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Magyar Onkologia Dec 2017The present review about the history of anticancer drug research in Hungary intends to call attention to the importance of studies on their mode of action. Several lines... (Review)
Review
The present review about the history of anticancer drug research in Hungary intends to call attention to the importance of studies on their mode of action. Several lines of evidence suggest that clinically usable oncopharmacological properties could be revealed by this way. Among the numerous compounds certain alkylating sugar alcohols and 2'-deoxyuridine derivatives were submitted to detailed investigations concerning their mode of action. Myelobromol with selective action on the myeloid elements of bone marrow has been justified for its application in chronic myeloid leukemia therapy and also in bone marrow ablation before transplantation. Mitolactol is able to cross bloodbrain barrier, consequently could control certain brain tumors. 5-etil-2'-deoxyuridine by reducing dihydropyrimidine dehydrogenase activity is able to increase 5-fluorouracil concentration in the blood, resulting in improved antitumor effect. In contrast, 5-hexil-2'-deoxyuridine, as an inhibitor of glycoconjugate pathway by reducing heparan sulfate production, has the ability to prevent metastasis. Noteworthy, the remarkable effects of vinca alkaloids, antiestrogens, and GNRH analogues were also presented in this review.
Topics: Antineoplastic Agents, Alkylating; Databases, Factual; Drug Design; Forecasting; Humans; Hungary; Mannomustine; Mitobronitol; Mitolactol; Pharmaceutical Research; Pharmacology, Clinical; Quality Improvement; Retrospective Studies
PubMed: 29257158
DOI: No ID Found -
Immunology Jan 1964Mice were injected with T.A.B. vaccine and, 2 days later, with various doses of different compounds. The relation between dose of compound, mortality and antibody...
Mice were injected with T.A.B. vaccine and, 2 days later, with various doses of different compounds. The relation between dose of compound, mortality and antibody production was studied, and therapeutic indices were calculated for a number of compounds. The most effective agent in suppressing antibody production at relatively non-toxic doses was cyclophosphamide, with next amethopterin (the effect of which was, however, inexplicably erratic), 6-thioguanine and 6-mercaptopurine, in that order. Vincaleukoblastine, triethylene melamine, triethylenethiophosphoramide, mannomustine and 5-fluorouracil were less effective. Compounds of a miscellaneous group (boric acid, caffeine, sodium nitrite, bacitracin, neomycin and polymyxin `B') were studied in the same way: they had no effect on antibody production, even in lethal doses.
Topics: Allergy and Immunology; Antibody Formation; Antineoplastic Agents; Autoimmune Diseases; Cyclophosphamide; Fluorouracil; Immunity; Mannomustine; Mercaptopurine; Methotrexate; Mice; Mortality; Research; Thioguanine; Toxicology; Transplantation; Triethylenemelamine; Typhoid-Paratyphoid Vaccines; Vinblastine
PubMed: 14113077
DOI: No ID Found -
British Medical Journal Aug 1959
Topics: Leukemia; Mannitol; Mannomustine; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Polycythemia
PubMed: 13671231
DOI: 10.1136/bmj.2.5146.208 -
British Journal of Cancer Dec 1963
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Mannomustine; Mice; Microscopy; Microscopy, Interference; Neoplasms; Neoplasms, Experimental; Pathology; Pharmacology; Research; Resins, Synthetic; Tragacanth
PubMed: 14111614
DOI: 10.1038/bjc.1963.95 -
British Journal of Cancer Mar 1960
Topics: Mannomustine; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Nucleic Acids
PubMed: 14401715
DOI: 10.1038/bjc.1960.16