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International Journal of Environmental... Dec 2022Deficiencies of micronutrients in calcareous soils have been reported in different areas of China's Loess Plateau. The objective of this research was to study the...
Deficiencies of micronutrients in calcareous soils have been reported in different areas of China's Loess Plateau. The objective of this research was to study the influence of the continuous application of micronutrient fertilizers on soil properties and micronutrient availability in this region. The micronutrient fertilizer field plot experiment began in 1984. It included Zn, Mn and Cu fertilizer treatments and the control treatment. The crop system was continuously cropped winter wheat. The soil properties and available Zn, Mn, Cu and Fe were measured. Their relationships were analyzed through correlation and path analysis. After 31 years, the soil pH, CaCO and available P levels decreased; in contrast, the organic matter, fulvic acid, reducing substances and soil moisture levels in the surface soil increased in the micronutrient fertilized treatments compared to the control treatment. Cu and Zn fertilizers promoted the available Cu and Zn levels in the surface and deep soil, but available Mn was not significantly affected by Mn fertilizer. It can be seen from the interaction between the micronutrient availability and micronutrient fertilizers that Zn, Cu and Mn fertilizers can increase the available Fe level; Mn fertilizer can increase the available Cu level, and Cu and Mn fertilizers can increase the available Zn level. This means that Fe, Cu and Zn availability were easy to implement, whereas the soil-available Mn was difficult to improve in calcareous soils on the Loess Plateau. Fulvic acid and organic matter showed a significant and direct effect on the available Zn; the available Mn and Fe were mainly affected by the soil CaCO and moisture; the available Cu was mainly affected by the soil organic matter, available P and reducing substances. These results indicate the importance of organic matter in calcareous soils; it can not only directly affect the availability of micronutrients but also indirectly affect their availability through the indirect interaction with fulvic acid, reducing substances, available P and CaCO. The above conclusions suggest that the long-term micronutrient fertilizers changed some important soil properties and increased the micronutrient availability in the loess-derived soil.
Topics: Fertilizers; Soil; Micronutrients; Trace Elements; Soil Pollutants
PubMed: 36498430
DOI: 10.3390/ijerph192316358 -
International Journal of Molecular... Feb 2016Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent... (Review)
Review
Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. In addition, the adsorption and excretion of various metals, in particular nickel, is discussed to further understand the pathogenesis of metal allergy.
Topics: Allergens; Animals; Humans; Hypersensitivity; Ion Transport; Nickel; Thymus Gland; Trace Elements
PubMed: 26848658
DOI: 10.3390/ijms17020202 -
Advances in Nutrition (Bethesda, Md.) Jan 2016Paramount among the challenges to our ability to address the role of food and nutrition in health promotion and disease prevention is how to design and implement... (Review)
Review
Integration to Implementation and the Micronutrient Forum: A Coordinated Approach for Global Nutrition. Case Study Application: Safety and Effectiveness of Iron Interventions.
Paramount among the challenges to our ability to address the role of food and nutrition in health promotion and disease prevention is how to design and implement context-specific interventions and guidance. The Integration to Effective Implementation (I-to-I) concept is intended to address the complexities of the global health context through engagement of the continuum of stakeholders involved in the food and nutrition enterprise. The 2014 Micronutrient Forum (MNF) Global Conference held in Addis Ababa, Ethiopia, in June 2014 offered the opportunity to apply the I-to-I approach with the use of current concerns about the safety and effectiveness of interventions to prevent and treat iron deficiency (ID) as a case study. ID is associated with a range of adverse outcomes, especially in pregnant and nonpregnant women, infants, and primary school-age children. Strategies to combat ID include iron supplementation, multiple micronutrient powders, and food-based interventions to enhance dietary iron intake. Recent reports indicate potential increased adverse risks when iron is provided in areas with high infection burdens (e.g., malaria). This paradox has weakened iron intervention programs. Furthermore, the selection and interpretation of available biomarkers for assessing iron nutrition have been found to be compromised by the inflammatory process. These issues highlight the need for a comprehensive approach that considers basic biology, assessment, interventions, and how these can be translated into appropriate programs and policies. The application of the I-to-I with the use of the MNF offered an opportunity to explore how that might be achieved.
Topics: Anemia, Iron-Deficiency; Female; Global Health; Health Status; Humans; Infections; Inflammation; Iron; Iron, Dietary; Pregnancy; Trace Elements
PubMed: 26773021
DOI: 10.3945/an.115.008581 -
Advances in Nutrition (Bethesda, Md.) Nov 2012Zinc was established as essential for green plants in 1926 and for mammals in 1934. However, >20 y would pass before the first descriptions of zinc deficiencies in farm... (Review)
Review
Zinc was established as essential for green plants in 1926 and for mammals in 1934. However, >20 y would pass before the first descriptions of zinc deficiencies in farm animals appeared. In 1955, it was reported that zinc supplementation would cure parakeratosis in swine. In 1958, it was reported that zinc deficiency induced poor growth, leg abnormalities, poor feathering, and parakeratosis in chicks. In the 1960s, zinc supplementation was found to alleviate parakeratosis in grazing cattle and sheep. Within 35 y, it was established that nearly one half of the soils in the world may be zinc deficient, causing decreased plant zinc content and production that can be prevented by zinc fertilization. In many of these areas, zinc deficiency is prevented in grazing livestock by zinc fertilization of pastures or by providing salt licks. For livestock under more defined conditions, such as poultry, swine, and dairy and finishing cattle, feeds are easily supplemented with zinc salts to prevent deficiency. Today, the causes and consequences of zinc deficiency and methods and effects of overcoming the deficiency are well established for agriculture. The history of zinc in agriculture is an outstanding demonstration of the translation of research into practical application.
Topics: Agriculture; Animal Feed; Animals; Animals, Domestic; Deficiency Diseases; Growth Disorders; History, 20th Century; History, 21st Century; Humans; Parakeratosis; Trace Elements; Zinc
PubMed: 23153732
DOI: 10.3945/an.112.002881 -
BioMed Research International 2018Micronutrient deficiencies are common in inflammatory bowel disease and have clinical impact, being both a sign of complicated disease and a cause of morbidity. The... (Review)
Review
Micronutrient deficiencies are common in inflammatory bowel disease and have clinical impact, being both a sign of complicated disease and a cause of morbidity. The involved systemic inflammatory response is responsible for altering the concentration of a wide range of trace elements in the serum, including zinc and selenium. This review summarizes recent advances and evidence-based knowledge regarding the impact of selenium and zinc on oxidative stress and microbiota changes in IBD patients. Getting new insight into the impact of malnutrition, particularly on the micronutrients' impact on the development, composition, and metabolism of microbiota, as well as the influence of oxidative stress and the mucosal immune response, could help in implementing new management strategies for IBD patients, with focus on a more integrated approach.
Topics: Humans; Inflammatory Bowel Diseases; Micronutrients; Selenium; Trace Elements; Zinc
PubMed: 30258848
DOI: 10.1155/2018/1813047 -
Nutrients Apr 2022Parenteral nutrition (PN) provides support for patients lacking sufficient intestinal absorption of nutrients. Historically, the need for trace element (TE)... (Review)
Review
Parenteral nutrition (PN) provides support for patients lacking sufficient intestinal absorption of nutrients. Historically, the need for trace element (TE) supplementation was poorly appreciated, and multi-TE products were not initially subjected to rigorous oversight by the United States Food and Drug Administration (FDA). Subsequently, the American Society for Parenteral and Enteral Nutrition (ASPEN) issued dosage recommendations for PN, which are updated periodically. The FDA has implemented review and approval processes to ensure access to safer and more effective TE products. The development of a multi-TE product meeting ASPEN recommendations and FDA requirements is the result of a partnership between the FDA, industry, and clinicians with expertise in PN. This article examines the rationale for the development of TRALEMENT (Trace Elements Injection 4*) and the FDA's rigorous requirements leading to its review and approval. This combination product contains copper, manganese, selenium, and zinc and is indicated for use in adults and pediatric patients weighing ≥10 kg. Comprehensive management of PN therapy requires consideration of many factors when prescribing, reviewing, preparing, and administering PN, as well as monitoring the nutritional status of patients receiving PN. Understanding patients' TE requirements and incorporating them into PN is an important part of contemporary PN therapy.
Topics: Adult; Child; Dietary Supplements; Humans; Manganese; Parenteral Nutrition; Pharmaceutical Preparations; Selenium; Trace Elements; United States
PubMed: 35565737
DOI: 10.3390/nu14091770 -
Nutrients Jul 2023Copper and zinc are micronutrients that play a crucial role in many cellular pathways, act as cofactors in enzymatic systems, and hence, modulate enzyme activity. The... (Review)
Review
Copper and zinc are micronutrients that play a crucial role in many cellular pathways, act as cofactors in enzymatic systems, and hence, modulate enzyme activity. The regulation of these elements in homeostasis is precisely controlled by various mechanisms. Superoxide dismutase (SOD) is an enzyme requiring both copper and zinc for proper functioning. Additionally, there is an interaction between the concentrations of copper and zinc. Dietary ingestion of large amounts of zinc augments intestinal absorption of this trace element, resulting in copper deficiency secondary to zinc excess. The presence of an overabundance of copper and zinc has a detrimental impact on the cardiovascular system; however, the impact on vascular contractility varies. Copper plays a role in the modulation of vascular remodeling in the cardiac tissue, and the phenomenon of cuproptosis has been linked to the pathogenesis of coronary artery disease. The presence of copper has an observable effect on the vasorelaxation mediated by nitric oxide. The maintenance of proper levels of zinc within an organism influences SOD and is essential in the pathogenesis of myocardial ischemia/reperfusion injury. Recently, the effects of metal nanoparticles have been investigated due to their unique characteristics. On the other hand, dietary introduction of metal nanoparticles may result in vascular dysfunction, oxidative stress, and cellular DNA damage. Copper and zinc intake affect cardiovascular function, but more research is needed.
Topics: Zinc; Copper; Trace Elements; Superoxide Dismutase; Heart
PubMed: 37447366
DOI: 10.3390/nu15133040 -
PloS One 2022Older adult populations are at risk for zinc deficiency, which may predispose them to immune dysfunction and age-related chronic inflammation that drives myriad diseases...
Older adult populations are at risk for zinc deficiency, which may predispose them to immune dysfunction and age-related chronic inflammation that drives myriad diseases and disorders. Recent work also implicates the gut microbiome in the onset and severity of age-related inflammation, indicating that dietary zinc status and the gut microbiome may interact to impact age-related host immunity. We hypothesize that age-related alterations in the gut microbiome contribute to the demonstrated zinc deficits in host zinc levels and increased inflammation. We tested this hypothesis with a multifactor two-part study design in a C57BL/6 mouse model. The two studies included young (2 month old) and aged (24 month old) mice fed either (1) a zinc adequate or zinc supplemented diet, or (2) a zinc adequate or marginal zinc deficient diet, respectively. Overall microbiome composition did not significantly change with zinc status; beta diversity was driven almost exclusively by age effects. Microbiome differences due to age are evident at all taxonomic levels, with more than half of all taxonomic units significantly different. Furthermore, we found 150 out of 186 genera were significantly different between the two age groups, with Bacteriodes and Parabacteroides being the primary taxa of young and old mice, respectively. These data suggest that modulating individual micronutrient concentrations does not lead to comprehensive microbiome shifts, but rather affects specific components of the gut microbiome. However, a phylogenetic agglomeration technique (ClaaTU) revealed phylogenetic clades that respond to modulation of dietary zinc status and inflammation state in an age-dependent manner. Collectively, these results suggest that a complex interplay exists between host age, gut microbiome composition, and dietary zinc status.
Topics: Animals; Mice; Zinc; Micronutrients; Phylogeny; Mice, Inbred C57BL; Microbiota; Trace Elements; Disease Models, Animal; Dietary Supplements; Inflammation
PubMed: 36534653
DOI: 10.1371/journal.pone.0275352 -
International Journal of Molecular... Mar 2024Trace elements are essential for maintaining the body's homeostasis, and their special role has been demonstrated in skin physiology. Among the most important trace... (Review)
Review
Trace elements are essential for maintaining the body's homeostasis, and their special role has been demonstrated in skin physiology. Among the most important trace elements are zinc, copper, and iron. A deficiency or excess of trace elements can be associated with an increased risk of skin diseases, so increasing their supplementation or limiting intake can be helpful in dermatological treatment. In addition, determinations of their levels in various types of biological material can be useful as additional tests in dermatological treatment. This paper describes the role of these elements in skin physiology and summarizes data on zinc, copper, and iron in the course of selected, following skin diseases: , , , and . In addition, this work identifies the potential of trace elements as auxiliary tests in dermatology. According to preliminary studies, abnormal levels of zinc, copper, and iron are observed in many skin diseases and their determinations in serum or hair can be used as auxiliary and prognostic tests in the course of various dermatoses. However, since data for some conditions are conflicting, clearly defining the potential of trace elements as auxiliary tests or elements requiring restriction/supplement requires further research.
Topics: Humans; Zinc; Copper; Trace Elements; Iron; Acne Vulgaris
PubMed: 38612631
DOI: 10.3390/ijms25073823 -
Nutricion Hospitalaria Nov 2023Introduction: the interaction between immunity and nutrition is complex and multifaceted. Micronutrients, including vitamins and minerals, are essential for immune... (Review)
Review
Introduction: the interaction between immunity and nutrition is complex and multifaceted. Micronutrients, including vitamins and minerals, are essential for immune function. In turn, immune function and lifestyle habits can affect nutritional needs and micronutrient utilization, creating an interdependence between nutrition and immunity that can be modulated by both external and internal factors. Objectives: to examine the relationship between micronutrient intake and immune function, and how debilitating factors such as aging, disease, and stress can impact this relationship. Methods: a review of scientific evidence and recommendations from major international scientific societies was conducted to identify the importance of micronutrients in immune function and how debilitating factors can alter their impact. Results: the effect of different micronutrients on immune function is described. Debilitating factors like aging, stress, and chronic diseases can compromise the immune system and make the body more susceptible to infections. However, adequate intake of micronutrients and healthy habits can help to strengthen immunity and mitigate the effects of these debilitating factors. Conclusion: immunonutrition is a critical component for maintaining a strong and healthy immune system. Sufficient intake of micronutrients and healthy lifestyle habits can help improve immunity, especially in the presence of debilitating factors.
Topics: Humans; Micronutrients; Immunonutrition Diet; Vitamins; Trace Elements; Minerals
PubMed: 37929894
DOI: 10.20960/nh.04945