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Report on Carcinogens : Carcinogen... 2011
Topics: Animals; Carcinogens; Humans; Neoplasms; Toluene
PubMed: 21850111
DOI: No ID Found -
Bioscience Reports Jun 2019Long noncoding RNAs (LncRNAs) refer to the RNA with a length of >200 nucleotides, which lack or have no open reading coding frame and have higher tissue and organ... (Review)
Review
Long noncoding RNAs (LncRNAs) refer to the RNA with a length of >200 nucleotides, which lack or have no open reading coding frame and have higher tissue and organ specificity compared with the protein coding genes. A surging number of studies have shown that lncRNA is involved in numerous essential regulatory processes, such as X chromosome silencing, genomic imprinting, chromatin modification, transcriptional activation, transcriptional interference and nuclear transport, which are closely related to the occurrence and development of human malignancies. FEZ family Zinc Finger 1-Antisense RNA 1 (FEZF1-AS1) of FEZ family is a recently discovered lncRNA. FEZF1-AS1 is highly expressed in pancreatic cancer, colorectal cancer, lung adenocarcinoma and other human malignancies, and is associated with poor prognosis. As an oncogene, it plays crucial role in the proliferation, migration, invasion and Warburg effect of various tumor cells. In addition, FEZF1-AS1 is also involved in the regulation of multiple signal pathways such as epithelial-mesenchymal transition (EMT), signal transducer and activator of transcription 3 (STAT3) and Wnt/ β-catenin. In this paper, the recent research progress of FEZF1-AS1 in tumorigenesis and development is reviewed systematically.
Topics: Animals; Carcinogenesis; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neoplasms; Oncogenes; RNA, Long Noncoding
PubMed: 31175144
DOI: 10.1042/BSR20191202 -
Molecules (Basel, Switzerland) Apr 2020The incidence of adverse reactions in food is very low, however, some food products contain toxins formed naturally due to their handling, processing and storage... (Review)
Review
The incidence of adverse reactions in food is very low, however, some food products contain toxins formed naturally due to their handling, processing and storage conditions. 5-(Hydroxymethyl)-2-furfural (HMF) can be formed by hydrogenation of sugar substances in some of manufactured foodstuffs and honey under elevated temperatures and reduced pH conditions following Maillard reactions. In previous studies, it was found that HMF was responsible for harmful (mutagenic, genotoxic, cytotoxic and enzyme inhibitory) effects on human health. HMF occurs in a wide variety of food products like dried fruit, juice, caramel products, coffee, bakery, malt and vinegar. The formation of HMF is not only an indicator of food storage conditions and quality, but HMF could also be used as an indicator of the potential occurrence of contamination during heat-processing of some food products such as coffee, milk, honey and processed fruits. This review focuses on HMF formation and summarizes the adverse effects of HMF on human health.
Topics: Animals; Carcinogens; Dairy Products; Dietary Exposure; Furaldehyde; Hot Temperature; Molecular Structure
PubMed: 32331408
DOI: 10.3390/molecules25081941 -
International Journal of Environmental... May 2023: Cancer is the leading cause of death in Canada and a major cause of death worldwide. Environmental exposure to carcinogens and environments that may relate to health... (Review)
Review
: Cancer is the leading cause of death in Canada and a major cause of death worldwide. Environmental exposure to carcinogens and environments that may relate to health behaviors are important to examine as they can be modified to lower cancer risks. Built environments include aspects such as transit infrastructure, greenspace, food and tobacco environments, or land use, which may impact how people move, exercise, eat, and live. While environments may play a role in overall cancer risk, exposure to carcinogens or healthier environments is not equitably spread across space. Exposures to carcinogens commonly concentrate among socially and/or economically disadvantaged populations. While many studies have examined inequalities in exposure or cancer risk, this has commonly been for one exposure. : This scoping review collected and synthesized research that examines inequities in carcinogenic environments and exposures. : This scoping review found that neighborhoods with higher proportions of low-income residents, racialized people, or same-sex couples had higher exposures to carcinogens and environments that may influence cancer risk. There are currently four main themes in research studying inequitable exposures: air pollution and hazardous substances, tobacco access, food access, and other aspects of the built environment, with most research still focusing on air pollution. : More work is needed to understand how exposures to these four areas intersect with other factors to reduce inequities in exposures to support longer-term goals toward cancer prevention.
Topics: Humans; Carcinogens; Neoplasms; Environmental Exposure; Air Pollution; Hazardous Substances
PubMed: 37174236
DOI: 10.3390/ijerph20095718 -
Journal of the National Medical... Jan 1997Increasing efforts to reduce the burden of cancer have brought into sharp relief the relevance of cancer risk assessment in preventing the occurrence and, when that is... (Review)
Review
Increasing efforts to reduce the burden of cancer have brought into sharp relief the relevance of cancer risk assessment in preventing the occurrence and, when that is not possible, preventing the progression of the disease. Methods for estimating human cancer risk have evolved steadily over the past few decades as more has been learned about molecular, genetic, and biological aspects of cancer. These methods have been applied with increasing frequency in community-based approaches to reduce the risk of environmentally provoked cancers. At the same time, patients are showing increased interest in estimates of their likelihood of developing cancer during the next 10, 20, or 30 years. This interest is involving more physicians in human cancer risk assessment in clinical counseling settings.
Topics: Biomarkers; Carcinogens; Counseling; Disease Progression; Environmental Exposure; Genes, p53; Humans; Mutation; Neoplasms; Patient Education as Topic; Proto-Oncogenes; Risk Assessment; Risk Factors; Tumor Suppressor Protein p53
PubMed: 9002413
DOI: No ID Found -
IARC Monographs on the Evaluation of... 1999
Topics: Animals; Carcinogenicity Tests; Carcinogens; Ethyl Chloride; Humans; Mutagenicity Tests; Mutagens; Neoplasms, Experimental
PubMed: 10476409
DOI: No ID Found -
IARC Monographs on the Evaluation of... 1999
Topics: Acetonitriles; Animals; Carcinogenicity Tests; Carcinogens; Humans; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Water Pollutants, Chemical
PubMed: 10476406
DOI: No ID Found -
IARC Monographs on the Evaluation of... 1999
Topics: Animals; Carcinogenicity Tests; Carcinogens; Humans; Hydrocarbons, Brominated; Neoplasms, Experimental
PubMed: 10476402
DOI: No ID Found -
IARC Monographs on the Evaluation of... 1999
Topics: Animals; Carcinogenicity Tests; Carcinogens; Chromosome Aberrations; Environmental Exposure; Humans; Morpholines; Mutagenicity Tests; Mutagens
PubMed: 10476435
DOI: No ID Found -
IARC Monographs on the Evaluation of... 1999
Topics: Acetonitriles; Animals; Carcinogenicity Tests; Carcinogens; Humans; Mutagenicity Tests; Mutagens; Salmonella typhimurium
PubMed: 10476415
DOI: No ID Found