral limbus radius were characterized with a high precision. The group average (mean ± standard deviation) of the maximum difference between estimates derived from all considered methods was 0.27 ± 0.14 mm and reached up to 0.55 mm. The four estimating methods lead to statistically significant differences (nonparametric ANOVA (the Analysis of Variance) test, p 0.05).
CONCLUSION
Precise topographical limbus demarcation is possible either from the frontal digital images of the eye or from the 3-D topographical information of corneoscleral region. However, the results demonstrated that the corneoscleral limbus estimated from the anterior eye topography does not always correspond to that obtained through image-only based techniques.
SIGNIFICANCE
The experimental findings have shown that 3-D topography of anterior eye, in the absence of a gold standard, has the potential to become a new computational methodology for estimating the corneoscleral limbus.
Topics: Algorithms; Corneal Topography; Humans; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Limbus Corneae; Ophthalmoscopy; Reproducibility of Results; Sensitivity and Specificity
PubMed: 27834636
DOI: 10.1109/TBME.2016.2624822 -
The Ocular Surface Apr 2016
Topics: Conjunctiva; Cornea; Humans; Limbus Corneae; Regeneration; Regenerative Medicine; Stem Cells
PubMed: 26945734
DOI: 10.1016/j.jtos.2016.02.002 -
Asia-Pacific Journal of Ophthalmology... Dec 2020Treatment of limbal stem cell deficiency is challenging. Multiple options can be adopted according to the underlying cause and the patient and physician preferences.... (Review)
Review
Treatment of limbal stem cell deficiency is challenging. Multiple options can be adopted according to the underlying cause and the patient and physician preferences. Stem cell transplant is a common treatment modality and several techniques have been described with outcomes varying by the laterality of the condition. Keratoprosthesis is a preferred option for bilateral conditions. Indications for type 1 and type 2 keratoprosthesis differ and the past 2 decades have seen a revolution in the field of keratoprosthesis with encouraging and improved outcomes. Management also includes preventive measures and measures to optimize/stabilize the ocular surface that would go a long way in reducing the deterioration of the ocular surface. The aim of this review is to provide an overview of the currently available techniques and to present a comprehensive algorithm to assist in decision making for unilateral and bilateral limbal stem cell deficiency.
Topics: Corneal Diseases; Humans; Limbus Corneae; Stem Cell Transplantation; Visual Acuity
PubMed: 33323706
DOI: 10.1097/APO.0000000000000326