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Osteoarthritis and Cartilage Jan 2021Low back pain (LBP) is a common musculoskeletal symptom, which can be developed in multiple clinical diseases. It is widely recognized that intervertebral disc (IVD)... (Review)
Review
Low back pain (LBP) is a common musculoskeletal symptom, which can be developed in multiple clinical diseases. It is widely recognized that intervertebral disc (IVD) degeneration (IVDD) is one of the leading causes of LBP. However, the pathogenesis of IVD-related LBP is still controversial, and the treatment means are also insufficient to date. In recent decades, the role of structure and function changes of sensory nervous system in the induction and the maintenance of LBP is drawing more and more attention. With the progress of IVDD, IVD cell exhaustion and extracellular matrix degradation result in IVD structural damage, while neovascularization, innervation and inflammatory activation further deteriorate the microenvironment of IVD. New nerve ingrowth into degenerated IVD amplifies the impacts of IVD-derived nociceptive molecules on sensory endings. Moreover, IVDD is usually accompanied with disc herniation, which could injure and inflame affected nerves. Under mechanical and pro-inflammatory stimulation, the pain-transmitting pathway exhibits a sensitized function state and ultimately leads to LBP. Hence, relevant pathogenic factors, such as neurotrophins, ion channels, inflammatory factors, etc., are supposed to serve as promising therapeutic targets for LBP. The purpose of this review is to comprehensively summarize the current evidence on 1) the pathological changes of sensory nervous system during IVDD and their association with LBP, and 2) potential therapeutic strategies for LBP targeting relevant pathogenic factors.
Topics: Extracellular Matrix; Humans; Inflammation; Intervertebral Disc; Intervertebral Disc Degeneration; Intervertebral Disc Displacement; Ion Channels; Low Back Pain; Molecular Targeted Therapy; Neovascularization, Pathologic; Nerve Compression Syndromes; Nerve Growth Factors; Nociceptors
PubMed: 33007412
DOI: 10.1016/j.joca.2020.09.002 -
Indian Journal of Otolaryngology and... Dec 2022There exists paucity in recorded literature on the detailed microscopic appearance of elongated styloid processes (ESPs) in patients with Eagle's syndrome (ES). Although...
There exists paucity in recorded literature on the detailed microscopic appearance of elongated styloid processes (ESPs) in patients with Eagle's syndrome (ES). Although literature is replete with numerous conflicting and inconclusive theories, the exact cause, mechanism of origin, development and progression of styloid apparatus enlargement remains unclear and ambiguous. To carry out detailed histopathogical examination of excised specimen of ESPs in a patient with ES, with the objective to determine its precise etiomorphogenesis, and to analyse the role of possible triggering factors. Light microscopic examination was carried out of the base, mid- and apical thirds of transorally excised ESPs in a 45-year-old patient with ES. Woven bone trabeculae were found emanating from tendinous insertions of the styloid group of muscles at the mid third of the ESPs. Apical region of the ESPs showed fibro-collagenous mesenchymal tissue with numerous, haphazardly scattered trabeculae of woven bone traversing it. Presence of deeply staining reversal lines all along the length of the ESPs was suggestive of multiple micro-fractures from recurrent traumatic/traction forces, and repeated attempts at repair and ossification. It is proposed that mesenchymal structures composing the stylohyoid ligament at its attachment, and tendinous insertions of styloid muscles into the ESPs are stimulated to undergo metaplastic alterations, by repetitive stress, traction or traumatic stimuli brought to bear upon them, from muscular contractions. This osseous metaplasia of connective cells within them, followed by dystrophic bone deposition, brings about SP thickening and lengthening with their attendant and associated clinico-pathological sequelae.
PubMed: 36742717
DOI: 10.1007/s12070-021-02438-7 -
Anais Brasileiros de Dermatologia Jun 2024
PubMed: 38853108
DOI: 10.1016/j.abd.2023.05.012 -
International Journal of Retina and... Oct 2021Intraocular osseous metaplasia is a rare histological finding associated with benign cellular transformation. Its development requires inflammatory cytokines and the...
BACKGROUND
Intraocular osseous metaplasia is a rare histological finding associated with benign cellular transformation. Its development requires inflammatory cytokines and the process takes many years. Previous case reports of intraocular ossification manifested as linear calcification or white plaques. In contrast, our case presented with a tumor-like solid mass, in which a long-standing chronic inflammatory stimulation may contribute to the stunning appearance.
CASE PRESENTATION
This is a 48-year-old woman with past history of advanced Coat's-like retinopathy and chronic retinal detachment in the left eye for 12 years. She underwent vitreoretinal surgery to prevent phthisis bulbi. During the operation, a 9 mm solid mass was found embedded within the proliferative tissue above the retina and was removed. Pathological findings revealed bone formation in the center of the mass surrounded by fibrous metaplasia and focal gliotic changes. Layers of cohesive cells were found lining on the external side of the mass, and further immuno-histochemical study suggested them retinal pigment epithelial cells. Postoperatively, the retina was attached with stable visual acuity and normal intraocular pressure.
CONCLUSION
To our knowledge, the appearance of a tumor-like mass representing intraocular osseous metaplasia in eyes with chronic inflammation or retinal detachment has not been reported in previous case reports. This case emphasizes the importance of considering osseous metaplasia as one of the differential diagnoses of an unknown intraocular mass, especially in eyes with great severity of chronic inflammation. Also, our immuno-histochemical study provided more evidence on the pathological role of retinal pigment epithelial cells in developing ossification.
PubMed: 34645522
DOI: 10.1186/s40942-021-00331-7 -
Drug Delivery and Translational Research Apr 2016Repair of non-healing bone defects through tissue engineering strategies remains a challenging feat in the clinic due to the aversive microenvironment surrounding the... (Review)
Review
Repair of non-healing bone defects through tissue engineering strategies remains a challenging feat in the clinic due to the aversive microenvironment surrounding the injured tissue. The vascular damage that occurs following a bone injury causes extreme ischemia and a loss of circulating cells that contribute to regeneration. Tissue-engineered constructs aimed at regenerating the injured bone suffer from complications based on the slow progression of endogenous vascular repair and often fail at bridging the bone defect. To that end, various strategies have been explored to increase blood vessel regeneration within defects to facilitate both tissue-engineered and natural repair processes. Developments that induce robust vascularization will need to consolidate various parameters including optimization of embedded therapeutics, scaffold characteristics, and successful integration between the construct and the biological tissue. This review provides an overview of current strategies as well as new developments in engineering biomaterials to induce reparation of a functional vascular supply in the context of bone repair.
Topics: Animals; Biocompatible Materials; Bone Regeneration; Bone and Bones; Humans; Neovascularization, Pathologic; Tissue Engineering; Wound Healing
PubMed: 26014967
DOI: 10.1007/s13346-015-0236-0 -
The Pan African Medical Journal 2021Endometrial osseous metaplasia is a rare condition in which there is abnormal presence of bone in the endometrium. There is paucity of reported cases of this...
Endometrial osseous metaplasia is a rare condition in which there is abnormal presence of bone in the endometrium. There is paucity of reported cases of this pathological condition in Africa and it is usually overlooked as a cause of infertility. Pathogenesis is not well understood but mostly occurs following pregnancy. Pathology may be suspected on ultrasound scan where a linear echogenic substance is seen in the endometrium but diagnosis is confirmed by and treated with hysteroscopy. We present a case of a 43-year-old woman with 2 previous miscarriages who presented with secondary infertility. She had an ultrasound scan done which revealed features suggestive of an intra-uterine copper device. She subsequently had hysteroscopy and a bone-like foreign body was found in the endometrium which was removed with the aid of a grasper and later sent for histopathological evaluation for which a subsequent diagnosis of endometrial osseous metaplasia was made. Indeed, endometrial intraosseous metaplasia should be considered an important differential cause of secondary infertility especially in patients with history of previous miscarriage. Confirmatory diagnosis can be made through hysteroscopy and/or histopathologically although the former is now used.
Topics: Abortion, Spontaneous; Adult; Endometrium; Female; Humans; Hysteroscopy; Infertility, Female; Metaplasia; Ossification, Heterotopic; Ultrasonography
PubMed: 34804329
DOI: 10.11604/pamj.2021.40.61.30691 -
Case Reports in Urology 2015Paratesticular liposarcoma is a rare tumour of the genitourinary track but the most common of all sarcomas in adults. The dedifferentiated variation occurs only in 10%...
Paratesticular liposarcoma is a rare tumour of the genitourinary track but the most common of all sarcomas in adults. The dedifferentiated variation occurs only in 10% of liposarcoma cases. The typical clinical presentation is similar to an inguinal hernia or a benign lipoma. We present the case of a dedifferentiated paratesticular liposarcoma with osseous metaplasia of the spermatic cord, in a male presented with acute scrotum.
PubMed: 25960913
DOI: 10.1155/2015/965876 -
Archives of Pathology & Laboratory... Oct 2003Although a xanthogranuloma is a relatively common benign cutaneous condition and ossification has been observed within many cutaneous lesions, the association between...
Although a xanthogranuloma is a relatively common benign cutaneous condition and ossification has been observed within many cutaneous lesions, the association between ossification and xanthogranuloma has not, to our knowledge, been reported previously. We believe we describe for the first time the case of a xanthogranuloma with marked osseous metaplasia on the trunk of a 41-year-old woman. Microscopically, the lesion showed typical features of a xanthogranuloma, with the exceptional feature of exuberant bone formation. The presence of bone within this lesion is likely secondary to a metaplastic process.
Topics: Adult; Dermis; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Metaplasia; Ossification, Heterotopic
PubMed: 14521441
DOI: 10.5858/2003-127-e409-OAX -
The Pan African Medical Journal 2018Chondroid and osseous metaplasia in a Type II Papillary renal cell carcinoma (PRCC) with extensive solid areas is a complex histological combination that has not been...
Chondroid and osseous metaplasia in a Type II Papillary renal cell carcinoma (PRCC) with extensive solid areas is a complex histological combination that has not been reported before. A 21 years old male presented with a comminuted fracture of right femur. On hematological investigations he was found to have low RBC count and hemoglobin. Radiological examination revealed an incidental, exophytic complex solid and cystic, mass lesion measuring 7 x 6.5 x 4.9 cm with thickened walls, septation and calcification. It was completely replacing upper pole of the left kidney with extension into perinephric fat. Enlarged para aortic and hilar nodes with necrosis were also noted. Radiological diagnosis was infectious processes such as tuberculosis versus malignancy. Surgical intervention comprising left partial nephrectomy was done. Histopathology and immunohistochemical analysis yielded the above diagnosis. Cytogenetic studies did not reveal gain of chromosome 7 and/or 17 or loss of chromosome Y, a characteristic genetic profile of PRCC. This case could be representative of a unique histological variant of PRCC in which the molecular profile yet needs to be unraveled.
Topics: Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Metaplasia; Nephrectomy; Ossification, Heterotopic; Young Adult
PubMed: 30918553
DOI: 10.11604/pamj.2018.31.26.16137 -
Frontiers in Endocrinology 2024Osteoporosis (OP) is a chronic systemic bone metabolism disease characterized by decreased bone mass, microarchitectural deterioration, and fragility fractures. With the... (Review)
Review
Osteoporosis (OP) is a chronic systemic bone metabolism disease characterized by decreased bone mass, microarchitectural deterioration, and fragility fractures. With the demographic change caused by long lifespans and population aging, OP is a growing health problem. The role of miRNA in the pathogenesis of OP has also attracted widespread attention from scholars in recent years. Type H vessels are unique microvessels of the bone and have become a new focus in the pathogenesis of OP because they play an essential role in osteogenesis-angiogenesis coupling. Previous studies found some miRNAs regulate type H vessel formation through the regulatory factors, including platelet-derived growth factor-BB (PDGF-BB), hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF), and so on. These findings help us gain a more in-depth understanding of the relationship among miRNAs, type H vessels, and OP to find a new perspective on treating OP. In the present mini-review, we will introduce the role of type H vessels in the pathogenesis of OP and the regulation of miRNAs on type H vessel formation by affecting regulatory factors to provide some valuable insights for future studies of OP treatment.
Topics: Animals; Humans; Bone and Bones; MicroRNAs; Microvessels; Neovascularization, Pathologic; Osteogenesis; Osteoporosis
PubMed: 38883597
DOI: 10.3389/fendo.2024.1394785