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Case Reports in Dermatological Medicine 2016Onychomadesis is a clinical sign of nail plate separation due to transient or permanent arrest of nail matrix activities. Onychomadesis can be considered as a severe...
Onychomadesis is a clinical sign of nail plate separation due to transient or permanent arrest of nail matrix activities. Onychomadesis can be considered as a severe form of Beau's line. This condition usually occurs after trauma, causal diseases, or medications, yet it rarely occurs as an idiopathic condition. We report a case of a 38-year-old Thai female who developed recurrence onychomadesis in several toenails in the absence of predisposing factors or associated conditions. To the best of our knowledge, our patient is the first reported case of idiopathic onychomadesis limited to toenails.
PubMed: 27437152
DOI: 10.1155/2016/6451327 -
BMC Dermatology Jan 2019Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease that is notoriously difficult to treat. Nail involvement in MMP is rare.
BACKGROUND
Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease that is notoriously difficult to treat. Nail involvement in MMP is rare.
CASE PRESENTATION
We report on a 58 years old man with severe MMP who presented with onychomadesis.
CONCLUSION
To our knowledge, mucous membrane pemphigoid associated paronychia and onychomadesis have not been reported before. We believe it is important for dermatologists to be aware of this entity.
Topics: Humans; Male; Middle Aged; Paronychia; Pemphigoid, Benign Mucous Membrane
PubMed: 30674299
DOI: 10.1186/s12895-019-0083-7 -
Proceedings of the Royal Society of... Sep 1937
PubMed: 19991264
DOI: No ID Found -
Indian Journal of Dermatology,... May 2024
PubMed: 38841936
DOI: 10.25259/IJDVL_1269_2023 -
Visual Journal of Emergency Medicine Jul 2021
PubMed: 34307903
DOI: 10.1016/j.visj.2021.101087 -
International Journal of STD & AIDS Jul 2016
Topics: Adult; Anti-Bacterial Agents; Humans; Injections, Intramuscular; Male; Nail Diseases; Nails; Penicillin G Benzathine; Syphilis; Treatment Outcome
PubMed: 27278451
DOI: 10.1177/0956462416628703 -
Skin Appendage Disorders Jan 2018Mycosis fungoides (MF) has a wide range of clinical presentations and it has been reported rarely to involve the nail apparatus.
BACKGROUND
Mycosis fungoides (MF) has a wide range of clinical presentations and it has been reported rarely to involve the nail apparatus.
OBJECTIVE
We intended to evaluate the frequency and characteristics of nail changes in patients with biopsy-proven MF.
METHODS
A retrospective analysis of 60 patients with MF who were evaluated at our cancer center from 2013 to 2014 was performed to identify patients with nail changes. Histological examinations of the skin around the nail apparatus were obtained from 10 patients with periungual skin erythema and scaling.
RESULTS
In 45 patients out of 60 cases, the skin around the nail apparatus was normal, and only in 5 patients of these 45 cases, nail changes were detected. These changes included leukonychia, longitudinal ridging, nail thickening, and opacity. In the remaining 15 patients, erythema and scaling was observed in periungual skin, and 13 of them demonstrated nail changes including longitudinal ridging, nail thickening, fragility of the nail plate, subungual hyperkeratosis, pigmented nail band, Beau's lines, onychomadesis, koilonychia, nail thinning, distal notching, subungual debris, leukonychia, and pitting. In biopsies of periungual skin, none of 10 cases revealed histological findings consistent with MF.
CONCLUSIONS
Evidence of nail changes was observed in 18 cases (30%). The most common nail changes detected in MF patients included longitudinal ridging, nail thickening, nail fragility, and leukonychia.
PubMed: 29457018
DOI: 10.1159/000478946 -
Proceedings (Baylor University. Medical... Jan 2021Kawasaki disease is a vasculitis of medium-sized vessels and the most common cause of acquired heart defects in the United States. Although its etiology is unclear, an...
Kawasaki disease is a vasculitis of medium-sized vessels and the most common cause of acquired heart defects in the United States. Although its etiology is unclear, an infectious trigger has been theorized, which has been highlighted by the recent pandemic. We present a case of a 17-month-old-girl with concurrent Kawasaki disease and non-SARS-CoV2 coronavirus infection and a sequela of onychomadesis.
PubMed: 33953481
DOI: 10.1080/08998280.2020.1866930 -
Euro Surveillance : Bulletin Europeen... Sep 2010In July 2008 an onychomadesis outbreak in a nursery setting was reported in Saragossa (Spain). Some of the cases had previously suffered from hand, foot and mouth...
In July 2008 an onychomadesis outbreak in a nursery setting was reported in Saragossa (Spain). Some of the cases had previously suffered from hand, foot and mouth disease (HFMD). In order to study the outbreak and to determine the relation between the two diseases, two epidemiological studies were conducted: a descriptive study focused on cases and a retrospective cohort study. Samples from stool, pharynx and nails were obtained from cases for microbiological analysis. During the study period, 27 children fulfilled the case definition. The average age was 1.8 years. A case shed on average four nails (minimum one maximum twelve). Twenty-four of the 27 cases had previously presented with HFMD which started an average of 40 days before the onset of onychomadesis (relative risk: 14). Unidentified non-polio enterovirus (n=10), coxsackie B1 (n=4) and coxsackie B2 virus (n=3) were isolated in 28 specimens obtained from 14 cases. The analysis showed a strong association between HMFD and onychomadesis. Microbiological results have not been conclusive; consequently more studies are necessary to determine the causal agent of infectious onychomadesis.
Topics: Child Day Care Centers; Child, Preschool; Cohort Studies; Disease Outbreaks; Epidemiologic Studies; Female; Hand, Foot and Mouth Disease; Humans; Infant; Male; Nail Diseases; Retrospective Studies; Spain
PubMed: 20929644
DOI: No ID Found -
BMC Pediatrics Aug 2020Evidence of hand, foot, and mouth disease (HFMD) in neonates is limited. The aim of this study was to evaluate the clinical symptoms, pathogens, possible transmission...
BACKGROUND
Evidence of hand, foot, and mouth disease (HFMD) in neonates is limited. The aim of this study was to evaluate the clinical symptoms, pathogens, possible transmission routes, and prognosis of neonatal HFMD in Shanghai.
METHODS
This was a case-control study based on the HFMD registry surveillance system. All neonates and infected family members were enrolled between 2016 and 2017 in Shanghai. Neonates with HFMD were followed for at least half a year. Detailed questionnaires, medical history, and physical examination were recorded. Routine blood examination, liver and renal function, immunophenotypes of peripheral blood lymphocytes (CD3, CD4, and CD8 T-cells; NK cells), immunoglobulin (Ig) M, IgG, and IgA, and cytokine interleukin (IL-1β, IL-2R, IL-6, IL-8, IL-10, and TNF-α) levels were measured. All rectal swab specimens were collected and genotyped for enterovirus, and phylogenetic analysis based on the VP1 sequences of coxsackievirus A6 (CV-A6) was performed to investigate molecular and evolutionary characteristics. T-test or nonparametric test was used to evaluate the differences. Logistic analysis was applied to calculate the risk of clinical manifestations in the group of HFMD neonates and their paired siblings.
RESULTS
There were 16 neonates among the 12,608 diagnosed patients with HFMD, accounting for 0.13%. All neonatal infections were transmitted by other members of the family, mainly the elder siblings, and were caused by CV-A6. CV-A6 was the emerging and predominant causative agent of HFMD in Shanghai. None of the neonates with HFMD experienced fever, onychomadesis, or severe complications. However, two elder sibling patients showed lethargy, and one developed hypoperfusion. In the elder siblings with HFMD, the proportion of white blood cells was generally higher than in neonates with HFMD. The immunologic function of the neonates with HFMD was basically normal. The levels of inflammatory markers were higher in both neonates and elder siblings with HFMD compared to age-matched controls. The clinical symptoms receded about 1 week after onset. None of the neonates had sequelae.
CONCLUSIONS
In our study, CV-A6 infection in neonates was benign, but had the character of family clustering. Due to the two-child policy in China, elder siblings may be the main route of HFMD transmission.
Topics: Aged; Case-Control Studies; Child; China; Enterovirus; Hand, Foot and Mouth Disease; Humans; Infant, Newborn; Phylogeny
PubMed: 32741368
DOI: 10.1186/s12887-020-02262-y