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Asian Pacific Journal of Cancer... 2016Leukemia is the most common neoplastic disease of the white blood cells which is important as a pediatric malignancy. Oral manifestations occur frequently in leukemic... (Review)
Review
Leukemia is the most common neoplastic disease of the white blood cells which is important as a pediatric malignancy. Oral manifestations occur frequently in leukemic patients and may present as initial evidence of the disease or its relapse. The symptoms include gingival enlargement and bleeding, oral ulceration, petechia, mucosal pallor, noma, trismus and oral infections. Oral lesions arise in both acute and chronic forms of all types of leukemia. These oral manifestations either may be the result of direct infiltration of leukemic cells (primary) or secondary to underlying thrombocytopenia, neutropenia, or impaired granulocyte function. Despite the fact that leukemia has long been known to be associated with oral lesions, the available literature on this topic consists mostly of case reports, without data summarizing the main oral changes for each type of leukemia. Therefore, the present review aimed at describing oral manifestations of all leukemia types and their dental management. This might be useful in early diagnosis, improving patient outcomes.
Topics: Disease Management; Granulocytes; Humans; Leukemia; Mouth Diseases; Neutropenia; Thrombocytopenia
PubMed: 27039811
DOI: 10.7314/apjcp.2016.17.3.911 -
Tropical Medicine and Health Jun 2022Noma is a bacterial, non-communicable, grossly destructive and disfiguring necrotising oro-facial disease. It is rare, but occurs most commonly in chronically... (Review)
Review
Noma is a bacterial, non-communicable, grossly destructive and disfiguring necrotising oro-facial disease. It is rare, but occurs most commonly in chronically malnourished children with other debilitating illnesses, in remote, poverty-stricken communities, mainly in sub-Saharan Africa, and much more rarely in central Latin America and in parts of Asia. In South Africa and in Zimbabwe, noma is observed, again rarely, in immunosuppressed HIV-seropositive subjects. The World Health Organization (WHO) has classified noma into five sequential stages: stage 1, acute necrotising ulcerative gingivitis; stage 2, oedema; stage 3, gangrene; stage 4, scarring; stage 5, sequela. In the opinion of the authors, this WHO classification requires fundamental re-appraisal. The purpose of this viewpoint article is to highlight the weaknesses of this classification, and to propose a simpler, more logical and practical evidence-based staging of noma, which if used should improve the quality and value of future epidemiological data about noma.
PubMed: 35698243
DOI: 10.1186/s41182-022-00431-6 -
Sensors (Basel, Switzerland) Mar 2023The enhanced proliferation of connected entities needs a deployment of innovative technologies for the next generation wireless networks. One of the critical concerns,... (Review)
Review
The enhanced proliferation of connected entities needs a deployment of innovative technologies for the next generation wireless networks. One of the critical concerns, however, is the spectrum scarcity, due to the unprecedented broadcast penetration rate nowadays. Based on this, visible light communication (VLC) has recently emerged as a viable solution to secure high-speed communications. VLC, a high data rate communication technology, has proven its stature as a promising complementary to its radio frequency (RF) counterpart. VLC is a cost-effective, energy-efficient, and secure technology that exploits the current infrastructure, specifically within indoor and underwater environments. Yet, despite their appealing capabilities, VLC systems face several limitations which constraint their potentials such as LED's limited bandwidth, dimming, flickering, line-of-sight (LOS) requirement, impact of harsh weather conditions, noise, interference, shadowing, transceiver alignment, signal decoding complexity, and mobility issue. Consequently, non-orthogonal multiple access (NOMA) has been considered an effective technique to circumvent these shortcomings. The NOMA scheme has emerged as a revolutionary paradigm to address the shortcomings of VLC systems. The potentials of NOMA are to increase the number of users, system's capacity, massive connectivity, and enhance the spectrum and energy efficiency in future communication scenarios. Motivated by this, the presented study offers an overview of NOMA-based VLC systems. This article provides a broad scope of existing research activities of NOMA-based VLC systems. This article aims to provide firsthand knowledge of the prominence of NOMA and VLC and surveys several NOMA-enabled VLC systems. We briefly highlight the potential and capabilities of NOMA-based VLC systems. In addition, we outline the integration of such systems with several emerging technologies such as intelligent reflecting surfaces (IRS), orthogonal frequency division multiplexing (OFDM), multiple-input and multiple-output (MIMO) and unmanned aerial vehicles (UAVs). Furthermore, we focus on NOMA-based hybrid RF/VLC networks and discuss the role of machine learning (ML) tools and physical layer security (PLS) in this domain. In addition, this study also highlights diverse and significant technical hindrances prevailing in NOMA-based VLC systems. We highlight future research directions, along with provided insights that are envisioned to be helpful towards the effective practical deployment of such systems. In a nutshell, this review highlights the existing and ongoing research activities for NOMA-based VLC systems, which will provide sufficient guidelines for research communities working in this domain and it will pave the way for successful deployment of these systems.
PubMed: 36991671
DOI: 10.3390/s23062960 -
SAGE Open Medicine 2022The aim of this review was to describe malnutrition and poor oral hygiene, the most common risk factors for noma. (Review)
Review
OBJECTIVES
The aim of this review was to describe malnutrition and poor oral hygiene, the most common risk factors for noma.
METHODS
A vigorous literature searches were conducted on databases such as Scopus, Elsevier, Web of Science, PubMed, Virtual Health Library, and Google Scholar by inserting keywords such as 'noma' OR 'cancrum oris' OR 'cancrum oris cases'. A total of 65 articles gathered. Of these, 38 articles found to be eligible for this study.
RESULTS
A total of 38 full-length articles were included in the review. According to the evidence gathered and summarized in this review, malnutrition, especially protein-energy malnutrition and vitamin deficiencies, makes the oral mucosa susceptible to opportunistic pathogens of noma, and then, in so doing, pathogens invade the oral cavities. Malnutrition has a bidirectional relationship with noma. Since noma is a disease of the oral cavity, poor oral hygiene has the potential of predispose and worsen the disease's progress.
CONCLUSION
Malnutrition and poor oral hygiene found to be ingrained in the pathogenesis of noma. For effective management and prevention of noma, it is necessary to underpin adequate nutritional supplementation (including vitamins). As a primary prevention strategy, healthcare workers' training should be strengthened to improve the diagnosis and treatment of oral infections, including noma.
PubMed: 35707345
DOI: 10.1177/20503121221098110 -
Transactions of the Royal Society of... Oct 2022Noma is a debilitating orofacial necrotizing bacterial disease that disproportionately affects impoverished malnourished persons, particularly young children, the vast...
Noma is a debilitating orofacial necrotizing bacterial disease that disproportionately affects impoverished malnourished persons, particularly young children, the vast majority of whom live in tropical and subtropical areas in sub-Saharan Africa. It has a very high mortality rate; causes significant physical and psychological morbidity, stigmatization and social discrimination; could be prevented, controlled and indeed eliminated by common public health interventions; and is overlooked with regard to public health awareness, in-depth scientific research activities and allocation of funding for prevention, treatment and research. According to the WHO, noma comprises five sequential 'stages': (1) necrotizing gingivitis, (2) edema, (3) gangrene, (4) scarring and (5) sequelae. This WHO staging of noma is contentious, leading to diagnostic confusion with misestimation of the number of noma cases reported in epidemiological studies. We therefore suggest a simpler, more practical and scientifically valid two-stage classification comprising only (1) acute noma and (2) arrested noma. Noma meets all the WHO criteria for classification as a neglected tropical disease (NTD). Most survivors of noma live with gross physical disfigurement and disability, and with impaired psychosocial functioning, so they are very often stigmatized and unjustifiably discriminated against. Owing to the paucity of evidence-based epidemiological data on noma, the relatively low number of people affected worldwide, and its apparently limited geographic distribution, noma does not yet feature on the WHO's list of NTDs, or on any global health agenda, and thus has not become a health priority for global action. We strongly support the inclusion of noma within the WHO list of NTDs. Without doubt this will increase the awareness of noma among healthcare providers and promote the systematic international accumulation and recording of data about noma.
Topics: Africa South of the Sahara; Child; Child, Preschool; Global Health; Humans; Malnutrition; Neglected Diseases; Noma
PubMed: 35576473
DOI: 10.1093/trstmh/trac043 -
Sensors (Basel, Switzerland) Sep 2020The secure full-duplex (FD) simultaneous wireless information and power transfer (SWIPT) system and non-orthogonal multiple access (NOMA) have been deemed two promising...
The secure full-duplex (FD) simultaneous wireless information and power transfer (SWIPT) system and non-orthogonal multiple access (NOMA) have been deemed two promising technologies for the next generation of wireless communication. In this paper, the network is combined with device-to-device (D2D) and a practical bounded channel state information (CSI) estimation scheme. A system total transmit power minimization problem is studied and formulated as a multi-objective optimization (MOO) problem via the weighted Tchebycheff approach. A set of linear matrix inequalities (LMI) is used to transform the non-convex form of constraints into the convex form. Considering the imperfect CSI of the potential eavesdropper for robust power allocation, a bounded transmission beamforming vector design along with artificial noise (AN) is used, while satisfying the requirements from the secrecy rates as well as the energy harvesting (EH) task. Numerical simulation results validate the convergence performance and the trade-off between the uplink (UL) and downlink (DL) data transmit power. It is also shown that by FD and NOMA, the performance of the proposed algorithm is higher than that of half-duplex (HD) and orthogonal multiple access (OMA).
PubMed: 32967155
DOI: 10.3390/s20185395 -
The Lancet. Global Health Feb 2024
Topics: Humans; Noma; Risk Factors; Neglected Diseases
PubMed: 38245102
DOI: 10.1016/S2214-109X(24)00006-8