-
The Pan African Medical Journal 2018Papillary fibroelastoma is a rare primary benign cardiac tumor which can cause severe embolic complications. We report the case of a 69-year old man presenting with...
Papillary fibroelastoma is a rare primary benign cardiac tumor which can cause severe embolic complications. We report the case of a 69-year old man presenting with dyspnea. The patient underwent transthoracic echocardiography that showed sessile mass on the mitral valve. Surgically excision of the mass was performed followed by histological examination. The diagnosis of papillary fibroelastoma was then confirmed.
Topics: Aged; Dyspnea; Echocardiography; Fibroma; Heart Neoplasms; Heart Valve Diseases; Humans; Male; Mitral Valve
PubMed: 30167043
DOI: 10.11604/pamj.2018.30.15.13649 -
The Canadian Veterinary Journal = La... Dec 1981Fibromas are frequent cutaneous neoplasms of young deer of many species, characterized by proliferation of both epithelial and dermal cells. Virus particles, similar to... (Review)
Review
Fibromas are frequent cutaneous neoplasms of young deer of many species, characterized by proliferation of both epithelial and dermal cells. Virus particles, similar to those found in fibrous skin tumors of several wild and domestic species, have been identified in some species by electron microscopy. Attempted transmission of fibromas has not been uniformly successful using filtered preparations.
Topics: Age Factors; Animals; Deer; Female; Fibroma; Male; New York; Sex Factors; Skin Neoplasms
PubMed: 7039810
DOI: No ID Found -
Annals of the Royal College of Surgeons... Feb 2020Elastofibroma is a rare soft-tissue tumour. This study retrospectively analysed and summarised the clinical, imaging and typical pathological features, together with the...
OBJECTIVE
Elastofibroma is a rare soft-tissue tumour. This study retrospectively analysed and summarised the clinical, imaging and typical pathological features, together with the short- and long-term surgical outcomes of patients with pathologically confirmed soft-tissue elastofibroma to improve their management.
MATERIALS AND METHODS
We enrolled 73 patients with pathologically confirmed soft-tissue elastofibroma from January 2010 to December 2018. The general, clinical, diagnostic and treatment-related data, operation notes, pathological examination results and follow-up status were obtained by reviewing inpatient medical records. Disease onset age, sex, tumour location and size were statistically analysed using the chi square and rank sum tests.
RESULTS
A total of 90 lesions from 73 patients were examined. Among these, 56 patients had single lesions: 27 were under the right scapula, 26 were under the left scapula, 1 at the umbilicus, 1 on the aortic valve, 1 on the right hip and 17 at the bilateral inferior angles of the scapula. The average age at onset was 56.4 years (range: 6-82 years). The male-to-female incidence ratio was about one to three. Tumour diameter and follow-up duration ranged from 2cm to 12cm and from one month to nine years, respectively; recurrence was not observed. The main postoperative complication was wound effusion, occurring in 24 sites among the 90 lesions, corresponding to an incidence rate of 26.7%.
CONCLUSIONS
A correct diagnosis of elastofibroma can be made prior to surgical resection by examining typical clinical features and characteristic imaging findings. Short- and long-term outcomes of local excision are good, with no further recurrence.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Child; Female; Fibroma; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Complications; Retrospective Studies; Sex Factors; Surgical Procedures, Operative; Treatment Outcome; Young Adult
PubMed: 31233334
DOI: 10.1308/rcsann.2019.0089 -
The Canadian Veterinary Journal = La... Feb 2022A 12-year-old, spayed female, Maltese dog with a round and firm mass on the dorsal part of the left rear paw and a cervical mass was brought to the clinic. The paw mass...
A 12-year-old, spayed female, Maltese dog with a round and firm mass on the dorsal part of the left rear paw and a cervical mass was brought to the clinic. The paw mass was contiguous to the adjacent tendon; it was composed of neoplastic mesenchymal cells and had scattered foci of calcification with chondroid differentiation microscopically. The neoplastic cells were positive for vimentin and S100, but negative for desmin and smooth muscle actin. Microscopic features and immunohistochemistry results were consistent with calcifying aponeurotic fibroma (CAF). The cervical mass was composed of polygonal cells forming acini with marked anisocytosis and anisokaryosis and diagnosed as thyroid follicular carcinoma. No recurrence or metastasis occurred during follow-up. To the best of our knowledge, this is the first case of canine CAF with features identical to its human counterparts. Key clinical message: This report describes the rare case of calcifying aponeurotic fibroma on the paw in a dog. This is apparently the first case in the veterinary literature with identical clinical and pathological features to the human counterpart.
Topics: Animals; Calcinosis; Dog Diseases; Dogs; Female; Fibroma; Fibroma, Ossifying; Soft Tissue Neoplasms
PubMed: 35110769
DOI: No ID Found -
Archives of Pathology & Laboratory... May 2016Liposclerosing myxofibrous tumor is a benign fibro-osseous lesion, with distinct radiographic and clinical features and diverse histologic patterns. This lesion occurs...
Liposclerosing myxofibrous tumor is a benign fibro-osseous lesion, with distinct radiographic and clinical features and diverse histologic patterns. This lesion occurs in the fourth decade of life, with equal male and female incidence. Most lesions are discovered incidentally, but patients can present with bone pain or fracture. Liposclerosing myxofibrous tumor exhibits a very strong predilection for the proximal femur with characteristic radiographic findings, often providing an initial clue to diagnosis. Microscopically, this tumor is characterized by a variety of patterns, including myxofibrous tissue, fibrous dysplasia-like features, and ischemic ossification. It can be mistaken for many other fibro-osseous lesions; therefore, this unique lesion should be included in the differential diagnosis of fibro-osseous lesions, particularly in this location. Patients with this lesion are generally successfully treated by curettage and bone graft and have a favorable prognosis. A small risk of malignant transformation has been suggested to be associated with these lesions. This necessitates the need for follow-up monitoring of this entity. In this review, we discuss current knowledge of this lesion and its clinical relevance.
Topics: Adult; Age of Onset; Bone Neoplasms; Calcinosis; Combined Modality Therapy; Diagnosis, Differential; Female; Fibroma; Humans; Incidence; Incidental Findings; Lipoma; Male; Prognosis; Sclerosis; Sex Factors
PubMed: 27128305
DOI: 10.5858/2014-0503-RS -
Asian Journal of Surgery Nov 2022
Topics: Duodenum; Fibroma; Humans; Soft Tissue Neoplasms; Stomach Neoplasms
PubMed: 35701273
DOI: 10.1016/j.asjsur.2022.05.150 -
Actas Dermo-sifiliograficas Apr 2022
Topics: Fibroma; Humans; Skin Diseases
PubMed: 35623736
DOI: 10.1016/j.ad.2020.05.019 -
Annals of Oncology : Official Journal... Feb 2003Despite the use of surgery and radiotherapy, 20-35% of patients with aggressive fibromatosis (AF) will have local recurrence. The purpose of this review was to collect... (Review)
Review
BACKGROUND
Despite the use of surgery and radiotherapy, 20-35% of patients with aggressive fibromatosis (AF) will have local recurrence. The purpose of this review was to collect and analyze all available information regarding the role of non-cytotoxic and cytotoxic chemotherapy in AF that has been accumulated over the past few decades.
PATIENTS AND METHODS
A systematic review of published clinical trials, studies and case series was carried out using the Medline Express Databases and the Cochrane Collaboration Database from 1970 to October 2000.
RESULTS
Most studies published in the literature are in the form of successful case reports and single-arm series with small patient numbers. Most commonly used agents include hormonal agents, non-steroidal anti-inflammatory drugs (NSAIDs), interferons and cytotoxics. The literature data support the use of hormonal agents. Several questions, however, remain unresolved, such as which is the most suitable endocrine manipulation and what is the optimal dose and duration of treatment. NSAIDs and interferons have demonstrated activity against AF either alone or in combination with hormone therapy or chemotherapy but the precise mechanism of action is still unknown. Finally, there is growing evidence in the literature that chemotherapy is effective against AF with almost one in two patients being likely to respond.
CONCLUSIONS
The evidence in the literature supports the opinion that both non-cytotoxic and cytotoxic chemotherapies are effective against AF. However, the lack of sufficient patient numbers and randomized trials compromises the validity of the reported results and mandates further investigation with properly designed prospective studies including larger patient numbers, with main end points to include not only tumor response rate and survival but also quality-of-life issues.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Fibroma; Humans; Prognosis; Survival
PubMed: 12562642
DOI: 10.1093/annonc/mdg064 -
In Vivo (Athens, Greece) 2020Nuchal-type fibroma is a rare benign tumor arising from the connective tissue. Our aim was to present our experience via two cases of this tumor and a comprehensive... (Review)
Review
BACKGROUND
Nuchal-type fibroma is a rare benign tumor arising from the connective tissue. Our aim was to present our experience via two cases of this tumor and a comprehensive review of the literature.
PATIENTS AND METHODS
We report a case of a 23-year-old female with a mass located in the posterior neck and the upper back and a case of a 50-year-old male with a mass located in the posterior neck, which were proved to be nuchal-type fibromas in the histopathological examination. We also searched the PubMed/Medline database for published cases of nuchal-type fibromas.
RESULTS AND DISCUSSION
Nuchal-type fibroma is a rare benign tumor arising from the connective tissue, usually in the posterior neck, which affects different ages, with most patients being male. It is a poorly circumscribed tumor consisting of hypocellular, thick, dense and haphazardly arranged collagen bundles with entrapped adipocytes, nerve fibers and muscle fascicles and a few scattered spindle cells, which are CD34 positive. Its excision is curative, and the recurrence risk is generally low. However, patients with Gardner's syndrome may experience recurrence more frequently.
CONCLUSION
Nuchal-type fibroma should be included in the differential diagnosis of subcutaneous, soft-tissue masses, especially when these involve the posterior neck.
Topics: Adult; Diagnosis, Differential; Female; Fibroma; Gardner Syndrome; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neck; Neoplasm Recurrence, Local; Young Adult
PubMed: 32871744
DOI: 10.21873/invivo.12032 -
The Canadian Veterinary Journal = La... Oct 2021A 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass...
A 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.
Topics: Animals; Diagnosis, Differential; Dog Diseases; Dogs; Eyelids; Fibroma; Lacrimal Apparatus; Male; Neoplasm Recurrence, Local
PubMed: 34602632
DOI: No ID Found