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The American Journal of Pathology 1959
Topics: Bacterial Infections; Chronic Disease; Humans; Micrococcus; Musculoskeletal Diseases
PubMed: 13617416
DOI: No ID Found -
The Journal of Investigative Dermatology Mar 1987
Topics: Actinomycetales; Axilla; Bacteria, Aerobic; Bacteria, Anaerobic; Face; Humans; Malassezia; Micrococcaceae; Perineum; Scalp; Skin
PubMed: 3102625
DOI: 10.1111/1523-1747.ep12468965 -
The European Respiratory Journal May 2022
Topics: Anti-Inflammatory Agents; Bacteria; Humans; Lung Diseases; Microbiota; Micrococcaceae; Respiratory System
PubMed: 35512808
DOI: 10.1183/13993003.03079-2021 -
Revista Chilena de Infectologia :... Feb 2008
Topics: Micrococcaceae
PubMed: 18273521
DOI: No ID Found -
Cell Host & Microbe Nov 2015Asthma is an increasingly prevalent chronic respiratory disease particularly affecting children. Microbial colonization during early life has emerged as a central factor... (Review)
Review
Asthma is an increasingly prevalent chronic respiratory disease particularly affecting children. Microbial colonization during early life has emerged as a central factor influencing asthma susceptibility. A recently published prospective study links the reduction in relative abundance of 4 bacterial genera at 3 months of age to the development of asthma.
Topics: Animals; Asthma; Disease Susceptibility; Firmicutes; Humans; Hypersensitivity; Microbiota; Micrococcaceae
PubMed: 26567506
DOI: 10.1016/j.chom.2015.10.018 -
Nature Communications Oct 2015Phosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates and proteins to outer cellular membranes. The defining step in...
Phosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates and proteins to outer cellular membranes. The defining step in phosphatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction, and either inositol in eukaryotes or inositol phosphate in prokaryotes as the acceptor alcohol. Here we report the structures of a related enzyme, the phosphatidylinositol-phosphate synthase from Renibacterium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 Å resolution, respectively. These structures reveal the location of the acceptor site, and the molecular determinants of substrate specificity and catalysis. Functional characterization of the 40%-identical ortholog from Mycobacterium tuberculosis, a potential target for the development of novel anti-tuberculosis drugs, supports the proposed mechanism of substrate binding and catalysis. This work therefore provides a structural and functional framework to understand the mechanism of phosphatidylinositol-phosphate biosynthesis.
Topics: Bacterial Proteins; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase; Crystallography, X-Ray; Kinetics; Micrococcaceae; Mycobacterium tuberculosis; Phosphatidylinositol Phosphates
PubMed: 26510127
DOI: 10.1038/ncomms9505 -
International Journal of Infectious... Nov 2023We report the isolation of a rare Gram-positive coccobacillary bacterium from synovial fluids of a patient with periprosthetic joint infection on three occasions over an...
We report the isolation of a rare Gram-positive coccobacillary bacterium from synovial fluids of a patient with periprosthetic joint infection on three occasions over an 8-month period. As routine microbiological methods were not able to identify the isolate definitely, sequence analyses of the bacterial 16S ribosomal RNA gene and whole genome were performed. Analysis of the bacterial 16S ribosomal RNA gene showed the highest similarity (98.1%) with that of Falsarthrobacter (previously known as Arthrobacter) nasiphocae, which was first isolated from the nasal cavities of common seals (Phoca vitulina). The genome size of the strain (designated as UM1) is 2.4 Mb. With a high G+C content (70.4 mol%), strain UM1 is phylogenetically most closely related to F. nasiphocae based on whole genome analysis. Strain UM1 was susceptible to vancomycin, linezolid, trimethoprim-sulfamethoxazole, doxycycline, and intermediate to penicillin and ciprofloxacin. Ceftriaxone resistance was noted. The patient who was also on hemodialysis for his end stage kidney disease died approximately 3 weeks following implant removal and fusion with an external fixator. This study describes the first isolation of F. nasiphocae from human clinical samples. The use of emerging technologies has supported more definitive etiological diagnosis associated with rarely encountered organisms in periprosthetic joint infection.
Topics: Humans; Prosthesis-Related Infections; Micrococcaceae; Bacteria; Arthritis, Infectious; Gram-Positive Bacteria
PubMed: 37660726
DOI: 10.1016/j.ijid.2023.08.025 -
Scientific Reports Oct 2020Recently, it was suggested that the nitrite (NO) produced from NO by oral bacteria might contribute to oral and general health. Therefore, we aimed to clarify the...
Recently, it was suggested that the nitrite (NO) produced from NO by oral bacteria might contribute to oral and general health. Therefore, we aimed to clarify the detailed information about the bacterial NO-production in the oral biofilm. Dental plaque and tongue-coating samples were collected, then the NO-producing activity was measured. Furthermore, the composition of the NO-producing bacterial population were identified using the Griess reagent-containing agar overlay method and molecular biological method. NO-producing activity per mg wet weight varied among individuals but was higher in dental plaque. Additionally, anaerobic bacteria exhibited higher numbers of NO-producing bacteria, except in the adults' dental plaque. The proportion of NO-producing bacteria also varied among individuals, but a positive correlation was found between NO-producing activity and the number of NO-producing bacteria, especially in dental plaque. Overall, the major NO-producing bacteria were identified as Actinomyces, Schaalia, Veillonella and Neisseria. Furthermore, Rothia was specifically detected in the tongue coatings of children. These results suggest that dental plaque has higher NO-producing activity and that this activity depends not on the presence of specific bacteria or the bacterial compositions, but on the number of NO-producing bacteria, although interindividual differences were detected.
Topics: Actinomyces; Actinomycetaceae; Adolescent; Adult; Bacteria, Anaerobic; Biofilms; Child; Child, Preschool; Dental Plaque; Female; Humans; Male; Microbiota; Micrococcaceae; Mouth; Neisseria; Nitrites; Veillonella; Young Adult
PubMed: 33024169
DOI: 10.1038/s41598-020-73479-1 -
Rhode Island Medical Journal (2013) Oct 2022For the 11% of dialysis patients worldwide who receive peritoneal dialysis (PD) to treat their end-stage kidney disease (ESKD), recent PD-associated peritonitis is...
For the 11% of dialysis patients worldwide who receive peritoneal dialysis (PD) to treat their end-stage kidney disease (ESKD), recent PD-associated peritonitis is estimated to contribute to 5-30% of reported mortality.1,2 These infections are most commonly caused by coagulase-negative Staphylococcus (32%), followed by culture-negative peritonitis (16%), and the timely identification and targeted treatment of peritonitis is critical to avoid complications such as PD catheter removal.3 Here, we present a case of atypical Rothia mucilaginosis peritonitis in a PD patient.
Topics: Coagulase; Humans; Micrococcaceae; Peritoneal Dialysis; Peritonitis; Renal Dialysis
PubMed: 36173909
DOI: No ID Found -
Cells Aug 2023is an opportunistic pathogen, particularly life-threatening for the immunocompromised. It is associated with pneumonia, endocarditis, peritonitis and many other serious...
is an opportunistic pathogen, particularly life-threatening for the immunocompromised. It is associated with pneumonia, endocarditis, peritonitis and many other serious infections, including septicemia. Of note, produces metabolites that support and increase overgrowth of , one of the ESKAPE bacteria. Endolysins are considered as antibacterial enzymes derived from bacteriophages that selectively and efficiently kill susceptible bacteria without harming human cells or the normal microbiome. Here, we applied a computational analysis of metagenomic sequencing data of the gastric mucosa phageome extracted from human patients' stomach biopsies. A selected candidate anti- sequence was produced in an expression system, purified and confirmed as a - and -specific endolysin PolaR, able to destroy bacterial cells even when aggregated, as in a biofilm. PolaR had no cytotoxic or antiproliferative effects on mammalian cells. PolaR is the first described endolysin selectively targeting species, with a high potential to combat infections caused by and , and possibly other bacterial groups. PolaR is the first antibacterial enzyme selected from the gastric mucosa phageome, which underlines the biological complexity and probably underestimated biological role of the phageome in the human gastric mucosa.
Topics: Animals; Humans; Bacteriophages; Micrococcaceae; Bacteria; Anti-Bacterial Agents; Mammals
PubMed: 37566076
DOI: 10.3390/cells12151997