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Ugeskrift For Laeger Jun 2017Patients with persistent cytopenia are frequently referred to the haematological departments , and a diagnosis of myelodysplastic syndrome is often suspected. After... (Review)
Review
Patients with persistent cytopenia are frequently referred to the haematological departments , and a diagnosis of myelodysplastic syndrome is often suspected. After routine assessment including a broad range of blood tests, bone marrow biopsy, and cytogenetics, a definite diagnosis can still not be found for some patients, although they have symptomatic cytopenia. In these cases, next generation sequencing is a valuable supplement in identifying patients with early stages of myeloid cancer.
Topics: Clone Cells; DNA Mutational Analysis; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Mutation; Myelodysplastic Syndromes; Pancytopenia; Risk Factors
PubMed: 28648154
DOI: No ID Found -
Turkish Journal of Haematology :... May 2019
Topics: Child; Disease-Free Survival; Female; Humans; Male; Orbital Neoplasms; Sarcoma, Myeloid; Survival Rate
PubMed: 30650963
DOI: 10.4274/tjh.galenos.2019.2019.0002 -
Haematologica Nov 2011
The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?
Topics: Female; Germ-Line Mutation; Humans; Janus Kinase 2; Leukemia, Myeloid, Acute; Male; Polymorphism, Single Nucleotide
PubMed: 22058280
DOI: 10.3324/haematol.2011.055392 -
BMJ Case Reports Sep 2020
Topics: Adult; Blood Cell Count; Female; Humans; Leukemia, Myeloid, Acute; Ophthalmoscopy; Retina; Retinal Hemorrhage
PubMed: 32878844
DOI: 10.1136/bcr-2020-238133 -
Blood Jan 2016
Topics: Humans; Leukemia, Myeloid, Acute
PubMed: 26660430
DOI: 10.1182/blood-2015-10-662684 -
Blood Apr 2013
Topics: Adult; Anemia; Biopsy; Bone Marrow; Humans; Leukemia, Myeloid, Acute; Male; Pancytopenia
PubMed: 23682361
DOI: 10.1182/blood-2012-11-467621 -
Journal of Korean Neurosurgical Society Mar 2011Myeloid sarcoma is a solid, extramedullary tumor composed of leukemic myeloblasts or immature myeloid cells. Intraparenchymal myeloid sarcoma without the involvement of...
Myeloid sarcoma is a solid, extramedullary tumor composed of leukemic myeloblasts or immature myeloid cells. Intraparenchymal myeloid sarcoma without the involvement of the skull or meninges is extremely rare. Here, we present the case of a 49-year-old man who developed intraparenchymal myeloid sarcoma on the left cerebellum after allogeneic bone marrow transplantation (BMT). He received radiotherapy after complete removal of intraparenchymal myeloid sarcoma, but he was diagnosed spinal myeloid sarcoma three month later. Nine months after the operation, new intracranial and spinal myeloid sarcoma were diagnosed and the patient's condition had been worsened rapidly. Although the spinal myeloid sarcoma was not histologically diagnosed, this report provides valuable insights into the clinical course of progression of intraparenchymal myeloid sarcoma.
PubMed: 21556238
DOI: 10.3340/jkns.2011.49.3.171 -
Haematologica Oct 2023
Topics: Humans; Hematopoietic Stem Cell Transplantation; Leukemia, Myeloid, Acute; Stem Cell Transplantation; Neoplasm, Residual
PubMed: 37345488
DOI: 10.3324/haematol.2023.283120 -
Blood Jul 2014In this issue of Blood, Placke et al identify the cell-cycle regulator CDK6 as a promising new target in mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia...
In this issue of Blood, Placke et al identify the cell-cycle regulator CDK6 as a promising new target in mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML) and show that its downregulation or pharmacological inhibition leads to growth inhibition and differentiation of MLL-driven leukemic cells.
Topics: Animals; Cyclin-Dependent Kinase 6; Humans; Leukemia, Myeloid, Acute; Myeloid-Lymphoid Leukemia Protein
PubMed: 24993876
DOI: 10.1182/blood-2014-05-572917 -
Indian Journal of Pathology &... 2023Myeloid sarcoma (MS) is considered as an extramedullary manifestation of acute myeloid leukemia (AML) with or without concurrent AML. It can present at any age and any...
Myeloid sarcoma (MS) is considered as an extramedullary manifestation of acute myeloid leukemia (AML) with or without concurrent AML. It can present at any age and any site, however, nasopharynx being an extremely rare site of manifestation. MS may precede AML by weeks, months or years, thereby necessitating an early diagnosis and timely intervention and treatment. We report a case of MS in a young female who presented with nasal obstruction and epistaxis for 3 months. The present case also highlights the significance of judicious use of immunohistochemistry panel while dealing with a hematolymphoid neoplasm devoid of expression of B-cell or T cell specific markers in head and neck region.
Topics: Humans; Female; Sarcoma, Myeloid; Early Detection of Cancer; Leukemia, Myeloid, Acute; Immunohistochemistry; Nasopharynx
PubMed: 36656231
DOI: 10.4103/ijpm.ijpm_791_21