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European Journal of Medical Research Nov 2013Here, we report a case of simultaneous osseous metaplasia nodules of the submucosa and mesosalpinx after a first trimester abortion.
OBJECTIVES
Here, we report a case of simultaneous osseous metaplasia nodules of the submucosa and mesosalpinx after a first trimester abortion.
CASE PRESENTATION
A 36-year-old woman presented to the Women's Hospital, School of Medicine, Zhejiang University with vaginal bleeding and infertility resulting from osseous metaplasia nodules of the submucosa and mesosalpinx after a first trimester abortion. Diagnostic and operative hysteroscopy and laparoscope procedures were performed. The osseous metaplasia nodules disappeared after hysteroscopy and laparoscope interventions; 2 weeks postoperatively, the patient underwent a transvaginal ultrasound examination and the abnormal ultrasound appearance had resolved.
CONCLUSIONS
Osseous metaplasia nodules in the submucosa and mesosalpinx can be a rare cause of vaginal bleeding and infertility. Autologous tissue, not persistent heterologous tissue, may be the true reason for metaplasia. Treatment is by ultrasound-guided curettage or by hysteroscopic and laparoscope removal.
Topics: Abortion, Spontaneous; Adult; Bone and Bones; Fallopian Tubes; Female; Humans; Hysterosalpingography; Metaplasia; Mucous Membrane; Multidetector Computed Tomography; Pelvis; Pregnancy; Pregnancy Trimester, First; Ultrasonography
PubMed: 24245923
DOI: 10.1186/2047-783X-18-47 -
Journal of Cytology 2024
PubMed: 38779610
DOI: 10.4103/joc.joc_115_23 -
Journal of Medical Case Reports Sep 2009Endometrial ossification is an uncommon disease related to secondary infertility and its etiology and pathogenesis are controversial. More than 80% of reported cases...
INTRODUCTION
Endometrial ossification is an uncommon disease related to secondary infertility and its etiology and pathogenesis are controversial. More than 80% of reported cases occur after pregnancy.
CASE PRESENTATION
A 33-year-old Caucasian woman was admitted with a history of secondary infertility and with a regular menstrual cycle. She reported a miscarriage at 12 weeks of gestation 7 years previously and subsequent dilatation and curettage in another medical facility. Vaginal ultrasound was performed and showed an intrauterine structure described as a hyperechogenic image suggesting calcification related to chronic endometritis. Office hysteroscopy revealed a wide endometrial cavity and proliferative endometrium, with a coral-like white plaque 1.5 cm in length on the right horn and posterior wall of the uterus. The lesion was treated by hysteroscopy without complications. Microscopic examination showed endometrial tissue with osseous metaplasia in the stroma. Nine months after the procedure, the patient became pregnant spontaneously.
CONCLUSION
In our patient, hysteroscopy was effective in the diagnosis and treatment of osseous metaplasia of the endometrium associated with infertility.
PubMed: 20687904
DOI: 10.4076/1752-1947-3-7427 -
Case Reports in Urology 2015Renal cell carcinoma (RCC) is the most common kidney malignancy, with many histologic subtypes. One of the rare forms of RCC is mucinous tubular and spindle cell...
Renal cell carcinoma (RCC) is the most common kidney malignancy, with many histologic subtypes. One of the rare forms of RCC is mucinous tubular and spindle cell carcinoma (MTSCC), which is newly described with limited information on clinical picture and outcome. Heterotopic bone formation (osseous metaplasia) is a rare finding within any renal mass. Here we report a case of a massive, bilateral MTSCC with histologic findings of heterotopic bone formation, which has not been described before.
PubMed: 26347846
DOI: 10.1155/2015/465450 -
International Journal For Parasitology.... Apr 2022A female Cuvier's Beaked Whale () specimen measuring 580 cm in length died after being stranded in Southeastern Brazil. Following a necropsy, organ samples were...
A female Cuvier's Beaked Whale () specimen measuring 580 cm in length died after being stranded in Southeastern Brazil. Following a necropsy, organ samples were obtained, fixed in 10% neutral buffered formalin and histopathologically analyzed. A severe and generalized hypodermis infection by (Phyllobothriidae) was observed, resulting in granulomatous panniculitis. Severe renal and arterial lesions were also noted, including a severe bone metaplasia in the aorta artery, associated with a massive infection by sp, (Tetrameridae). A significant thoracic hemorrhage due to thoracic aorta artery rupture was noted, also likely due to this infection, resulting in a fatal injury. This study contributes towards knowledge on histopathologic changes in the scarcely studied Cuvier's Beaked Whale, is the first to associate a sp. infection in this whale species in the Brazilian region and also the first to indicate a resulting osseous metaplasia due to this parasitism and granulomatous dermatitis associated with . Furthermore, this is also, to the best of our knowledge, the first report of cysts in a specimen to date.
PubMed: 34984168
DOI: 10.1016/j.ijppaw.2021.12.005 -
Human Pathology May 2017Heterotopic ossification (HO, also termed myositis ossificans) is the formation of extra-skeletal bone in muscle and soft tissues. HO is a tissue repair process gone...
Heterotopic ossification (HO, also termed myositis ossificans) is the formation of extra-skeletal bone in muscle and soft tissues. HO is a tissue repair process gone awry, and is a common complication of surgery and traumatic injury. Medical strategies to prevent and treat HO fall well short of addressing the clinical need. Better characterization of the tissues supporting HO is critical to identifying therapies directed against this common and sometimes devastating condition. The physiologic processes of osteogenesis and angiogenesis are highly coupled and interdependent. However, few efforts have been made to document the vascular patterning within heterotopic ossification. Here, surgical pathology case files of 29 human HO specimens were examined by vascular histomorphometric analysis. Results demonstrate a temporospatial patterning of HO vascularity that depends on the "maturity" of the bony lesion. In sum, human HO demonstrates a time- and space-dependent pattern of vascularization suggesting a coupled pathophysiologic process involving the coordinate processes of osteogenesis and angiogenesis. Further imaging studies may be used to further characterize vasculogenesis within HO and whether anti-angiogenic therapies are a conceivable future therapy for this common condition.
Topics: Adolescent; Adult; Aged; Arteries; Baltimore; Biopsy; Blood Vessels; Bone and Bones; Capillaries; Child; Female; Humans; Los Angeles; Male; Middle Aged; Neovascularization, Pathologic; Ossification, Heterotopic; Osteoblasts; Osteogenesis; Time Factors; Veins; Young Adult
PubMed: 28315426
DOI: 10.1016/j.humpath.2017.03.005 -
Antioxidants & Redox Signaling Oct 2014Significance: Patients with diabetes mellitus suffer an excess of cardiovascular complications and recover worse from them as compared with their nondiabetic peers. It... (Review)
Review
UNLABELLED
Significance: Patients with diabetes mellitus suffer an excess of cardiovascular complications and recover worse from them as compared with their nondiabetic peers. It is well known that microangiopathy is the cause of renal damage, blindness, and heart attacks in patients with diabetes. This review highlights molecular deficits in stem cells and a supporting microenvironment, which can be traced back to oxidative stress and ultimately reduce stem cells therapeutic potential in diabetic patients.
RECENT ADVANCES
New research has shown that increased oxidative stress contributes to inducing microangiopathy in bone marrow (BM), the tissue contained inside the bones and the main source of stem cells. These precious cells not only replace old blood cells but also exert an important reparative function after acute injuries and heart attacks.
CRITICAL ISSUES
The starvation of BM as a consequence of microangiopathy can lead to a less efficient healing in diabetic patients with ischemic complications. Furthermore, stem cells from a patient's BM are the most used in regenerative medicine trials to mend hearts damaged by heart attacks.
FUTURE DIRECTIONS
A deeper understanding of redox signaling in BM stem cells will lead to new modalities for preserving local and systemic homeostasis and to more effective treatments of diabetic cardiovascular complications.
Topics: Animals; Bone Marrow; Cell Differentiation; Cell Survival; Cellular Microenvironment; Cellular Senescence; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Endothelium; Hematopoiesis; Homeostasis; Humans; MicroRNAs; Neovascularization, Pathologic; Oxidative Stress; Reactive Oxygen Species; Signal Transduction
PubMed: 25089632
DOI: 10.1089/ars.2014.5944 -
Experimental Animals Apr 1995Myocardial infarction was induced by ligation of the coronary artery in fifteen 32-week-old male spontaneously hypertensive rats (SHR) and fifteen 32-week-old male... (Comparative Study)
Comparative Study
Myocardial infarction was induced by ligation of the coronary artery in fifteen 32-week-old male spontaneously hypertensive rats (SHR) and fifteen 32-week-old male normotensive Wistar-Kyoto rats (WKY). Age-matched male SHR (n = 6) and WKY (n = 7) without the operation were used as non-infarcted control rats. Four weeks after the operation, cartilaginous metaplasia and osseous metaplasia were observed histopathologically in all SHR and 13 of the 15 WKY with myocardial infarction, but not in the control rats. The mean rates of infarction to the heart and the mean areas of metaplasia per rat showing metaplasia were greater in SHR than in WKY. The metaplastic areas were well correlated with the infarct percentage in SHR. It is therefore considered that extensive myocardial infarction is associated with the pathogenesis of cartilaginous and osseous metaplasia.
Topics: Animals; Bone and Bones; Cartilage; Hypertension; Incidence; Male; Metaplasia; Myocardial Infarction; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY
PubMed: 7601227
DOI: 10.1538/expanim.44.163 -
Breast Cancer (Dove Medical Press) 2021Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show... (Review)
Review
Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies.
PubMed: 33664587
DOI: 10.2147/BCTT.S296784 -
BMC Medical Imaging Aug 2015Ossifying metaplasia is an unusual feature of urothelial carcinoma, with only a few cases reported. The largest series included 17 cases and was published in 1991. The... (Review)
Review
BACKGROUND
Ossifying metaplasia is an unusual feature of urothelial carcinoma, with only a few cases reported. The largest series included 17 cases and was published in 1991. The mechanism of ossification is unknown and hypotheses of osteogenic precursor cells, inducing bone formation, are proposed.
CASE PRESENTATION
A 75 year-old patient was treated for a high grade transitional cell carcinoma of the bladder by surgery, chemotherapy and radiotherapy. Histology showed foci of bone metaplasia, both at the periphery of the tumor, and in a lymph node metastasis. 1 year later, a heterotopic bone formation was discovered in the right retroperitoneal space, near the lumbar spine, increasing rapidly in size during follow-up. Several imaging exams were performed (2 CT, 1 MRI, 1 Pet-CT), but in the absence of typical features of sarcoma, diagnosis remained unclear. Histology of a CT-guided percutaneous biopsy showed urothelial carcinoma and mature lamellar bone. Integration of these findings with the radiological description of extraosseous localization was consistent with a diagnosis of osseous metaplasia of an urothelial carcinoma metastasis. The absence of bone atypia in both the primary and metastases argues against sarcomatoid urothelial carcinoma with osteosarcomatous differentiation.
CONCLUSION
Osseous metaplasia of an urothelial carcinoma metastasis is unusual, and difficult to distinguish from radiotherapy induced sarcoma, or from sarcomatoid carcinoma. Rapid progression, sheathing of adjacent structures such as vessels (like inferior vena cava in our case) and nerves and bony feature of lymph node metastases necessitate histological confirmation and rapid treatment. Our case illustrates this disease and evaluates the imaging features. In addition we discuss the differential diagnosis of osseous retroperitoneal masses.
Topics: Aged; Carcinoma, Transitional Cell; Diagnosis, Differential; Humans; Lymphatic Metastasis; Male; Ossification, Heterotopic; Urinary Bladder Neoplasms
PubMed: 26264044
DOI: 10.1186/s12880-015-0072-1