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Annals of Transplantation 2005This review paper outlines the physiological evidence for the benefit derived from sport after an organ transplant. The psychological and social benefit which follows... (Review)
Review
This review paper outlines the physiological evidence for the benefit derived from sport after an organ transplant. The psychological and social benefit which follows the taking part in sporting competitions is also briefly examined. The part played by the World Transplant Games Federation, the proficiency, the results achieved and details of the various events held are described. The surprisingly effective part which graded physical exercise plays in overcoming the handicaps imposed on the recipients of a successful organ transplant by the effects of preceding long-term illness, necessary medication including immunosuppressive therapy and a non innervated organ is examined.
Topics: Exercise; Health Status; Humans; Life Style; Organ Transplantation; Sports
PubMed: 15926755
DOI: No ID Found -
Transplant International : Official... Jun 2019Transplantation is the only curative treatment option available for patients suffering from end-stage organ failure, improving their quality of life and long-term... (Review)
Review
Transplantation is the only curative treatment option available for patients suffering from end-stage organ failure, improving their quality of life and long-term survival. However, because of organ scarcity, only a small number of these patients actually benefit from transplantation. Alternative treatment options are needed to address this problem. The technique of whole-organ decellularization and recellularization has attracted increasing attention in the last decade. Decellularization includes the removal of all cellular components from an organ, while simultaneously preserving the micro and macro anatomy of the extracellular matrix. These bioscaffolds are subsequently repopulated with patient-derived cells, thus constructing a personalized neo-organ and ideally eliminating the need for immunosuppression. However, crucial problems have not yet been satisfyingly addressed and remain to be resolved, such as organ and cell sources. In this review, we focus on the actual state of organ de- and recellularization, as well as the problems and future challenges.
Topics: Animals; Bioreactors; Extracellular Matrix; Humans; Immunosuppression Therapy; Intestines; Kidney; Kidney Transplantation; Liver; Liver Transplantation; Lung; Lung Transplantation; Organ Transplantation; Pancreas; Pancreas Transplantation; Tissue Engineering; Tissue Scaffolds; Tissue and Organ Procurement; Waiting Lists
PubMed: 31099920
DOI: 10.1111/tri.13462 -
European Urology Focus Apr 2018Patients undergoing solid organ transplantation have experienced increased graft survival rates over the past several decades. With increased longevity making fatherhood... (Review)
Review
Patients undergoing solid organ transplantation have experienced increased graft survival rates over the past several decades. With increased longevity making fatherhood a viable option, many patients desire to pursue this path. However, many patients and practitioners are likely unaware of the feasibility and safety for a man on a transplant immunosuppression regimen to safely pursue fatherhood. In this review, we discuss effects of organ transplantation and post-transplantation treatment on male hormones, fertility, and the risk to potential offspring. Briefly, providers should be aware that organ transplant recipients may be at an increased risk for hypogonadism and erectile dysfunction, but fathering a child is a realistic and safe aspiration. PATIENT SUMMARY: In this mini-review, we discuss the effects of solid organ transplantation (such as lung, heart, kidney, and liver) on a man's sexual health, and his ability to have children. We focus on the most common problems encountered by patients after their transplant, and the effects of medications.
Topics: Erectile Dysfunction; Graft Survival; Heart Transplantation; Humans; Hypogonadism; Immunosuppression Therapy; Infertility, Male; Kidney Transplantation; Liver Transplantation; Lung Transplantation; Male; Organ Transplantation
PubMed: 30194032
DOI: 10.1016/j.euf.2018.08.012 -
The Journal of Nursing Research : JNR Nov 2020Organ transplantation was one of the greatest achievements of medical science during the 20th century. Knowledge, education, and culture all play prominent roles in...
BACKGROUND
Organ transplantation was one of the greatest achievements of medical science during the 20th century. Knowledge, education, and culture all play prominent roles in transplantation because of the complexity of the process from donation to transplantation.
PURPOSE
The aim of this research was to determine and analyze the knowledge and attitudes about organ donation and transplantation among the general population in Limassol, Cyprus.
METHODS
A quantitative research approach was followed, and a questionnaire consisting of closed-ended questions was completed by adults from the general population in Limassol.
RESULTS
One thousand two hundred adults out of the 1,346 adults who were contacted responded to the survey (response rate: 89%) and were included as participants. Of the participants, 93.4% (p < .05) considered organ donation to be lifesaving, 57% expressed interest (and 39.8% expressed disinterest) in becoming organ donors, 80.6% (p < .05) expressed awareness of there being a waiting list for people in need of organ transplantation, 50.4% agreed that brain death must be confirmed before organ removal for transplantation, and 47% recalled having been informed about organ donation through the media, with 31.5% stating that they had never been informed about organ donation.
CONCLUSIONS
The participants demonstrated limited awareness regarding the organ donation system in Cyprus. Furthermore, a significant percentage stated that they lacked a source for obtaining related information. The Cypriot society should be informed and encouraged to participate in organ donation to increase the rate of organ transplantation.
Topics: Adult; Cyprus; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Middle Aged; Organ Transplantation; Patient Acceptance of Health Care; Surveys and Questionnaires; Tissue Donors
PubMed: 33156139
DOI: 10.1097/jnr.0000000000000409 -
Critical Care Clinics Jan 2019Infections in solid organ transplant recipients are complex and heterogeneous. This article reviews the clinical syndromes that will likely be encountered in the... (Review)
Review
Infections in solid organ transplant recipients are complex and heterogeneous. This article reviews the clinical syndromes that will likely be encountered in the intensive care unit and helps to guide in the therapy and management of these patients.
Topics: Adult; Aged; Critical Care Nursing; Female; Humans; Infection Control; Male; Middle Aged; Organ Transplantation; Postoperative Care; Postoperative Complications; Practice Guidelines as Topic
PubMed: 30447777
DOI: 10.1016/j.ccc.2018.08.004 -
Arquivos Brasileiros de Cardiologia Aug 2022
Topics: Exercise Therapy; Humans; Organ Transplantation
PubMed: 35946687
DOI: 10.36660/abc.20220373 -
American Journal of Transplantation :... Oct 2019
Topics: Health Care Rationing; Health Policy; Humans; Organ Transplantation; Resource Allocation; Tissue Donors; Tissue and Organ Procurement
PubMed: 31267655
DOI: 10.1111/ajt.15521 -
Acta Biochimica Polonica 2018Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and... (Review)
Review
Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism. Fast cooling of the organ slows down metabolism and activates intracellular enzymes, which minimizes the effects of warm ischemia. Unfortunately, hypothermia also results in inhibition of ATP synthesis, cell swelling and intracellular acidity. That is why research is continually being conducted to develop new fluids for rinsing and storing organs, as well as to optimize the composition of those that are already in use, which will allow for longer and more effective graft storage and restoration of their optimal functions after transplantation. This article provides current information on rinsing and storage fluids available on the global market. It also discusses tips for the fluid modifications with hormones and micronutrients.
Topics: Humans; Organ Preservation Solutions; Organ Transplantation; Reperfusion Injury; Temperature
PubMed: 29352749
DOI: 10.18388/abp.2017_2312 -
Medicina (Kaunas, Lithuania) Jun 2020Bone and mineral disorders are common after organ transplantation. Osteoporosis post transplantation is associated with increased morbidity and mortality. Pathogenesis... (Review)
Review
Bone and mineral disorders are common after organ transplantation. Osteoporosis post transplantation is associated with increased morbidity and mortality. Pathogenesis of bone disorders in this particular sub set of the population is complicated by multiple co-existing factors like preexisting bone disease, Vitamin D deficiency and parathyroid dysfunction. Risk factors include post-transplant immobilization, steroid usage, diabetes mellitus, low body mass index, older age, female sex, smoking, alcohol consumption and a sedentary lifestyle. Immunosuppressive medications post-transplant have a negative impact on outcomes, and further aggravate osteoporotic risk. Management is complex and challenging due to the sub-optimal sensitivity and specificity of non-invasive diagnostic tests, and the underutilization of bone biopsy. In this review, we summarize the prevalence, pathophysiology, diagnostic tests and management of osteoporosis in solid organ and hematopoietic stem cell transplant recipients.
Topics: Aged; Body Mass Index; Bone Density; Cigarette Smoking; Disease Management; Female; Heart Transplantation; Hematopoietic Stem Cell Transplantation; Humans; Immobilization; Kidney Transplantation; Liver Transplantation; Lung Transplantation; Male; Organ Transplantation; Osteoporosis; Risk Factors; Steroids
PubMed: 32575603
DOI: 10.3390/medicina56060302 -
American Journal of Transplantation :... Jun 2015Variant anatomy may be challenging at retrieval, with failure to identify variance being associated with organ damage, particularly vascular damage. On implantation,... (Review)
Review
Variant anatomy may be challenging at retrieval, with failure to identify variance being associated with organ damage, particularly vascular damage. On implantation, some variants demand nonstandard techniques of reconstruction or implantation. This review covers the common and less common anatomical variants of the liver, kidney and pancreas, and gives guidance as to how they may be managed during organ retrieval and implantation.
Topics: Humans; Kidney; Kidney Transplantation; Liver; Liver Transplantation; Organ Transplantation; Pancreas; Pancreas Transplantation; Tissue and Organ Harvesting
PubMed: 25981150
DOI: 10.1111/ajt.13310