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BMJ Case Reports Jul 2018
Topics: Brain; Humans; Infant; Lumbosacral Region; Magnetic Resonance Imaging; Male; Mongolian Spot; Sandhoff Disease
PubMed: 30061129
DOI: 10.1136/bcr-2018-225013 -
Indian Pediatrics Dec 2016
Topics: Back; Buttocks; Female; Gangliosidosis, GM1; Humans; Infant; Mongolian Spot
PubMed: 28064276
DOI: No ID Found -
Cancer Science Jun 2004The goal of this study was to elucidate whether beta-catenin gene mutations might contribute to glandular stomach carcinogenesis in Helicobacter pylori...
The goal of this study was to elucidate whether beta-catenin gene mutations might contribute to glandular stomach carcinogenesis in Helicobacter pylori (H.pylori)-infected Mongolian gerbils. Firstly, exon 3 of gerbil beta-catenin cDNA, a mutation hot spot, was cloned and sequenced and found to have 89.3% homology with the human form and 95.5% with the rat and mouse forms. Peptide sequence in this region was shown to be 100% conserved in these mammals. Then, 45 stomach adenocarcinomas induced with N-methyl-N-nitrosourea (MNU) plus H. pylori infection and 7 induced with MNU alone were examined for beta-catenin expression by immunohistochemistry and for DNA mutations using a combination of microdissection and PCR-single strand conformation polymorphism analysis. One gastric cancer in the MNU + H. pylori group (2.2%) displayed nuclear (N) beta-catenin localization, 3 (6.7%) showed cytoplasmic (C) distribution in local regions, and 41 (91.1%) demonstrated cell membrane (M) localization. Tumors induced by MNU alone showed only membranous beta-catenin localization (7/7). Analysis of exon 3 of the beta-catenin gene dem-onstrated all tumors with membrane or cytoplasmic staining as well as surrounding normal mucosa (S) to feature wild-type beta-catenin. In contrast, the lesion with nuclear staining had a missense mutation at codon 34 [GAC (Gly) --> GAA (Glu)] in exon 3 (1/1 = 100%, N vs. M, P < 0.05; and N vs. S, P < 0.05). In conclusion, these results suggest that beta-catenin may not be a frequent target for mutation in stomach carcinogenesis in MNU + H. pylori-treated gerbils.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Base Sequence; Cytoskeletal Proteins; Exons; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Molecular Sequence Data; Mutation; Stomach Neoplasms; Trans-Activators; beta Catenin
PubMed: 15182428
DOI: 10.1111/j.1349-7006.2004.tb03237.x -
Indian Journal of Dermatology 2015Dermatologic conditions have different presentation and management in pediatric age group from that in adult; this to be studied separately for statistical and...
BACKGROUND
Dermatologic conditions have different presentation and management in pediatric age group from that in adult; this to be studied separately for statistical and population based analysis.
OBJECTIVE
To study the pattern of various dermatoses in infants and children in tertiary health care center in South Gujarat region.
MATERIALS AND METHODS
This is a prospective study; various dermatoses were studied in pediatric patients up to 14 years of age attending the Dermatology OPD of New Civil Hospital, Surat, Gujarat over a period of 12 months from June 2009 to June 2010. All patients were divided into four different study groups: <1 month (neonates), 1 month to 1 year, >1 to 6 years and 7 to 14 years.
RESULTS
There were 596 boys and 425 girls in total 1021 study populations. Majority of the skin conditions in neonates were erythema toxicum neonatorum (12.97%), scabies (9.92%), mongolian spot (9.16%), and seborrheic dermatitis (7.63%). In > 1 month to 14 years age group of children among infectious disorder, children were found to be affected most by scabies (24.49%), impetigo (5.96%), pyoderma (5.62%), molluscum contagiosum (5.39%), tinea capitis (4.49%), leprosy (2.02%), and viral warts (1.35%) while among non-infectious disorders, they were affected by atopic dermatitis (4.27%), pityriasis alba (4.16%), seborrheic dermatitis (3.60%), pityriasis rosea (3.15%), others (3.01%), phrynoderma (2.70%), lichen planus (2.58%), contact dermatitis (1.57%) and ichthyosis (1.45%).
CONCLUSION
There is a need to emphasize on training the management of common pediatric dermatoses to dermatologists, general practitioners and pediatricians for early treatment.
PubMed: 26677296
DOI: 10.4103/0019-5154.169147 -
Annals of Dermatology Nov 2010Dermal melanocytosis is characterized by the presence of ectopic melanocytes in the dermis. The most common forms include the Mongolian spot, blue nevus, nevus of Ota,...
Dermal melanocytosis is characterized by the presence of ectopic melanocytes in the dermis. The most common forms include the Mongolian spot, blue nevus, nevus of Ota, and nevus of Ito. Some types of dermal melanocytosis do not fit into any of these morphologic categories, however. Our case demonstrated an extensive amount of uniform deep blue patches of nevi with unilateral distribution on the left face, neck, chest, shoulder, and back. On histopathologic examination, a number of elongated melanocytes scattered throughout the dermis were found. We herein report a case of congenital unilateral dermal melanocytosis.
PubMed: 21165221
DOI: 10.5021/ad.2010.22.4.460 -
Journal of Fungi (Basel, Switzerland) Jan 2024Black spot needle blight is a minor disease in Mongolian Scots pine ( var. ) caused by , but it can cause economic losses in severe cases. Sodium pheophorbide a (SPA),...
Black spot needle blight is a minor disease in Mongolian Scots pine ( var. ) caused by , but it can cause economic losses in severe cases. Sodium pheophorbide a (SPA), an intermediate product of the chlorophyll metabolism pathway, is a compound with photoactivated antifungal activity, which has been previously shown to inhibit the growth of . In this study, SPA significantly reduced the incidence and disease index and enhanced the chlorophyll content and antioxidant enzyme activities of var. . To further study the molecular mechanism of the inhibition, we conducted a comparative proteomic analysis of mycelia with and without SPA treatment. The cellular proteins were obtained from mycelial samples and subjected to a tandem mass tag (TMT)-labelling LC-MS/MS analysis. Based on the results of de novo transcriptome assembly, 613 differentially expressed proteins (DEPs) ( < 0.05) were identified, of which 360 were upregulated and 253 downregulated. The 527 annotated DEPs were classified into 50 functional groups according to Gene Ontology and linked to 256 different pathways using the Kyoto Encyclopedia of Genes and Genomes database as a reference. A joint analysis of the transcriptome and proteomics results showed that the top three pathways were Amino acid metabolism, Carbohydrate metabolism, and Lipid metabolism. These results provide new viewpoints into the molecular mechanism of the inhibition of by SPA at the protein level and a theoretical basis for evaluating SPA as an antifungal agent to protect forests.
PubMed: 38392774
DOI: 10.3390/jof10020102 -
Acta Dermato-venereologica Jan 2018
Topics: Asian People; Cafe-au-Lait Spots; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Japan; Male; Mongolian Spot; Neurofibromatosis 1; Skin; Skin Neoplasms; Skin Pigmentation
PubMed: 28902947
DOI: 10.2340/00015555-2796 -
The American Journal of Pathology Jun 2010Middle ear cholesteatoma is characterized by enhanced proliferation of epithelial cells with aberrant morphological characteristics. To investigate the origin of the...
Middle ear cholesteatoma is characterized by enhanced proliferation of epithelial cells with aberrant morphological characteristics. To investigate the origin of the cholesteatoma cells, we analyzed spontaneously occurring cholesteatomas associated with a new transplantation model in Mongolian gerbils (gerbils). Cholesteatomas were induced in gerbils with a transplanted tympanic membrane by using the external auditory canal (EAC) ligation method. After the pars flaccida of the tympanic membranes were completely removed from male gerbils, corresponding portions of tympanic membranes of female gerbils were transplanted to the area of defect, and then we ligated the EAC (hybrid-model group). As a control group, the EAC of normal male and female gerbils was ligated without myringoplasty. In all ears of each group, the induced cholesteatomas were seen. In situ PCR was then performed to detect the mouse X chromosome-linked phosphoglycerate kinase-1 (pgk-1) gene on the paraffin sections. One pgk-1 spot in the epithelial nuclei was detected in male cholesteatoma, and two pgk-1 spots were detected in female cholesteatoma, respectively. On the other hand, in the hybrid-model group, we detected not only one but also two pgk-1 spots in the epithelial nuclei of cholesteatoma. These results strengthened the evidence that the origin of epithelial cells in cholesteatoma is the tympanic membrane in this model, but not the residential middle ear epithelial cells or the skin of the EAC.
Topics: Animals; Cholesteatoma, Middle Ear; Disease Models, Animal; Ear Canal; Epithelial Cells; Female; Gerbillinae; Male; Mice; Phosphoglycerate Kinase; Polymerase Chain Reaction; Tympanic Membrane
PubMed: 20413684
DOI: 10.2353/ajpath.2010.091182 -
Journal of Korean Medical Science Aug 2004Ota's nevus is mongolian spot-like macular blue-black or gray-brown patchy pigmentation that most commonly occurs in areas innervated by the first and second division of...
Ota's nevus is mongolian spot-like macular blue-black or gray-brown patchy pigmentation that most commonly occurs in areas innervated by the first and second division of the trigeminal nerve. Acquired, bilateral nevus of Ota-like macules (ABNOM) is located bilaterally on the face, appears later in life, is blue-brown or slate-gray in color. It is not accompanied by macules on the ocular and mucosal membranes. There is also debate as to whether ABNOM is part of the Ota's nevus spectrum. We report an interesting case of ABNOM associated with Ota's nevus. A 36-yr-old Korean women visited our clinic with dark bluish patch on the right cheek and right conjunctiva since birth. She also had mottled brownish macules on both forehead and both lower eyelids that have developed 3 yr ago. Skin biopsy specimens taken from the right cheek and left forehead all showed scattered, bipolar or irregular melanocytes in the dermis. We diagnosed lesion on the right cheek area as Ota's nevus and those on both forehead and both lower eyelids as ABNOM by clinical and histologic findings. This case may support the view that ABNOM is a separate entity from bilateral Ota's nevus.
Topics: Adult; Biopsy; Face; Female; Humans; Melanocytes; Nevus of Ota; Nevus, Pigmented
PubMed: 15308859
DOI: 10.3346/jkms.2004.19.4.616 -
Archives of Disease in Childhood Jul 1984Three cases, one of bullous impetigo, one of a Mongolian spot, and one of constriction of the toe by a hair, were mistakenly diagnosed as cases of child abuse. The...
Three cases, one of bullous impetigo, one of a Mongolian spot, and one of constriction of the toe by a hair, were mistakenly diagnosed as cases of child abuse. The diagnosis of child abuse is not usually simple and requires a careful evaluation of the injuries and the family if cases are not to be either overlooked or overdiagnosed.
Topics: Child Abuse; Child, Preschool; Constriction, Pathologic; Diagnostic Errors; Foot Diseases; Humans; Impetigo; Infant; Male; Pigmentation Disorders; Toes
PubMed: 6465937
DOI: 10.1136/adc.59.7.665