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British Medical Journal Jan 1974A policy of immediate investigation of patients with haematemesis or melaena or both led to the diagnosis of the Mallory-Weiss syndrome in 16 out of 121 patients...
A policy of immediate investigation of patients with haematemesis or melaena or both led to the diagnosis of the Mallory-Weiss syndrome in 16 out of 121 patients admitted to a combined medical-surgical unit over three and a half years. A typical history suggestive of the diagnosis was obtainable in only nine of the 16 patients, though recent alcohol intake was high in another four. All patients survived the episode. Establishment of the diagnosis by oesophagogastroscopy was of special benefit when surgery was needed for control of continuing blood loss, but it also simplified the subsequent medical management of those patients in whom bleeding stopped spontaneously. The incidence of 13.2% in this series suggests that the Mallory-Weiss syndrome may be a relatively common cause of upper gastrointestinal bleeding.
Topics: Adult; Aged; Alcohol Drinking; Cough; Diagnosis, Differential; Esophagoscopy; Female; Gastric Mucosa; Gastroenteritis; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Humans; Male; Mallory-Weiss Syndrome; Melena; Middle Aged; Radiography; Vomiting
PubMed: 4544226
DOI: 10.1136/bmj.1.5899.140 -
British Medical Journal Jan 1972
Topics: Dihydroxyphenylalanine; Gastritis; Humans; Male; Melena; Middle Aged; Parkinson Disease
PubMed: 5008367
DOI: 10.1136/bmj.1.5791.53-d -
British Medical Journal Feb 1977
Topics: Gastrointestinal Hemorrhage; Hematemesis; Humans; Melena
PubMed: 300036
DOI: 10.1136/bmj.1.6057.380-a -
British Medical Journal May 1977
Topics: Gastrointestinal Hemorrhage; Hematemesis; Humans; Injections, Intra-Arterial; Melena; Technology, Radiologic
PubMed: 301048
DOI: 10.1136/bmj.1.6071.1279 -
British Medical Journal Jan 1949
Topics: Hematemesis; Melena
PubMed: 18106301
DOI: 10.1136/bmj.1.4593.110 -
British Medical Journal Apr 1937
PubMed: 20780617
DOI: 10.1136/bmj.1.3981.847 -
British Medical Journal Aug 1939
PubMed: 20782569
DOI: 10.1136/bmj.2.4101.332 -
The Turkish Journal of Gastroenterology... 2012Data concerning peptic and infectious ulcers in children are limited. The aim of the study was to investigate the prevalence, presenting symptoms and significance of...
BACKGROUND/AIMS
Data concerning peptic and infectious ulcers in children are limited. The aim of the study was to investigate the prevalence, presenting symptoms and significance of symptomatology in ulcer diagnosis in the pediatric age group.
MATERIALS AND METHODS
Between January 2000 and 2009, upper gastrointestinal endoscopy charts were examined retrospectively. All children in whom a diagnosis of ulcer was established were included in the study. Demographic, clinical, endoscopic, and histopathologic data were obtained from the patients' records. Peptic ulcer disease prevalence, presenting symptoms and symptomatology were evaluated.
RESULTS
Ulcer disease was observed in 31 (3.4%) of 902 patients. The mean age was 10.85 ± 4.25 (range: 2-17 years), and the male to female ratio was 2:1. The most common symptom was chronic abdominal pain (68%), hematemesis and melena (55%) and vomiting (39%). Helicobacter pylori was identified in 19 patients (61%) with ulcer. In the Helicobacter pylori-positive group, upper intestinal bleeding and pain were the major symptoms. Symptom frequency was not different between Helicobacter pylori-positive and -negative patients (p>0.05).
CONCLUSIONS
Ulcer disease is an uncommon disorder in children with nonspecific clinical symptoms. Unlike the adult population, symptoms fail to diagnose peptic ulcer disease before gastrointestinal bleeding occurs.
Topics: Abdominal Pain; Adolescent; Age Distribution; Age of Onset; Child; Child, Preschool; Esophagitis; Female; Helicobacter Infections; Helicobacter pylori; Hematemesis; Humans; Male; Melena; Peptic Ulcer; Prevalence; Retrospective Studies
PubMed: 23794302
DOI: 10.4318/tjg.2012.0562 -
Computational and Mathematical Methods... 2022As the most commonly used drug in the world, aspirin has shown benefits for myocardial infarction, stroke, and vascular death in many secondary prevention trials and...
OBJECTIVE
As the most commonly used drug in the world, aspirin has shown benefits for myocardial infarction, stroke, and vascular death in many secondary prevention trials and their meta-analysis. The purpose of this study was to evaluate the association between aspirin and its adverse reactions as a preventive drug using the FDA adverse event reporting system (FAERS).
METHODS
The FAERS database was queried for the adverse drug events (ADE) reported from the first quarter of 2004 to the second quarter of 2021. We counted and trended reports to FAERS in which aspirin was associated with anaphylaxis or anaphylaxis followed by death.
RESULTS
The search retrieved 858 aspirin-associated cases within the reporting period; 108 AE pairs with significant disproportionality were retained. The top 10 AE pairs associated with using aspirin for prophylaxis were melaena, duodenal ulcer, gastritis erosive, gastric ulcer hemorrhage, etc. The top 10 AE pairs for thrombosis prophylaxis were melaena, duodenal ulcer, microcytic anemia, lip erosion, vascular stent thrombosis, etc. The screened adverse event reports are classified and counted according to the system organ class (SOC); it mainly focuses on gastrointestinal disorders, general disorders, and administration site conditions. Among the 858 cases of aspirin used as prophylaxis medication in the FAERS database, the reporting areas were mainly in Europe and the Americas.
CONCLUSION
Adverse drug reactions may occur in the clinical use of aspirin. It should strengthen patient medication education, pay close attention to adverse reactions, and adjust the administration method in time to ensure the safety of medication.
Topics: Adverse Drug Reaction Reporting Systems; Anaphylaxis; Aspirin; Duodenal Ulcer; Humans; Melena; United States
PubMed: 35664643
DOI: 10.1155/2022/7882277 -
World Journal of Gastroenterology Apr 2013A hemocholecyst (HC) is a clot-filled gallbladder caused by bleeding into its lumen. Obstructive jaundice caused by the compression of HC to the hilar biliary tract is...
A hemocholecyst (HC) is a clot-filled gallbladder caused by bleeding into its lumen. Obstructive jaundice caused by the compression of HC to the hilar biliary tract is likely to be misdiagnosed as cholangiocarcinoma and is extremely rare. We herein report a case of obstructive jaundice and melena caused by HC. A 57-year-old male patient presented with right upper quadrant pain associated with icteric sclera and melena was suspiciously diagnosed as having malignant cholangiocarcinmoa by abdominal ultrasonography, computed tomography and magnetic resonance imaging. Laparotomy found a hematoma in the gallbladder. The hematoma spread to the left hepatic lobe forming an exogenous mass which compressed the hilar biliary tract. Radical cholecystectomy and bile duct exploration with T-tube drainage were performed. Histopathological examination revealed massive necrosis of the gallbladder mucosa with inflammatory cells infiltration as well as intraluminal hematoma formation. One month after operation, a T-tube cholangiography revealed a normal biliary tree. We suggest that HC should be considered in patients with obstructive jaundice and melena after common causes are ruled out.
Topics: Abdomen; Cholangiocarcinoma; Diagnosis, Differential; Gallbladder Diseases; Humans; Jaundice, Obstructive; Laparotomy; Male; Melena; Middle Aged; Thrombosis; Tomography, X-Ray Computed; Ultrasonography
PubMed: 23599637
DOI: 10.3748/wjg.v19.i13.2126