-
Head and Neck Pathology Dec 2021Ameloblastic fibro-odontoma (AFO) is a controversial, rare benign mixed odontogenic tumour that was re-defined as "developing odontoma" in the 2017 WHO classification...
Ameloblastic fibro-odontoma (AFO) is a controversial, rare benign mixed odontogenic tumour that was re-defined as "developing odontoma" in the 2017 WHO classification arguing that once dental hard tissues form, it is programmed to transform into odontoma. However, AFO still remains unclear in terms of its nature. We aimed to analyze a large series of AFOs and compare it to a large series of odontomas (ODs) in an attempt to set cut-off diagnostic parameters between these entities and discuss latest updates on AFO histopathologic, clinical and molecular features. A total of 23 well-documented AFOs were analyzed versus 310 ODs focusing on the age of the patients and size of the lesions. For AFO, mean age was 9.4 ± 3.9 years (range 3-16 years) and mean size (greatest diameter) was 2.9 ± 1.5 cm (range 0.8-5.5 cm). For OD-mean age was 26.5 ± 15.6 years (range 3-81 years), mean size 1.9 ± 0.9 cm (range 1-5 cm). Receiver operating curve (ROC) showed that a cut-off age of 13.5 years and below [area under the curve (AUC) 0.902, 95%CI 0.859-0.945; p < 001; sensitivity 80%, specificity 87%] and a cut-off size of 2.1 cm and above are likely to be associated with AFO (AUC 0.7, 95%CI 0.574-0.827; p = 0.001; sensitivity 57%, specificity 77%). Thus, the combination of age and lesion size may be used to distinguish between lesions of a true neoplastic nature (i.e., AFO) and hamartomatous formation (i.e., OD). Further molecular and genetic specifications are needed to provide a better understanding on the pathogenesis of AFO in support of our suggestion and aid in an accurate classification of AFO.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Female; Humans; Male; Mandibular Neoplasms; Maxillary Neoplasms; Odontoma; Radiography, Panoramic; Retrospective Studies; Sensitivity and Specificity; Tomography, X-Ray Computed
PubMed: 33991318
DOI: 10.1007/s12105-021-01332-6 -
Sultan Qaboos University Medical Journal Aug 2017Odontogenic tumours are lesions that occur solely within the oral cavity and are so named because of their origin from the odontogenic (i.e. tooth-forming) apparatus.... (Review)
Review
Odontogenic tumours are lesions that occur solely within the oral cavity and are so named because of their origin from the odontogenic (i.e. tooth-forming) apparatus. Odontogenic tumours comprise a variety of lesions ranging from non-neoplastic tissue proliferations to benign or malignant neoplasms. However, controversies exist regarding the pathogenesis, categorisation and clinical and histological variations of these tumours. The recent 2017 World Health Organization classification of odontogenic tumours included new entities such as primordial odontogenic tumours, sclerosing odontogenic carcinomas and odontogenic carcinosarcomas, while eliminating several previously included entities like keratocystic odontogenic tumours and calcifying cystic odonogenic tumours. The aim of the present review article was to discuss controversies and recent concepts regarding odontogenic tumours so as to increase understanding of these lesions.
Topics: Ameloblastoma; Carcinoma; Humans; Odontogenesis; Odontogenic Tumors; Odontoma; World Health Organization
PubMed: 29062548
DOI: 10.18295/squmj.2017.17.03.003 -
Journal of Clinical and Experimental... May 2019Ameloblastic fibroma (AF) and ameloblastic fibro-odontoma (AFO) are uncommon benign mixed odontogenic neoplasms. Although unusual microscopic changes including hybrid... (Review)
Review
BACKGROUND
Ameloblastic fibroma (AF) and ameloblastic fibro-odontoma (AFO) are uncommon benign mixed odontogenic neoplasms. Although unusual microscopic changes including hybrid tumors have been documented in publications, their clinical outcome prediction and treatment modality selection are still challenging due to scarcity. Objective: Analysis of AF/AFO's unusual microscopic variants in order to improve histopathologic diagnosis and to help clinicians in making informed treatment choices.
MATERIAL AND METHODS
An electronic search was performed in PubMed's database using keywords: "ameloblastic fibroma", "ameloblastic fibroodontoma", "ameloblastic fibro-odontoma". The search scheme was limited to articles in English, dated 'January 1998' to 'October 2018', with full texts (case reports and series) and human studies. Eligibility criteria included publications having enough clinical, radiological, and histological data to confirm their diagnosis. Age, sex, lesions' location, radiologic features, signs, symptoms, treatment approaches, and recurrences were recorded and analyzed.
RESULTS
In this systematic review, 11 articles (reporting 14 cases) were selected. Patients' mean age was 13.75 years (male/female = 1.8). The posterior region of the mandible was the lesions' commonest location (57.14%). Swelling was reported in 78.57% of the cases, pain in 28.57% but 21.42% were asymptomatic. Radiolucent unilocular appearance was the commonest radiographic feature, but 28.57% of the cases showed a mixed radiolucent-radiopaque appearance. Other reported radiographic findings were impacted tooth (78.57%), root resorption (28.57%), tooth mobility (35.71%), and cortical perforation (14.28%). No recurrences were reported. Calcifying odontogenic cyst (COC) was the commonest lesion associated with AF/AFO (53.33%). Unicystic ameloblastoma and cystic changes without prominent epithelial lining were other reported hybrid lesions. Reported microscopic variations were pigmentation and ghost cell differentiation.
CONCLUSIONS
COC was the commonest lesion associated with AF/AFO. Although COC commonly occurs in the jaws' anterior region, hybrid cases were more common in the posterior area. No malignant transformations were reported. The treatment modality is mostly chosen based on the lesion's most aggressive part. Ameloblastic fibroma, Ameloblastic fibro-odontoma, Odontogenic tumor, Jaw.
PubMed: 31275522
DOI: 10.4317/jced.55460 -
Journal of Istanbul University Faculty... 2017Odontogenic tumors are a heterogeneous group of lesions of diverse clinical behavior and histopathologic types, ranging from hamartomatous lesions to malignancy. Because... (Review)
Review
Odontogenic tumors are a heterogeneous group of lesions of diverse clinical behavior and histopathologic types, ranging from hamartomatous lesions to malignancy. Because odontogenic tumors arise from the tissues which make our teeth, they are unique to the jaws, and by extension almost unique to dentistry. Odontogenic tumors, as in normal odontogenesis, are capable of inductive interactions between odontogenic ectomesenchyme and epithelium, and the classification of odontogenic tumors is essentially based on this interaction. The last update of these tumors was published in early 2017. According to this classification, benign odontogenic tumors are classified as follows: Epithelial, mesenchymal (ectomesenchymal), or mixed depending on which component of the tooth germ gives rise to the neoplasm. Malignant odontogenic tumors are quite rare and named similarly according to whether the epithelial or mesenchymal or both components is malignant. The goal of this review is to discuss the updated changes to odontogenic tumors and to review the more common types with clinical and radiological illustrations.
PubMed: 29354306
DOI: 10.17096/jiufd.52886 -
The Veterinary Clinics of North... Sep 2016The order Rodentia comprises more than 2000 species divided into 3 groups based on anatomic and functional differences of the masseter muscle. Myomorph and sciuromorph... (Review)
Review
The order Rodentia comprises more than 2000 species divided into 3 groups based on anatomic and functional differences of the masseter muscle. Myomorph and sciuromorph species have elodont incisors and anelodont cheek teeth, unlike hystrichomorph species which have full anelodont dentition. Diseases of incisors and cheek teeth of rat-like and squirrel-like rodents result in a wide variety of symptoms and clinical signs. Appropriate diagnostic testing and imaging techniques are required to obtain a definitive diagnosis, formulate a prognosis, and develop a treatment plan. A thorough review of elodontoma, odontoma, and pseudo-odontoma is provided, including treatment of pseudo-odontomas in prairie dogs.
Topics: Animals; Mouth; Rats; Rodent Diseases; Sciuridae; Stomatognathic Diseases; Tomography, X-Ray Computed
PubMed: 27497210
DOI: 10.1016/j.cvex.2016.04.008 -
Head and Neck Pathology Sep 2022Peripheral or extraosseous odontogenic tumors are rare oral soft tissue enlargements which demonstrate the same histologic features of their intraosseous counterparts... (Review)
Review
Peripheral or extraosseous odontogenic tumors are rare oral soft tissue enlargements which demonstrate the same histologic features of their intraosseous counterparts but emerge in gingiva and mucosa. In this paper we report a case of peripheral odontoma in a 12-years-old female patient presented asymptomatic swelling in the palatal site. After the clinical and radiographic examination, excisional biopsy was applied to the lesion located entirely in the soft tissue of maxillary incisors. Histopathologically presence of tooth-like structures containing dentin with regular canals and partly enamel matrix were observed. Our aim is to present the extremely rare case of peripheral odontoma and to review the literature for demonstrating the frequency and clinicopathologic features of this entity.
Topics: Biopsy; Child; Face; Female; Humans; Odontogenic Tumors; Odontoma
PubMed: 35119618
DOI: 10.1007/s12105-022-01421-0 -
Head and Neck Pathology Mar 2023Homeobox genes play crucial roles in tooth morphogenesis and development and thus mutations in homeobox genes cause developmental disorders such as odontogenic lesions.... (Review)
Review
BACKGROUND
Homeobox genes play crucial roles in tooth morphogenesis and development and thus mutations in homeobox genes cause developmental disorders such as odontogenic lesions. The aim of this scoping review is to identify and compile available data from the literatures on the topic of homeobox gene expression in odontogenic lesions.
METHOD
An electronic search to collate all the information on studies on homeobox gene expression in odontogenic lesions was carried out in four databases (PubMed, EBSCO host, Web of Science and Cochrane Library) with selected keywords. All papers which reported expression of homeobox genes in odontogenic lesions were considered.
RESULTS
A total of eleven (11) papers describing expression of homeobox genes in odontogenic lesions were identified. Methods of studies included next generation sequencing, microarray analysis, RT-PCR, Western blotting, in situ hybridization, and immunohistochemistry. The homeobox reported in odontogenic lesions includes LHX8 and DLX3 in odontoma; PITX2, MSX1, MSX2, DLX, DLX2, DLX3, DLX4, DLX5, DLX6, ISL1, OCT4 and HOX C in ameloblastoma; OCT4 in adenomatoid odontogenic tumour; PITX2 and MSX2 in primordial odontogenic tumour; PAX9 and BARX1 in odontogenic keratocyst; PITX2, ZEB1 and MEIS2 in ameloblastic carcinoma while there is absence of DLX2, DLX3 and MSX2 in clear cell odontogenic carcinoma.
CONCLUSIONS
This paper summarized and reviews the possible link between homeobox gene expression in odontogenic lesions. Based on the current available data, there are insufficient evidence to support any definite role of homeobox gene in odontogenic lesions.
Topics: Humans; Genes, Homeobox; Homeodomain Proteins; Transcription Factors; Ameloblastoma; Odontogenic Tumors; Carcinoma; Odontogenic Cysts
PubMed: 36344906
DOI: 10.1007/s12105-022-01481-2 -
International Journal of Clinical... 2011Odontomas are the most common type of odontogenic tumors. They are included under the benign calcified odontogenic tumors. Odontomas are basically classified into two... (Review)
Review
Odontomas are the most common type of odontogenic tumors. They are included under the benign calcified odontogenic tumors. Odontomas are basically classified into two types, complex and compound odontomes. Various theories or etiological factors are been quoted for the occurrence of odontomes. Generally, they are asymptomatic. Occasionally, signs and symptoms relating to their presence do occur. The sole management depends upon the early diagnosis, histopathological examination and excision of these tissues. This article briefs regarding its classification, etiological factors, occurrence, differences between complex and compound odontomes, diagnosis and management.
PubMed: 27678223
DOI: 10.5005/jp-journals-10005-1106 -
Clinical Case Reports Apr 2022The World Health Organization (WHO) classifies odontomas as odontogenic tumors, consisting of odontogenic epithelium and ectomesenchyme. They result from developmental...
The World Health Organization (WHO) classifies odontomas as odontogenic tumors, consisting of odontogenic epithelium and ectomesenchyme. They result from developmental abnormalities and, therefore, do not constitute authentic tumors. It is a local malformation that has no growth autonomy. They are rarely symptomatic and are usually discovered accidentally during the realization of a radiographic examination. There are two variants of odontomas: complex and compound. Complex odontomas are made of a mass consisting of an anarchic assembly of mineralized tissue (enamel, dentin, and cementum) and dental pulp; while compound odontomas are consisting of a set of small rudimentary teeth, assembling in clusters. They rarely show the features of both types together. The aim of this work is to report a rare presentation of an odontoma in a 24-year-old male patient, which present the characteristics of both complex and compound variants. Surgical excision of the lesion was performed. Anatomopathological examination confirmed the diagnosis. Clinical and radiological survey does not show any recurrence.
PubMed: 35387291
DOI: 10.1002/ccr3.5658 -
Journal of Clinical and Experimental... Aug 2019The variety of characteristics related to odontoma research, including an unexplored one such as size, merits a multivariate approach that allows the adequate drawing of...
BACKGROUND
The variety of characteristics related to odontoma research, including an unexplored one such as size, merits a multivariate approach that allows the adequate drawing of inferences with pertinent conclusions. The objective of this study is to establish the possible association between some characteristics related to the odontoma, tumor size among them.
MATERIAL AND METHODS
The sociodemographic characteristics of 60 patients were evaluated. Diagnosis, size, location, type of treatment performed, and prognosis were determined. These data were analyzed descriptively and through multivariate models.
RESULTS
Thirty-four compound and 26 complex odontomas in 32 men and 28 women were observed. The age average of patients was 15.6±11 years. Most of the odontomas presented a size inferior to 10 mm. A statistically significant association was observed between the routine radiographic finding and the absence of dental eruption (=0.0001). The model of linear regression adjusted between odontoma size and age (β=0.321, =0.01), as well as the model of logistic regression adjusted between gender (men) and tumor size (OR=12; 1.7 - 93 IC 95%, (=0.01) were statistically significant.
CONCLUSIONS
Statistically significant associations between odontoma size and age, and between the male gender and odontomas smaller than 10 mm were found adjusting by other confounding variables. These results could grant clinicians a greater knowledge of the context of odontoma characteristics, which in turn could favor a better diagnostic and therapeutic decision-making. Odontoma, compound odontoma, diagnosis, multivariate analysis.
PubMed: 31598198
DOI: 10.4317/jced.55733