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Journal of Neural Transmission (Vienna,... May 2020The substantial contributions of Dr. Gerald Stern to past and current treatments for Parkinson's disease patients are reviewed, which form the foundation for an... (Review)
Review
The substantial contributions of Dr. Gerald Stern to past and current treatments for Parkinson's disease patients are reviewed, which form the foundation for an evaluation of future options to control symptoms and halt progression of the disease. These opportunities will depend on a greater understanding of the relative contributions of the environment, genetic and epigenetic influences to disease onset, and promise to emerge as strategies for improving mitochondrial function, halting accumulation of synuclein and neuromelanin, in addition to refinement of stem cell and gene therapies. Such advances will be achieved through deployment of improved models for the disease.
Topics: History, 20th Century; History, 21st Century; Humans; Neurology; Parkinson Disease
PubMed: 32172471
DOI: 10.1007/s00702-020-02167-1 -
Neurology Sep 2018To update the 1995 American Academy of Neurology (AAN) practice parameter on persistent vegetative state and the 2002 case definition on minimally conscious state (MCS)... (Review)
Review
Practice guideline update recommendations summary: Disorders of consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability,...
OBJECTIVE
To update the 1995 American Academy of Neurology (AAN) practice parameter on persistent vegetative state and the 2002 case definition on minimally conscious state (MCS) and provide care recommendations for patients with prolonged disorders of consciousness (DoC).
METHODS
Recommendations were based on systematic review evidence, related evidence, care principles, and inferences using a modified Delphi consensus process according to the AAN 2011 process manual, as amended.
RECOMMENDATIONS
Clinicians should identify and treat confounding conditions, optimize arousal, and perform serial standardized assessments to improve diagnostic accuracy in adults and children with prolonged DoC (Level B). Clinicians should counsel families that for adults, MCS (vs vegetative state [VS]/unresponsive wakefulness syndrome [UWS]) and traumatic (vs nontraumatic) etiology are associated with more favorable outcomes (Level B). When prognosis is poor, long-term care must be discussed (Level A), acknowledging that prognosis is not universally poor (Level B). Structural MRI, SPECT, and the Coma Recovery Scale-Revised can assist prognostication in adults (Level B); no tests are shown to improve prognostic accuracy in children. Pain always should be assessed and treated (Level B) and evidence supporting treatment approaches discussed (Level B). Clinicians should prescribe amantadine (100-200 mg bid) for adults with traumatic VS/UWS or MCS (4-16 weeks post injury) to hasten functional recovery and reduce disability early in recovery (Level B). Family counseling concerning children should acknowledge that natural history of recovery, prognosis, and treatment are not established (Level B). Recent evidence indicates that the term chronic VS/UWS should replace permanent VS, with duration specified (Level B). Additional recommendations are included.
Topics: Consciousness Disorders; Humans; Neurology; Physical and Rehabilitation Medicine; Practice Guidelines as Topic; Rehabilitation Research; United States
PubMed: 30089618
DOI: 10.1212/WNL.0000000000005926 -
Developmental Medicine and Child... Jan 2016
Topics: Brain; Humans; Neurology; Psychology
PubMed: 26767660
DOI: 10.1111/dmcn.12985 -
Annals of Neurology Oct 2020
Topics: COVID-19; Humans; Neurology; Remote Consultation; SARS-CoV-2
PubMed: 32662149
DOI: 10.1002/ana.25849 -
Brain : a Journal of Neurology Jan 2014
Topics: Neurology; Periodicals as Topic; Publishing
PubMed: 24371216
DOI: 10.1093/brain/awt349 -
Nature Reviews. Neurology Nov 2020Advances in neurology over the past 15 years have transformed the treatment of a number of conditions but have also raised new questions and challenges.
Advances in neurology over the past 15 years have transformed the treatment of a number of conditions but have also raised new questions and challenges.
Topics: Anniversaries and Special Events; Humans; Nervous System Diseases; Neurology
PubMed: 33024327
DOI: 10.1038/s41582-020-00424-1 -
Developmental Medicine and Child... Apr 2019
Topics: Child; Child Welfare; History, 20th Century; Humans; Neurology
PubMed: 30835826
DOI: 10.1111/dmcn.14169 -
AJNR. American Journal of Neuroradiology Oct 2018Deep learning is a form of machine learning using a convolutional neural network architecture that shows tremendous promise for imaging applications. It is increasingly... (Review)
Review
Deep learning is a form of machine learning using a convolutional neural network architecture that shows tremendous promise for imaging applications. It is increasingly being adapted from its original demonstration in computer vision applications to medical imaging. Because of the high volume and wealth of multimodal imaging information acquired in typical studies, neuroradiology is poised to be an early adopter of deep learning. Compelling deep learning research applications have been demonstrated, and their use is likely to grow rapidly. This review article describes the reasons, outlines the basic methods used to train and test deep learning models, and presents a brief overview of current and potential clinical applications with an emphasis on how they are likely to change future neuroradiology practice. Facility with these methods among neuroimaging researchers and clinicians will be important to channel and harness the vast potential of this new method.
Topics: Deep Learning; Humans; Neuroimaging; Neurology; Radiology
PubMed: 29419402
DOI: 10.3174/ajnr.A5543 -
Neuro-oncology Nov 2015
Topics: Humans; Immunotherapy; Medical Oncology; Neoplasms; Neurology
PubMed: 26516220
DOI: 10.1093/neuonc/nov261 -
Arquivos de Neuro-psiquiatria Dec 2023Jean-Martin Charcot, widely regarded as a leading founder of modern neurology, made substantial contributions to the understanding and characterization of numerous...
Jean-Martin Charcot, widely regarded as a leading founder of modern neurology, made substantial contributions to the understanding and characterization of numerous medical conditions. His initial focus was on internal medicine, later expanding to include neuropathology, general neurology, and eventually emerging fields such as neuropsychology and neuropsychiatry. Furthermore, Charcot's intellectual pursuits extended beyond medicine, encompassing research in art history, medical iconography, sociology, religious studies, and the arts, solidifying his status as a polymath.
Topics: Humans; Neurology; Neuropathology; Neuropsychiatry; France
PubMed: 37899048
DOI: 10.1055/s-0043-1775984