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British Journal of Pharmacology Feb 19791 The effects of frusemide (a diuretic acting on the loop of Henle) and methyclothiazide (a thiazide diuretic) on renin release were studied on rat kidney slices. 2... (Comparative Study)
Comparative Study
1 The effects of frusemide (a diuretic acting on the loop of Henle) and methyclothiazide (a thiazide diuretic) on renin release were studied on rat kidney slices. 2 Frusemide at concentrations of 1.5 and 7.5 mmol/l produced significant increases in renin release but had no effect at 0.15 mmol/l. 3 Methyclothiazide in a similar concentration range did not increase renin release; instead, at the highest concentration used, methyclothiazide (3.5 mmol/l) inhibited renin release. 4 Indomethacin (25 mumol/l) did not inhibit the increase of renin induced by frusemide. 5 Our limited study in vitro is consistent with the findings of other workers who have shown in vivo, in the absence of systemic electrolyte depletion, that only "loop diuretics" increase renin secretion. Under our experimental conditions, it is suggested that frusemide exerts a direct action either upon the epithelioid cells or upon the macula densa since the renal prostaglandin system does not intervene.
Topics: Animals; Drug Interactions; Furosemide; In Vitro Techniques; Indomethacin; Kidney; Male; Methyclothiazide; Rats; Renin
PubMed: 760897
DOI: 10.1111/j.1476-5381.1979.tb07818.x -
Frontiers in Pharmacology 2018The aim of this study was to elucidate the effects of warfarin on senkyunolide I in a rat model of biliary drainage after oral administration Chuanxiong extract based on...
The aim of this study was to elucidate the effects of warfarin on senkyunolide I in a rat model of biliary drainage after oral administration Chuanxiong extract based on pharmacokinetics. Thirty-two rats were randomly divided into four groups: CN, healthy rats after a single administration of Chuanxiong; CO, rats with biliary drainage after a single administration of Chuanxiong; WCN, healthy rats after the administration of Chuanxiong and warfarin; WCO, rats with biliary drainage after the administration of Chuanxiong and warfarin. A series of blood samples were collected at different time points before and after oral administration. An ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for quantification of the main components of Chuanxiong and methyclothiazide (internal standard) have been established. The validated method was successfully applied to a comparative pharmacokinetics study. After calculated by the DAS 2.1.1 software, the pharmacokinetics parameters of senkyunolide I showed a significant difference between the CN and CO groups, the AUC, and C of CO group increased by 5.45, 4.02 folds, respectively. There was a significant difference between the WCO and WCN groups, the T of WCO group prolonged 67%; compared to the CN group, the AUC, and C of WCN group raised 4.84, 3.49 folds, respectively; the T and C between the CO and WCO groups also showed a significant difference. The drug warfarin significantly affected the senkyunolide I disposition, which partly due to its enterohepatic circulation process in rat plasma after oral administration of Chuanxiong. The present study highlights an urgent evidence for drug-herb interactions.
PubMed: 30631279
DOI: 10.3389/fphar.2018.01461 -
The Journal of Clinical Investigation Jul 1972In order to clarify the mechanisms of thiazide diuretic-induced hypocalciuria, the effect of a thiazide was studied for 7 days in seven patients with hypoparathyroidism... (Clinical Trial)
Clinical Trial
In order to clarify the mechanisms of thiazide diuretic-induced hypocalciuria, the effect of a thiazide was studied for 7 days in seven patients with hypoparathyroidism on Vitamin D and one on calcium infusion, and seven euparathyroid patients with hypercalciuria. In the control group, calcium excretion (mg/24 hr) fell by 44% from 415 to 232 within 4 days and remained at this level. Plasma total calcium corrected for total protein did not change. In the hypoparathyroid group, calcium excretion fell by 11% from 351 to 311 and then returned to the base line level. Plasma total calcium (mg/100 ml) increased from 10.09 to 10.88, 11.29 and 10.77 at the end of the 2nd, 4th, and 7th day of thiazide administration. In the patient having i.v. calcium and no Vitamin D, neither plasma nor urinary calcium changed significantly. In both groups sodium excretion increased on the first 2 days and fell to or below base line level thereafter. Urinary phosphate, magnesium, and potassium increased, plasma phosphate rose, and magnesium and potassium fell. It is concluded that: (a) The hypocalciuric effect of thiazides requires the presence of parathyroid hormone and is not solely a result of sodium depletion. (b) The hypercalcemic effect of thiazides in hypoparathyroidism is due to increased release of calcium from bone and requires the presence of a pharmacologic dose of Vitamin D. (c) Thiazides enhane the action of parathyroid hormone on bone and kidney; Vitamin D can replace parathyroid hormone in this interaction in bone but not in kidney.
Topics: Adult; Aged; Bone and Bones; Calcium; Chlorothiazide; Cholecalciferol; Clinical Trials as Topic; Dihydrotachysterol; Drug Interactions; Ergocalciferols; Female; Humans; Hypoparathyroidism; Kidney Tubules; Magnesium; Male; Methyclothiazide; Middle Aged; Natriuresis; Parathyroid Hormone; Phosphates; Potassium; Urinary Calculi; Vitamin D
PubMed: 4338123
DOI: 10.1172/JCI106990 -
Journal of the American Geriatrics... Apr 1967
Clinical Trial
Topics: Adult; Cerebrovascular Disorders; Clinical Trials as Topic; Depression; Female; Humans; Hypertension; Male; Methyclothiazide; Methylphenidate; Middle Aged; Phytotherapy; Placebos; Plants, Medicinal; Rauwolfia; Reserpine
PubMed: 5335634
DOI: 10.1111/j.1532-5415.1967.tb02802.x -
Gastroenterologie Clinique Et Biologique Oct 2000
Topics: Acute Disease; Aged; Diuretics; Female; Humans; Methyclothiazide; Pancreatitis; Triamterene
PubMed: 11084441
DOI: No ID Found -
California Medicine Mar 1964The mechanism whereby sulfonamyl diuretics are effective is through the blockage of the renal tubular reabsorption of chloride. The excretion of sodium, potassium and...
The mechanism whereby sulfonamyl diuretics are effective is through the blockage of the renal tubular reabsorption of chloride. The excretion of sodium, potassium and water is a passive one to maintain ionic equilibrium. Chlorothiazide has been shown to be almost ineffective as a diuretic agent per se. Although it does block a moiety of the renal tubular reabsorption of bicarbonate, the effect is merely a transient one.
Topics: Acetazolamide; Acidosis; Alkalosis; Ammonia; Benzothiadiazines; Blood Chemical Analysis; Chlorothiazide; Diuretics; Hydrochlorothiazide; Kidney Tubules; Methyclothiazide; Pharmacology; Potassium; Toxicology; Water-Electrolyte Balance
PubMed: 14131396
DOI: No ID Found -
Henry Ford Hospital Medical Bulletin Sep 1961
Topics: Chlorothiazide; Diuretics; Immunotherapy, Adoptive; Methyclothiazide
PubMed: 14487339
DOI: No ID Found -
Canadian Medical Association Journal May 1964
Topics: Humans; Methyclothiazide
PubMed: 14158963
DOI: No ID Found