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Anaesthesiology Intensive Therapy 2020Shivering is a common complication of neuraxial anaesthesia. We compared the efficacy of tramadol, clonidine and pregabalin in preventing post-spinal anaes-thesia... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Shivering is a common complication of neuraxial anaesthesia. We compared the efficacy of tramadol, clonidine and pregabalin in preventing post-spinal anaes-thesia shivering in hysteroscopic procedures.
METHODS
A prospective, randomized, triple-blind, controlled clinical trial involving 120 ASA I-II women, aged 18-60 years. The patients were randomly allocated to receive either oral clonidine 0.2 mg (group C), tramadol 100 mg (group T), pregabalin 150 mg (group P) or (group O) 90 minutes before spinal anaesthesia. The body tempe-rature was monitored at the forehead and tympanic membrane. The primary outcome was the occurrence of perioperative shivering. The secondary outcomes were the side effects and meperidine requirements to treat shivering.
RESULTS
All groups had comparable demographic data. Group C showed the lowest incidence, severity and number of intraoperative and postoperative shivering attacks. The time to the first shivering attack was significantly longer in group C than the other groups and in group T than groups P and O. The severity of shivering attacks was comparable among groups C, T and P while being significantly lower than group O. Meperidine requirements were significantly lower in group C. Groups C, T and P had a significantly higher sedation score than group O. The incidences of dizziness, nausea and vomiting were highest in group T.
CONCLUSIONS
Tramadol, pregabalin and clonidine seem to be effective oral premedications to reduce the incidence, frequency and severity of post-spinal shivering but clonidine proved to be more effective and tolerable.
Topics: Adolescent; Adult; Anesthesia, Spinal; Body Temperature; Clonidine; Conscious Sedation; Double-Blind Method; Female; Humans; Hysteroscopy; Meperidine; Middle Aged; Narcotics; Pregabalin; Premedication; Prospective Studies; Shivering; Tramadol; Treatment Outcome; Young Adult
PubMed: 32876405
DOI: 10.5114/ait.2020.97579 -
Canadian Medical Association Journal Apr 1982Data collected by the Quebec Board of Physicians show that during the 5 years from 1974 to 1978 the prevalence of addiction to opiates among Quebec physicians was...
Data collected by the Quebec Board of Physicians show that during the 5 years from 1974 to 1978 the prevalence of addiction to opiates among Quebec physicians was 2.8/1000. The physician addicts had greater mobility and a higher attrition rate than their peers. The typical addict was male, a general practitioner and married. He often suffered from pain, fatigue, overwork, and financial and marital difficulties. His addiction had begun at approximately 35 years of age and had become evident about 3 1/2 years later. Meperidine was the preferred opiate. Some of the physicians lost their licences to practise for variable periods of time; for these the prognosis was gloomy. Depression was the main psychiatric disorder diagnosed.
Topics: Age Factors; Depression; Ethnicity; Humans; Life Style; Marriage; Meperidine; Opioid-Related Disorders; Physician Impairment; Quebec; Sex Factors; Stress, Psychological
PubMed: 7074490
DOI: No ID Found -
Canadian Medical Association Journal Aug 1971
Topics: Female; Hallucinations; Hallucinogens; Heart Arrest; Humans; Meperidine
PubMed: 5563342
DOI: No ID Found -
Anesthesiology Dec 1980
Topics: Absorption; Analgesia; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Kinetics; Meperidine; Pain, Postoperative; Pharmaceutical Preparations
PubMed: 7457958
DOI: 10.1097/00000542-198012000-00002 -
British Medical Journal Nov 1952
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Meperidine; Piperidines
PubMed: 12987782
DOI: 10.1136/bmj.2.4794.1135 -
CA: a Cancer Journal For Clinicians 1987
Topics: Half-Life; Humans; Meperidine; Neoplasms; Pain Management; Radiotherapy
PubMed: 3119171
DOI: 10.3322/canjclin.37.6.375 -
British Journal of Anaesthesia Aug 1971
Topics: Aminophylline; Anesthesia, General; Atropine; Bronchial Spasm; Humans; Male; Meperidine; Prostatectomy
PubMed: 5569147
DOI: 10.1093/bja/43.8.822-a -
British Medical Journal Jul 1947
Topics: Female; Humans; Labor, Obstetric; Meperidine; Pregnancy; Work
PubMed: 20344014
DOI: 10.1136/bmj.2.4514.71-b -
British Medical Journal May 1947
Topics: Female; Humans; Labor, Obstetric; Meperidine; Pharmaceutical Preparations; Pregnancy; Work
PubMed: 20343524
DOI: 10.1136/bmj.1.4505.656-a -
Anaesthesia Sep 2000
Topics: Analgesia, Obstetrical; Analgesics, Opioid; Female; Humans; Meperidine; Midwifery; Pregnancy
PubMed: 10947793
DOI: 10.1046/j.1365-2044.2000.01664-37.x